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7622422 |
Ionic conducting gels, preparation method thereof and use of same
A method of preparing an ionic conducting gel in solid form, known as ionogel. The method includes a step of mixing an ionic liquid with at least one molecular precursor containing at least one...
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7619088 |
Demethylation of 14-hydroxy substituted alkaloid derivatives
The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is...
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7553968 |
Synthesis of nicotine derivatives from nicotine
Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful...
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7547782 |
Met kinase inhibitors
The present invention is directed to compounds having the formula I or II:
including salts thereof, and methods for using them for the treatment of cancer.
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7521435 |
Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
Silicon-containing compounds having selective COX-2 inhibitory activity, as well as compositions thereof are provided. The subject compounds find use in a variety of applications, including...
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7495099 |
High-molecular weight derivatives of camptothecins
It is intended to provide water-soluble derivative of camptothecins which are excellent in therapeutic effect and suitable for chemotherapy for cancer. Namely, a water-soluble high-molecular weight...
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7482345 |
P38 kinase inhibiting agents
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof:
are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of...
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7456308 |
Grignard processes with improved yields of diphenylchlorosilanes as products
A Grignard process for preparing phenyl-containing chlorosilane products, in particular diphenylchlorosilanes, is carried out in three embodiments. In the first embodiment, the reactants of the...
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7442797 |
Platinum complex and light emitting device
Provision of a novel platinum complex which is useful as a material for a light-emitting device of good light emission characteristic and light emission efficiency, and a novel light-emitting...
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7390900 |
Silane coupling agent and method for manufacturing the same
The present invention relates to a novel silane coupling agent represented by Formula 1 below and a method for manufacturing the same. Because the compound has urethane and pyridine functional...
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7365198 |
Silyl compound, light emitting material, and organic light emitting device using the same
Provided is an organic light emitting device capable of emitting light with high efficiency by incorporating a silyl compound in which a silyl group is directly bonded to an anthracene ring...
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7354927 |
6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents
This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I:
The invention further provides compositions including the compounds, methods for the use of the...
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7351847 |
Grignard processes with increased content of diphenylchlorosilanes
Three improved Grignard processes are used for preparing phenyl-containing chlorosilane products wherein the yield of diphenylchlorosilanes as a product is maximized, while the yield of...
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7335373 |
Biocidal siloxane coating material containing N-halogenated amine and amide functional groups
N-halamine compounds which contain hindered amine and amide functional groups. Compounds include
wherein X, X′, and X″ independently are H, Cl, or Br, wherein no more than two of X, X′,...
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7329654 |
Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders...
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7312331 |
Stable cyclic (alkyl)(amino) carbenes as ligands for transition metal catalysts
Stable carbene ligands are provided having a carbene center flanked by a quaternary carbon and an amino group, and having utility in the preparation of various transition metal complexes.
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7309737 |
Acrylic pressure sensitive adhesive
The present invention relates to an acrylic pressure sensitive adhesive composition containing organic functional groups of urethane and pyridine, more precisely an acrylic pressure sensitive...
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7285674 |
Silane molecules with pre-activated and protein-resistant functionalities and silane films comprising such molecules
The present invention provides a silane molecule which combines pre-activated and protein-resistant functionalities in one molecule; the molecule has a general formula:
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RE39707 |
Camptothecin derivatives
(20S) esters of camptothecin analogs are provided. The compounds are (20S) esters of an oxyalkanoic acid and camptothecin, which is are optionally substituted at the 7, 9, 10, 11, and 12...
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7217822 |
Process for making cabergoline
A process for making cabergoline uses silyl-protecting agents to protect the indole nitrogen atom.
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7211270 |
Anthranilamide insecticides
This invention provides compounds of Formula I, N-oxides and suitable salts thereof
wherein A is O or S(O)?m#191;J is a phenyl or heterocyclic ring as defined herein; and R 1 through R 12 , n,...
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7179804 |
Tachykinin receptor antagonists
The present invention relates to selective NK-1 receptor antagonists of Formula (I); or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of...
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7157475 |
Diamide invertebrate pest control agents
Compounds of Formula (I), and their N-oxides and suitable slats, are disclosed which are useful as invertebrate pest control agents, wherein A and B are independently O or S; E is C or N; J is a...
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7112678 |
Regiospecific synthesis of nicotine derivatives
Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having...
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7087625 |
Phosphodiesterase 4 inhibitors
PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I–III:
wherein A, B, D,...
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7064206 |
Highly lipophilic camptothecin intermediates and prodrugs and methods of preparation thereof
The present invention relates to novel, highly lipophilic silatecan intermediates and prodrugs of DB-67 and other silatecans.
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7012079 |
Optically pure camptothecin analogues
The invention relates in particular to the compounds of general formula
in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 represent various radicals; their use as medicaments and pharmaceutical...
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6939867 |
β3 agonists and uses thereof
Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity,...
