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8138259 |
Polyamide molding materials with an improved flowability, the production thereof and its use
The invention relates to a housing from a polyamide molding compound containing 70 to 99.5% by weight of at least one thermoplastic polyamide and 0.5 to 30% by weight of at least one polyamide...
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8071605 |
Piperidine compounds for use in the treatment of bacterial infections
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their...
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8026255 |
Substituted piperidines as somatostatin receptor subtype 5 (SSTR5) antagonists
This invention is concerned with compounds of the formula and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a...
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7968568 |
Substituted piperidine derivatives as SST5 modulators
This invention is concerned with compounds of the formula wherein A, R1 to R5 and G are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention...
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7951952 |
Method for preparing N-aminopiperidine and its salts
The invention concerns a novel method for preparing N-aminopiperidine of formula (I):
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7910652 |
Polyamide molding materials with an improved flowability, the production thereof and its use
The invention relates to a polyamide moulding compound containing 70 to 99.5% by weight of at least one thermoplastic polyamide and 0.5 to 30% by weight of at least one polyamide oligomer with...
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7879999 |
Method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines
The invention relates to a method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines The invention is characterised in that...
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7825140 |
3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinase and glycogen synthase kinase-3 modulators
The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers...
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7786222 |
Polyamide oligomers and their use
The present invention relates to polyamide oligomers with linear or branched chain structure with a number average molar mass of 800 to 5000 g/mol, with basic end groups which are at least...
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7786308 |
Muscarinic modulators
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic...
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7767692 |
1-amidomethylcarbonyl-piperidine compounds, methods and intermediate products for the production thereof and pharmaceutical formulations containing said compounds
4-substituted 1-amidomethylcarbonyl-piperidine compounds having motilin-agonistic properties and their acid addition salts, pharmaceutical compositions containing these compounds, processes and...
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7728008 |
N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form...
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7700622 |
p-38 kinase inhibitors
Compounds and compositions for modulating the activity of p38 kinases are provided, including p38α and p38β kinase. Methods for treating, preventing or ameliorating one or more symptoms of a p38 k...
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7645822 |
Basic deactivators for POM production
Process for preparation of polyoxymethylenes via polymerization of the monomers a) in the presence of cationic initiators b) and also, if appropriate, in the presence of regulators c), followed by...
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7626032 |
Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers,...
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7550599 |
Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines
Sterically hindered alkoxyamine and hydroxy substituted alkoxyamine stabilizer compounds are made water compatible via certain backbones with affinity towards water. The sterically hindered amines...
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7432280 |
3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active...
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7388112 |
Immunomodulation with novel pharmaceutical compositions
The synthesis and use of a novel class of tumor necrosis factor (TNFα) inhibitors and immunomodulators are provided. Examples are those having the structures: wherein a, b and c are integers from ...
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7199245 |
4-imino-n-alkoxy or oxy-polyalkyl-piperidine compounds and their use as polymerization regulators
The present invention relates to selected 4-imino-N-alkoxy-polyalkyl-peperidine compounds preparation, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and...
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7125825 |
Amidoamine salt-based viscosifying agents and methods of use
Viscoelastic surfactants are described for use in aqueous systems to generate thickened fluids. The surfactants are alkyl amidoamine salts of inorganic acids and/or organic acids. The fluids may...
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7084277 |
3-Amino-piperidine derivatives and methods of manufacture
This invention relates to 3-amino piperidine derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formulas (Ia)...
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7045630 |
Method for preparing 4-amino-4-phenylpiperidines
The invention relates to a process for preparing a 4-amino-4-phenylpiperidine (I): in which R is hydrogen or a (C1–C3)alkyl group, characterized in that a 1-protected 4-piperidone (II): in which P...
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7015323 |
Thiocarbamate inhibitors of alpha-4 integrins
The invention provides novel thiocarbamate alpha-4 inhibitors of the general formula (I) that are resistant to metabolism having improved half-life and/or clearance properties compared to...
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6936717 |
Tinuvin P-hindred amine light stabilizer and derivatives thereof
The present invention relates to a photo-stabilizer of the general formula (I): wherein R1 is hydrogen, halogen, C1 to C12 alkyl, alkoxy (linear and branched), R2 is hydrogen, C1-C8 alkyl,...
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6875870 |
Long chain hindered amines and compositions stabilized therewith
Hindered amine compounds which are substituted by a long hydrocarbon chain are useful in a number of applications where the solubility or compatibility afforded by said substitution is needed. This...
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6835841 |
Asymmetric catalytic hydrogenation process for preparation of chiral cyclic β-aminoesters
A novel process for the asymmetric synthesis of substituted cyclic β-amino-carboxylates of the type shown in the specification from appropriate β-enamino-ester starting materials is described. T...
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6815458 |
Azacyclic compounds
Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a...
