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6703404 |
Tert -butyl-(7-methyl-imidazol &lsqb 1,2-a&rsqb pyridin-3-yl)-amine derivatives
A Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amine derivatives of Formula I: wherein the pharmaceutically acceptable salts, methods of making and method of use, in particular for the...
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6686358 |
Bicyclic amino-pyrazinone compounds
A compound of formula (I): wherein: R 1 represents hydrogen, or linear or branched (C 1 -C 6 )alkyl optionally substituted by one or more identical or different groups selected from aryl,...
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6653477 |
Imidazopyridin-8-ones
Compounds of formula (I), in which the substituents have the meanings mentioned in the description, are valuable intermediates for preparing active compounds for the prevention and treatment of...
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6653320 |
Imidazopyridine derivatives
The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel...
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6642246 |
Quinuclidine acrylamides
Compounds of formula I wherein A represents: and R, R 1 , R 2 , R 3 and R 4 are as defined in the specification, pharmaceutically-cceptable salts thereof, processes for preparing them,...
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6638933 |
Bicyclic imidazo-3-yl-amine derivatives
Substituted bicyclic imidazo-3-yl-amines and medicaments comprising these compounds, useful, inter alia, as analgesics.
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6635652 |
Azaindolizinone derivatives and cerebral function improvers containing the same as the active ingredient
Azaindolizinon derivatives or pharmaceutically acceptable salts thereof represented by the formula I: wherein R 1 represents hydrogen atom, halogen atom or C 1 -C 6 alkyl, R 2 represents...
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6624162 |
Imidazopyridine compounds as 5-HT4 receptor modulators
This invention provides a compound of the formula (I): or the pharmaceutically acceptable salts thereof wherein R 1 is hydrogen, halo or alkyl; R 2 and R 3 are independently hydrogen, alkyl,...
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6613775 |
Imidazo&lsqb 1,2-a&rsqb pyridine compounds
The present invention relates to novel compounds, and therapeutically acceptable salts thereof of the formula (I), which inhibit exogenously or endogenously stimulated gastric acid secretion and...
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6605611 |
Base analogues
Nucleoside analogues or base analogues having structure (I), where X=O or NH or S, Y=N or CHR 6 or CR 6 , W=N or NR 6 or CHR 6 or CR 6 or S, n=1 or 2; each R 6 is independently H or O or alkyl...
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6596731 |
Substituted imidazo&lsqb 1,2-A&rsqb pyridine derivatives
The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount...
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6586452 |
C1 to C4 side chain modified nodulisporic acid analogs
The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
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6552037 |
2-Substituted imidazo&lsqb 1,2-A&rsqb pyridine derivatives
Disclosed are compounds of the formula: and the pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X, A, B, C, D and W are defined herein, which compounds bind with high...
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6498166 |
Pyrazolopyridines
The invention provides the compounds of formula (I) wherein: R 0 and R 1 are independently selected from H, halogen, C 1-6 alkyl, C 1-6 alkoxy, or C 1-6 alkoxy substituted by one or more...
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6476045 |
Azaindole derivatives and their use as therapeutic agents
The present invention relates to compounds of the formula (I): wherein: Het represents a heterocyclic residue selected from: where the dotted line in (b) represents an optional double bond; A...
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6420365 |
Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors
Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein A, B, C, D, Y, R 1 , R 3 , R 4 , R 5 , and R 6 are variables defined herein, which...
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6407240 |
Process for preparing N,N,6- trimethyl-2-(4-methylphenyl)-imidazo- &lsqb 1,2-a&rsqb -pyridine- 3-acetamide and salts thereof
It comprises reducing the hydroxy ester of formula (X) by reacting it in DMF and then with an iminium salt of formula (XIII) formed in situ with thionyl chloride and dimethylformamide, and...
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6395683 |
Heterocyclylbenzonitriles
The invention relates to new heterocyclylbenzonitriles of the general formula (I) in which R 1 , R 2 , R 3 and Het have the meanings given in the description, new processes and new intermediate...
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6384222 |
N-benzenesulfonyl-L-proline compounds, preparation method and method for using the compounds in therapy
The present invention relates to compounds selected from the group consisting of: (i) the compounds of the formula in which X is a halogen atom, A is a group —NH—(CH 2 ) n —NH—CO—,...
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6384226 |
Process for the preparation of 2-phenyl-imidazo &lsqb 1, 2-a&rsqb pyridine-3-acetamides
A process for the preparation of 2-phenyl-imidazo[1,2-a]pyridine-3-acetamides comprises the reaction of a 2-phenyl-imidazo[1,2-a]pyridine with an oxalic ester reactive derivative, followed by...
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6379649 |
Imidazo(1,2-a)pyridines as peripheral benzodiazepine receptor binding agents
The invention provides imidazo [1,2-a] pyridines of formula (1), wherein Y is selected from F, Cl, Br, I, OH, SH, NH 2 , CN and COOH; Z is selected from N(R 3 )C(O)R 4 and C(O)NR 3 R 4 ; R 1 , R 2...
