|
Match
|
Document |
Document Title |
|
|
7625889 |
Substituted bis aryl and heteroaryl compounds as selective 5HT2A antagonists
The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I):
Wherein X, Y, Z, A, B, D, Ar, R 1 and R 2 are as defined herein. The compounds of...
|
|
|
7612065 |
Inhibitors of c-JUN N-terminal kinases (JNK)
The present invention relates to inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
|
|
|
7598271 |
Crystalline paroxetine methane sulfonate
The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I:
wherein:
R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl...
|
|
|
7592359 |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
This invention generally relates to derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment...
|
|
|
RE40793 |
Bicyclic benzamides of 3-or 4-substituted 4-(aminomethyl)-piperidine derivatives
The present invention of compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R 1 and R 2 ...
|
|
|
7517892 |
Ligands for monoamine receptors and transporters, and methods of use thereof
One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian...
|
|
|
7498347 |
Hydroxycarbonylphenyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4 antagonists
The present invention is concerned with novel compounds of formula (I) having 5HT 4 -antagonistic properties. The invention further relates to methods for preparing such novel compounds,...
|
|
|
7485706 |
Neurodegenerative protein aggregation inhibition methods and compounds
Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting...
|
|
|
7479500 |
Antidepressant piperidine derivatives of heterocyclefused benzodioxans
Compounds of the Formula:
are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
|
|
|
7452891 |
MCH antagonists and their use in the treatment of obesity
The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention...
|
|
|
7408067 |
Aza-cyclic compounds as modulators of acetylcholine receptors
Compounds comprising an aza-cyclic portion and an aromatic portion linked via a sulphur atom are disclosed. The compounds disclosed are selective modulators of beta 4 subtype nicotinic...
|
|
|
7393861 |
Derivatives of 4-aminopiperidine and their use as a medicament
A subject of the present application is new derivatives of 4-aminopiperidines of formula
in which R 1 , R 2 and R 3 represent various radical, and their preparation processes by synthetic...
|
|
|
7388020 |
Benzimidazol derivatives modulate chemokine receptors
The invention provides compounds of general formula (I) wherein A, X, m, R 1 , N, R 2 , Z 1 , Z 2 , Q, R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , t and R 16 are as defined in the specification, processes...
|
|
|
7342114 |
Podophyllotoxin derivatives
4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and...
|
|
|
7329654 |
Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders...
|
|
|
7294637 |
Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a...
|
|
|
7271264 |
Pentacyclic oxepines and derivatives thereof, compositions and methods
The present invention provides a compound of the formula (I) wherein R 1 is —H, —OH, —O(C 1 -C 4 alkyl), —OCOC 6 H 5 , —OCO(C 1 -C 6 alkyl), or —OSO 2 (C 2 -C 6 alkyl); R 0 , R 2 ...
|
|
|
7220862 |
Calcitonin gene related peptide receptor antagonists
The present invention relates to compounds of Formula (I)
as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods...
|
|
|
7205410 |
4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
The present invention of compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, —R 1 —R 2...
|
|
|
7176236 |
Water-soluble etoposide analogs and methods of use thereof
Etoposide analogs with improved water-solubility such as 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-n
itroanilino)-4-desoxy-podophyllotoxin (8) and...
|
|
|
7144890 |
Spiro-pentacyclic compounds
The present invention relates to compounds of the formula (I)
and pharmaceutically acceptable salts thereof, for use as therapeutically active substances. The compounds are useful for the...
|
|
|
7144883 |
Bicyclic sulfonamide compounds
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
|
|
|
7138523 |
Preparation of 4-(4-fluorophenyl)-N-alkylnipecotinate esters, 4-(4-fluorophenyl)-N-arylnipecotinate esters and 4-(4-fluorophenyl)-N-aralkylnipecotinate esters
A process for the industrial scale manufacture of 4-(4-fluorophenyl)-N-alkylnipecotinate esters by the addition of 4-fluorophenylmagnesium halide in tetrahydrofuran to 3,4-unsaturated-3-piperidine...
