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8173810 |
Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's...
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8173655 |
Bicyclic anilide heterocyclic CGRP receptor antagonists
Compounds of formula I: (wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or...
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8163909 |
Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's...
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8163766 |
Beta-secretase modulators and methods of use
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's...
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8163752 |
Tricyclic anilide heterocyclic CGRP receptor antagonists
Compounds of formula I: wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein, which are antagonists of CGRP receptors and which are useful in the treatment or...
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8158791 |
Aza-substituted spiro derivatives
A compound of the following formula (I) or its pharmaceutically-acceptable salt is provided: [wherein X, Y, Z and W each independently represent a methine group or a nitrogen atom, provided that a...
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8148390 |
Monocyclic anilide spirolactam CGRP receptor antagonists
The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful...
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8143266 |
Aryl heterocyclic CGRP receptor antagonists
Compounds of formula I: (wherein variables A1, A2, B, m, n, J, X, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or...
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8134017 |
Compound and use thereof
A compound represented by the following formula (1) or (2):
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8119816 |
Merocyanine dye and use thereof
The present invention provides a blue laser light-absorbent substance, which is suitably used in organic photo conductor, laser optical data carrier or organic light-emitting diodes. The blue laser...
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8088765 |
Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
Compounds of formula (I): wherein R1, R2, R3, R4, Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
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8076348 |
Acylguanidine derivative or salt thereof
[Problem] To provide a compound which can be used in the prevention and/or treatment of diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in the treatment of...
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8071770 |
Spirohydantoin aryl CGRP receptor antagonists
Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in...
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8071772 |
Spirolactam bicyclic CGRP receptor antagonists
Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2, J and K are as described herein) which are antagonists of CGRP receptors and which are useful...
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8071771 |
Bicyclic spirohydantoin CGRP receptor antagonists
Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in...
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8067620 |
Dispiro 1,2,4-trioxolane antimalarials
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one...
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8062768 |
Compound comprising phenyl pyridine units
Organic compounds of formula I may be used in optoelectronic devices wherein R1 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20...
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8053095 |
Compound comprising phenyl pyridine units
Compounds of formula I may be used in optoelectronic devices wherein R1 is, independently at each occurrence, a C1-C20 aliphatic radical, a C3-C20 aromatic radical, or a C3-C20 cycloaliphatic...
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8013174 |
Photochromic spirodihydrophenanthropyrans
Specific photochromic spirodihydrophenanthropyrans and their use in synthetic resin materials of all kinds, particularly for ophthalmic purposes. The compounds of the invention are photochromic...
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7998959 |
Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of ...
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7964624 |
Inhibitors of serine proteases
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof. These compounds inhibit serine protease, particularly the hepatitis C virus NS3-NS4A protease.
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7947677 |
Spirolactam tricyclic CGRP receptor antagonists
Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, J, K, T, U, V, W, X, Y and Z are as described herein) which are...
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7943630 |
3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
This invention relates to novel 3,9-diaza-spiro[5.5]undecane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these...
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7928232 |
Method for producing asymmetric tetrasubstituted carbon atom-containing compound
The invention provides an industrial method for producing a spiroaminopyrrolidone derivative, which is an intermediate for producing a quinolone antibacterial agent. The invention provides a method...
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7923559 |
N-aryl diazaspirocyclic compounds and methods of preparation and use thereof
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl diazaspirocyclic compounds, bridged analogs of...
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7892658 |
Compound and organic light emitting device using the same
Disclosed is an organic light emitting device. The organic light emitting device comprises a first electrode, organic material layer(s) comprising a light emitting layer, and a second electrode....
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7842404 |
Compound and organic light emitting device using the same
Disclosed is an organic light emitting device. The organic light emitting device comprises a first electrode, organic material layer(s) comprising a light emitting layer, and a second electrode....
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7842405 |
Compound and organic light emitting device using the same
Disclosed is an organic light emitting device. The organic light emitting device comprises a first electrode, organic material layer(s) comprising a light emitting layer, and a second electrode....
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7838129 |
Compound and organic light emitting device using the same
Disclosed is a novel compound which is capable of significantly improving a lifespan, efficiency, and electrochemical and thermal stabilities of an organic light emitting device, the production of...
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7825152 |
Organic compounds and their uses
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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7824779 |
Compound and organic light emitting device using the same
Disclosed is an organic light emitting device. The organic light emitting device comprises a first electrode, organic material layer(s) comprising a light emitting layer, and a second electrode....
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7825115 |
Cyclic urea compounds, preparation thereof and pharmaceutical use thereof as kinase inhibitors
The disclosure relates to a cyclic urea compound of formula I: as defined herein, to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use as an...
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7820306 |
Compound and organic light emitting device using the same
Disclosed is an organic light emitting device. The organic light emitting device comprises a first electrode, organic material layer(s) comprising a light emitting layer, and a second electrode....
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7820691 |
Indoloquinoline compounds as calcium channel blockers
Various calcium channel blockers and pharmaceutical compositions containing these compounds are disclosed. Calcium channel blockers are compounds capable of inhibiting calcium ion channels. Methods...
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7816019 |
Compound and organic light emitting device using the same
Disclosed is an organic light emitting device. The organic light emitting device comprises a first electrode, organic material layer(s) comprising a light emitting layer, and a second electrode....
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7811682 |
Compound and organic light emitting device using the same
Disclosed is a novel compound which is capable of significantly improving a lifespan, efficiency, and electrochemical and thermal stabilities of an organic light emitting device, the production of...
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7812021 |
Pyrrolidine aryl-ether as NK3 receptor antagonists
The invention relates to a compound of general formula wherein Ar, R1, R2, R3, R4, n, o, p, s, X and are as defined herein or to a pharmaceutically active salt thereof, including all stereoisomeric...
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7799798 |
Spiroheterocyclic compounds and their uses as therapeutic agents
This invention is directed to spiroheterocyclic compounds of formula (I) wherein k, j, p, Q, R1, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or...
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7799441 |
Compound and organic light emitting device using the same
Disclosed is an organic light emitting device. The organic light emitting device comprises a first electrode, organic material layer(s) comprising a light emitting layer, and a second electrode....
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7795249 |
Certain pyrazoline derivatives with kinase inhibitory activity
The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in...
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7785720 |
Compound and organic light emitting device using the same
Disclosed is an organic light emitting device. The organic light emitting device comprises a first electrode, organic material layer(s) comprising a light emitting layer, and a second electrode....
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7776874 |
Amido compounds and their use as pharmaceuticals
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The ...
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7772247 |
Substituted thieno[3,2-d]pyridines as inhibitors of the VEGF receptor and HGF receptor
The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor...
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7754708 |
N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds,...
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7723372 |
Spiroindolinone derivatives
There are provided compounds of the general formulas wherein W, X, Y, R1, R2, R3, and R4 are as described herein. The compounds exhibit anticancer activity.
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7700611 |
Synthesis and crystalline forms of NPY5 antagonist
The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaiso
benzofuran-1(3H),1′-cyclohexane]-4′-carboxamide and novel sal...
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RE41149 |
Optically active pyridonecarboxylic acid derivatives
N1-(1,2-cis-2-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by the following formula (I) the terms of which are defined in the specification and the salts thereof...
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7648994 |
Heterocyclic cyclopamine analogs and methods of use thereof
The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
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7608712 |
Pyridine imidazoles and aza-indoles as progesterone receptor modulators
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or...
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7538122 |
Heterocyclic antiviral compounds
This invention relates to piperidine derivatives of formulae Ia and Ib with substituents as defined herein useful in the treatment of a variety of disorders, including those in which the modulation...
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