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6362191 |
Aminometyl oxooxazolidinyl benzene derivatives
The invention concerns compounds of formula (I), wherein: A is a 5 membered heteroaryl ring, a bicyclic benzo system containing such a 5 membered heteroaryl ring or a bicyclic or tricyclic...
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6358971 |
Anti-viral compounds
The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A...
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6344462 |
Heterocyclic compounds as bradykinin antagonists
This invention relates to a compound of the formula: wherein A 1 is lower alkylene, R 1 is substituted quinolyl, etc., R 2 is hydrogen, halogen or lower alkyl, R 3 is halogen or lower alkyl,...
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6333335 |
Phenyl-protein transferase inhibitors
The present invention is directed to tetrahydro-imidazopyridinyl compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further...
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6323229 |
N-acyl and N-aroyl aralkylamides
A compound of the formula ##STR1## wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined, useful in treating or preventing migraine, depression and other disorders for which a 5-HT 1 ...
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6323227 |
Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
This invention relates to compounds of formula ##STR1## which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of...
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6313137 |
Imidazo pyridine derivatives which inhibit gastric acid secretion
The present invention relates to imidazo pyridine derivatives of the formula (I), in which the phenyl moiety is substituted, and in which the imidazo pyridine moiety is substituted with a...
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6294672 |
Indole and azaindole inhibitors of Fructose-1,6-biphosphatase
The present invention is directed towards novel azaindole compounds which bind to the AMP site and are potent FBPase inhibitors. The present invention also is directed towards the clinical use of...
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6281360 |
Imidazopyridine derivatives and process for making them
Imidazopyridine compounds of the formula 1 are can be made in high purity, e.g. greater than 95% pure, by a process that use a novel intermediate of formula 5: ##STR1## wherein R 1 and R 2 each...
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6265415 |
Compounds for inhibition of gastric acid secretion
The present invention relates to imidazo pyridine derivatives of the formula (I), in which the phenyl moiety is substituted with lower alkyl in 2- and 6-position, which inhibit exogenously or...
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6251829 |
Herbicidal benzoyloxy carboxylates and carboxamides
This invention relates to herbicidal alpha-(2,4,5-trisubstituted)- and alpha-(2,5-disubstituted)-benzoyloxy-alpha-beta-, and/or beta-gamma-unsaturated-carboxylates and their derivatives, to...
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6242460 |
Zolpidem salt forms
Zolpidem salts having improved physical stability do not exhibit a melting endotherm corresponding to zolpidem free base when heated at 5° C./minute from about 25° C. to 250° C. The salts are...
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6229016 |
Method for treating tumors using 2-aryl-naphthyridin-4-ones
The present invention provides compounds of Formula I: ##STR1## wherein A and R 1 -R 8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic...
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6229011 |
N-aroylphenylalanine derivative VCAM-1 inhibitors
Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose...
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6228867 |
Antagonists of gonadotropin releasing hormone
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
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6228868 |
Oxazoline antiproliferative agents
Compounds having Formula I ##STR1## are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.
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6159975 |
Antagonists of gonadotropin releasing hormone
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
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6124313 |
Imidazopyridine azolidinones
Imidazopyridine-azolidinones are useful for treating or preventing amenable gastro-intestinal ailments.
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6096758 |
3-methylimidazopyridines
The invention relates to certain substituted imidazo[1,2-a]pyridines useful in the treatment of gastro-intestinal disorders.
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6093717 |
Imidazopyridine thrombin inhibitors
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein Y 1 and Y 2 are independently selected from the...
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6080755 |
1,9-diazabicyclo[4.3.0]nona-3,8-diene derivatives
Disclosed are diazabicyclo compounds of formula (I) ##STR1## in which R 1 is a substituted or unsubstituted lower alkyl, lower alkenyl or lower alkynyl; R 2 is a hydroxy; R 3 is a lower...
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6060432 |
Herbicidal sulfonamides
Compounds of Formula I, and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein X, Y, J, R 1 , and R 2 are as...
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6028034 |
Substituted pyrazolyl-pyrazole derivatives, processes for their preparation and their use as agents with herbicidal action
The invention relates to new substituted pyrazol derivatives of general formula (I) in which: R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have the meanings given in the description, agents with...
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6013654 |
Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
The present invention relates to imidazo[1,2-a]pyridine compounds of formula I which are dopamine D-4 antagonists and useful as anti-psychotic agents. ##STR1##
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5994379 |
Bisaryl COX-2 inhibiting compounds, compositions and methods of use
The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically...
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5981547 |
Homochroman derivatives and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
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5972957 |
Dihydrobenzopyran compounds and related compounds useful as anti-inflammatory agents
A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or...
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5919932 |
Biphenylamide derivatives as 5HT.sub.1D antagonists
Biphenyl amide derivatives as 5HT 1D antagonists, processes for their preparation, pharmaceutical compositions containing them and their use for the treatment of CNS disorders.
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5916888 |
Imidazo 1,5A!pyridine derived serine protease inhibitors
The invention relates to an imidazole 1,5a!pyridine derived serine protease inhibitor comprising a unit having general formula (I) ##STR1## wherein R 1 is hydrogen, lower alkyl or an acyl group; R...
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