Matches 201 - 250 out of 422 < 1 2 3 4 5 6 7 8 9 >
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5428160 Substituted imidazo[5-a]pyridine derviatives and other substituted bicyclic derivatives  
Disclosed are compounds of formula I ##STR1## wherein R 1 represents hydrogen, lower alkyl, substituted lower alkyl, nitro, halogen, free, etherified or esterified hydroxy, free, etherified,...
5426105 Conformationally restricted angiotensin II antagonists  
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders. Compounds of particular interest...
5420138 Bicyclic pyridines which are angiotensin II inhibitors  
The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are...
5405828 Tetrahydrofuran derivative and herbicide containing the same as active ingredient  
A tetrahydrofuran derivative represented by the following general formula [I]: ##STR1## [wherein A represents direct bonding or a group represented by --B--CHR 1 -- (wherein B represents oxygen...
5405829 Substituted pyrazolypyrazoles and their use as herbicides  
5403817 Arylaminocarbonyl compounds  
Novel arylaminocarbonyl compounds, intermediates therefore, and the use of said compounds for the control of weeds are disclosed.
5401747 Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer  
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin...
5395839 Imidazopyridine derivatives and their use  
A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are...
5376150 Use of pyridine dyes in the textile sector, dye mixtures with pyridine dyes, and triazolopyridine dyes having a thienyl radical  
There are described the use of pyridine dyes of the formula ##STR1## where R 1 is substituted or unsubstituted C 1 -C 20 -alkyl, substituted or unsubstituted phenyl or hydroxyl, R 2 is a...
5350751 Substituted imidazoles, pharmaceutical compositions containing these, and the use thereof as antagonists of angiotensin II receptors for the treatment of high blood pressure  
The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR 2 , R 1 and R 2 are as defined in the description, L is an alkylene...
5344927 Tetrahydrobenzimidazole derivatives and pharmaceutical compositions containing same  
A tetrahydrobenzimidazole derivative represented by formula (I): ##STR1## wherein Het represents a heterocyclic group which may be substituted with 1 to 3 substituents selected from the group...
5336679 Tetrahydroimidazopyridine derivatives and salts thereof  
Tetrahydroimidazopyridine derivatives which are useful for the treatment of irritable bowel syndrome are provided and can be represented by the following formula, ##STR1## wherein either one of X...
5296490 Pharmaceutically useful pyrazolopyridines  
The disclosure concerns pyrazolopyridine compounds of the formula wherein the variables are defined in the specification. The compounds are useful as a diuretic, anti-hypertensive agent, etc.
5294612 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof  
Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclylcarboxaldehyde or by...
5278161 Amino acid derivatives useful as renin inhibitors  
Compounds of the formula ##STR1## wherein A, B, X, Y, R 1 , R 2 , R 3 , R 4 and R 5 are as set forth in the specification, in the form of optically pure diastereomers, mixtures of diastereomers,...
5270322 Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them  
Imidazo[1,2-a]pyridines of the formula ##STR1## wherein R a to R e are as defined herein, the enantiomers and the salts thereof, which are useful as angiotensin antagonists and for treating...
5266576 N-myristoyl transferase inhibitors  
The invention relates to a compound of formula (I): ##STR1## which can be used as N-myristoyltransferase inhibitors, in which R 1 represents hydrogen, substituted or unsubstituted (C 1 -C 6 )...
5246945 Piperidine derivatives  
Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT 3 receptors and useful in the treatment of psychotic disorders,...
5244908 Imidazopyridine derivatives and their pharmaceutical use  
A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are...
5234930 Pyrazolopyridine compounds which have useful pharmaceutical utility  
This invention relates to pyrazolopyridine compounds for the treatment of melancholia, heart failure, hypertension, renal insufficiency, renal toxicity, nephrosis, nephritis, edema, obesity,...
5231182 Method of making certain aryl containing amides  
Methods of preparing bis-aryl amide and urea compounds of the general formula: ##STR1## wherein x is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds...
5229386 Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same  
The invention relates to new thiazole compounds, of antithrombotic, vasodilating, antiallergic, antiinflammatory and 5-lipoxygenase inhibitory activity, of the formula: ##STR1##
5225414 Substituted azoles, a process for their preparation, and their use  
The invention relates to compounds of the formula (I) ##STR1## in which X, Y and Z are identical or different and are N or CR 2 , and the other radicals have the meaning defined in the description,...
5223510 Alkylaminoalkyl derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation and compositions containing them  
The subject of the invention is benzofuran, benzothiophene, indole or indolizine compounds of general formula: ##STR1## in which: Het represents one of the groups: ##STR2## in which T,T' and...
5204352 Compounds exhibiting anti-parasitic activity and a method for their use  
Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted...
5202334 Pyrazolo[1,5-a]pyridine compounds, and production and use thereof  
A novel anti-serotonergic compound and the synthetic intermediates thereof are provided. The compound and intermediates are pyrazolo[1,5-a]pyridine compounds represented by the formula, ##STR1##...
5200415 Pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives and their pharmaceutical use  
Described herein are pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives represented by the following formula (I): ##STR1## wherein R 1 and R 2 individually mean a hydrogen atom or a lower...
5182291 Pyrozala-pyridyl aminoabkoxyphenol compounds  
Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO 2 -- group,...
