Patents in Class 546/142

Matches 1 - 50 out of 221

1 2 3 4 5 >

Match	Document	Document Title
1	7615565	VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridinamides, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis, as well as...
2	7345062	Substituted acylhydroxamic acids and method of reducing TNFαlevels Imido and amido substituted acylhydroxamidic acids which reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
3	7205315	Bicyclic imino acid derivatives as inhibitors of matrix metalloproteinases The present invention is directed to a compound of formula (I), or a stereoisomer or a mixture of stereoisomer thereof in any ratio, or its physiologically tolerable salt, which is useful as an...
4	7173057	Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
5	7153963	Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin
6	RE39265	Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
7	7030201	Bottom antireflective coatings The present invention relates to bottom antireflective coating compositions and polymers useful in making such compositions.
8	6870055	Isoquinolinone potassium channels inhibitors The present invention concerns certain isoquinolinone compounds and their utility as inhibitors of voltage-dependent potassium channels or currents, such as K v 1.5 and I Kur , that could serve as...
9	6818774	Isoquinoline derivatives Disclosed are isoquinolino derivatives of the formula wherein Y is >C═O or —CH 2 —, Z is >C═O or —CH 2 —, and R 1 , R 2 and m are as defined herein as well as the...
10	6720427	Thiazole derivatives The invention provides compounds of formula 1 wherein R 1 , R 3 , and R 4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity...
11	6716853	Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase The invention is related to compounds of formula I to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds, and to methods of prevention and...
12	6656911	Serine protease inhibitors The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for...
13	6602864	Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from...
14	6602867	Triazole compounds with dopamine-D3-receptor affinity Triazole compounds of the following formula where R 1 , R 2 , A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity...
15	6586447	3,3-disubstituted-oxindole derivatives useful as anticancer agents The present invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein n is 0 or 1 and R 1 , R 2 , R 3 , R 4 , and R 5 are as...
16	6479436	Hetaroyl cyclohexanedione derivatives with herbicidal effect Hetaroyl derivatives of the formula I where: R 1 and R 2 are each hydrogen, nitro, halogen, cyano, thiocyanato, hydroxyl, mercapto, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, C 1...
17	6472405	Glycoprotein IIB/IIIA antagonists This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or...
18	6452009	4-unsubstituted dihydroisoquinolinone derivatives and combinatorial libraries thereof The present invention relates to novel dihydroisoquinolinone (DHQ) derivative compounds of the following formula: wherein R 1 to R 7 , X, Y, Z, b, c and d have the meanings provided herein. The...
19	6417178	Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other...
20	6403607	Sulfonamide derivatives and drugs containing the same as the active ingredient The present invention discloses a sulfonamide derivative represented by the following formula (1): [wherein A represents a nitrogen atom, —CH═, etc.; Z represents an oxygen atom, etc.; Ar 1 ...
21	RE37729	4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
22	6362193	Cycloalkenyl substituted compounds Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.
23	RE37478	1-(arylthioalkyl, arylaminoalkyl, or arylmethylenealkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
24	6255479	Process for the preparation of α-oxolactams A method for preparing an α-oxolactam comprising, reacting a corresponding α-diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding...
25	6214857	Substituted alkanohydroxamic acids and method of reducing TNFα levels Imido and amido substituted alkanohydroxamic acids reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
26	RE37029	N-[(3-heteroaryl-1-pyrrolidinyl)-alkyl]phthalimides and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
27	6174901	Substituted pyridine and pyridazine compounds and methods of use Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies,...
28	6168776	Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to...
29	6140339	Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof The present invention provides new monomeric derivatives of the C-8'-7 linked naphthylisoquinoline alkaloid dioncophylline D. The invention also provides new C-4 substituted monomeric...