|
|
|
7122675 |
Gamma secretase inhibitors
Novel aryl and heteroaryl sulfonamides are disclosed. The sulfonamides, which are gamma secretase inhibitors, are represented by the formula:
wherein Ar 1 and Ar 2 independently represent...
|
|
|
7115634 |
4-aminopiperidine and their use as a medicine
A subject of the present application is new derivatives of 4-aminopiperidines of formula
in which R 1 , R 2 and R 3 represent various radical, and their preparation processes by synthetic...
|
|
|
7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
|
|
|
7105679 |
Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders...
|
|
|
7084144 |
Sulfonyl group containing compounds and their use for the treatment of erectile dysfunction
A compound having the general formula (I):
wherein: X is N or C; R 0 is H, a lower alkyl group, a lower O-alkyl group,
lower alkyl group, a benzyl group, a phenyl group, a heterocyclic...
|
|
|
7084140 |
Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds
The invention relates to new arylglycinamide derivatives of general formula I
and the pharmaceutically acceptable salts thereof, wherein R 1 and R 2 together with the N to which they are...
|
|
|
7081466 |
2-aroylimidazole compounds for treating cancer
Disclosed is a compound represented by Structural Formula (I):
R 1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl...
|
|
|
7071201 |
Quinoline derivatives
A novel compound of the formula:
wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R 1, R 2 , R 3 , R 4 , and R 5 represent each a substituent; n represents 0 or an integer...
|
|
|
7060725 |
Substituted sulfamate anticonvulsant derivatives
The present invention is directed to novel compounds of the formula (I)
wherein X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described in the specification, processes for the...
|
|
|
7053086 |
4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
The present invention relates to certain 4-heteroaryl-3-heteroarylidenyl-2-indolinones compounds and their physiologically acceptable salts which modulate the activity of protein kinases...
|
|
|
7041683 |
Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
Compounds of the formula
useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction,...
|
|
|
6987117 |
Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
Compounds of the formula
useful for the treatment of depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating...
|
|
|
6984651 |
Piperidine amides as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
|
|
|
6956121 |
Preparation of paroxetine involving novel intermediates
Disclosed are processes for preparing novel carbamate intermediates of paroxetine comprising dealkylating N-alkylparoxetine by reaction thereof with a haloalkyl ester of a haloformic acid, in a...
|
|
|
6949546 |
N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
|
|
|
6943178 |
Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
Compounds of the formula
useful for the treatment of diseases such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic...
|
|
|
6930186 |
Process for the preparation of paroxetine substantially free of alkoxy impurities
The present invention is directed to methods for preparing intermediates useful in the synthesis of paroxetine wherein the intermediates are substantially free of alkoxy impurities as well as to...
|
|
|
6906098 |
Mixed steroidal 1,2,4,5-tetraoxane compounds and methods of making and using thereof
Disclosed herein are mixed steroidal tetraoxanes having the following structural formula 1
wherein n is 0, 1, 2, or 3; R is H; ethanoyl, propanoyl, or benzoyl; R1 is H, methyl, ethyl, or...
|
|
|
6903116 |
Methods of treating cancer using a heat shock factor activity inhibitor
A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an...
|
|
|
6900327 |
4-phenylpiperidine compounds
The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I:
wherein:
R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl...
|
|
|
6900227 |
Benzodioxole derivatives
The present invention relates to compounds of the general formula
and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such...
|
|
|
6900222 |
Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein...
|
|
|
6890928 |
Aromatic sulfone hydroxamic acids and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix...
|
|
|
6887869 |
Mikanolide derivatives, their preparation and therapeutic uses
The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general...
|
|
|
6867230 |
Hygromycin A derivatives
This invention relates to compounds of the formula
and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 and R 10 are as defined herein. The...
|
|
|
6861530 |
Piperidine derivatives
This invention relates to substituted piperidine derivatives having at least one six-membered ring substituent. The piperidine derivatives exhibit antitumor activity and are useful as...
|
|
|
6861434 |
Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one
Compounds of the formula:
useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced...
|