Matches 101 - 150 out of 319 < 1 2 3 4 5 6 7 >
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5747423 Herbicidal 6-thienyl and 4-thienyl pyrimidines  
The novel 6-thienyl pyridines and 4-thienyl pyrimidines of formula I: ##STR1## (A, R 1 to R 5 and Z are defined in the specification) show selective herbicidal activity. The new compounds can be...
5710170 Tri-aryl ethane derivatives as PDE IV inhibitors  
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the...
5710160 Diphenyl pyridyl ethane derivatives as PDE IV inhibitors  
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the...
5708171 Imidazole derivatives for pharmaceutical use  
A compound selected from the group consisting of a compound of the formula ##STR1## having antagonist properties to histamine H 3 -receptors.
5698674 Triheterocyclic peptides capable of binding the minor and major grooves of DNA  
The present invention provides a triheterocyclic peptide having first, second, and third 5-member heterocyclic moieties having the following formula CR 3 CONH--Q 1 --CONH--Q 2 --CONH--Q 3 ...
5665746 Mono- and bicyclic DNA gyrase inhibitors  
The present invention relates to a compound of the formula ##STR1## wherein X 1 , R 1 , R 2 , OP, R 3 , R 4 , R 5 , R 6 , and R 0 are as described herein, and their pharmaceutically acceptable...
5665738 Imidazole derivatives and processes for the preparation thereof  
Novel imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: ##STR1## wherein: A is a straight, branched or cyclic C 1 ...
5663350 Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists  
The present invention relates to a novel process for the preparation of highly potent histamine receptor antagonists, in particular histamine H 3 -receptor antagonists. Also disclosed is a novel...
5659065 Alpha-aminoalkanoic acids and reduction products  
Compounds of formula I ##STR1## wherein R 1 is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or heteroaromatic radical, a hydroxy group that is aliphatically, araliphatically or...
5637262 Photochromic substituted naphthopyran compounds  
Described are novel reversible photochromic 3H-naphtho[2,1-b]pyran compounds, of the following graphic formula: ##STR1## wherein R 1 is hydrogen or alkyl, R 2 is hydrogen or preferably a...
5635521 Imidazolylmethyl-pyridines  
Compounds of formula I, ##STR1## wherein R 1 to R 4 possess the significances given in the description, may be used in the treatment of senile dementia, Alzheimer's disease and depression.
5622977 Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same  
Compounds of the general formula (1) ##STR1## are described wherein Y is halogen or --OR 1 , where R 1 is a substituted or unsubstituted alkyl; X is --O--, --S-- or --N(R 8 )--, where R 8 is...
5621010 Urea derivatives and their use as ACAT inhibitors  
Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those...
5616579 Anti-ulcer pyridyloxy derivatives, their preparation and uses  
Compounds of formula (I): ##STR1## [wherein: R 1 is a cyclic amino group, or a dialkylamino group; R 2 a group of formula --NHCHR 3 R 4 wherein R 3 and R 4 are each alkyl aryl or aralkyl, or...
5616725 Pyrrolo[3,4-C]pyrrole synthesis  
Pyrrolo[3,4-c]pyrroles of formula ##STR1## wherein D and E are each independently of the other a group of formula ##STR2## The symbols Q, R 8 , R 9 , R 10 , R 11 , X, Y, Z, m and n are as defined...
5610297 Peptides ketoamides  
A novel class of peptide α-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally...
5587390 Imidazole derivatives having a II antagonist activity  
Imidazole derivatives having A II antagonist activity, of Formula I, the processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof as therapeutic...
5580888 Styryl derivatives as anti-inflammatory agents  
Compounds of general formula (1) ##STR1## are described wherein Y is a halogen atom or a group --OR 1 , wherein R 1 is an optionally substituted alkyl group; X is --O--, --S-- or --N(R 6 )--,...
5574034 Pyrrolyl naphthopyrans  
The invention provides pharmaceutical compounds of the formula: ##STR1## in which A - - - B is CH 2 --CH 2 or CHCH; X is a pyridine or benzene ring; when X is pyridine n is 0; when x...
5569763 Hydrazone compound and the use thereof  
Hydrazone compound useful as an excellent organic nonlinear optical material and a highly sensitive coloring chelation agent, represented by the following formula (1): ##STR1## wherein Ar is a...
5561142 Substituted sulfonamides as selective β.sub.3 agonists for the treatment of diabetes and obesity  
Substituted sulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis...
5552402 Five-membered heteroaromatic compounds as 5-HT receptor agonists  
A class of substituted five-membered heteroaromatic compounds are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular...
5545651 Imidazole 5-position substituted angiotensin II antagonists  
Novel substituted imidazoles of Formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##
5545655 Substituted oxathiolanes  
This invention relates to novel imidazole and triazole substituted oxathiolane compounds and compositions containing said compounds having fungicidal and plant growth regulant activity and methods...
5543522 Process for preparing an ambient temperature molten salt using thionyl chloride  
There are disclosed a process for preparing an ambient temperature molten salt, which comprises treating an ambient temperature molten salt consisting essentially of 20 to 50 mole % of an aluminum...