30	6040442	Process for preparing 1,2,5-thiadiazole containing ethers The presently claimed process provides a method for preparing compounds of the formula ##STR1## phosphorous (III) compound and a diester of azodicarboxylate.
31	6015820	4-Aryl-thio-pyridin-2(1H)-ones, medicines containing them and their uses in the treatment of illnesses linked to HIV Compounds of formula (3) in which: R 1 and R 2 independently represent an atom of hydrogen, an aliphatic group or an alkyloxyalkyl group in which the alkyl chains are from C 1 to C 4 or...
32	5977367	N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R 1 , R 2 , R 3 , R 4 are the same or different and represent hydrogen, C...
33	5861380	Serine protease inhibitors-keto and di-keto containing ring systems The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of...
34	5837703	Amino-alcohol substituted cyclic compounds Therapeutic compounds have the formula: (X)j-(core moiety), j being an integer from one to three, the core moiety comprising a core moiety, the core moiety being a heterocycle having one ring or...
35	5776963	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
36	5767141	Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Propane derivatives of the formula I ##STR1## in which the radicals have the...
37	5741798	2-benzyl-4-sulfonyl-4H-isoquinolin-1,3-diones and their use as antiinflammatory agents Antiinflammatory compounds of the formula I or IA ##STR1## wherein, R 1 is hydrogen, halogen, C 1 -4 alkyl, or C 1 -4 alkoxy; R 2 and R 3 are the same or different and each is hydrogen, halogen,...
38	5739134	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran, dihydrobenzodioxin, benzodioxole, dihydrobenzodioxepin, or tetrahydrobenzoxepin)carboxamide derivatives N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal...
39	5728712	3,4-disubstituted-phenylsulphonamides and their therapeutic use 3,4-Disubstituted-phenylsulphonamides have therapeutic utility via TNF or phosphodiesterase inhibition.
40	5728845	Immunotherapeutic nitriles Novel nitriles are inhibitors of tumor necrosis factor α and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A...
41	5723473	Propenoic acid derivatives useful as fungicides A fungicidal compound of formula (I): ##STR1## wherein A is hydrogen, halogen, hydroxy, C 1 -4 alkyl, C 1 -4 alkoxy, C 1 -4 haloalkyl, C 1 -4 haloalkoxy, C 1 -4 alkylcarbonyl, C 1 -4...
42	5719151	Substituted benzene compounds Phthalazinedione compounds and pharmaceutical compositions are described. The compositions are useful in treating human or animal patients to alleviate or cure disease or disease symptoms caused by...
43	5698581	Substituted N-heteroaroylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament containing them The invention relates to heteroaroylguanidines of the formula I ##STR1## in which the substituents HA and R(1) to R(5) have the meanings given in the specification. These compounds exhibit very...
44	5663449	Intermediate compounds in the synthesis of heteroarylpiperidines, pyrrolidines and piperazines Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
45	5658940	Succinimide and maleimide cytokine inhibitors Novel succinimides and maleimides are inhibitors of tumor necrosis factor α and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and...
46	5654319	N-[(4-heteroaryl-1-piperidinyl)alkyl]-2,3-naphthalimides and related compounds and their therapeutic utility Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
47	5652250	N-substituted β-aryl- and β-heteroaryl-α-cyanoacrylamide derivatives and process for their preparation The present invention relates to new compounds of formula ##STR1## wherein A is a bicyclic ring chosen from naphthalene, tetrahydronaphthalene, quinoline, isoquinoline and indole. B is a R 2 ...
48	5652367	Halo-nitro-isoquinolinone compounds and pharmaceutical compositions thereof Unsubstituted or substituted halo nitro and nitroso compounds and their metabolites are potent, selective and non-toxic inhibitors and supressants of cancer growth and vital infections in a...
49	5646161	Heteroarylpyrrolidines and their use as antipsychotics and analgesics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
50	5639884	Arylidene-heterocyclic derivatives and process for their preparation The invention relates to compounds of formula ##STR1## wherein Ar is mono- or bicyclic ring system chosen from benzene, naphthalene, tetrahydronaphthalene, quinoline and indole; Het is ##STR2##...

Matches 1 - 50 out of 221

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