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6790845 |
Fused heterocyclic inhibitors of factor Xa
This invention relates generally to a novel class of fused heterocyclic compounds of the Formula (I) or Formula (II): or pharmaceutically acceptable salt forms thereof, which are inhibitors of...
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6747044 |
Neurokinin antagonists
The invention relates to new compounds of formula I or the pharmaceutically acceptable salts thereof,whereinR1 denotes 3-hydroxypropyl, 1,3-dihydroxyprop-2-yl or C3-C6-cycloalkylmethyl, and R2, R3,...
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6737528 |
Vinylic hindered amine light stabilizers
Vinylic hindered amine light stabilizers as novel polylmerizable light stabilizers are disclosed and have the general formula (I): wherein:R1 is C1 to C8: alkyl, alkoxy, alkyl phenyl, hydroxy alkyl...
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6727300 |
Polymeric articles containing hindered amine light stabilizers based on multi-functional carbonyl compounds
Polymeric articles containing at least one polymeric material and a sufficient amount of at least one novel hindered amine light stabilizers to inhibit at least one of photo- or thermal...
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6713492 |
N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor
Drugs or reagents containing as the active ingredient N-acyloxylated cycloalkyl compounds represented by general formula (I): wherein A is optionally substituted C4 or C5 cycloalkyl which may have...
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6683151 |
Supramolecular compound
The invention relates to a compound comprising a reaction product of (A) an isocyanate functional compound of which at least 40 wt. %, relative to the total amount of (A), has a molecular weight of...
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6667342 |
Benzenesulfonamide-derivatives and their use as medicaments
Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens...
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6667422 |
Process for the preparation of α-haloketones
A process for preparing an α-haloketone of the formula (1) where R1 is an optionally heteroatom-containing and optionally substituted hydrocarbon radical,R2 is a hydrogen, alkyl, aralkyl or aryl ...
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6664248 |
2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides
Compounds of formula whereinA is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by a group...
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6610709 |
2-n-substituted or unsubstituted-2-amino-5-methylpiperidine-3,4-diols and processes for the preparation thereof
This invention relates to (2R,3S,4R,5R)-2-amino-5-methylpiperidine-3,4-diol or a (2S,3S,4R,5R)-2-N-substituted-2-amino-5-methylpiperidine-3,4
-diol represented by the general formula (I): wherein...
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6596863 |
Medical composition containing nitroetheneamine Derivative or salt there of as active constituent
Process for producing a nitroetheneamine derivative or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula with a compound of the formula R6—CH2NO2 to o...
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6489482 |
Process for the preparation of novel vinylic hindered amine light stabilizers
Novel hindered amine light stabilizers of the formula whereinR1 is C1 to C8 alkyl, alkoxy, alkylphenyl, hydroxy alkyl, allyl, acyl, or cycloalkyl;R2 is hydrogen or methyl;R3 is vinyl or C1-4 alkyl...
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6489327 |
Tryptase inhibitors
The invention relates to novel inhibitors of human tryptase which are used in the pharmaceutical industry for the production of medicaments.
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6479502 |
Hydroxamic acid derivatives as proteinase inhibitors
Compounds of formula (I) are matrix metalloprotemase inhibitors wherein X represents a carboxylic acid group —COOH, or a hydroxamic acid group —CONHOH;R2 represents a radical of formula (II): R3—...
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6448286 |
Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors
The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
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6420558 |
Aminopiperidine derivates as integrin αvβ3 antagonists
An objective of the present invention is to provide compounds having integrin αvβ3 antagonistic activity, cell adhesion inhibitory activity, GP IIb/IIIa antagonistic activity, and/or human p...
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6420556 |
Acyl isothiocyanate resins and their use in solid-supported synthesis of guanidines
The subject invention involves novel acyl isothiocyanate resins of formula (I) and processes for making them: (a) starting with a phenyl carboxy resin, treating the resin with any reagent that...
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6384052 |
Anticoccidial compounds
Trisubstituted pyrroles are useful in the control of coccidiosis in poultry.
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6376674 |
Piperidine compounds
Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety....
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6369077 |
Protease inhibitors
This invention relates to compounds of formula (I): wherein:Y is Ar or NR1R2;R1 is R″, R″C(O), R″C(S), R″SO2, R″OC(O), R″R′NC(O), or R″R′NC(S);R2 is H, C1-6alkyl, C2-6alkenyl, Ar-C0-6alkyl, or ...
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6313302 |
Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists
A compound of the following formula: ##STR1##and the salts thereof, wherein A is hydrogen, halo, or hydroxy; the broken line represents an optional double bond with proviso that if the broken line...
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6284892 |
Method for producing salts of cyclic amidines
The present invention relates to a process for the production of salts of cyclic amidines of the general formula (I) ##STR1##The processes described hitherto as prior art enable salts of the...
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6251919 |
Heterocyclic substituted aniline calcium channel blockers
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