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7205407 |
3-Substituted oxindole β3 agonists
The present invention relates to a β3 adrenergic receptor agonist of Formula (I) or a pharmaceutical salt thereof; useful for treating Type II diabetes and/or obesity
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7196196 |
Substituted imidazo[1, 2-a]-5,6,7,8-tetrahydropyridine-8-ones, method for their production and the use thereof for producing imidazo[1,2-a]pyridines
A process for the preparation of imidazo[1,2-a]-5,6,7,8-tetra hydropyridin-8-ones by reaction of γ-butyrolactones with imidazols, novel imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-ones, and their...
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7160897 |
Therapeutic compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7151109 |
Pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators
The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives of general formula I:
that bind with high affifnity to CRF 1 receptors, including human CRF 1 receptors. This...
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7151104 |
Pyrazolopyridines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7148353 |
Imidazo[1,2-a] pyridine anxiolytics
Imidazo[1,2-a]pyridines of the formulae I and II:
are disclosed. The compounds are useful to treat anxiety and insomnia. Pharmaceutical compositions and methods are also disclosed. A...
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7148219 |
Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
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7141579 |
Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient
Heterocyclic compound represented by the formula I
wherein
represents
or the like; R 1 represents hydrogen atom, C 1 –C 6 alkyl or benzyloxy; R 2 represents methyl or nil; R 3 ...
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7129355 |
Process for preparing kifunensine intermediate and kifunensine therefrom
A novel method for the preparation of a compound of formula (I) from an N—protected-D-mannosamine. A compound of formula (I) is a useful intermediate for the preparation of kiftnensine, a potent...
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7125888 |
Tyrosine kinase inhibitors
The present invention relates to imidazopyridine compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of...
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7112582 |
Bicyclic 6-alkylidene-penems as β-lactamase inhibitors
The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
wherein...
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7112592 |
Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid:
The invention also relates to a process for the preparation of these compounds...
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7105533 |
Fused heterobicyclo substituted phenyl metabotropic glutamate-5 modulators
Phenyl compounds substituted with a fused-heterobicyclo moiety, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety,...
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7091352 |
Compounds substituted with bicyclic amino groups
Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof:
wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R 1...
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7087626 |
Pyrrole derivatives as pharmaceutical agents
Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the...
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7087757 |
Phenyl-substituted imidazopyridines
The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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7081466 |
2-aroylimidazole compounds for treating cancer
Disclosed is a compound represented by Structural Formula (I):
R 1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl...
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7074801 |
Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
The present invention discloses compounds and compositions of formula (I):
having inhibitory activity on activation of STAT6, wherein X represents quinoline, isoquinoline, quinazoline or...
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7041675 |
Heterocyclic compounds and their use as PARP inhibitors
The invention relates to compounds of the formula I
and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.
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7034154 |
Synthesis of substituted pyrazolopyrimidines
Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimi
din-7-yl}phenyl)acetamide. Such compounds have...
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7030134 |
Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7022701 |
Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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7012080 |
Imidazopyridine compounds as 5-HT4 receptor agonists
This invention provides a compound of the formula (I):
or a pharmaceutically acceptable salt thereof, wherein
R 1 represents a hydrogen atom or a halogen atom; R 2 represents a methyl group...
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6992188 |
Substituted heterocyclic derivatives
Corticotropin-releasing factor (CRF) antagonists having the formula
wherein the dashed lines, A, B, D E, F, Z, G, R 3 , and R 5 having the definitions set forth in the specification...
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6984646 |
Imidazopyridinones as p38 map kinase inhibitors
The invention relates to imidazopyridinones of the formula
wherein the groups R 1 , R 2 , R 3 , and R 4 are as defined in claim 1, to the process for their preparation, to pharmaceutical...
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6951867 |
N-substituted piperidinyl-imidazopyridine compounds as 5-HT4 receptor modulators
This invention provides a compound of the formula (I):
or a pharmaceutically acceptable salt, amide or ester thereof, wherein R 1 represents a hydrogen atom or a halogen atom; R 2 represents...
