Matches 51 - 100 out of 273 < 1 2 3 4 5 6 >
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6498251 Tetrahydrobenzindole derivatives  
Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling...
6492421 Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4  
Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
6472404 HIV protease inhibitors  
The present invention discloses novel isoquinoline carboxamide derivatives which are HIV protease inhibitors or prodrugs thereof, a process for their manufacture, pharmaceutical compositions and...
6472416 Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors  
The present invention encompasses novel sulfonylphenylpyrazole compounds useful in the treatment of cyclooxygenase-2 mediated diseases.
6469041 Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands  
Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF 1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such...
6469047 Tyrosine derivatives  
The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.
6465482 Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression  
Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise Wherein: R 1 , R 2 and R 3 are each, independently, hydrogen, halogen, CF...
6458950 Compounds and pharmaceutical compositions containing the same  
A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the...
6452009 4-unsubstituted dihydroisoquinolinone derivatives and combinatorial libraries thereof  
The present invention relates to novel dihydroisoquinolinone (DHQ) derivative compounds of the following formula: wherein R 1 to R 7 , X, Y, Z, b, c and d have the meanings provided herein. The...
6420375 Fused ring compounds, process for producing the same and use thereof  
To provide a novel compound of the formula: [wherein A 1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A 2 is an aromatic ring which may be...
6407112 Optically active tetrahydrobenzindole derivative  
Optically active tetrahydrobenzindole type compounds having affinity for a 5-HT receptor, useful for prevention and treatment of mental diseases. A species compound is...
6403608 3-Substituted isoquinolin-1-yl derivatives  
3-Substituted isoquinoline containing squaric acids of formula (1) are described: wherein Ar 1 is a 3-substituted isoquinolin-1-yl group; L 2 is a covalent bond or a linker atom or group; Ar 2...
RE37729 4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
6362201 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R 1 , R 2 , R 3 , R 4c , R 4d , and R 4f are defined herein) which are useful as modulators of chemokine...
6362195 Branched alkoxy-substituted 2-aminopyridines as NOS inhibitors  
The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula wherein R 1 , R 2 , R 3 and R 4 are defined as in the specification, that exhibit activity as nitric...
6352985 Benzimidazole compounds  
A benzimidazole compound represented by the formula (I): wherein R 3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl...
RE37478 1-(arylthioalkyl, arylaminoalkyl, or arylmethylenealkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
6323217 Piperidine-4 sulphonamide compounds  
A compound of formula (I): ##STR1## wherein: R 1 represents hydrogen or alkyl, R 2a and R 2b represent a group selected from hydrogen, halogen, alkyl, hydroxy, alkoxy, trihaloalkyl, cyano,...
6300342 Antithrombotic phenylalkyl derivatives  
Antithrombotic phenylalkyl derivatives of the formula ##STR1## Exemplary compounds are: (a) 1-[3-(4-amidino-phenyl)propionyl]-6-(4-fluoro-phenylsulphona mido)-1,2,3,4- tetrahydro-quinoline, ...
6284775 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds  
There are disclosed compounds of the formula, ##STR1## where n is 0, 1 or 2; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy,...
6281359 Aminomethyl phenyl pyridine derivatives  
Disclosed are compounds of the formula: ##STR1## where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR' where R' is an organic...
6268379 Substituted aryl hydroxamic acids as metalloproteinase inhibitors  
The present application describes novel substituted aryl hydroxamic acids of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein ring A is a 5-8 membered ring containing...
6262074 4-Hetaroylpyrazol derivatives and the use thereof as herbicides  
Hetaroyl derivatives of the formula I ##STR1## where: R 1 and R 2 are each hydrogen, nitro, halogen, cyano, thiocyanato, hydroxyl, mercapto, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 ...
6245780 Tetrahydroisoquinolinyl-indole derivatives for the treatment of depression  
Compounds are provided which have the formula: ##STR1## wherein: R 1 , R 2 , R 3 , and R 4 are, independently, hydrogen, halogen, alkoxy, or carboxamide; R 5 is hydrogen, halogen, CF 3 ,...
6235750 6-phenylpyridyl-2-amine derivatives useful as NOS inhibitors  
The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula ##STR1## wherein G, R 1 and R 2 are defined as in the specification, that exhibit activity as nitric...
6211196 Benzyloxy-substituted, fused N-heterocycles, processes for their preparation, and their use as bradykinin receptor antagonists  
Benzyloxy-substituted, fused N-heterocycles, because of their ability to act as bradykinin receptor antagonists, have been found to be useful as therapeutics for the treatment and prevention of...
6207671 Cycloalkano-pyridines  
The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the...
6197968 Decolorizable dye  
Described is a decolorizable dye represented by the following formula (I): ##STR1## wherein R 1 represents an alkyl, aryl or heterocyclic group; R 2 and R 3 independently each represents a...
RE37029 N-[(3-heteroaryl-1-pyrrolidinyl)-alkyl]phthalimides and related compounds and their therapeutic utility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
6174901 Substituted pyridine and pyridazine compounds and methods of use  
Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies,...
