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7531535 |
Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
The present application describes lactam-containing compounds and derivatives thereof of Formula I:
or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7...
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7473697 |
2-Oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders
This invention relates to new 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives of formula (1) having anticonvulsant activity which are useful as therapeutic agents for the treatment...
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7375230 |
Fermentation and purification of migrastatin and analog
Migrastatin and a migrastatin analog can be produced by fermentation of Streptomyces platensis NRRL 18993 and used in pharmaceutical formulations to treat cancer and/or inhibit metastasis of...
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7326789 |
Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them
The present invention relates to compounds of the formula I
wherein A 1 , A 2 , R 1 , R 2 , R 3 , X and n are as defined in the claims, which are valuable pharmaceutically active compounds for...
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7220869 |
Brønsted acidic room temperature ionic liquids each having a N-protonated lactam cation and method for preparing the same
The invention relates to a class of novel Brønsted acidic ionic liquids each having a lactam cation, and to a method for preparing the same through simple neutralization reaction of a lactam,...
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7053085 |
EP4 receptor agonist, compositions and methods thereof
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which...
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6992103 |
Benzamide derivatives, processes for their preparation, and their pharmaceutical use
The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them...
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RE38934 |
Method and reagents for N-alkylating ureides
A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I
with an alkylating agent of structure III
in the presence of a basic catalyst...
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6924251 |
Substituted benzoylcyclohexandiones
The invention relates to novel substituted benzoylcyclohexanediones of the general formula (I),
in which
m, n, A, R 1 , R 2 , R 3 , R 4 and Z are each as defined in the description,
and...
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6831176 |
Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to...
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6770658 |
Substituted &ggr -phenyl-&Dgr -lactams and uses related thereto
γ-Phenyl-substituted Δ-lactams are disclosed. They may be formulated into pharmaceutical compositions, and/or used in the treatment or prevention of inflammation or other conditions or disease...
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6723711 |
Propanoic acid derivatives that inhibit the binding of integrins to their receptors
A compound of the structure A method for the inhibition of the binding of α 4 β 1 integrin to its receptors, for example VCAM-1(vascular cell adhesion molecule-1) and fibronectin;...
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6673920 |
Method for the production of N-alkenyl-amides
A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises...
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6653272 |
Detergent composition
A detergent composition that contains inorganic powder and a soap such as a soda soap, wherein the inorganic powder is zeolite powder, calcium carbonate powder, silica powder, ceramic powder, alga...
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6653480 |
Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to...
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6624303 |
Method for producing N-alkenyl amides
A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises...
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6509359 |
Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors
A compound having the formula: wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.
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6472529 |
Retroviral protease inhibiting compounds
A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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6362333 |
Method for simultaneously producing a cyclic lactam and a cyclic amine
A cyclic lactam and a cyclic amine are coproduced by coreacting an aliphatic alpha, omega-diamine and an aliphatic alpha, omega-aminonitrile with water in the gas phase in the presence of a...
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6362332 |
Coproduction of a cyclic lactam and a cyclic amine
A cyclic lactam and a cyclic amine are coproduced by reacting an aliphatic alpha, omega-diamine with water in the gas phase in the presence of a heterogeneous catalyst.
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6274580 |
Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus
Compounds selected from the group consisting of formulae I, II, III, IV, VI, VII, and VIII ##STR1## wherein R is H or NH 2 , and pharmacologically acceptable salts thereof, are suitable for use in...
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6262222 |
Copolymers containing N-vinyllactam derivatives, preparation methods thereof and photoresists therefrom
Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv...
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6255479 |
Process for the preparation of α-oxolactams
A method for preparing an α-oxolactam comprising, reacting a corresponding α-diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding...
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6214857 |
Substituted alkanohydroxamic acids and method of reducing TNFα levels
Imido and amido substituted alkanohydroxamic acids reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
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6160126 |
Synthetic Intermediates for the preparation of N, N'-Di-substituted isothiourea derivatives and N-cyclic(methyl)-N'-Substituted isothiourea derivatives
Novel Intermediates ##STR1## wherein R is a substituted or unsubstituted hydrocarbon residue or acyl group; X is an electron withdrawing group; Y 1 and Y 2 , which are the same or different, are...