5527922 Pyrrolo[3,4-c]pyrroles containing cyanimino groups  
The invention relates to pyrrolo[3,4-c]pyrroles of formula ##STR1## wherein D and E are each independently of the other hydrogen, C 1 -C 18 alkyl, C 2 -C 4 alkenyl, C 7 -C 10 aralkyl,...
5523312 Antipicornaviral agents  
Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1##...
5521179 Heterocyclic amides  
The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also...
5514693 Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines and process for their preparation  
Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines of formula (I) ##STR1## wherein Het is ##STR2## A represents a direct linkage, --CH 2 --, CH 2 --CH 2 -- or, when...
5508426 Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation  
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I:...
5506227 Pyridine-substituted benzyl alcohols as leukotriene antagonists  
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents....
5484943 Pyrrolo[3,4-c]pyrroles  
Pyrrolo[3,4-c]pyrroles of formula ##STR1## wherein D and E are each independently of the other a group of formula ##STR2## The symbols Q, R 8 , R 9 , R 10 , R 11 , X, Y, Z, m and n are as defined...
5474998 Arthropodicidal pyrazolines, pyrazolidines and hydrazines  
Arthropodicidal pyrazoline, pyrazolidine and hydrazine compounds, including all their geometric and stereoisomers, agriculturally suitable salts thereof and compositions containing them; and a...
5470982 Disubstituted pyridines  
For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R 1 is optionally substituted aryl or heteroaryl, R 2 is cycloalkyl...
5463071 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical compositions containing these compounds  
Compounds of the formula ##STR1## wherein X 1 to X 5 are as defined herein, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically...
5447949 N-(heteroaryl) imidazolyl-alkenoic acids having angiotension II receptor antagonist activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5444080 Substituted [1H-imidazol-5-ylialkanoic acids having angiotension II receptor antagonist activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5416097 Potassium channel activators/openers  
This invention relates to novel potassium channel activators and their acid addition salts. The compounds of the invention as potassium channel activators/openers have therapeutic value in a number...
5412104 Ester and alkoxy substituted benzopyrans  
Compounds useful as antihypertensive agents and useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0:...
5405830 Herbicidal bicyclic ethers  
This invention relates to certain herbicidal ethers, agriculturally suitable compositions thereof, and a method for their use as broad spectrum preemergent or postemergent herbicides.
5391762 Nir dyes, methods of preparing them and their use  
The compounds of the formula I ##STR1## in which Y and Y 1 are each, independently of one another, O, S, NH or N-alkyl, N-cycloalkyl, N-phenyl or N-benzyl, or Y and Y 1 are together N-alkylene-N,...
5385919 Imidazolinyl indole derivatives useful in the treatment of diabetes  
The invention relates to compound of formula I: ##STR1## wherein R 1 is hydrogen or hydroxy; R 2 is hydrogen or methyl; R 3 is hydrogen or methyl; and R is 2-pyridyl, 3-pyridyl or --C 6 H 4 ...
5362729 Dihydropyridine derivatives useful in antitumor therapy  
Compounds which are useful in anti-tumors therapy having the formula (I) ##STR1## wherein Het imidazole, A represents a direct linkage at the phenyl 4-position: R is hydrogen; one of R 3 and R 4 ...
5360910 Pesticidal 1-aryl-5-(substituted alkylideneimino)pyrazoles  
The invention describes novel 1-aryl-5-(substituted alkylideneimino)pyrazoles of formula (I) ##STR1## wherein typically preferred substituents are: R 1 is cyano, nitro, or halogen; R 2 is R 9 ...
5356891 Phenylalkyl amine derivatives having anti-ischaemic activity  
The present invention relates to compounds having anti-ischaemic activity of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 and Z are as defined herein. The present invention further...
5352687 Substituted phenylacetamides  
Substituted phenylacetamides can be prepared by reaction of appropriately substituted phenylacetic acids with imidazoles and subsequent amidation. The substituted phenylacetic acid derivatives can...
5338740 Angiotensin II receptor antagonists  
The present invention relates to novel heterocyclic derivatives of the formula Ar--W--Het wherein Ar, W and Het are as defined below, and related compounds, pharmaceutical compositions comprising...
5316852 Coated material and the use thereof  
A coated material comprising a substrate which is coated with a layer of a pyrrolopyrrole of formula I ##STR1## wherein R 1 and R 2 may be 4-pyridyl and X 1 and X 2 are O, said compound of...
5298512 Substituted chromans and their use in the treatment of asthma, arthritis and related diseases  
Substituted chromans which by inhibiting 5-lipoxygenase enzyme are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction, stroke and related disease...
5296493 1-substituted-2-(N-pheny l-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells  
The present patent application discloses compounds of the formula ##STR1## wherein R 1 is C 1 -10 saturated or unsaturated alkyl; or ##STR2## wherein R'" is H or ##STR3## R 2 is phenyl which is...
Matches 101 - 150 out of 319 < 1 2 3 4 5 6 7 >