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7544682 |
Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof
The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I)
and acid addition salts, hydrates and solvates thereof,...
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7402639 |
1-alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators
The present invention relates to 1-alkoxy-polyalkyl-peridine derivatives containing a structural element of formula (I)
G 1 , G 2 , G 3 , G 4 are independently C 1 -C 6 alkyl with the proviso...
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7368443 |
2,6-disubstituted piperidines and piperazine compounds
The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula:
which are used to treat diseases of the central nervous system,...
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7223779 |
Azasugar derivative and drug containing the same as the active ingredient
A novel azasugar derivative, and a drug containing the same as an active ingredient are disclosed. The drug is useful for treatment of keratinocyte-proliferative diseases.
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7189742 |
Piperidin-2,6-dione bisulphate salts and their use for the treatment of stress related affective disorders
Novel bisulphate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-dion
es and pharmacologically acceptable solvates thereof are devoid of the weight loss and hepatocyte...
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RE39263 |
Substituted aromatic thiocarboxylic acid amides and their use as herbicides
There is disclosed substituted thiocarboxamides of the general formula (I)
useful as herbicides.
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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6967196 |
Sulfonamide compounds and uses thereof
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the...
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6956046 |
4-hydroxypiperidine derivatives having analgesic activity
A compound represented by the following Formula (I):
(wherein A represents oxygen atom or —NR 3 — (R 3 represents hydrogen atom or lower alkyl group); R 1 represents nitro group, lower...
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6946269 |
Alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates
The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.
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6943179 |
Biurethane derivatives
Novel compounds of the formula I in which X, Y, Z, R, R 1 , R 2 and R 3 are as defined in Patent Claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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6943177 |
Cis-2,6-disubstituted piperidines for the treatment of psychostimulant abuse and withdrawal, eating disorders, and central nervous system diseases and pathologies
Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula:
are used to treat diseases of the central nervous system, drug abuse and withdrawal therefrom as well...
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6927294 |
Nitrogen-containing heterocycles
Functionalized nitrogen heterocyclic compounds, including benzodiazepines and azasugars, and synthetic methods for preparing such compounds. Nitrogen-containing heterocycles are prepared by...
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6689909 |
Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity
A compound of formula (I) wherein: n is 1 or 2; R 1 is chloro, fluoro, bromo, methyl or methoxy; R 2 is as defined within; R 3 is as defined within; and R 4 is hydrogen or fluoro; or a...
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6670477 |
Synthesis of enantiomerically enriched 4-piperidinylglycine
A process for making enantiomerically enriched 4-piperidinylglycine having the formula (I), said process comprising (a) combining N-protected glycine ester with 4-piperidone to form...
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6590102 |
Process for producing piperidinecarbinols
A process for producing a piperidinecarbinol represented by the general formula (2), which comprises reducing the trans isomer of a compound represented by the general formula (1): wherein R 1 ...
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6586598 |
α, α-dibromo-α-chloro-acetophenones as synthons
This disclosure relates to the use of α,α-dibromo-α-chloroacetophenone compounds as intermediates for the preparation of aromatic carbonyl compounds, especially aromatic amides. The compound...
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6552225 |
Chemical compounds
A compound of formula (I) wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined within; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described....
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6534536 |
Alkylsulfonamido heterocyclic thrombin inhibitors
Alkylsulfonamido heterocyclic thrombin inhibitors are provided which have the structure wherein G is wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; R is hydrogen, hydroxyalkyl,...
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6472529 |
Retroviral protease inhibiting compounds
A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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6469173 |
Alkyl esters of 3-(3,4-dihalogenophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates
The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.
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6452012 |
3-phenyl-2,6-dioxopiperidin-3-ylpropionamide derivatives and method for preparing same
This invention relates to 3-(3-phenyl-2,6-dioxopiperidin-3-yl) propionamide derivatives, and to processes for preparing the same.
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6444190 |
Reduction compositions and processes for making the same
Novel reduction compositions are prepared from an active hydride, an additive, and a Lewis base in a hydrocarbon solvent. Such compositions can provide a superior reducing system for organic...
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6342607 |
3-phenyl-2, 6-dioxopiperidin-3-yl propionamide derivatives and method for preparing same
This invention relates to 3-(3-phenyl-2,6-dioxopiperidin-3-yl)propionamide derivatives, and to processes for preparing the same.
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6251829 |
Herbicidal benzoyloxy carboxylates and carboxamides
This invention relates to herbicidal alpha-(2,4,5-trisubstituted)- and alpha-(2,5-disubstituted)-benzoyloxy-alpha-beta-, and/or beta-gamma-unsaturated-carboxylates and their derivatives, to...
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6242466 |
Substituted phenylamidines
Phenylamidines of the formula (I) ##STR1## wherein: R 6 is a C 5 -12 -alkyloxycarbonyl group, and R 7 is a hydrogen atom, or a C 1 -8 -alkyl, C 4 -7 -cycloalkyl, phenyl-C 1 -4 -alkyl, or R...
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6080864 |
Derivatives of 1-oxyl-4-hydroxy-2,2,6,6-tetramethylpiperidine
Selected derivatives of 1-oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine are surprisingly effective as inhibitors to prevent the premature polymerization of acrylic and methacrylic acids, their...
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6080742 |
Substituted benzamides
Substituted benzamides corresponding to the formula I ##STR1## wherein R 1 , R 2 and R 3 have the meanings given herein, and their use in pharmaceutical compositions. The compounds are...