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6916865 |
Organic carboxylic acid salt composition, process for preparation thereof and additives for epoxy resins
The present invention provides an organic carboxylate composition that has long working life, cures epoxy resins, and improves adhesive properties, and also provides a method for producing the...
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6916555 |
Organic luminescence device
In an organic luminescence device formed of one or plural layers of organic films between an anode and a cathode, at least one layer is any one of a luminescence layer, an electron injection layer...
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6897306 |
3-heterocyclylpropanohydroxamic acids
Compounds of formula (I):
and their salts, solvates, prodrugs, etc., wherein the substituents have the values mentioned herein, are Procollagen C-Proteinase (PCP) inhibitors and have utility...
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6855720 |
Nitrogen-based camptothecin derivatives
(20S) esters of camptothecin analogs are provided. The compounds are (20S) esters of an aminoalkanoic acid or an imidoalkanoic acid and camptothecin, which is optionally substituted at the 7, 9,...
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6794509 |
Compounds for fluorescence labeling
There are provided fluorescent compounds that can be used for DNA sequencing, measurement of physiologically active substance or the like based on fluorescence immunoassay and so forth. Compounds...
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6783812 |
Alkyl silane liquid crystal compounds
Compounds useful as components of LC and FLC compositions which in turn are useful in the manufacture of optical devices. Compounds of this invention have a silane tail, which can contain more than...
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6750213 |
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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6727361 |
Phosphino substituted pyridine amine ligands
New ligands, compositions, metal-ligand complexes and arrays with pyridyl-amine ligands are disclosed that catalyze the polymerization of monomers into polymers. Certain of these catalysts with...
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6723849 |
Process for making camptothecin derivatives
A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with an aldehyde in a modified Minisci-type alkylation...
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6716986 |
Sulfuric acid mono-&lsqb 3-(&lcub 1-&lsqb 2-(4-fluoro-phenyl)-ethyl&rsqb -piperidin-4-YL&rcub -hydroxy-methyl)-2-methoxy-phenyl&rsqb ester
The present invention is directed to sulfuric acid mono-[3-({1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydr
oxy-methyl)-2-methoxy-phenyl]ester, a metabolite of the 5HT 2A antagonist...
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6703502 |
Spiroazo bicyclic heterocyclic
A compound of formula wherein n is 0 or 1; m is 0 or 1; p is 0 or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H 2 or F 2 ; A is N or C(R 2 ); G is N or C(R 3 ); D is N or C(R 4 );...
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6703399 |
Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
Halo-alkyl esters of camptothecin are described. Processes for making these compounds and for using them in cancer treatment, are also described.
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6696568 |
Process and intermediates for production of cabergoline and related compounds
A process for preparation of N-(ergoline-8β-carbonyl)ureas of the formula [I] their stereoisomers as well as acid addition salts thereof which process comprises silylating an...
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6653319 |
Pharmaceutical formulation for poorly water soluble camptothecin analogues
The present invention provides a general method to retard the precipitation inception time for poorly water-soluble camptothecin analogues from a supersaturated solution by a chemical conversion...
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6620937 |
Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel...
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6599924 |
2-hetaryl-3,4-dihydro-2H-pyrrole derivatives
The invention relates to novel 2-hetaryl-3,4-dihydro-2H-pyrrole derivatives of the formula (I) in which Hetaryl represents substituted heterocyclyls and Ar represents substituted phenyl, to a...
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6596738 |
Heterocyclic compound, composition and method for inhibiting adenosine deaminase
Heterocyclic compounds of the following formula: wherein B is [wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen or lower alkyl; and X is hydrogen or hydroxy protective group], lower...
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6586613 |
Substituted tetrahydronaphthaline and analogous compounds
Substituted tetrahydro-naphthalenes and analogous compounds are prepared by reducing or condensing appropriate functional substituents in substituted tetrahydro-naphthalenes and analogous compounds...
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6548673 |
2-pyridylsilane, processes for producing and using the same
The present invention provides a compound which can be purified by conventional acid/base extraction. There is disclosed 2-pyridylsilane of formula (1): wherein R 1 represents an alkyl group,...
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6548496 |
Substituted 3-cyano-&lsqb 1.7&rsqb , &lsqb 1.5&rsqb , and &lsqb 1.8&rsqb naphthyridine inhibitors of tyrosine kinases
This invention provides compounds of formula I having the structure Wherein substitutions at A″, Z, n, and X are set forth in the specification.
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6534653 |
3,5-Dioxa-8-aza-tricyclo&lsqb 5.2.1.00,0&rsqb decane-9-methanols, their metal complexes and enantio-selective hydrogenation processes
Compounds of the formula I, in the form of their racemates, mixtures of stereoisomers or mainly pure stereoisomers in which Y is C 1 -C 4 alkylene or —SiR 1 R 2 —; X is a carbon atom and A 1...
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6531602 |
2-Pyridysilane, processes for producing and using the same
The present invention provides a compound which can be purified by conventional acid/base extraction. There is disclosed 2-pyridylsilane of formula (1): wherein R 1 represents an alkyl group,...
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