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6100396 |
Method for purifying lactams
A method for purifying lactams by liquid-liquid extraction and/or processing with an ion exchange resin is disclosed. The method is useful for purifying lactams produced by the cyclising...
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6080857 |
Method of preparation of β-amino acids
A method for the preparation of β-amino acid compounds is provided. The method includes contacting an amine nucleophile with an α,β-unsaturated amide compound in the presence of a chiral Lewis...
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6069144 |
N-heterocyclic compounds, intermediate products used to prepare them, agents containing them and their use in antifungal applications
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6066642 |
Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivative, their preparation and their use as adenosine receptor antagonists
The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the...
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6034215 |
3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof,...
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5986092 |
Process for the preparation of N-substituted lactams
The invention relates to a process for the preparation of N-substituted lactams by reaction of a lactam, which is unsubstituted on the nitrogen, with an organic halide in the presence of at least...
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5985815 |
Bleach activators
New compounds useful as bleach activators as well as new percarboxylic acids, which may be formed as intermediates upon reaction of such activators with peroxygen bleach source in aqueous solution,...
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RE36359 |
Long chain carboxylic acid imide ester
Provided is a long chain carboxylic acid imide ester (I) represented by the following general formula (I) ##STR1## wherein W is a divalent long chain hydrocarbon group which may optionally be...
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5952376 |
Trienyl compounds
Triene-containing compounds which mimic the chemical and/or biological activity of the spongistatins are provided, as are methods and intermediates useful in their preparation.
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5945544 |
Process for production of N-vinyllactam
A process for producing an N-vinyllactam by reacting a lactam with acetylene in the presence of a particular catalyst (an alkali metal alcoholate between an alicyclic alcohol and an alkali metal)...
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5914407 |
Preparation of piperid-2-one
A process for preparing piperid-2-one by reacting polymers of delta-valerolactone having a molecular weight of from 200 to 20,000 with ammonia under an inert atmosphere at temperatures of from 250...
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5912189 |
Compositions containing reaction product of a cyclic compound containing both a nitrogen atom and a carbonyl group, an aldehyde or ketone, and an etheramine
The present invention is directed to a composition containing the reaction product of: (A) a cyclic compound containing a 5, 6, or 7-member ring, the ring containing at least one nitrogen and at...
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5872191 |
Process for producing a polyoxyalkylene derivatives substituted with succinimidyl group
A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide...
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5869024 |
Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
In accordance with the present invention a novel method and composition for using nonionic contrast media to reduce the risk of clot formation in a diagnostic procedure is disclosed. Novel...
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5869653 |
Hydrogenation of nitriles to produce amines
An improved process for the catalytic hydrogenation of nitriles. The basic process comprises contacting the nitrile with hydrogen in the presence of a sponge or Raney cobalt catalyst under...
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5863903 |
Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes
The present invention relates to hydroxy alkyl piperidine compounds and pharmaceutical compositions thereof which can be used to treat diabetes.
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5856476 |
Processes for preparing azepiones useful as intermediates in the preparation of inhibitors of angiotensin converting enzyme and neutral endopeptidase
Processes are disclosed for preparing the azepine intermediates of the formula ##STR1## These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the...
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5847213 |
Process for production of tertiary amine compound
There is provided a process for producing a tertiary amine compound in one step without using any subsidiary raw material or any solvent, by subjecting a secondary amine compound and an alcohol to...
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5808078 |
Process for preparation of 1-alkyl-3-methylpiperidone-2 and 1-alkyl-5-methylpiperidone-2
This invention relates to an improved process for the preparation of 1-alkyl-3-methylpiperidone-2 and 1-alkyl-5-methylpiperidone-2 from 2-methylglutaronitrile wherein the selectivity of the process...
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5789404 |
3-substituted 1-arylindole compounds
3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or...
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5777117 |
Method for preparing substituted amino alcohol compounds
Disclosed is a process for preparing compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an...
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5719287 |
Intermediates for inhibitors of HIV protease and method of preparation thereof
The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of their use.
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5708167 |
Method for the preparation of an N-vinyl compound
Proposed is a novel and very efficient method for the preparation of an N-vinyl compound such as N-vinyl-2-pyrrolidone and N-vinyl-N-ethyl acetamide by the thermal decomposition of an...
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5703208 |
3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof,...
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5696256 |
Process for preparing and using guanidine derivatives
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