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6838475 |
Imidazolidinones as NS3-serine protease inhibitors of hepatitis C virus
The present invention discloses novel imidazolidinones which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
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6833375 |
N-&lsqb 4-(heteroarylmethyl)phenyl&rsqb -heteroarylamines
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R 1 is...
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6706711 |
Pyrazole derived kinase inhibitor
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein R 1 , R 2 , T, n and Q are as described in the specification. The compounds are useful for...
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6683192 |
Small organic molecule regulators of cell proliferation
A compound represented in general formula (X) and (XI):
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6683097 |
Imidazole derivatives
Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating...
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6642379 |
Benzamide derivatives, insecticides for agricultural and horticultural use and usage thereof
Benzamide derivatives represented by the general formula (I): and insecticides for agricultural and horticultural use and usage thereof, wherein Z 1 is O or S; R is H, (substituted) alkyl, or...
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6576656 |
Oxindole derivative
An oxindole of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser: wherein R 1 , R 2 , R 3 and R 4 are independently hydrogen,...
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6566359 |
2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs
A new series of derivatives of 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid and their synthesis have been discovered. Surprisingly, by modifying the substituent of the 3-carboxylic...
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6562817 |
Tricyclic compound
The present invention provides a compound of the formula (I): wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5-...
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6562861 |
Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl,...
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6548519 |
Pyridoxine and pyridoxal analogues: novel uses
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions...
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6534503 |
Melanocortin receptor-3 ligands to treat sexual dysfunction
Methods for treating sexual dysfunction, such as erectile dysfunction or sexual arousal disorder, with a compound having the generic formula X 1 —X 2 -(D)Phe-Arg-(D)Trp-X 3 . A particularly...
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6518287 |
Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists
The present invention discloses novel substituted imidazole compounds which have either or dual histamine-H 1 and H 3 receptor antagonist activity as well as methods for preparing such compounds....
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6495550 |
Pyridine-substituted benzanilides as potassium ion channel openers
The present invention provides a genus of pyridine-substituted benzanilides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and...
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6479666 |
Phenyl-keto-imidazolidine thioamide derivatives
It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4...
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6465493 |
Triarylimidazoles
Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 , R 2 and R 3 are various substituent groups; and one of X 1 and X 2 is N or CR′, and the other is NR′...
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6465486 |
Pyridyl/quinolinyl imidazoles
Certain imidazo pyridines/quinolines of the formula: where n is 0, 1, 2; X is independently selected from the group consisting of C 1-4 alkyl, bromine, chlorine, iodide, trifluoromethyl, C 1-4...
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6458950 |
Compounds and pharmaceutical compositions containing the same
A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the...
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6420384 |
Proton pump inhibitors
Compounds and methods of treating or preventing bone disorders including osteoporosis, rheumatoid arthritis, and metastatic bone disease are provided. The inventive compounds comprise a bone...
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6417204 |
Pyridoxine AMD pyridoxal analogues: cardiovascular therapeutics
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions...
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6407103 |
Indeno &lsqb 1,2-c&rsqb pyrazol-4-ones and their uses
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases,...
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6399606 |
Neuroprotective agents and methods related thereto
Neuroprotective agents are disclosed having the following structure: wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Such compounds have utility in the treatment of conditions...
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6344564 |
Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones
Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones, processes for their preparation, fungicidal compositions containing them, and methods of using them to treat or prevent fungal disease in...
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6329371 |
α-substrates benzyl heterocyclic derivatives, intermediates for producing the same and agrochemical composition containing the same as active ingredient
A compound represented by the formula (I): ##STR1## wherein R 1 is an optionally substituted heterocyclic group; R 2 is optionally substituted aryl or heterocyclic group; R 3 is hydrogen, alkyl,...
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6297256 |
Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
Disclosed are aryl and heteroaryl substitated pyridino compounds. These compounds are highly selective agonists, antagonists or inverse agonists for GABA A brain receptors or prodrugs of agonists,...
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6277865 |
Piperididinyl and N-amidinopiperidinyl derivatives
This invention is directed to a compound of formula I which is useful for inhibiting the activity of Factor Xa, by combining said compound with a composition containing Factor Xa. The present...
