Patents in Class 546/179

Matches 1 - 50 out of 132

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Match	Document	Document Title
1	7585976	Hemiasterlin derivatives and uses thereof The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein...
2	7265115	Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
3	7084276	Phenyl quinolines and their use as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined in the specification, or a N-oxide...
4	7071177	P-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use,...
5	6933301	1,2,3,6-tetrahydropyrimidine-2-one compositions, articles and therapeutic methods for upper airway breathing disorders A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in a therapeutically effective amount. The cold...
6	6897317	4-Phenyltetrahydrochinoline utilized as an inhibitor of the cholesterol ester transfer protein The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by...
7	6855824	Processes for preparing quinoline derivatives and intermediates thereof The present invention provides a production method of quinoline derivative (V) wherein each symbol is as defined in the Specification, which includes reacting quinolinecarbaldehyde (I) with...
8	6855711	Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators Use of a compound of formula (I), wherein R 1 is H or hydrocarbyl; R 2 is a hydrophobic radical; R 3 is 3-(C 2 -C 6 )acyl-4-hydroxyphenyl, 3-hydroxyimino (C 2 -C 6 )-alkyl-4-hydroxyphenyl, or...
9	6818767	Quinoline derivatives Quinoline derivatives are useful as neuropeptide Y (NPY) receptor ligands and are particularly effective as neuropeptide Y (NPY) antagonists. These compounds are useful in pharmaceutical...
10	6815547	Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described.
11	6806277	Quinolylpropylpiperidine derivatives, preparation process and intermediates, and compositions including them Quinolylpropylpiperidine derivatives of general formula (I) in which: R 1 is NH 2 , alkylamino, dialkylamino, hydroxyamino, alkyl(alkyloxy)amino or alkyloxyamino, R 2 is a carboxyl,...
12	6620947	Compounds for use in 11-oxa prostaglandin synthesis Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.
13	6602884	Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described.
14	6562750	Catalyst for the production of olefin polymers A catalyst composition for the polymerization of olefins is provided, comprising a bis(hydroxy aromatic nitrogen ligand) transition metal catalyst precursor and an activating cocatalyst.
15	6482834	Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56 lck tyrosine kinase activity, to pharmaceutical compositions comprising these...
16	6362339	Method of making metal 8-quinolinolato complexes A method for making metal (8-quinolinolate) complexes from air and moisture stable reagents is described. For example, the making of aluminum tris(quinolinolates), such as...
17	6291477	Tetrahydroquinolines, processes for their preparation, pharmaceutical compositions containing them, and their use to prevent or treat hyperlipoproteinaemia The tetrahydroquinolines can be prepared by condensing appropriately substituted tetrahydroquinoline aldehydes with suitable substances and subsequently varying the substituents present by...
18	6166041	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma Novel compounds which are effective PDE IV inhibitors are disclosed. The present invention is directed to compounds having the general formula I ##STR1## wherein: X is a halogen; Q is --CH 2 ...
19	6117884	4-substituted quinoline derivatives having fungicidal activity This invention provides compounds of formula (1) ##STR1## wherein the substituents are described in the specification. The compounds of formula (1) are plant fungicides.
20	6093821	Process for preparing steroid receptor modulator compounds Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds,...
21	5952349	Muscarinic antagonists for treating memory loss 1,4 Di-substituted piperidine muscarinic antagonists of formula I ##STR1## or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein X is a bond, --O--, --SO 0 -2 --, --CO--, --C(OR...
22	5872117	1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
23	5817520	Spectrophotometric methods for assaying total mercaptans, reduced glutathione (GSH) and mercaptans other than GSH in an aqueous medium reagents and kits for implementing same According to the invention, the total mercaptans in an aqueous sample are assayed by means of the formation of a chromophoric substitution product between all the mercaptans present in the sample...
24	5597833	Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives are prepared by reacting correspondingly substituted phenols with quinolylmethyl halides or by reacting unsubstituted phenols with...
25	5597924	Coversion of substituted 8-chloroquinolines to substituted 8-hydroxyquinolines The invention is a process for preparing substituted 8-hydroxyquinolines from substituted 8-chloroquinolines.
26	5519022	α, α dialkylbenzyl derivatives The invention concerns α,α-dialkylbenzyl derivatives of the formula I ##STR1## wherein Ar 1 is phenyl or naphthyl, or a 10-membered bicyclic heterocyclic moiety containing one or two nitrogen...
27	5492915	Substituted quinolyl compounds exhibiting selective leukotriene B.sub.4 antagonist activity This invention relates to compounds having selective LTB 4 antagonist properties. Therapeutic compositions comprising said compounds and methods for the treatment of disorders involving LTB 4 ...
