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7612088 |
Heterocyclic compounds and their use as aldosterone synthase inhibitors
The application relates to novel heterocyclic compounds of the general formula (I) in which R, R 1 , R 2 , W, X, Y, Z and n have the meanings defined in the description, to a process for their...
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7592351 |
Substituted imidazo[1,2-a]pyridine compounds and pharmaceutical preparations containing substituted imidazo[1,2-a]pyridine compounds
Substituted imidazo[1,2-a]pyridine compounds, a process for the production thereof, pharmaceutical preparations containing such compounds and methods of using such substituted...
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7585874 |
Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives
The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives of formula I:
wherein
R 1 to R 5 are as defined in the specification and pharmaceutically...
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7578856 |
Dyeing compositions comprising at least one aminopyrazolopyridine oxidation base, at least one coupler and at least one C4-C30 polyol and methods and use thereof
Disclosed herein are compositions for dyeing keratinous fibers comprising, in an appropriate dyeing medium, at least one aminopyrazolopyridine oxidation base chosen from those of formula (I),
...
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7578855 |
Composition for dyeing keratin fibers comprising at least one cationic 3-amino-pyrazolopyridine derivative, and methods of use thereof
The present disclosure relates to a composition for the dyeing of keratin fibers, such as the hair, comprising at least oneoxidation base chosen from cationic 3-amino pyrazolo-[1,5-a]-pyridine...
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7566781 |
Imidazopyridine compound
The present invention provides an imidazopyridine compound represented by formula (I),
wherein R 1 and R 2 each independently represent a C 1-6 alkyl group et al; R 3 and R 4 each...
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7566725 |
Imidazo[1,2-A] pyridine anxiolytics
Imidazo[1,2-a]pyridines of the formulae I and II:
are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A...
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7563797 |
Substituted imidazo(1,2-A)pyrimidines and imidazo(1,2-A) pyridines as cannabinoid receptor ligands
The present invention relates to compounds of formula I, II, III or IV:
wherein R 1 -R 4 , R 7 -R 10 , R 13 -R 17 and R 20 -R 24 are as described herein. The compounds are active as...
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7563788 |
Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents
Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable...
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7524860 |
Antibacterial agents
The present invention is directed to a new class of triazolopyridine derivatives, to their use as antimicrobials, and to pharmaceuticals containing these compounds.
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7511056 |
TGF-β inhibitors
The present invention is directed to inhibitors of TGF-β of Formula I:
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7504501 |
Antiprotozoal imidazopyridine compounds
Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and...
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7504413 |
N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
Provided herein are certain substituted N-phenethylbenzamide of formula V:
that may be useful for treating certain cellular proliferation diseases and disorders by modulating the activity of...
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7504412 |
Imidazopyridine derivatives
The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R 1 and R 2 may be the same or different and stand for C 1-6 alkyl or the like, R 3 and R 4 ...
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7501438 |
Pyridoimidazole derivatives
The present invention relates to pyridoimidazole derivatives that act as cannabinoid receptor ligands, e.g., CB2 ligands. The invention also relates to methods of preparing the compounds,...
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7498327 |
Indolylalkylamine metabolites as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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7459463 |
Crystalline forms of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a] pyridine-6-carboxamide mesylate salt
The present invention relates to novel crystalline forms of 2,3-dimethyl-8-(2,6 -dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-
6-carboxamide mesylate salt and to mixture thereof....
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7446113 |
Acetylenyl-pyrazolo-pyrimidine derivatives
The present invention relates to compounds of formula (I):
wherein R 1 to R 3 , A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for...
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7432278 |
Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents
A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum , in a subject in need thereof by...
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7417053 |
Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof
A pyrazolo[1,5-a]pyridine derivative represented by formula (I) and salt thereof exhibit excellent MAPKAP-K2 inhibitory activity. Accordingly, medicines comprising this compound as an active...
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7417041 |
Imidazopyrimidines as transforming growth factor (TGF) inhibitors
Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described....
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7399769 |
Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives
The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives of formula
wherein:
R 1 , R 2 , and R 3 are as defined herein and pharmaceutically acceptable...
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7385056 |
Synthesis of heteroaryl acetamides
An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provied. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide...
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7365066 |
Pyrazolopyridine derivatives as pharmaceutical agents
Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of...
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7348432 |
Pyridine imidazoles and aza-indoles as progesterone receptor modulators
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or...
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7348324 |
Cyclic amine compounds as CCR5 antagonists
A compound of formula (I) (wherein R 1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R 2 is a hydrocarbon group...
