Patents in Class 546/146

Matches 101 - 150 out of 636

Match	Document	Document Title
101	6794507	Compounds that inhibit factor Xa activity The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, hydrate or a pharmaceutically acceptable formulation thereof. Those compounds can be...
102	6777425	Isoquinoline compounds having antiinfective activity Isoquinoline compounds having the formula where R 1 , R 2 , Y, m, n, and Z are as defined herein, bind to the minor groove of DNA and have antifungal and antibacterial activity.
103	6774086	3-Aminocarbonyl-substituted benzoylcyclohexanediones There are described derivatives of benzoylcyclohexanediones of the formula (I) and their use as herbicides. In this formula (I), R 1a , R 1b , R 1c , R 2 , R 3 , R 4 and R 5 are various...
104	6770656	Amine derivatives for the treatment of apoptosis The present invention is related to substituted amine derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such amine derivatives...
105	6753317	Dmt-Tic di- and tri-peptide derivatives and related compositions and methods of use A compound of formula: comprising the Dmt-Tic pharmacophore and related compositions and methods of use in the inhibition of the binding of an opioid receptor-binding compound with a...
106	6747041	Heterocyclic dicarboxylic acid diamide derivatives, agricultural/horticultural insecticides and method of using the same Heterocyclic dicarboxylic acid diamide derivative represented by the general formula (I): wherein R 1 , R 2 and R 3 represent each H, optionally halogenated C 3-6 cycloalkyl, etc.; Het...
107	6747050	Isoxazoline derivative and a process for the preparation thereof The present invention provides to an isoxazoline derivative of formula (I), the pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof, and the use of the derivative...
108	6720427	Thiazole derivatives The invention provides compounds of formula 1 wherein R 1 , R 3 , and R 4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity...
109	6710056	Amidinophenylpyruvic acid derivatives An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood...
110	6693199	Method of making HIV protease inhibitors A method of making HIV protease inhibitors of general formula (1): These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV...
111	6677354	Piperdines for use as orexin receptor antagonists Disclosed are compounds of formula (I): wherein: Y represents a group (CH 2 ) n , wherein n represents 0, 1 or 2; R 1 is phenyl, naphthyl, a mono or bicyclic heteroaryl group containing up to 3...
112	6664393	N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I, in which A, L, Y, and k have the meanings indicated in the specification and claims. The compounds of the formula I are valuable...
113	6664277	Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical...
114	6653321	Naphthylsulfonic acids and related compounds as glucose uptake agonists Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or...
115	6642228	α1b-adrenergic receptor antagonists There are provided compounds represented by the general formula (I): [wherein Ar is indole etc., R 1 is hydrogen etc., B is bond, or B—N—R 1 forms a ring structure and is piperidine etc.,...
116	6627641	Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial...
117	6620947	Compounds for use in 11-oxa prostaglandin synthesis Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.
118	6610701	Thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: wherein R 3 is hydrogen or halogen,...
119	6605721	Intermediates for making HIV-protease inhibitors and methods for making HIV-protease inhibitors HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel...
120	6602864	Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from...
121	6596732	1,3-dihydro-2h-indol-2-one, preparation method and pharmaceutical compositions containing same The invention relates to compounds of formula: and their solvates and/or hydrates exhibiting an affinity and a selectivity for arginine-vasopressin V 1b receptors or for both V 1b and V 1a ...
122	6586597	Continuous process for the preparation of optically pure decahydroisoquinolinecarboxamide The present invention relates to a continuous process for the preparation of [3S-(3α, 4 a β, 8 a β)]-N-tert-butyl-decahydro-3-isoquinolinecarboxamide, an intermediate useful in the synthesis of...
123	6579886	Selective iglur5 receptor antagonists The present invention provides compounds of formula (I): wherein W represents hydrogen, C 1 -C 4 alkyl, —CH 2 CO 2 H, or CO 2 H; and X represents hydrogen, C 1 -C 4 alkyl, —CH 2 CO 2 H, or CO...
124	6562822	Heterocyle carboxamides as antiviral agents The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
125	6538006	Retroviral protease inhibitors N-heterocyclic moiety-containing hydroxyethylamine protease inhibitor compounds, methods for making the compounds, and intermediates useful in the method. Also, a method for inhibiting retroviral...