5171858 Preparation of certain 5,6-dihydro-8-phenyl-imidazo[1,5-a]pyridines  
This invention relates to novel substituted imidazo-[1,5-a]pyridines, most especially novel 8-phenylimidazo-[1,5-a]pyridines. It also relates to novel intermediates and to a novel process for the...
5149814 Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds  
Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R 3 is lower alkyl; Y is...
5145858 Pyrrolo [1,2-a] imidazole and imidazo [1,2a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors  
Compounds comprising pyridyl and phenyl substituted pyrrolo[1,2-a]imidazole derivatives and pyridyl and phenyl substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions containing...
5134239 Latent catalysts for epoxy-phenolic reactions  
Latent catalyst compounds for catalyzing the reaction between epoxide groups and aromatic hydroxyl groups are prepared by contacting a nitrogen-containing heterocyclic compound with an acid having...
5130319 Pharmacologically active 2,5-dioxo-octahydro-imidazo [1,2-a]pyridines  
Imidazole derivatives are described which are useful in restoring learning and treating memory difficulties. A compound of the invention is 2,5-dioxohexahydro-1H-pyrrolo[1,2-a]imidazole.
5126339 Anti-allergic bicyclic heterocyclyl-containing N-(bicyclic heterocyclyl)-4-piperidinamines  
Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of...
5118849 Herbicidal and plant growth-regulating substituted n-aryl nitrogen heterocycles  
Intermediates of the formula ##STR1## are new, where R stands for alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, or cycloalkenylalkyl, in each case having up to 20 carbon atoms, in...
5116954 Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety  
Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S➝(O) n (n=0 or 2); R 1 is phenyl, phenyl substituted by methoxy, hydroxy, chlorine,...
5112833 1-azaindolizine derivatives, synthetic intermediates thereof and antiallergic agents containing 1-azaindolizine derivatives  
Novel 1-azaindolizine derivatives having excellent antiallergic action, synthetic intermediates thereof and antiallergic agents containing 1-azaindolizine derivatives.
5112834 Imidazole protectorant for the stomach and intestine  
Compounds of formula I, ##STR1## wherein the substituents and symbols having the meanings stated in the description are new compounds having interesting pharmacological properties. They have a...
5109006 Certain pharmaceutically active 6H-imidazo[1,2-a]pyridine-5-ones  
This invention relates to novel derivatives of 1,7'-[imidazo-[1,2-a]pyridine]5'-(6'H)ones, to the method for their preparation and to their use as anti-hypertensive, anxiety, anti-depressant and...
5098911 Hemihydrate of 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride  
The invention relates to a novel crystalline form, containing water of crystallization, of 4-(5,6,7,8-tetrahydroimidazol[1,5-a] pyridin-5-yl)-benzonitrile hydrochloride of formula Ia ##STR1## and...
5087629 Pharmacologically active pyrazolopyridine compounds  
The invention relates to novel pyrazolopyridine compounds useful as a diuretic, antihypertensive agaent, for renal insufficiency, for thrombosis, and as a cardiotonic agent.
5077409 Method of preparing bis-aryl amide and urea antagonists of platelet activating factor  
Methods of preparing bis-aryl amide and urea compounds of the general formula: ##STR1## wherein x is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds...
5068337 1,4-dihydropyridines and their ability to inhibit blood platelet aggregation, inhibit thromboxane sy  
The invention concerns compounds of formula ##STR1## or salts thereof; wherein Ar is an optionally substituted aryl radical; R represents hydrogen or an optionally substituted alkyl or aralkyl...
5068235 Diazabicycloalkane derivative  
The present invention provides a diazabicycloalkane derivative which has the following formula and is useful as medicaments for treating senile dementia, i.e., as cerebral function improving agents...
5066656 Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives  
(6,7-dihydro-5H-pyrrolo[1,2-c]imidazolyl-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridinyl-5-yl) substituted 1H-benzotriazole derivatives, compositions containing the same and methods of...
5063229 Imidazolo [1,2-a]pyrimidines and medical use thereof  
A compound selected from the group consisting of a compound of the formula ##STR1## and its non-toxic, pharmaceutically acceptable acid addition salts having anti-inflammatory activity and their...
5063237 1,4-dihydro-2-(4-[benzimidazol-l-yl]phenyl)-pyridines as platelet activating factor antagonists  
Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C 1 -C 4 alkyl, C 1 -C 4 alkoxy,...
5053422 Psychotropic perhydroazacycloalka [1,2-A] imidazole derivatives  
Imidazole derivatives are described which are useful in restoring learning and treating memory difficulties. A compound of the invention is 2,5-dioxohexahydro-1H-pyrrolo[1,2-a]imidazole.
5053071 Chromane herbicides  
This invention pertains to novel heterocyclic 2,3-dihydrobenzofuran and chromane compounds, including stereoisomers, agriculturally suitable compositions containing them, and their use as broad...
5049181 Novel herbicidally active n-phenyl-azoles  
The invention relates to novel phenyl substituted pyrazoles, 4,5,6,7-tetrahydro-indazoles, 2,4,5,6-tetrahydro-cyclopenta[c]pyrazoles, octahydroimidazo[1,5-a]pyridin-1,3-diones,...
Matches 201 - 250 out of 422 < 1 2 3 4 5 6 7 8 9 >