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7632950 |
Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them
The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention...
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7629337 |
Chemokine receptor binding heterocyclic compounds
Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert...
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7625930 |
Chelating agents and highly luminescent and stable chelates and their use
This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates,...
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7622475 |
EP2 agonists
The invention provides EP2 agonists, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for lowering...
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7622486 |
Pyridine compounds, process for their preparation and compositions containing them
The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a...
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7612153 |
Heterobifunctional poly(ethylene glycol) and uses thereof
The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of...
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7560563 |
Process for producing 2-substituted pyridine derivative
The present invention provides a method of producing a pyridine derivative having a substituent at the 2-position of a heterocyclic structure conveniently and with fine selectivity. The present...
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7534802 |
Compounds having 4-pyridylalkylthio group as substituent
A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a...
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7524966 |
Method for preparing ladderanes
Ditopic molecules in the form of linear reaction templates have been used to construct ladder-like hydrocarbons known as [n]-ladderanes (n=3,5). The templates assemble and position reactant...
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7507817 |
Prostaglandin prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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7501413 |
Dicarboxamide derivatives
The invention is concerned with novel dicarboxamide derivatives of formula (I)
wherein A, B, R c , D and E are as defined in the description and in the claims, as well as physiologically...
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7468437 |
Phenyl pyrrolidine ether tachykinin receptor antagonists
The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular...
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7465811 |
Indoline compounds
Sulfonylindoline compounds of formula I,
wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
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7456197 |
Pyridinium cationic lipids as gene transfer agents
Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of...
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7427693 |
Polar liquid crystal
Compounds that are useful in compositions for flat panel displays, for example, are provided. The compounds provided are polar, and are useful in low threshold voltage mixtures. The compounds...
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7414359 |
Low work function metal complexes and uses thereof
The present invention provides conductive metal-ligand coordination complexes that are useful in a variety of electronic devices. For example, such complexes are useful in organic light emitting...
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7410979 |
Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
The present invention relates to anti-HCV dihaloacetamide compounds in synergistic combination with an interferon and/or ribavirin and pharmaceutical compositions thereof for inhibition of the...
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7388021 |
Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various...
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7371763 |
Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in...
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7351826 |
Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds
The invention provides compounds of Formula (I) that bind to GABA A receptors. In the above formula, variables are defined herein. Such compounds may be used to modulate ligand binding to GABA A ...
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7326723 |
Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same
The present invention relates to compounds of formula (I):
in which
X represents N or CH; R 1 represents a hydrogen or halogen atom or a CF 3 group; n is an integer from 1 to 5; A...
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7319149 |
Chelants and macrocyclic metal complex radiopharmaceuticals thereof
Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes...
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7304066 |
Pyridyl cyanoguanidine compounds
Compounds according to formula (I)
wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C 1-6 hydrocarbon radical, optionally substituted with...
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7291631 |
CXCR4 chemokine receptor binding compounds
The present invention relates to compounds that bind to chemokine receptors, and having the formula
wherein each A, X, Y, R 1 , R 2 and R 3 are substituents. The present invention also...
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7291739 |
Chiral catalysts for asymmetric acylation and related transformations
A chiral catalyst comprising a 3, 4-disubstituted pyridine, or a salt, N functionalised derivative, dimer or oligomer thereof, wherein the 3-substituent is substantially hindered from rotation...
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7247735 |
Octupolar molecules used as organic semiconductors
In the case of the materials according to the invention, the charge carrier mobility in the correspondingly prepared films is achieved if the molecules are composed in such a way that side...
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7244748 |
Pyridines for treating injured mammalian nerve tissue
The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited...
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7238714 |
Aryl or heteroaryl amide compounds
This invention provides a compound of the formula (I):
wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R 1 and R 2 ...
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7235658 |
Imidazol derivatives as Raf kinase inhibitors
Compounds of formula (I):
wherein
X is O, CH 2 , S or NH, or the moiety X—R 1 is hydrogen; V is CH or N; R 1 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, arylC 1-6 alkyl,...
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7226935 |
Hypoglycemic agent
A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent...
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7217299 |
Dye composition comprising at least one direct dye of the azo-pyridinio-pyridone family and at least one different synthetic dye, and process
The present invention relates to a dye composition comprising, as direct dye, at least one dye of the azo-pyridinio-pyridone family and at least one synthetic dye different from the first dye. The...
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7211578 |
Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity
This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the...
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RE39575 |
Substituted thioacetamides
The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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7202260 |
VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones
Novel VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones and their use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are selected.
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7202093 |
Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds
Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated...
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7199136 |
1,4-dihydro-1,4-diphenylpyridine derivatives
The invention relates to novel 1,4-dihydro-1,4-diphenylpyridine derivatives of formula (I)
wherein the variable groups are as defined in the text and claims. Processes for their preparation,...
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7173046 |
CD40:CD154 binding interrupter compounds and use thereof to treat immunological complications
The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with...
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7129235 |
Amides useful for treating pain
The present invention relates to compounds of formula (I-VII)
or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R 6 , R 7 and R 8 are defined herein. The present...
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7129252 |
Six membered amino-amide derivatives an angiogenisis inhibitors
The present invention relates to six membered amino-amide derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment...
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7109218 |
Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same
Compounds of the formula (I)
a process for their preparation and their use as medicaments are described.
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7109220 |
Amino substituted pyridinyl methanone compounds useful in treating kinase disorders
The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are...
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7087603 |
Pyrazole compounds useful as protein kinase inhibitors
This invention describes novel pyrazole compounds of formula IV:
wherein Z 1 or Z 2 is nitrogen, Q is —S—, —O—, —N(R 4 )—, —C(R 6′ ) 2 —, 1,2-cyclopropanediyl,...
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7045536 |
Compound having anti-viral activity
The present invention discloses an organic ionic compound having anti-viral activity and the method for antagonizing virus in vitro by putting the compounds in contact with the virus.
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7022858 |
Unsymmetrical methine and polymethine dye-molecules for fluorescent intracellular applications
A new class of alpha-cyanomethine and alpha-cyanopolymethine dyes is provided having moieties which serve for the covalent attachment to biological substrates and resulting in the fluorescent...
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6995175 |
Chemical derivatives and their application as antitelomerase agent
The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their...
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6989397 |
Iron chelators and uses thereof
The present invention provides 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) analogues suitable for use as an in vivo iron chelators, the PCIH analogue having Formula 1:
wherein R1 is...
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6960599 |
Heterocyclic aminoalkylpyridine derivatives as psychopharmaceuticals
The invention relates to heterocyclic aminoalkylpyridine derivatives of the formula I:
where
R 1 is the radical of a heterocycle having 1 to 3 ring structures, where each ring structure is...
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6949655 |
Acyclic piperidine derivatives
A compound having the formula (I):
wherein:
each R 1 , R 2 , R 3 and R 4 are independently selected from (C 1 -C 10 )-straight or branched alkyl, Ar-substituted- (C 1 -C 10 )-straight...
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6943180 |
Substituted N-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors
Compounds of formula (I) are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These...
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