Patents in Class 546/177

Matches 1 - 50 out of 168

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Match	Document	Document Title
1	7572810	Alkene piperidine derivatives as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine...
2	7550482	Tetrahydroquinolones and their use as modulators of metabotropic glutamate receptors The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of...
3	7541467	Fluorescent zinc ion sensor A compound represented by the following general formula (I) or a salt thereof: wherein R 1 , R 2 , R 3 , and R 4 independently represent 2-quinolyl group which may be substituted,...
4	7491714	Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents Quinoline and naphthridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.
5	7456196	Bicyclic-substituted amines as histamine-3 receptor ligands Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
6	7317102	Diarylmethyl and related compounds This invention provides compounds of formula I: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , Ar 1 , Ar 2 , E, a, b, c and z are as defined in the specification, or a pharmaceutically...
7	7265115	Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
8	7223776	Compounds with anti-bacterial activity The present invention describes novel anti-bacterial compounds of formula (I).
9	7183299	Tetrazoyl oxime derivative and agricultural chemical containing the same as active ingredient The present invention provides a tetrazoyloxime derivative which is less likely to cause chemical injury to useful plants and is also superior in chemical efficacy to a conventional hetero...
10	7122672	Quinolin-, isoquinolin-, and quinazolin-oxyalkylamides and their use as fungicides Fungicidal compounds of the general formula (1) wherein one of X and Y is N or N-oxide and the other is CR or both of X and Y are N
11	7105537	2-substituted cyclic amines as calcium sensing receptor modulators The present invention relates to modulators of the calcium sensing receptor having the formula I wherein Ar 1 , X, n, R 1 , R 2 , R 3 and Q are as defined herein.
12	7009055	Preparation of Sulfonyl quinoline A dibromomethyl moiety is converted to a sulfonylmethyl moiety by treatment with a sulfinic acid salt. For example, (methyl-sulfonyl)methyl bromo-quinoline is prepared by the treatment of...
13	6982334	Crystalline form of (3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(2-thienylthio)ethyl]piperindine-3-carboxylic acid The present invention comprises crystalline forms of 3R,4R)-4-[3-(S)-hydroxy-3-(6-methoxyquinolin-4-yl)propyl]-1- [2-(2-thienylthio)ethyl]piperidine-3-carboxylic acid, represented by the structure:...
14	6841562	Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor Quinolylpropylpiperidine derivatives of general formula (I) in which R 1a is hydrogen, halogen, hydroxyl, amino, alkylamino, dialkylamino, hydroxyamino, alkoxyamino or alkylalkoxyamino and R 1b ...
15	6815547	Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described.
16	6806277	Quinolylpropylpiperidine derivatives, preparation process and intermediates, and compositions including them Quinolylpropylpiperidine derivatives of general formula (I) in which: R 1 is NH 2 , alkylamino, dialkylamino, hydroxyamino, alkyl(alkyloxy)amino or alkyloxyamino, R 2 is a carboxyl,...
17	6777427	Tetrahydroquinoline compounds Tetrahydroquinoline compounds of general formula (I) or pharmacologically acceptable salts thereof, which have a specific and strong binding affinity for AR, exhibit AR agonism or antagonism, have...
18	6734306	N-benzenesulfonyl L-proline compounds as bradykinin antagonists This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein X 1 and X 2 are halo; R 1 and R 2 are independently hydrogen or C 1-4 alkyl;...
19	6689792	Antipsychotic indolyl derivatives Compounds of formula (1) are provided: wherein R 1 and R 2 are H, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, aryl, OR 5 , nitro, amino, CF 3 or R 1 and R 2 are...
20	6653312	Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing same Amidine compounds of the formula wherein the substituents are defined as in the application useful as NO-synthase enzyme inhibitors.
21	6653308	3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to...
22	6602884	Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described.
23	6429213	Cyclic hydroxamic acids as metalloproteinase inhibitors The present application de gibes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2...
24	6410562	Hypoglycemic imidazoline compounds This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases...
25	6403610	Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them Quinolylpropylpiperidine derivatives of formula (I) which are particularly advantageous antimicrobial agents, their compositions, and their use.
26	6391064	Composition for hair dyeing comprising condensates of quinoline-5, 8-diones or of quinoxaline-5,8-diones and substituted pyrroles, anilines or indoles The use of derivatives of quinoline- or quinoxaline-5,8-diones or -diols in cosmetics, especially for the dyeing of keratinous matter and, in particular, the hair. It also relates to novel...
27	6340697	Oxime derivatives and agricultural chemicals containing the same Various oxime derivatives are provided, which do not cause any chemical damage to plants and which exhibit sufficient effectiveness against various plant diseases. The oxime derivatives are...