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6066737 |
Process for the preparation of optically enriched 4-aryl-3-hydromethyl substituted piperidines to be used as intermediates in the synthesis of paroxetine
The subject invention pertains to optically-enriched compounds of formula (1), wherein Ar is a C 6 -20 aryl group; and R 1 and R 2 are independently H, alkyl or aryl. The subject invention also...
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6066642 |
Dihydropyridine-, pyridine-, benzopyran-4-one- and triazoloquinazoline derivative, their preparation and their use as adenosine receptor antagonists
The present invention provides certain novel compounds, compositions, and a method of treating a mammal by blocking its adenosine receptors comprising administering at least one compound of the...
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6022971 |
Azetidines
The present invention provides compounds of the formula (I): ##STR1## and the pharmaceutically acceptable salts thereof, wherein R is C 3 -C 7 cycloalkyl, aryl or C 1 -C 6 alkyl, said C 1 -C 6...
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6008360 |
Substituted 3-aryl-3-carboxyalkyl glutaramides, method for preparing same by 4-arylo-4-cyanoheptane dicarboxylic acid cyclisation, and use thereof for preparing 3-aryl-3-hydroxyalkylpiperidines
The invention relates to glutarimides of formula (I): ##STR1## in which Ar represents a phenyl non substituted or substituted one or more times with one of the substitutents selected from a halogen...
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5981539 |
Piperidine compounds as calcium channel blockers
The present invention discloses compounds of the formula ##STR1## any of its enantiomers or any mixture thereof, or a pharmaceutically-acceptable addition salt thereof, wherein X, Ar, R, R 1 , R 2...
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5958952 |
Substituted phenylamindines, medicaments containing these compounds and process for producing them
The present invention relates to phenyl amidines of general formula (I), ##STR1## in which R 1 to R 5 are as defined in claim 1, their tautomers, their stereoisomers and their mixtures and their...
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5936090 |
Processes for the reduction of imide ester functionality
The present invention provides improved processes for the chemical reduction of imide esters to the corresponding amino alcohols with yields greater than 76%. A specific range of ethereal to...
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5935951 |
1-acyl-4-aliphatylaminopiperidine compounds
The invention relates to novel 1-acyl-4-aliphatylaminopiperidine compounds of ##STR1## formula (I), in which R 1 is a benzoyl, naphthoyl or cycloalkanoyl radical which is unsubstituted or...
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5908934 |
Process for the preparation of chiral ketone intermediates useful for the preparation of flavopiridol and analogs
A process for the preparation of compounds of formula I ##STR1## where R 1 , R 2 , R 3 , m, n and q are as defined herein; which comprises the steps of (a)reacting a compound of formula III...
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5874589 |
Methods for synthesizing diverse collections of tetramic acids and derivatives thereof
Disclosed are methods for synthesizing very large collections of diverse diverse tetramic acids, tetronic acids, pentamic acids, pentonic acids, and derivatives thereof and synthetic compound...
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5844102 |
Glycohydrolase inhibitors, their preparation and use thereof
A compound of the formula ##STR1## wherein n, m, and p, which may be the same or different, are a number between 0 and 5; q is a number between 0 and 10; R 1 , R 2 R 3 R 4 and R 5 , which may be...
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5789405 |
Oxaspiro(2,5)octane derivative
An oxaspiro 2,5!octane derivative of the formula: ##STR1## useful in inhibiting angiogenesis in solid tumors.
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5783702 |
Preparation of cisapride
Cisapride, i.e. cis-4-amino-5-chloro-N- 1- 3-(4 fluoro-phenoxy)propyl!-3-methoxy-4-piperidinyl!-2-methoxy-be
nzamide, and similar benzamide derivatives, are prepared from novel 1-aryloxyalkyl- or...
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5631209 |
Herbicidal glutarimides
This invention relates to glutarimide compounds exhibiting herbicidal activity having the structure ##STR1## wherein A is carbonyl, thiocarbonyl or methylene, A 1 is carbonyl or methylene, Q is O...
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5616711 |
Methods of producing aminobutene derivatives
A method of producing an aminobutene derivative of formula (I) by allowing a butenol derivative of formula (II) to react with an amide derivative of formula (III) is disclosed. The aminobutene...
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5596005 |
Omega-deoxy-azasugars
Omega-deoxy-azapyranose compounds, processes of making and using the same are disclosed, as are a process of making omega-deoxy-azafuranose compounds.
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5585387 |
Prepration of cisapride
Cisapride, i.e. cis-4-amino-5-chloro-N-[1-[3-(4 fluoro-phenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-be
nzamide, and similar benzamide derivatives, are prepared from novel 1-aryloxyalkyl- or...
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5559237 |
Process for preparation of 2-oxo-1-piperidinyl derivatives
The present process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the...
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5496943 |
Heterocyclic compounds and their production
Disclosed is a novel heterocyclic compound selected from the group consisting of the compounds [IV] to [VII], [IX] and [X]. The heterocyclic compound is useful for reactive materials in chemical...
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5459270 |
Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them
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5424319 |
Piperidinyl-terminated non-peptidyl α-succinamidoacyl aminodiols as anti-hypertensive agents
Non-peptidyl compounds characterized generally as α-succinamidoacyl aminodiols having a piperidinyl-type group at the N-terminus are useful as renin inhibitors for the treatment of hypertension.
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5423998 |
Peroxy carboxylic amino-derivatives
Amino-derivative (poly)peroxycarboxylic acids which have the formula: ##STR1## wherein the symbols have the following meanings: R, R 1 , and R 2 , which may be equal to or different from one...
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