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7615563 |
Compositions useful as inhibitors of voltage-gated sodium channels
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
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7612089 |
Tetrahydroisoquinolines as factor Xa inhibitors
The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The...
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7608617 |
Naphthaline derivatives as H3 inverse agonists
The present invention relates to compounds of formula I:
and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The...
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7601739 |
Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases
Compounds for the treatment of estrogen-receptor related maladies are provided. Compounds with anti-androgenic properties also are provided. In particular, the invention provides compounds that are...
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7601738 |
Excitatory amino acid receptor antagonists
The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative...
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7598242 |
Compounds for the treatment of inflammatory disorders
This invention relates to compounds of the Formula (I):
or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions...
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7566726 |
3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
(wherein n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 15 , R 16 , R 17 , R 18 , Y and Z are defined herein) which are modulators of chemokine receptor activity and are useful...
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7557124 |
Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
Compounds of Formula I:
(wherein n, R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 15 , R 16 , Y and Z are as defined herein) which are modulators of chemokine receptor activity and...
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7557123 |
Heterocyclic compound and medicinal use thereof
The novel heterocyclic compound of the present invention is a novel heterocyclic compound having the formula (I)
Y:
R 15 —C(R 14 )═N—O—
wherein R 1 is H or C 1-6 alkyl, R 2 is...
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7528136 |
Prolinamide derivatives as NK3 antagonists
The present invention relates to a compound of formula I
wherein
R 1 , R 2 , R 3 , R 4 , R 5 , X, n, and o are as defined herein and to a pharmaceutically acceptable acid addition salt thereof...
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7524883 |
Eponemycin and epoxomicin analogs and uses thereof
The present invention provides compounds having formula (1): wherein R 1 -R 6 , A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally...
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7521461 |
Benzoic acid derivatives as modulators of PPAR alpha and gamma
A compound of formula (I) wherein R 1 represents aryl optionally substituted by a heterocyclic group or a heterocyclic group optionally substituted by aryl wherein each aryl or heterocyclic group...
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7517988 |
Hydroxamates as therapeutic agents
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore...
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7511060 |
Opiate intermediates and methods of synthesis
Novel opiate intermediate compositions and methods of synthesis that include changing the substitution pattern on the aromatic ring of the pre-Grewe intermediate are provided.
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7498441 |
Biaryltetrahydroisoquinoline piperidines as selective MCH receptor antagonists for the treatment of obesity and related disorders
The present invention discloses compounds which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In other aspects, the invention is...
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7495011 |
Anti-coronavirus drug
The present invention provides an anti-coronavirus agent including as an active ingredient as exemplified by nelfinavir and salts thereof, an anti-SARS agent including the anti-coronavirus agent,...
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7482449 |
Process for making spirolactone compounds
This invention relates to a process for making spirolactone compounds analogous to formula I.
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7482361 |
Crystalline form for quinapril hydrochloride and process for preparing the same
A novel crystalline form of quinapril hydrochloride of formula (I)
An amorphous form of quinapril hydrochloride substantially free of impurities, specially diketopiperazine compound, and...
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7482341 |
Pyridines
Compounds of formula
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 6 have the significance given in claim 1 can be used in the form of pharmaceutical...
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7470787 |
Isoquinoline compounds
Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of...
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7442710 |
Substituted phenyl methanones
The present invention relates to compounds of general formula IA or IB
wherein
X 1 and X 2 are each independently N or C—R″ and R 1 , R 2 ,R 3 , R 4 , R 5 , and R 6 are as defined in...
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7439242 |
PPARγ modulators
Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
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7407976 |
Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions...
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7407972 |
Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
The present invention provides compounds of Formula (I):
wherein A, B, C, G, and W 1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
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7402594 |
Sulfated bis-cyclic agents
Sulfated bis-cyclic compounds that are potent anticoagulants and methods for their manufacture are provided. The sulfated compounds are bis-cyclic moieties comprised of an isoquinoline ring joined...
