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7569579 |
Cyclopropyl compounds as ccr5 antagonists
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in...
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7538224 |
Hsp90 family protein inhibitors
The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I):
(wherein n represents an integer of 0...
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7504512 |
N-acylsulfonamide apoptosis promoters
N-Benzoyl arylsulfonamides having the formula
are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis...
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7473698 |
Secondary amino anilinic piperidines as MCH1 antagonists and uses thereof
This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a...
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7452908 |
Amide derivatives
This invention relates to compounds which are represented by the general formula [I]
[in which A stands for a group of the following formula [a o ] or [b 0 ]
Ar 1 , Ar 2 and Ar 3 ...
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7452891 |
MCH antagonists and their use in the treatment of obesity
The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention...
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7427632 |
Factor Xa inhibitors
Compounds of formula (I)
in which R 1 , n, Z, R 3 and R 4 have any of the meanings given in the specification, are inhibitors of the serine protease Factor Xa and are useful in the treatment...
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7381721 |
Substituted piperidine compounds
3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are...
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7361666 |
Heterocyclic analgesic compounds and methods of use thereof
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various...
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7326722 |
N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy
The present invention discloses and claims a compound of general formula (I)
wherein A, X and R 2 are as described herein. Also disclosed and claimed is application of this compound in a...
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7259173 |
Derivatives of 3-phenyl-n-(2-(4-benzyl)-piperidin-1-yl)-ethyl)-acrylamid with ccr-3-receptor antagonistic activity for use in the treatment of inflammations and allergic conditions
This invention relates to organic compounds of formula I,
in which Ar 1 is unsubstituted phenyl substituted by one or more halogen atoms; Ar 2 is unsubstituted phenyl or phenyl substituted by...
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7253171 |
Urea derivatives as integrin α4 antagonists
Novel antagonists of ∝4β1 integrin and/or ∝4β7 integrin of the general Formula I: wherein R1, R2, R5, L1, L2, Rb, W and Z are as defined in any one of claims 1 to 13, A represents...
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RE39558 |
5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis
Compounds of this formula
are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.
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7199265 |
Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor β, to methods of preparing such compounds...
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7148355 |
Process for the preparation of repaglinide
The present invention relates to a cost effective and industrially advantageous process for the preparation of repaglinide.
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7135472 |
3-Heterocyclic benzylamide derivatives as potassium channel openers
The present invention provides novel 3-heterocyclic benzylamides and related derivatives having the general Formula I
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A and Het are as defined in the...
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7129228 |
Heterocyclic analgesic compounds and methods of use thereof
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various...
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7129251 |
Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use
The invention describes novel nitrosated and/or nitrosylated H 2 receptor antagonist compounds, and novel compositions comprising at least one H 2 receptor antagonist compound that is optionally...
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7105544 |
Substituted alkyl amido piperidines
This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a...
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7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
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7091219 |
Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors
Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease...
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7084140 |
Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds
The invention relates to new arylglycinamide derivatives of general formula I
and the pharmaceutically acceptable salts thereof, wherein R 1 and R 2 together with the N to which they are...
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7067534 |
Substituted anilinic piperidines as MCH selective antagonists
This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a...
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7064210 |
Light resistant colorant and composition containing the same
A light resistant colorant is obtained by coupling a dye or a pigment with a light resistant material. A light resistant colorant-containing composition has no additional light stabilizer....
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7056922 |
Acylamino cyclopropane derivatives
A compound of the formula
wherein D, E, F, G, L, T, W, X, Y, Z, U, A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 R 7 are as defined in the specification, pharmaceutical compositions thereof, and...
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7049441 |
Process for preparation of benzylpiperidine compounds
According to the process as shown in the following scheme having a step for reacting Compound (I) with Compound (II) to produce Compound (III), benzylpiperidine compounds useful as synthesis...
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RE39088 |
Amide compounds and use of the same
An amide compound of the formula (I):
wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R 1 , R 2 , R 3 and R 4 are H,...
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7019007 |
CCR-3 receptor antagonists (I)
The invention provides compounds of Formula (I):
wherein: R 1 –R 4 , A, D, and L have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical...
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6969713 |
Piperidine and piperazine acetamide derivatives
The invention provides piperidine and piperazine derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the...
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6949545 |
Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have...
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6875775 |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
The invention provides novel selective estrogen receptor modulator compounds of the general formula:
wherein R1 and R2, which are the same or different are
a) H, halogen, OCH 3 , OH; or...
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6821965 |
Amidobenzamide derivatives which are useful as cytokine inhibitors
The invention concerns amide derivatives of the Formula (I) wherein R 3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy,...
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6770644 |
Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient
Hydroxamic acid derivatives of the formula (I) (wherein all the symbols have the same meaning as defined in the specification.), non-toxic salt thereof or prodrugs thereof. The compounds of the...
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6756387 |
Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain
Compounds of general formula I R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, triazolyl and thiazolyl; where each R 1 phenyl ring and R 1 heteroaromatic ring...
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6753335 |
Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain
Compounds of general formula I R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, and triazolyl; where each R 1 phenyl ring and R 1 heteroaromatic ring may...
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6743929 |
Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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6727264 |
Substituted anilinic piperidines as MCH selective antagonists
This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a...
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6696449 |
Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
This invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some...
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6686497 |
Synthesis of 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid, a key acid synthon of repaglinide
The present invention relates to a new and industrially advantageous process for the preparation of 3-ethoxy-4-ethoxy-carbonyl-phenyl acetic acid. This compound is a key intermediate for the...
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6673794 |
Substituted aminomethyl-phenyl-cyclohexane derivatives
A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are...
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6576645 |
Triphenylalkene derivatives and their use as selective estrogen receptor modulators
The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH 3 , OH; or where...
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6552022 |
Benzamide derivatives and their use as ApoB-100 secretion inhibitors
The invention relates to therapeutic benzamide compounds of formula (I) wherein A, X, Z, R 1 , Y, R 2 , R 3 , are as defined herein, and physiologically acceptable salts, solvates or derivatives...
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6521619 |
Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
The present invention relates to novel cyclopropane-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising...
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6515131 |
Imagining agents for diagnosis of Parkinson's disease
Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to...
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6511993 |
Metalloprotease inhibitors
Compounds of formula (I) and pharmaceutically-acceptable derivatives thereof, are matrix metalloprotease inhibitors, useful in treatment of conditions mediated by matrix metalloproteases, such as...
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6476054 |
Cyclic amine modulators of chemokine receptor activity
The present invention is directed to cyclic amines of the formula I: (wherein R 1 , R 2 , R 3 , m and n are defined herein) which are useful as modulators of chemokine receptor activity. In...
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6472394 |
MCH antagonists and their use in the treatment of obesity
Disclosed are compounds represented by structural formula I: or a pharmaceutically acceptable salt, ester or solvate thereof, wherein W is R 1 —CR 3 R 12 NR 4 C(O)— or R 11 C(O)NR 4 —; the...
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6458812 |
Muscarinic antagonists
Amide derivatives of 1,4 di-substituted piperidine compounds of the formula: or a pharmaceutically acceptable salt, ester or solvate thereof, wherein R 1 is optionally substituted cycloalkyl,...
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6455549 |
Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
A pharmaceutical composition, especially a pharmaceutical composition for the alleviation or treatment of symptoms due to ischemic diseases and symptoms derived from seizures, epilepsy, and...
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6451791 |
Amidoaromatic ring sulfonamide hydroxamic acid compounds
An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a...
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