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RE37303 |
Imidazole compounds and their therapeutic applications
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having antagonist properties to histamine H 3 ...
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6245774 |
Tri-substituted phenyl or pyridine derivatives
Compounds of general formula (1) are described: ##STR1## wherein W-- is (1) C(Y)-- where Y is a halogen atom, or an alkyl or --XR a group where X is --O--, --S(O) m -- [where m is zero...
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6232329 |
Tetrahydropyridine-(or 4-hydroxypiperidine) alkylazoles
The present invention relates to the compounds of general formula ##STR1## used as medicaments possessing therapeutic activity for the treatment of anxiety, psychosis, epilepsy, convulsion,...
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6221886 |
Thio acid derived monocyclic N-heterocyclics as anticoagulants
This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to...
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6194438 |
Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one, and compositions and methods for inhibiting abnormal cell growth comprising said derivatives
The present invention relates to compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are as defined herein. The invention also relates to pharmaceutical compositions containing...
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6187929 |
Dye usable for photographic lightsensitive material, fine solid particle dispersion of said dye and silver halide photographic lightsensitive material containing said fine solid particle dispersion of said dye
A dye represented by the following formula (1); Formula (1) ##STR1## wherein A represents an acidic nucleus, L 1 , L 2 and L 3 represent a methine group, n represents 0, 1 or 2, Z...
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6166028 |
Diaminopuridine-containing thiourea inhibitors of herpes viruses
Compounds of the formula ##STR1## are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus,...
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6133202 |
Cyclohexenone oxime ether metal salts
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6103733 |
Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
An HDL cholesterol level inducing compound and a method of administering the compound having the structural formula I. ##STR1## wherein n is 1 or 2; R 1 is a heteroaromatic substituent...
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6100404 |
Erythromycin compounds
Intermediates for the preparation of compounds selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## n is an integer from 3 to 5, Ar is an optionally...
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6011039 |
Aminopyridine derivatives
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for hyperphagia, obesity or diabetes, which comprises such a compound or...
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6004985 |
Thio acid derived monocylic N-heterocyclics as anticoagulants
This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to...
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6004963 |
Substituted 2, 4-imidazolidinedione compounds as pharmaceutical active ingredients
A substituted 2,4-imidazolidinedione compound corresponding to the formula I ##STR1## a process for production thereof and the use of these compounds in a pharmaceutical preparation are described....
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5972971 |
Fungicidal active compound combinations
The present application relates to new active compound combinations composed, on the one hand, of prior art compounds metaconazole,...
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5932606 |
Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors
A compound which inhibits human thrombin and where has the structure and pharmaceutically acceptable salts thereof, wherein such as ##STR1## which are useful for inhibiting formation of blood...
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5932740 |
Thioheterocyclic near-infrared dyes
Disclosed is a novel near-infrared absorbing dye of formula: ##STR1## wherein X 1 , X 2 independently represents --CR 8 R 9 --, --S--, --Se--, --NR 10 --, --CHCH-- or --O--; n is an integer...
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5925651 |
Inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
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5877119 |
Substituted pyridine compounds
Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR 2 moiety where R 2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as...
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5872136 |
Arylheteroaryl inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
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5861407 |
Tetrahydropyridine derivatives as dopamine receptor subtype ligands
A class of substituted 1,2,3,6-tetrahydropyridine derivatives are disclosed that are ligands for dopamine receptor subtypes within the body. These compounds are therefore useful in the treatment...
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5856343 |
Imidazolylmethyl-pyridines used for senile dementia
Compounds of formula I, ##STR1## wherein R 1 to R 4 possess the significances given in the description, may be used in the treatment of senile dementia, Alzheimer's disease and depression.
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5854232 |
Acyclic anc cyclic amides as neurotransmitter release enhancers
This invention relates to compounds of formula (IA), (IB), (IC) or (ID), wherein m, X, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 14 and the dotted lines are as defined below, their pharmaceutically...
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5801115 |
Catalyst composition and methods for using and preparing same
A catalyst composition for a catalyst that reduces the emissions of sulfur compounds from industrial processes is disclosed. This catalyst is a spheroidal particle comprised of a mixture of...
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5760029 |
Spirocycle integrin inhibitors
This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3- 8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro- 4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are...
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