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6936617 |
Heteroaryl substituted fused bicyclic heteroaryl compound as GABAA receptor ligands
This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and...
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6919352 |
Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and...
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6916826 |
Substituted imidazo[1,2-a]pyridine derivatives
The present invention is a series of novel compounds of formula I and a method of treatment or prevention of a mGluR5 receptor mediated disease by administering an therapeutically effective amount...
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6903112 |
Heterocyclylindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
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6900324 |
Process for preparing a substituted imidazopyridine compound
The present invention provides a new process for large-scale preparation of substituted imidazopyridine compound of formula (1) wherein R 1 is C 1 -C 6 alkoxy or NH 2 group, comprising the step...
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6897225 |
Inhibitors of αLβ2 mediated cell adhesion
The present invention relates to a compound of the following formula:
or a pharmaceutically acceptable salt thereof. Also disclosed are compositions containing the compound and methods of...
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6894041 |
Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6872731 |
Imidazo-pyridine derivatives as ligands for GABA receptors
A class of 3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or...
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6867208 |
Vitronectin receptor antagonists, their preparation and their use
The present invention relates to compounds of the formula I
A—B—D—E—F—G (I)
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6861525 |
Process for the preparation imidazo[1,2-A]pyridine-3-acetamides
The present invention relates to an improved synthesis of imidazo[1,2-a]pyridine-3-N,N-dialkylacetamides, including zolpidem tartrate.
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6858613 |
Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease
The invention provides compounds of Formula I:
These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful...
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6852739 |
Methods using proton pump inhibitors and nitric oxide donors
The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is...
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6849642 |
Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring
Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring, and pharmaceutical compositions containing these compounds, useful, inter alia, as analgesics.
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6841679 |
Process for the preparation of imidazopyridines
A compound of the general formula (1), in which: Y denotes hydrogen, a halogen or a C 1-4 alkyl group; X 1 and X 2 denote, independently of each other, hydrogen, a halogen, a C 1-4 alkoxy, C...
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6818657 |
Bioprecursors of a retinoic derivative and pharmaceutical and/or cosmetic compositions
The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents...
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6818643 |
Neurotrophic bicyclic diamides
The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel bicyclic diamide compounds that are neuroprotective...
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6806268 |
Method for treating glaucoma V
Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the...
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6790960 |
Compounds
The present invention relates to novel compounds, and therapeutically acceptable salts thereof of the formula (I), which inhibit exogenously or endogenously stimulated gastric acid secretion and...
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6784293 |
Process for making Boc-protected 3-aminohydantoins/thiohydantoins and 3-aminodihydrouracils/dihydrothiouracils
The present invention provides a process for the efficient assembly of Boc-protected 3-aminohydantoins/thiohydantoins and 3-aminodihydrouracils/dihydrothiouracils via a one-pot solution phase or...
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6756498 |
Process for the preparation of chemical compounds
The invention provides a process for preparing a compound of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R 0 and R 1 are independently selected from H, halogen, C...
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6743919 |
2-aroylimidazole compounds for treating cancer
Disclosed is a compound represented by Structural Formula (I): R 1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Z...
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6740649 |
Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)
The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from...
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6730789 |
Composition for dyeing keratinous fibers containing 3 amino pyrazolo- &lsqb 1,5-a&rsqb pyridines, dyeing method, novel 3-amino pyrazolo-&lsqb 1,5-a&rsqb pyridines
The invention concerns novel oxidative composition for dyeing keratinous fibres comprising at least a 3-amino-pyrazolo-[1,5-a]-pyridine of Formula (I), the dyeing method using said composition,...
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6716837 |
Heterocyclic compounds for the treatment of migraine
Described herein are compounds useful in the treatment of migraine, which have the general formula: wherein: W is a CH group or a N atom; Z is N or C—R4; B and D are selected independently...
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