Patents in Class 546/117

Matches 1 - 50 out of 68

1 2 >

Match	Document	Document Title
1	7601840	Carboline derivatives useful in the inhibition of angiogenesis In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the...
2	7576072	Heterocyclic inhibitors of MEK and methods of use thereof Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X, Y and Z are as defined in the specification....
3	7482336	Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment...
4	7465726	Substituted pyrrolo[2.3-B]pyridines Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3,...
5	7417041	Imidazopyrimidines as transforming growth factor (TGF) inhibitors Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described....
6	7265128	3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and...
7	7230100	Stereoselective method for the preparation of nucleosides A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof...
8	7179910	3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to...
9	7074929	Certain alkylene diamine-substituted heterocycles This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the...
10	7038053	Process for imidazo[4,5-c]pyridin-4-amines A process and intermediates for preparing 1H-imidazo[4,5-c]pyridin-4-amines are disclosed. The process includes providing a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine and converting a...
11	6992188	Substituted heterocyclic derivatives Corticotropin-releasing factor (CRF) antagonists having the formula wherein the dashed lines, A, B, D E, F, Z, G, R 3 , and R 5 having the definitions set forth in the specification...
12	6984646	Imidazopyridinones as p38 map kinase inhibitors The invention relates to imidazopyridinones of the formula wherein the groups R 1 , R 2 , R 3 , and R 4 are as defined in claim 1, to the process for their preparation, to pharmaceutical...
13	6875772	[1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R 1 ) or N; R 1 and R 1a are H, (C 1 -C 6 )-alkyl, halo, CN or —CF 3 ; X is —C(O)—, —O—, —SO...
14	6867217	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods...
15	6673810	Imidazo-heterobicycles as factor Xa inhibitors The present application describes imidazo-heterobicycles of formulas I and III: or pharmaceutically acceptable salt or prodrug forms thereof. Compounds of the present invention are useful as...
16	6610692	Thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is NY...
17	6569869	Annulated azole derivatives useful as microbicidal agents Novel fused azole derivatives of the formula in which R 1 , R 2 , A and G are as defined in the description, and also their acid addition salts and metal salt complexes, a plurality of processes...
18	6525056	Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (CRH) antagonists, useful for treating cns and stress-related disorders Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress...
19	6479506	Triazolo-pyridine derivatives as ligands for GABA receptors Substituted or 6,7-ring fused 1,2,3-triazolo[4,5-b]pyridine derivatives are selective ligands for GABA A receptors useful in the treatment of disorders of the central nervous system.
20	6458950	Compounds and pharmaceutical compositions containing the same A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the...
21	6159975	Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety...
22	6156766	Benzamide compounds and pharmaceutical use thereof Benzamide compounds of the formula ##STR1## wherein each symbol is defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical...
23	6046136	Herbicidal heterocyclic N-oxides compounds This invention relates to novel optionally substituted heterocyclic N-oxide compounds of formula (I): ##STR1## wherein: R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , A, X, Z and m are defined...
24	5912348	Method of making arylamino triazolopyridines Method for making 4-arylamino-1-alkyl- 1,2,3!triazolo 4,5-c!pyridines by base-promoted isomerization of 7-alkylamino-3-aryl- 1,2,3!triazolo 4,5-b!pyridines.
25	5874382	Cyclic sulfonamide herbicides Compounds of Formula I and II, and their agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein X is a direct bond; O; S; NH; N(C 1 -C...
26	5846990	Substituted biphenyl isoxazole sulfonamides Compounds of the formula ##STR1## inhibit the activity of endothelin. The symbols are defined as follows: R 1 , R 2 , R 3 and R 4 are each directly bonded to a ring carbon and are each...
27	5840894	Preparation of 1,2,4-triazolium salts and 1,2,4-triazolines A process for the preparation of 1,2,4-triazolium salts Ia ##STR1## where R 1 , and R 2 and R 3 are C-organic radicals, it being possible for R 2 and R 3 to be connected to give a 5- to...
28	5767141	Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Substituted propane derivatives, a process for their preparation and the use of the compounds for treating diseases Propane derivatives of the formula I ##STR1## in which the radicals have the...