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7345055 |
Substituted C-imidazo [1,2-α] pyridin-3-yl-methylamines
Novel C-imidazo[1,2-α]pyridin-3-yl-methylamine compounds corresponding to formula I,
wherein R 1 -R 6 have the meanings provided in the description. Pharmaceutical compositions containing...
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7345050 |
Pyrimidine compounds
The present invention relates to new compounds of the formula (I) a process for their preparation, pharmaceutical formulations containing said therapeutically active compounds and to the use of...
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7342025 |
Substituted C-imidazo[1,2-a]pyridin-3-yl-methylamines
Substituted C-imidazo [1,2-a]pyridine-3-yl methylamines and physiologically acceptable salts thereof, a method for the production thereof, pharmaceutical compositions containing these compounds,...
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7326784 |
Intermediates for the preparation of tricyclic dihydropyrano-imidazo-pyridines derivatives
The invention relates to compounds of the formula 1,
in which R1, R2, R3, Arom and PG have the meanings as indicated in the description. These compounds are valuable intermediates for the...
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7326718 |
8-Substituted imidazopyridines
The present invention relates to 8-substituted imidazopyridines of a certain formula (1)
in which the substitutents and symbols have the meanings indicated in the description. The compounds...
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7323569 |
7-phenylpyrazolopyridine compounds
A compound represented by the formula:
[wherein R 1 is methoxy, methylthio, ethyl, etc.; R 5 and R 6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R...
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7314940 |
Jun kinase inhibitors
The present invention provides novel compounds of formula I
and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in...
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7285666 |
Pyrazolo[1,5-a] pyridines and medicines containing the same
Compounds represented by the general formula:
[wherein R 1 represents methoxy, ethyl, methylthio, etc., R 2 , R 3 and R 4 each represent hydrogen, a halogen, etc., R 5 and R 6 each...
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7285551 |
Fused-ring compounds and use thereof as drugs
The present invention provides a fused ring compound of the following formula [I]
wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a...
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7279580 |
Imidazo-pyridine derivatives as ligands for GABA receptors
A class of 8-fluoro-3-phenylimidazo[1,2-α]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl...
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7271178 |
Heterocyclic inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula V
and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 11 and W are as defined in the...
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7265127 |
β3 adrenergic agonists
The present invention relates to 2-imidazo[1,2-a]pyridine group containing β 3 adrenergic receptor agonists or pharmaceutical salts thereof.
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7259263 |
Method of synthesis of azole-containing amino acids
The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I):
The invention is also relates to compounds of formula (I) and to intermediate compounds in the...
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7256293 |
Imidazopyridine intermediates
The invention relates to compounds of the formula 1,
in which the substituents and symbols have the meanings indicated in the description. The compounds are valuable intermediates for the...
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7226926 |
8-fluoroimidazo 1,2-a pyridine derivatives as ligands for GABA receptors
A class of 8-fluoroimidazo[1,2-α]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for...
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7223866 |
Imidazo[1,5-a]pyridine derivatives and methods for treating aldosterone mediated diseases
Compounds of the formula (I)
provide pharmacological agents which are inhibitors of the P450 enzyme, aldosterone synthase, and thus may be employed for the treatment of aldosterone mediated...
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7220756 |
N-sulfonylheterocyclopyrrolyl-alkylamine compounds as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor
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7205407 |
3-Substituted oxindole β3 agonists
The present invention relates to a β3 adrenergic receptor agonist of Formula (I) or a pharmaceutical salt thereof; useful for treating Type II diabetes and/or obesity
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7205316 |
Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
Compounds of formula (I)
wherein R 1 or R 2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, X, X′, Y,...
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7196196 |
Substituted imidazo[1, 2-a]-5,6,7,8-tetrahydropyridine-8-ones, method for their production and the use thereof for producing imidazo[1,2-a]pyridines
A process for the preparation of imidazo[1,2-a]-5,6,7,8-tetra hydropyridin-8-ones by reaction of γ-butyrolactones with imidazols, novel imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-ones, and their...
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7160897 |
Therapeutic compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7151109 |
Pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators
The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives of general formula I:
that bind with high affifnity to CRF 1 receptors, including human CRF 1 receptors. This...
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7151104 |
Pyrazolopyridines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7148353 |
Imidazo[1,2-a] pyridine anxiolytics
Imidazo[1,2-a]pyridines of the formulae I and II:
are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A...
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