Patents in Class 546/213

Matches 1 - 50 out of 288

1 2 3 4 5 6 >

Match	Document	Document Title
1	7585858	N-sulfonylcarboximidamide apoptosis promoters Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
2	7579346	Carboxamides Novel compounds of the formula (I), in which D, W, X, Y, T, m and R 1 have the meaning indicated in Patent claim 1 , are inhibitors of coagulation factor Xa and can be employed for the...
3	7579340	Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
4	7528136	Prolinamide derivatives as NK3 antagonists The present invention relates to a compound of formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, n, and o are as defined herein and to a pharmaceutically acceptable acid addition salt thereof...
5	7521473	Inhibitors of protein tyrosine phosphatase 1B Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for...
6	7446195	High affinity thiophene-based and furan-based kinase ligands Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions...
7	7427632	Factor Xa inhibitors Compounds of formula (I) in which R 1 , n, Z, R 3 and R 4 have any of the meanings given in the specification, are inhibitors of the serine protease Factor Xa and are useful in the treatment...
8	7396944	Thiophene derivatives, their manufacture and use as pharmaceutical agents Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the...
9	7381721	Substituted piperidine compounds 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are...
10	7365196	Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
11	7361666	Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various...
12	7335670	Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and application of same in therapeutics Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form)...
13	7326716	Treatment of inflammatory bowel disease The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of...
14	7288538	Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
15	7259157	N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
16	7226933	4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders Compounds of general formula I R 1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, and pyridine N-oxide; where each R 1 phenyl ring and R 1 ...
17	7173129	Sulfonamide-substituted chalcone derivatives and their use to treat diseases The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents...
18	7125895	Cyclic amine derivatives and their uses This invention relates to novel arylalkyl cyclic amine derivatives. This invention also relates to chemokine receptor antagonists that are be effective as therapeutic agents and/or preventive...
19	6984637	Cyclic amine derivatives-CCR-3 receptor antagonists This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods...
20	6960602	Piperidine derivatives as modulators of chemokine receptors The invention provides a compound of formula (I): wherein R 1 , R 2 , R 3 , R 3a , R 4 , R 4a , R 5 , and R 6 are as defined; or a pharmaceutically acceptable salt thereof or a solvate thereof;...
21	6903119	Amino acid derivatives and drugs containing the same as the active ingredient The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I)...
22	6890928	Aromatic sulfone hydroxamic acids and their use as protease inhibitors This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix...
23	6887871	Use of phenylheteroakylamine derivatives There is disclosed the use of a compound of formula (I) wherein R 1 , R 2 , X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates...
24	6864249	Piperidine and azetidine thrombin inhibitors The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of...
25	6861530	Piperidine derivatives This invention relates to substituted piperidine derivatives having at least one six-membered ring substituent. The piperidine derivatives exhibit antitumor activity and are useful as...
26	6841682	Heterocycles useful in the treatment of benign prostatic hyperplasia This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds...
27	6828318	2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission Compounds of formula (1): wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from hydrogen, alkyl, aryl and non-aromatic heterocyclic groups, or each of one or more pair(s)...
28	6787650	Urea compounds, process for producing the same and use thereof A compound of the formula: [wherein R 1 is a hydrocarbon group which may be substituted; R 2 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be...
29	6756387	Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain Compounds of general formula I R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, triazolyl and thiazolyl; where each R 1 phenyl ring and R 1 heteroaromatic ring...
30	6753335	Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain Compounds of general formula I R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, and triazolyl; where each R 1 phenyl ring and R 1 heteroaromatic ring may...
31	6710060	4-hydroxypiperidine derivatives having antiarrhythmic activity The present invention relates to a compound represented by the following formula (I) or a salt thereof, or a pharmaceutical composition containing the compound as an effective ingredient: ...
32	6696234	Silver halide photosensitive material and isothiazolidine-3-one derivative A silver halide photosensitive material contains a compound of the following general formula (I): wherein A 1a represents a group selected from among CR 1a R 2a , NR 1a , an oxygen atom and...
33	6689794	Aromatic sulfone hydroxamates and their use as protease inhibitors This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known...
34	6664273	Piperidine based MCH antagonists for treatment of obesity and CNS disorders The present invention discloses compounds, which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention...
35	RE38257	Piperdine derivatives and hypotensives containing the same A piperidine compound of the formula (I): wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH 2 ) n , which may be substituted, in which n is 0 or an integer of 1 to...
36	6617325	Biphenyl derivatives, production thereof and uses as medicines The present invention relates to biphenyl derivatives of general formula wherein R a to R g and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically...
37	6528532	Urea derivatives as HIV aspartyl protease inhibitors The present invention provides HIV aspartyl protease inhibitors of the formula: and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof,...
38	6451797	Muscarinic antagonists Heterocyclic derivatives of di-N-substituted piperazine or 1,4 di-substituted piperidine compounds in accordance with formula I (including all isomers, salts and solvates) wherein wherein one of...
39	6303637	Heterocyclic potassium channel inhibitors The present invention relates to a class of heterocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like....
40	6288085	Piperidine derivatives for treating psychoses The present invention relates to certain novel piperidine derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medical therapy,...
41	6265433	LTA4 hydrolase inhibitors The present invention provides compounds having the structure: ##STR1## and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases...
42	6262044	Modulators of protein tyrosine phosphatases (PTPASES) The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein...
43	6197791	N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases...
44	6174900	Substituted piperidine derivative for treating urinary disturbance Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): ##STR1## wherein R 1 means an aryl or heteroaryl group which may have at least one...
45	6083943	Substituted azaheterocyclecarboxylic acid A compound of the chemical formula (I) and its pharmaceutically acceptable salt: ##STR1## wherein Y is C 2 -C 4 alkylene; Z is a valence bond or C 1 -C 6 alkylene; R 1 is substituted or...
46	6066650	Inhibitors of microsomal triglyceride transfer protein and method Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the...
47	6013656	2-(arylalkenyl) azacycloalkane derivatives as ligands for sigma receptors New 2-(arylalkenyl)azacycloalkane derivatives which are ligands for sigma receptors, of the formula (I) ##STR1## in which: Ar is aryl or heteroaryl, optionally mono- to trisubstituted, m has the...
48	6008223	Therapeutic compounds Compounds of formula I ##STR1## wherein Q 1 , Q 2 , Q 3 , and Q 4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide...
49	5968956	Substituted piperidine derivative and medicine comprising the same Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): ##STR1## wherein R 1 means an aryl or heteroaryl group which may have at least one...
50	5948792	Fluorine-containing 1,4-disubstituted piperidine derivatives Novel fluorine-containing 1,4-disubstituted piperidine derivatives, represented by general formula I! ##STR1## such as, for example, (2R)-N- 1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl!-2-...

Matches 1 - 50 out of 288

1 2 3 4 5 6 >