28	6211196	Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of...
29	6159985	Imidazo-isoquinoline compounds, their compositions and uses The subject invention involves compounds having the structure: wherein the C α --N β and C 5 -C 6 bonds are independently single or double bonds, R1 is selected from alkyl, aryl, and...
30	6140341	Aminoalkyl and acylaminoalkyl ethers, process for their preparation, and their use as bradykinin receptor antagonists Aminoalkyl and acylaminoalkyl ethers which are distinguished by high affinity for the bradykinin B 2 receptor and improved solubility in water are described. These aminoalkyl and acylaminoalkyl...
31	6124415	Crosslinked polyvinylpyrrolidone (PVPP) copolymer of vinyl pyrrolidone (VP) and monomer derived from 1-vinyl-3-(E)-ethylidene pyrrolidone (EVP) What is described herein is a crosslinked polyvinylpyrrolidone (PVPP) copolymer of vinyl pyrrolidone (VP) and monomer derived from 1-vinyl-3-(E)-ethylidene pyrrolidone (EVP).
32	6083959	Quinoline derivatives, processes for their preparation and their use as medicaments A compound of the formula: ##STR1## wherein R 1 is lower alkyl, R 2 is hydrogen, lower alkyl or a heterocyclic group, R 3 is hydrogen, lower alkyl or halogen, R 4 is lower alkyl or...
33	6063791	N-benzenesulfonyl-L-proline derivatives, method for preparing and therapeutic use The present invention relates to compounds selected from the group consisting of (i) the compounds of formula I: ##STR1## in which: X is a halogen atom or a methyl group, A is a group --N(R 3 )CO--...
34	5905149	Substituted quinolymethylen-oxindole analogues as tyrosine kinase inhibitors Quinolylmethylen-oxindole derivatives having general formula (I), wherein R is H or --(CH 2 ) n --COR 7 group in which n is an integer of 1 to 4 and R 7 is hydroxy, amino, C 1 -C 6 alkoxy or...
35	5866295	Photosensitive quinolone compounds and a process of preparation The present invention relates to novel photosensitive quinolone compounds, specifically novel 3-diazo 2,4-quinolinedione compounds, that may be used in a variety of applications, such as,...
36	5756422	Substituted quinoline compounds and their use as safeners Substituted quinoline compounds, processes for their preparation, composition containing them, and their use as safeners Compounds of the formula I and salts thereof ##STR1## in which R 1 lacuna!...
37	5741789	Compounds having effects on serotonin-related systems A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1 A receptor. The...
38	5721255	Substituted benzylamino nitrogen containing non-aromatic heterocycles The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R 1 , R 2 , R 3 and...
39	5670511	Indolepiperidine derivatives Indolepiperidine derivatives of the formula I ##STR1## and their physiologically acceptable salts exhibit action on the central nervous system, in particular dopamine-agonistic or...
40	5576437	7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists The subject invention involves methods of treating nasal congestion comprising administration, to a human or lower animal in need of such treatment of a safe and effective amount of a compound...
41	5569669	Alkylaminoindane compounds The invention relates to a compound selected from those of formula (I): ##STR1## in which R 1 , R 2 , R 2 ', R 2 ", R 2 '", R 3 and n are as defined in the description, an optical isomer, and an...
42	5541199	Chroman-2-ylmethylamino derivatives Compounds of the formula: ##STR1## in which n is one of the integers 1, 2, 3,or 4; m is one of the integers 0 or 1; R is ##STR2## or a pharmaceutically acceptable salt thereof, are inhibitors of...
43	5519022	α, α dialkylbenzyl derivatives The invention concerns α,α-dialkylbenzyl derivatives of the formula I ##STR1## wherein Ar 1 is phenyl or naphthyl, or a 10-membered bicyclic heterocyclic moiety containing one or two nitrogen...
44	5492915	Substituted quinolyl compounds exhibiting selective leukotriene B.sub.4 antagonist activity This invention relates to compounds having selective LTB 4 antagonist properties. Therapeutic compositions comprising said compounds and methods for the treatment of disorders involving LTB 4 ...
45	5488057	2-oxindole compounds which have useful tyrosine kinase activity The present invention provides novel aryl- and heteroarylethenylene derivatives which are useful as tyrosine kinase activity inhibitors.
46	5438141	Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents....
47	5436344	3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones Compounds of the formula ##STR1## wherein R 1 is hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, C 1 to C 4 alkoxy, C 1 to C 4 alkylthio or C 1 to C 6 alkyl and R 2 is a group of...
48	5407945	Pyran derivatives and their use as inhibitors of 5-lipoxygenase The invention concerns a cyclic ether derivative of the formula I ##STR1## wherein Ar 1 is optionally substituted phenyl, naphthyl or a 9- or 10-membered bicyclic heterocyclic moiety; A 1 is a...
49	5380852	5-chloroquinolin-8-oxyalkanecarboxylic acid derivatives, useful as antidotes for herbicides Disclosed are compounds of the formula (I): ##STR1## The substituents are disclosed in the specification. The compounds are herbicidal safenets. Accordingly, processes for the preparation and use...
50	5380850	(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...

Matches 1 - 50 out of 168

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