6166041 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma  
Novel compounds which are effective PDE IV inhibitors are disclosed. The present invention is directed to compounds having the general formula I ##STR1## wherein: X is a halogen; Q is --CH 2 ...
6166037 Pyrrolidine and piperidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine and piperidine compounds of the formula I: ##STR1## (wherein R 1 , R 2 , R 3 , R 4a , R 4b , R 4c , R 4d , R 4e , R 4f , R 4g , R 4h , m, n, x and y...
6162809 Pyridylthio compounds for controlling helicobacter bacteria  
Pyridinylthiomethyl- and pyrimidinylthiomethyl-pyridines and their pharmacologically-acceptable compositions are useful for controlling Helicobacter bacteria and for treating those afflicted with...
6140340 Derivatives of 2-[3-phenyl-2-propenyl]-1,2,3,4-tetrahydro isoquinoline, their process and their use as fungicides  
Derivatives of 2-[3-phenyl-2-propenyl]-1,2,3,4-tetrahydro-isoquinoline compounds of the formula in all their possible stereoisomer forms as well as their mixtures ##STR1## wherein X is nitrogen or...
6127380 4-aminoalkoxy-1H-benzoimidazoles  
This invention relates to D 2 dopaminergic compounds of the formula ##STR1## wherein: R 1 is hydrogen, trifluoromethyl, pentafluoroethyl, heptafluoropropyl, straight-chain or branched alkyl group...
6028080 Quinolin-2-(1H)-ones  
The invention relates to quinoline-2-(1H)-one derivatives of the general formula I ##STR1## in which R 1 , R 2 and R 3 are in each case independently of one another H, Hal, A or OA; R 4 is H,...
6025367 Sulfonamide derivatives as 5HT.sub.7 receptor antagonists  
The invention relates to sulphonamide compounds of formula (I) or a salt thereof having pharmacological activity, processes for their preparation, to compositions containing them and to their use...
6011037 Thiazole derivatives with phosphodiesterase-inhibiting action  
5998623 Process and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-a mide  
A process for preparing the compound of formula (1) is disclosed. ##STR1## The starting materials are an N-triazolylmethyl-6-aminoisoquinoline and a 4-biphenyl-2-carboxylic acid derivative.
5972958 4-aminoalkoxy-1,3-dihydro-benzoimidazol-2-thiones  
This invention relates to a novel series of compounds having potency at the dopamine D 2 receptor which are illustrated by the following Formula I: ##STR1## wherein: R 1 is hydrogen or C 1 -C 6 ...
5942618 1-fluor-5,6,7,8-tetrahydroisoquinoline derivatives, and their use in liquid-crystal line mixtures  
1-Fluoro-5,6,7,8-tetrahydroisoquinoline derivatives, and their use in liquid-crystalline mixtures 1-Fluoro-5,6,7,8-tetrahydroisoquinoline derivatives of the formula (I) R 1 ( --M 1 ) a (--A 1 ...
5925653 Substituted pyridines and pyrimidines processes for their preparation and their use as pesticides and fungicides  
Substituted pyridines and pyrimidines, processes for their preparation and their use as pesticides and fungicides. The invention relates to compounds of the formula ##STR1## in which A is N or CH,...
5904877 Trifluoratetrahydroisoquinoline derivatives, and the use thereof in liquid-crystalline mixtures  
1,8,8-Trifluoro-5,6,7,8-tetrahydroisoquinoline derivatives, and their use in liquid-crystalline mixtures 1,8,8-Trifluoro-5,6,7,8-tetrahydroisoquinoline derivatives of the formula (I) R 1 (--M 1...
5882546 1,8-Difluorisoquinoline derivatives and the use thereof in liquid crystalline mixtures  
1,8-Difluoroisoquinoline derivatives of the formula (I) R 1 (--M 1 ) a (--A 1 --M 2 ) b (--A 2 --M 3 ) c --B(--M 4 --A 3 ) d (--M 5 --A 4 ) e (--M 6 ) f --R 2 (I) in...
5880135 Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them  
A compound, as well as its stereoisomers and addition salts, possssing antagonist activity with respect to corticotropin releasing hormone (CRF) has the formula: ##STR1## in which R 1 , and R 21 ...
5849769 N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection  
A method for treating HIV which comprises a compound of the formula ##STR1## wherein A is ##STR2## and Z i is O, Se, NR a or C(R a ) 2 , and Z ii is --O or (O) 2 ; wherein R 1 , R 2 ,...
5807868 Isoquinoline derivatives as therapeutic agents  
Tetrahydroisoquinoline compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof, in which: R 1 represents one or more substituents selected from H, halo, hydroxy, alkyl...
5789408 Antiviral thiazoles  
Compounds of formula (I) are active antiviral compounds useful in the treatment of viral infections in mammals. The compounds of the invention are readily prepared by reaction of a suitable...
5776963 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5756516 1,2,3,4-tetrahydroisoquinoline derivatives and pharmaceutical composition thereof  
The invention relates to compounds of formula (I) ##STR1## wherein R 1 is an optional substituent any position of phenyl ring and is selected from halogen, --NO 2 , --NH 2 , --OH and --O--CR 1 -6...
Matches 51 - 100 out of 273 < 1 2 3 4 5 6 >