126	6534650	Benzisoxazole and 4-amidino-3-hydroxyphenyl chemical intermediates This invention relates to compounds of Formula V H—Y—G—R V and Formula VI (wherein f, X, Y, G and R have the values defined in the description) which are useful as intermediates for the...
127	6531478	Amino pyrazole derivatives useful for the treatment of obesity and other disorders Amino pyrazole derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor and pharmaceutical compositions containing an amino pyrazole derivative as the active...
128	6528525	Amidocarboxylic acid derivatives Amidocarboxylic acid derivatives of the formula: wherein R 1 represents a hydrogen atom, etc.; R 2 represents an alkylene group; R 3 represents a hydrogen atom, etc.; R 4 represents a...
129	6511990	Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof The present invention provides the compound having the formula: wherein each of R 1 and R 2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino,...
130	6492387	Isoindolyl and isoquinolinyl aroyl pyrrole compounds This invention is directed to isoindolyl and isoquinolinyl aroyl pyrrole compounds pharmaceutically useful as agents or modulators for the treatment of central nervous system disorders and methods...
131	6482859	Microbicidal N-sulfonylglycin alkynyloxyphenethyl amide derivatives The invention relates to novel pesticidally active compounds of the general formula I as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R 1 is...
132	6479436	Hetaroyl cyclohexanedione derivatives with herbicidal effect Hetaroyl derivatives of the formula I where: R 1 and R 2 are each hydrogen, nitro, halogen, cyano, thiocyanato, hydroxyl, mercapto, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, C 1...
133	6476048	Substituted phenanthridinones and methods of use thereof This invention provides a novel class of substituted 6(5H)phenanthridinone compounds. Pharmaceutical compositions, and methods of making and using the compounds, or a pharmaceutically acceptable...
134	6469041	Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF 1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such...
135	6469047	Tyrosine derivatives The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.
136	6452009	4-unsubstituted dihydroisoquinolinone derivatives and combinatorial libraries thereof The present invention relates to novel dihydroisoquinolinone (DHQ) derivative compounds of the following formula: wherein R 1 to R 7 , X, Y, Z, b, c and d have the meanings provided herein. The...
137	6441196	Processes and novel intermediates for 11-oxa prostaglandin synthesis Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.
138	6437134	Process for a phenylthiobutyl-isoquinoline and intermediates therefor A method for making phenylthiobutyl-isoquinoline compounds of formula and novel intermediates therefor.
139	6436960	Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof The present invention relates to a novel piperidine derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts...
140	6436989	Prodrugs of aspartyl protease inhibitors The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl...
141	6433177	Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide It is here described a new process for the synthesis of (S)-N-tertbutyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide wherein the N-carboxy anhydride of formula is treated with tert-butylamine...
142	6432962	Benzophenones as inhibitors of IL-1β and TNF-α Heteroaryl aminobenzophenones of general formula I inhibit interleukin-1β and TNF-α and may therefore be useful in the therapy of inflammatory diseases and conditions.
143	6432995	Aromatic heterocyclic compounds and their use as anti-inflammatory agents Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are...
144	6429312	N-aminoalkyldibenzothiopencarboxamide receptor subtype specific ligands Disclosed are compounds of the formula: or the pharmaceutically acceptable acid addition salts thereof, wherein: R 1 , R 2 , R 3 , R 4 are the same or different and represent hydrogen, C 1 -C 6...
145	6417362	Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can...
146	6410529	Phenyl urea and phenyl thiourea derivatives as HFGAN72 antagonists Phenyl urea and phenylthiourea derivatives, processes for their production and their uses as pharmaceuticals are disclosed.
147	6403577	Hexamethyleneiminyl tachykinin receptor antagonists This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention...
148	RE37729	4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
149	6399627	Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
150	6395749	Carboxamide compounds, methods, and compositions for inhibiting PARP activity The present invention provides carboxamine compounds, methods and compositions for inhibiting PARP activity.

Matches 101 - 150 out of 636

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