29	5719170	Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparations Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the given meaning. The compounds are pharmacologically active and may therefore be used as pharmaceuticals, in...
30	5679700	Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents Novel phosphinic acid-containing peptidyl compounds of formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis,...
31	5599773	(2-imidazolin-2-yl) fused heteropyridine compounds and use of said compounds as herbicidal agents There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and...
32	5593943	Heteroaromatically condensed hydroxypyridonecarboxamides, their preparation and use as herbicides Heteroaromatically condensed hydroxypyridonecarboxamides of the structure I ##STR1## where the substituents and the ring Q have the following meanings: R 1 hydrogen, hydroxyl, substituted or...
33	5536839	(2-Imidazolin-2-yl) fused heteropyridine compounds There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and...
34	5514688	Carbocyclic adenosine analogs useful as immunosuppressants This invention relates to carbocyclic adenosine compounds of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic...
35	5459129	Condensed heterocyclic compounds, their production and use A novel compound of the formula: ##STR1## wherein a ring A stands for an optionally substituted 5-membered ring; B stands for an optionally substituted divalent cyclic or chain group; either one of...
36	5302596	Tricyclic compounds as TXA.sub.2 antagonists Novel tricyclic compound represented by formula ##STR1## possess a TXA 2 biosynthesis inhibiting activity and/or a TXA 2 receptor antagonizing activity, and are expected to have preventive and...
37	5290936	Nitro substituted chemiluminescent labels and their conjugates, and assays therefrom A novel chemiluminescent labeling compositions comprising an ester, thiolester or amide covalently and jointly bonded to (1) a carbon of a heterocyclic ring or ring system that is susceptible to...
38	5256661	Substituted 2-aminotetralins and pharmaceutical use Certain novel compounds having the structural formula ##STR1## where R 2 , R 3 and R 4 are each selected from the group consisting of H and OA; A is H or is selected from the group consisting of...
39	5248681	Dihydropyridine antiallergy agents
40	5240937	Pharmaceutically active triazolopyridine compounds This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals.
41	5232930	2-heteroaryl-substituted benzodioxoic having 5-lipoxygenase inhibitory activity The invention concerns a benzodioxole derivative of the formula I ##STR1## wherein Ar 1 is an optionally substituted 9- or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen...
42	5214044	1,4-dihydropyridines useful as pharmaceuticals The invention provides compounds of the formula: ##STR1## The variables are defined in the specification. The compounds are useful e.g. for the curative or prophylactic treatment of allergic...
43	5166209	Pharmacologically active compounds This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals.
44	5133798	Certain herbicidal 1,2,4-triazolo[4,5-b]pyridines A compound of formula (I): ##STR1## in which the dotted lines indicate the presence of two double bonds arranged so as to form a fused hetero-aromatic ring system; Ar is an optionally...
45	5077407	Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles The present invention provides novel substituted 2-[monoannelated(3,4- 4,5-, and 5,6-)pyridylalkylenesulfinyl]-benzimidazoles with gastric acid inhibiting effects.
46	5039689	Antiparasitic 3(4-amino benzotriazo-1-yl-)1,2-cyclopentanediols The present invention relates to the use of a compound of formula (I) ##STR1## wherein R represents a hydrogen atom; a C 1 -4 alkyl group; a group COR 1 wherein R 1 represents amino or C 1...
47	5010198	Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents Benzoxazol- and benzothiazolamine derivatives having anti-anoxic properties which compounds are useful in the treatment of anoxia. These compounds are produced from certain benzoxazol- and...
48	4908056	Heterocyclic acyl sulfonamides This invention relates to novel heterocyclic carbonyl sulfonamides which are particularly useful as agricultural chemicals.
49	4861785	Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents Benzoxazol-and benzothiazolamine derivatives having anti-anoxic properties which compounds are useful in the treatment of anoxia.
50	4816457	Aralkylaminoethanol heterocyclic compounds Heterocyclic aminoethanols of the formula: Het--CHOH--CH 2 --NH-aralkyl where Het is a 6-10 membered N-heterocycle are disclosed. The compounds are useful as pharmaceuticals.

Matches 1 - 50 out of 68

1 2 >