28	5488057	2-oxindole compounds which have useful tyrosine kinase activity The present invention provides novel aryl- and heteroarylethenylene derivatives which are useful as tyrosine kinase activity inhibitors.
29	5350754	Heterocyclic cycloalkanes The invention concerns a heterocyclic cycloalkane of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one...
30	5322946	Process for producing aromatic hydroxy compound An industrially useful process for the production of an aromatic hydroxy compound which comprises reacting an aromatic sulfonic acid alkali metal salt and/or an aromatic sulfonic acid with an...
31	5283336	Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired...
32	5283245	Heterocyclic thiazole derivatives and pharmaceutical compositions comprising said derivatives The invention concerns a thiazole of the formula I, ##STR1## wherein Q 1 is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two...
33	5236919	Quinoxalinyl derivatives suitable for use in leukotriene mediated disease The invention concerns a heterocycle of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two...
34	5221677	5-lipoxygenase inhibitors quinoline or isoquinoline derivatives The invention concerns a heterocyclic derivative of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or...
35	5109009	Quinoline and pyridine compounds and inhibition of 5-lipoxygenases therewith The present invention relates to compounds of formula ##STR1## in which formula I X stands for O, S, ##STR2## R 1 and R 2 which can be the same or different stand for hydrogen, straight or...
36	5075303	Pyridine derivatives Pyridine derivatives of formula ##STR1## their heteroaromatic N-oxides and their pharmaceutically acceptable acid addition salts are disclosed. In the formula z is 0, 1 and 2 and R, R 1 , R 2 and...
37	5071860	Insecticidally active substituted heteroaryl phenyl ethers Insecticidally active substituted heteroaryl phenyl ethers of the formula ##STR1## in which Het represents an optionally substituted heteroaromatic radical, X represents O, S, --CH 2 --,...
38	4997946	Process for the iodination of hydroxyaromatic and aminoaromatic compounds A method of iodinating hydroxyaromatic and aminoaromatic compounds is disclosed, comprising reacting the hydroxyaromatic or aminoaromatic compound with an aqueous solution of a metal iodide and a...
39	4965361	Preparation of 4-substituted aryl olefins Process is disclosed for the preparation of 4-substituted aryl olefins from 4-substituted aryl iodides. 4-Substituted aryl iodides are contacted with an olefin in an ester solvent in the presence...
40	4962198	Process for the hydroxylation of electrophilic aromatic compounds The invention relates to a generally applicable process for the hydroxylation of electrophilic aromatic compounds, according to which the electrophilic aromatic compounds are reacted with organic...
41	4960893	7-bromomethyl-5-halo-8-hydroxyquinoline and method of preparation Halogenated hydroxyquinoline compounds such as 5-chloro-7-bromomethyl-8-hydroxyquinoline are prepared by contacting a 5-halo-8-hydroxyquinoline with formaldehyde to produce a cyclic dioxane and...
42	4920133	Quinoline derivatives and use thereof as antagonists of leukotriene D.sub.4 This invention relates to certain quinoline-diaryl compounds and their use as leukotriene D 4 antagonists for the treatment of hypersensitive disorders.
43	4847268	8-phenylthio-tetrahydroquinolines and anti-allergic use thereof A compound selected from the group consisting of 8-phenylthio-tetrahydroquinolines of the formula ##STR1## wherein R 1 and R 2 are individually selected from the group consisting of hydrogen,...
44	4843082	1,2,3,4-tetrahydro-8-quinolinol derivatives and anti-allergic use thereof Leukotriene biosynthesis in macrophage cells is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R 1 and R 2 are each hydrogen and R 3 is...
45	4792559	1,2,3,4-tetrahydroquinoline substituted 5-aminopentanenitrile compounds and their use as calcium modulators 5-aminopentanenitrile compounds of the formula: ##STR1## in which: Ar represents ##STR2## in which: R 1 is hydrogen, halogen trifluoromethyl or C 1 -C 5 -alkoxy, and R 2 and R 3 , which are...
46	4769461	Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents There are disclosed compounds of the formula ##STR1## wherein W represents a covalent bond or ##STR2## X is N or CR 2 ; Y is O, S, NR 2 or C(R 2 ) 2 when n=0, or N or CR 2 when n=1 Z is...
47	4742059	Substituted quinoxalinediones and their methods of use This disclosure describes novel 6-(4-substituted-1-piperazinyl)-5,8-quinolinediones, 7-(4-substituted-1-piperazinyl)-5,8-quinolinediones, and 6-(4-substituted-1-piperazinyl)-5,8-quinoxalinediones...
48	4738970	Benzimidazolyl-thio-tetrahydroquinolines and anti-peptic ulcer compositions containing the same Novel tetrahydroquinoline derivatives and salts thereof and novel imidazopyridine derivatives and salts thereof, both having excellent anti-peptic ulcer activities, and are useful as treating...
49	4698429	Alkylated 8-hydroxyquinoline derivatives via a diels-alder cycloaddition to 5,7-diallyl or 7-allyl substituents thereon Substituted 8-hydroxyquinoline metal extractants having a cyclic hydrocarbon substituent at either the 5 and 7 or only the 7 position are described.
50	4692449	Substituted quinolinediones This disclosure describes novel 6-(4-substituted-1-piperazinyl)-5,8-quinolinediones, 7-(4-substituted-1-piperazinyl)-5,8-quinolinediones, and 6-(4-substituted-1-piperazinyl)-5,8-quinoxalinediones...

Matches 1 - 50 out of 132

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