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8183378 Ligands, their preparation and uses thereof in asymmetric reactions  
Novel chemical agents are described herein. More a ligand of general Formula I: wherein R1, R2, R3 and R4, are independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-C10...
8163921 Hepatitis C virus inhibitors  
Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
8115002 Preparation of substituted morphinan-6-ones and salts and intermediates thereof  
The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.
7906655 Hepatitis C virus inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
7902218 Substituted tetrahydroisoquinolines as β-secretase inhibitors  
There is provided a series of tetrahydroisoquinoline diaminopropane compounds of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R, R8 and R9 are as defined...
7838677 Processes for preparing morphinans and intermediates thereof  
The present invention is directed to processes for the synthesis of morphinans. In particular, a process for cyclizing a β,γ-bicyclic ketone compound to form a nordihydrothebainone product using t...
7834184 Opiate intermediates and methods of synthesis  
Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided. The intermediates are...
7601739 Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases  
Compounds for the treatment of estrogen-receptor related maladies are provided. Compounds with anti-androgenic properties also are provided. In particular, the invention provides compounds that are...
7595399 Tyrosine derivatives  
The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.
7538121 Vanilloid receptor modulators  
Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, P, X, Y, q, r ans s are as defined in the specification, a process for preparing such...
7511060 Opiate intermediates and methods of synthesis  
Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided.
7312222 Heterocyclic piperidines as modulators of chemokine receptor activity  
The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
7309708 Hepatitis C virus inhibitors  
Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for u...
7217706 Propanolamine derivatives  
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have...
RE39265 Heteroarylpiperidines, and their use as antipsychotics and analgetics  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
7041664 2-aminoquinolinecarboxamides: neurokinin receptor ligands  
Disclosed are compounds of the formula: or pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, wherein R1, R2, R3, X, Q1 and Q2 are defined herein, which compounds...
6949565 Protein kinase inhibitors  
Novel isoquinoline derivatives which are useful as inhibitors of protein kinases for experimental, medical, and drug design purposes are disclosed. Preferred compounds which are specific inhibitors...
6875765 Arylsulfonamide ethers, and methods of use thereof  
The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are ...
6809091 Substances capable of inducing apoptosis  
A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and...
6784186 Therapeutic compounds  
This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of...
6703392 1,2,3,4-tetrahydroisoquinoline derivatives  
The invention relates to novel 1,2,3,4-tetrahydroisochinoline derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also...
6653321 Naphthylsulfonic acids and related compounds as glucose uptake agonists  
Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or...
6627641 Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof  
The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial...
6573278 Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases  
The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the...
6509351 Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity  
The present invention relates to compounds of formula (I): as well as the salts or solvates thereof, to pharmaceutical compositions containing them, to a process for preparing them and to synthetic...
6476226 Isoxazoline fibrinogen receptor antagonists  
This invention relates to novel isoxazolines and isoxazoles of formula (I): or a pharmaceutically acceptable salt or prodrug form thereof. The invention relates to novel isoxazolines which are...
6417362 Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same  
Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can...
6414154 Tetraisoquinoline derivatives as modulators of dopamine D3 receptors  
Compounds of formula (I), wherein: R1 represents a substituent selected from: a hydrogen or halogen atom; a hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy,...
RE37729 4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
6288071 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides  
Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
6265408 Sulphonamide derivatives and their use in the treatment of CNS disorders  
Sulphonamide compounds according to formula (I) or pharmaceutically acceptable salts thereof: ##STR1##wherein: Ar is naphthyl, phenyl or thienyl optionally substituted by one or more substituents...
6211196 Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists  
Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of...
6184381 Process for preparing optically active compounds  
This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various...
RE37029 N-[(3-heteroaryl-1-pyrrolidinyl)-alkyl]phthalimides and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
6087346 Sigma receptor ligands and the use thereof  
6063925 Separation of enantiomers of octahydroisoquinoline  
This invention describes a process for the isolation of (-)1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline from a racemic mixture, which involves treating partially resolved mixtures...
6046190 Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors  
The invention relates to sulfonamide-containing hydroxyethylamine protease inhibitor compounds, their process of making, composition and method of use for inhibiting retroviral proteases such as...
6043253 Fused piperidine substituted arylsulfonamides as β3-agonists  
Fused piperidine substituted arylsulfonamides are β3 adrenergic receptor agonists with very little β1 and β2 adrenergic receptor activity and as such the compounds are capable of increasing li...
6015903 Method of resolving racemic mixtures  
A process for resolving racemates of compounds of the formula I ##STR1## in which a, A, B, D, E, F, M, Q and R have the meanings given in the description is described. The process is carried in a...
5994507 Method for binding albumin and means to be used in the method  
A method for binding albumin by contacting an aqueous liquid containing an albumin with an albumin-binding compound is selected from albumin-binding compounds containing the scaffold...
5981521 Tetrahydroisoquinoline derivatives as LHRH antagonists  
Tetrahydroisoquinoline derivatives of the formula: ##STR1## or a pharmaceutically acceptable salt, ester, or prodrug thereof, having activity as an LHRH antagonist, as well as pharmaceutical...
5955471 Tetrahydroisoquinolinealkanol derivatives and pharmaceutical compositions containing same  
The present invention provides novel 1,2,3,4-tetrahydroisoquinoline carbamate and thiocarbamate derivatives represented by Formula I ##STR1## wherein: X1 and X2 are the same or different from each...
5904877 Trifluoratetrahydroisoquinoline derivatives, and the use thereof in liquid-crystalline mixtures  
1,8,8-Trifluoro-5,6,7,8-tetrahydroisoquinoline derivatives, and their use in liquid-crystalline mixtures 1,8,8-Trifluoro-5,6,7,8-tetrahydroisoquinoline derivatives of the formula (I) R1 (--M1)a...
5882546 1,8-Difluorisoquinoline derivatives and the use thereof in liquid crystalline mixtures  
1,8-Difluoroisoquinoline derivatives of the formula (I) R1 (--M1)a (--A1 --M2)b (--A2 --M3)c --B(--M4 --A3)d (--M5 --A4)e (--M6)f --R2 (I)in which the symbols and indices have the following...
5880285 Process for manufacture of optically active isochinole compounds  
A process for the manufacture of optically active (R)- or (S)-1-(4-methoxy-benzyl)-1,2,3,4,5,6,7,8-octahydro-isoquinol ine adducts of the formula ##STR1## wherein HX signifies a mineral acid from...
5856503 Aminoalkyl-substituted benzo-heterocyclic compounds  
Aminoalkyl-substituted benzo-heterocyclic compounds of the formula ##STR1## wherein M, Q, R and T are as defined in the specification, as well as acid addition salts thereof. These compounds are...
5817674 Quinoline compounds  
Compounds of the formula ##STR1## in all possible racemic, enantiomeric and diastereoisomeric forms and their non-toxic, pharmaceutically acceptable salts with acids and bases having antagonistic...
5776963 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5763613 Monomeric naphthylisoquinoline alkaloids and synthesis methods thereof  
The present invention provides methods of preparing monomeric naphthylisoquinoline alkaloids, including the antiparasitic korupensamines and related compounds, as well as non-korupensamines and...
5756516 1,2,3,4-tetrahydroisoquinoline derivatives and pharmaceutical composition thereof  
The invention relates to compounds of formula (I) ##STR1## wherein R1 is an optional substituent any position of phenyl ring and is selected from halogen, --NO2, --NH2, --OH and --O--CR1-6 alkyl;...
Matches 1 - 50 out of 242 1 2 3 4 5 >