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7396838 |
Use of 1H-indol-3-yl-2-oxoacetamide compounds
A method of treating cancer including administering to a subject in need thereof an effective amount of a compound of the formula 1:
wherein R 1 , R 2 , R 3 , R 4 , and n are as defined herein.
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7388017 |
Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease
The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds,...
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7378428 |
Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient
A nitrogen-containing bicyclic compound of formula (I) or a pharmaceutically acceptable salt thereof (wherein the symbols have the same meanings as described in the specification).
The compound...
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7378421 |
Chromenone derivatives
Novel compounds of the formula I
in which
R 1 , R 2 , R 3 and Het are as defined herein, which
are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for the treatment of...
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7371762 |
3-substituted 6,7-dihydroxytetrahydroisoquinoline derivatives for use as antibacterial agents
The invention relates to novel tetrahydroisoquinoline derivatives of general formula I and theirs use as active ingredients in the preparation of pharmaceutical compositions. The invention also...
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7354919 |
Isoxazole compositions useful as inhibitors of ERK
Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula:
where A, B, R 1 , R 2 , T and Ht are described in the...
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7323475 |
Nitrogen-containing heteroaryl compounds and methods of use thereof
The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in...
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7314938 |
Modulators of cellular adhesion
The present invention provides compounds having formula (I):
and pharmaceutically acceptable derivatives thereof, wherein R 1 -R 4 , n, p, A, B, D, E, L and AR 1 are as described...
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7312218 |
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If:
or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
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7309708 |
Hepatitis C virus inhibitors
Hepatitis C virus inhibitors are disclosed having the general formula:
wherein R 1 , R 2 , R 3 , R′, B, Y and X are described in the description. Compositions comprising the compounds and...
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7307086 |
3-(4-heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors
The present invention is directed to compounds of Formula I:
which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment...
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7276500 |
Substituted amides, their preparation and use
An amide of the formula I
and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the...
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7271192 |
Substituted 2-pyrrolidine-2-yl-1H-indole compounds
Novel 2-pyrrolidin-2-yl-1H-indole compounds corresponding to formula (I)
wherein R 1 , R 2 , R 3 and R 4 have the meanings given in the description, and pharmaceutical compositions containing...
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7268147 |
Compounds useful for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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7253168 |
Substituted 1-benzyl-4-substituted piperazine analogues
Compounds of Formula I are provided, in which variables are as described herein:
Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly...
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7244743 |
Non-peptidic BRS-3 agonists
Selectively BRS-3-agonistic compounds of formula I
wherein A 1 , A 2 , A 3 , R 1 , R 2 , R 3 , Ar 1 , Ar 2 , Ar 3 , m and n have the meanings given in the description, and also pharmaceutical...
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7241775 |
Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines
Substituted 4-phenyltetrahydroisoquinolines of formula I, process for their preparation, their use as a medicament and medicaments containing them.
The compounds of formula I can be used, among...
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7241319 |
Dye composition comprising at least one polycationic direct dye, dyeing processes, uses, and multi-compartment devices
Disclosed herein is a dye composition for dyeing human keratin fibers, such as the hair, comprising a direct polycationic dye of formula (I) below:
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7211586 |
Substituted tetrahydroisoquinolines
The invention is directed to physiologically active compounds of formula (I):
wherein:
R 1 represents optionally substituted aryl, optionally substituted heteroaryl, R 3 NH—Ar 1 —L 2 —...
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7208601 |
Aryl and heteroaryl compounds, compositions, and methods of use
This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The...
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7205313 |
Excitatory amino acid receptor antagonists
The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative...
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7199265 |
Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor β, to methods of preparing such compounds...
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7186276 |
Dye composition comprising at least one direct dye, dyeing processes, uses and multi-compartment devices
Disclosed herein is a dye composition for dyeing human keratin fibers, such as the hair, comprising a direct polycationic dye of formula (I) below:
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