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7592356 |
Triazoles as farnesyl transferase inhibitors
a prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L 1 and L 2 are R 1 —Y— wherein each (R 1 —Y)— substituent is defined independently...
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7589114 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-azetidine-carboxylic acids, esters and amides
Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonyl]-azetidin
e-carboxylic acids, esters and amides which exhibit good inhibitory effect upon the interaction of CAMs and...
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7579347 |
Vanilloid receptor ligands and their use in treatments
Compounds having the general structure
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7576110 |
Benzothiazole cyclobutyl amine derivatives
Compounds of formula (I)
are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
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7576099 |
Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
Compounds are disclosed that have a formula represented by the following:
The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a...
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7576098 |
Heterocyclic compounds as inhibitors of factor VIIa
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable...
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7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
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7569584 |
4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihydro-imidazole-2-thione as specific alpha2b agonist and methods of using the same
The compound of the formula
wherein the * indicates an asymmetric carbon, is specific to alpha 2B adrenergic receptors in preference over alpha 2A and alpha 2C adrenergic receptors, and...
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7566716 |
Imidazopyrazines as Raf inhibitor compounds
Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, tautomers, solvates and...
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7550597 |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising...
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7550474 |
Substituted phenyl acetamides and their use as protease inhibitors
Phenyl acetamide compounds are described, including compounds of Formula I:
or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R 3 -R 6 , R 11 , B, Y and W are set forth...
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7524869 |
Taxanes having a C10 ester substituent
Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7514452 |
2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same
The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof:
...
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7514432 |
Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis
The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as...
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7511061 |
Triazoles as farnesyl transferase inhibitors
A prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L 1 and L 2 are R 1 —Y— wherein each (R 1 —Y)— substituent is defined independently...
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7504508 |
PGD2 receptor antagonists for the treatment of inflammatory diseases
Disclosed herein are compounds represented by Structural Formula (I) and (I-A):
Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as...
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7482458 |
Quinoline derivatives
NK 3 receptor antagonists of formula (I):
are useful in treating inter alia pulmonary disorders, CNS disorders and neurodegenerative disorders.
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7476686 |
Substituted aryl thioureas and related compounds; inhibitors of viral replication
The invention provides compounds and pharmaceutically acceptable salts of Formula I
wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of...
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7470787 |
Isoquinoline compounds
Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of...
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7462637 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide
Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidi
ne-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are...
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7459564 |
Substituted biaryl compounds as factor XIa inhibitors
The present invention provides compounds of Formula (I):
or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R 3 , and ring B...
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7452994 |
Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an...
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7446103 |
Bicyclic benzamide compound as histamine H3 receptor ligand useful in the treatment of neurological diseases
The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the...
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7439257 |
Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics
The invention relates to a compound of formula (I):
Wherein m, n, X, Y, R 1 , R 2 , R 3 and R 4 are as defined herein. The invention also relates to the use of same in therapeutics.
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7429665 |
Heteroaromatic quinoline compounds
The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors...
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7429592 |
Cyanoanthranilamide derivatives and the use thereof as medicaments
Substituted cyanoanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds...
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7408065 |
P2X7 receptor antagonists and their use
The invention provides compounds of formula (IA), processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.
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7405262 |
Preparation of functionalized anionic polymerization initiators
A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound.
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7399865 |
Protein tyrosine kinase enzyme inhibitors
This invention provides compounds of formula 1, having the structure
wherein R 1 , R 2 , R 3 , R 4 , and R 5 are described within the specification.
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7378240 |
Synthesis and evaluation of new cyanine dyes as minor groove of [POLY(dA-dT)]2 binders
The present invention relates to new cyanine dyes according to the formula (I), wherein A 1 and A 2 are each independently O, S, or N, and R is H or a carbohydrate that may contain a hetero atom,...
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7361796 |
Orangic electroluminescence device
A compound having a diphenylanthracene structure at the center and a specific structure substituted with an aryl group at end portions. An organic electroluminescence device comprises a plurality...
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7335753 |
Bifunctional heterocyclic compounds and methods of making and using same
The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of...
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7323477 |
7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline
A compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also...
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7320992 |
Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7304066 |
Pyridyl cyanoguanidine compounds
Compounds according to formula (I)
wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C 1-6 hydrocarbon radical, optionally substituted with...
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7279478 |
Cathepsin cysteine protease inhibitors
This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating...
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7276522 |
4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
The compound of the formula
wherein the * indicates an asymmetric carbon, is specific to alpha 2B adrenergic receptors in preference over alpha 2A and alpha 2C adrenergic receptors, and as...
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7268135 |
Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
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7265115 |
Diazabicyclic CNS active agents
Compounds of formula I:
or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
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7253188 |
Aminobenzamide derivative
This invention relates to a novel compound represented by the formula (I):
or a pharmaceutically acceptable salt thereof,
wherein R 1 is —S(O)p-A, —S—(O)q-B or —O-D, wherein p...
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7241893 |
Thiazolinone 2-substituted quinolines
Thiazolinone substituted quinoline derivatives where the quinoline ring is substituted at the 2 position which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer...
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7241776 |
Cyanoamidine P2X7 antagonists for the treatment of pain
Novel cyanoamidines compounds of formula (I) and (II)
and their derivatives wherein R 1 -R 12 are as defined in the specification act as antagonists of the P2X 7 receptor. These compounds are...
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7232832 |
Antibacterial agents
Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.
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7230010 |
1,2,4-triazole derivative, method for preparing the same, and pharmaceutical composition containing the same
A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient...
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7223759 |
Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of...
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7220760 |
Quinoline derivatives as CRTH2 antagonists
The invetion relates to compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined in the description, their use as medicament, pharmaceutical...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7211671 |
Substituted 1,3-dihydro-imidazol-2-one and 1,3-dihydro-imidazol-2-thione derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
The present invention describes novel 1,3-dihydro-imidazol-2-one or 1,3-dihydro-imidazol-2-thione compounds of formula (I):
or a stereoisomer or pharmaceutically acceptable salt or solvate...
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7202362 |
Transition metal complexes from solid state synthesis
Methods and compositions related to the synthesis of photosensitizers of titanium dioxide performed in situ, stepwise, in the solid state, and directly on the surface of the titanium dioxide...
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