Matches 101 - 150 out of 491 < 1 2 3 4 5 6 7 8 9 10 >
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6867217 Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade  
The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods...
6861438 Antiviral agents  
The invention provides a compound of formula I: wherein G, R 2 , and R 3 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
6858734 Preparation of (S)-Clopidogrel and related compounds  
A process for producing enantiomerically enriched (S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5 (4H)-acetic acid hydrocarbyl ester, represented by the formula: Is provided,...
6852734 Indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof  
According to this invention, there is provided an indole derivative having the general formula (I) wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted...
6852731 Antiviral compounds  
The invention provides a compound of formula I: wherein G, R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
6849620 N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease  
The invention provides compounds of Formula I: wherein Azabicyclo is W 0 is a bicyclic moiety and is These compounds may be in the form of pharmaceutical salts or...
6849622 Aliphatic nitrogenous five-membered ring compounds  
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH 2 — or —S—, R 1 ...
6841559 Pyridinones to treat and prevent bacterial infections  
Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods...
6833375 N-&lsqb 4-(heteroarylmethyl)phenyl&rsqb -heteroarylamines  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R 1 is...
6833370 Heterocycle substituted aminoazacycles useful as central nervous system agents  
Heterocyclic substituted aminoazacyclic compounds of formula I Z—R 3 I, wherein Z is a defined aminoazacycle and R 3 is a defined heterocycle moiety, pharmaceutical compositions of these...
6833456 Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use  
The invention relates to compounds represented by the formula I and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein X, R 1 and R...
6831081 4-Oxo-4,7-dihydrothieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents  
The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
6828330 Quinuclidine-substituted hetero-bicyclic aromatic compounds for the treatment of disease  
The invention provides compounds of Formula I: wherein W 0 is a bicyclic moiety and is These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric...
6815440 Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids  
Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course...
6812247 Organometallic complex  
A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen,...
6809203 Oxazolo, thiazolo and selenazolo &lsqb 4,5-C&rsqb -quinolin-4-amines and analogs thereof  
Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators...
6797710 Heterocyclic derivatives and their use as antithrombotic agents  
The present invention relates to antithrombotic compounds comprising the group Q, Q having formula (I), wherein the substructure (i) is a structure selected from (a, b and c), wherein X is O or S;...
6797717 Anilide compounds and drugs containing the same  
The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same. The invention relates to a compound represented by the following general formula: ...
6780887 Anti-ischemic compounds  
The present invention is related to a compound of formula (I), salts and pro-drugs of the compound (I) and methods for treating and/or preventing partial or total ischemia, methods for treating...
6770647 Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)  
The present application describes to novel bicyclic hydroxamates derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, B 1 , B 2 , R 1 , and C are...
6767913 CRYSTAL FORMS III, IV, V, AND NOVEL AMORPHOUS FORM OF CLOPIDOGREL HYDROGENSULFATE, PROCESSES FOR THEIR PREPARATION, PROCESSES FOR THE PREPARATION OF FORM I, COMPOSITIONS CONTAINING THE NEW FORMS AND METHODS OF ADMINISTERING THE NEW FORMS  
The present invention provides new crystalline Forms III, IV and V of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical...
6765011 7-heterocyclyl quinoline and thieno&lsqb 2,3-b&rsqb pyridine derivatives useful as antagonists of gonadotropin releasing hormone  
The present invention is directed to novel 7-heterocyclyl quinoline and thieno[2,3-b]pyridine derivatives of the general formula (I) or (II) wherein all variables are as herein defined,...
6743793 Indole derivatives, process for preparation of the same and use thereof  
Indole derivatives represented by formula (I): (wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an...
6737411 Racemization and enantiomer separation of clopidogrel  
Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by...
6727258 Allosteric adenosine receptor modulators  
The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators...
6716841 Nitrogen containing heterobicycles as factor Xa inhibitors  
This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical...
6713507 Ether compounds and compositions for cholesterol management and related uses  
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
6703422 Sulfide and disulfide compounds and compositions for cholesterol management and related uses  
The present invention relates to novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular...
6693199 Method of making HIV protease inhibitors  
A method of making HIV protease inhibitors of general formula (1): These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV...
6693115 Acid addition salts of hydropyridine derivatives  
Acid addition salts of 2-acetoxy-5-(α-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7 -tetrahydrothieno[3,2-c]-pyridine. The acid addition salts of tetrahydrothienopyridine derivatives of the present...
6673780 Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses  
The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing...
6635763 Process to prepare clopidogrel  
The present invention relates to a process for the preparation of thieno[3,2-c]pyridine derivatives having pharmacologically significant anti-aggregating and anti-thrombotic properties.
6620810 4-thioxo-4,7-dihydro-thieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents  
The invention provides a compound of formula I: wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
6613903 Modulators of protein tyrosine phosphatases (PTPases)  
The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful...
6596863 Medical composition containing nitroetheneamine Derivative or salt there of as active constituent  
Process for producing a nitroetheneamine derivative or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula with a compound of the formula R 6 —CH 2...
6534520 Antiviral compounds  
The present invention relates to heterocyclic Compounds having antiviral activity. In particular, Compounds of formula (I): wherein B, W, X, Y, Q, R 1 , R 2 , R 3 , R 4 and n are as defined...
6525056 Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (CRH) antagonists, useful for treating cns and stress-related disorders  
Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress...
6518281 Immunotherapeutic agents  
Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory...
6514988 Condensed-ring thiophene derivatives, their production and use  
A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or...
6504030 Polymorphic form of clopidogrel hydrogen sulphate  
Novel orthorombic polymorph of clopidogrel hydrogen sulfate or hydrogen sulfate of methyl (+)-(S)-α-(2-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]p yridine-5-acetate and a process for its...
6498251 Tetrahydrobenzindole derivatives  
Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling...
6495691 Process for the preparation of tetrahydrothieno&lsqb 3,2-c&rsqb pyridine derivatives  
A process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives of general formula I: or their pharmaceutically acceptable salts, wherein the meaning of X is hydrogen, carboxyl,...
6492383 Thienopyrimidine and thienopyridine derivatives useful as anticancer agents  
The invention relates to compounds of the formulas 1 and 2 and to pharmaceutically acceptable salts and hydrates thereof, wherein X 1 , R 1 , R 2 and R 11 are as defined herein. The invention...
6486171 Piperidine compounds  
A compound selected from those of formula (I): wherein: W represents optionally substituted naphthyl, or a group of formula Y (wherein) as defined in the description, n represents an integer...
6476022 Oxathiepino&lsqb 6,5-b&rsqb dihydropyridines, and related compositions and methods  
This invention provides novel oxathiepino[6,5-b]dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity....
6458950 Compounds and pharmaceutical compositions containing the same  
A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the...
6448261 Arylamino fused pyridines  
Corticotropin releasing factor (CRF) antagonists of formula I; and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
6448262 Pesticidal and parasiticidal use of 2-(substituted thio) thiazolo-&lsqb 4,5-b&rsqb pyridine compounds  
The present invention relates to the pesticidal and parasiticidal use of 2-(substituted thio)thiazolo[4,5-b]pyridine compounds having the structural formula I
6444617 Fused-heterocycle dicarboxylic acid diamide derivatives or salts thereof, herbicide and usage thereof  
A fused heterocyclic dicarboxylic acid diamide derivative represented by formula (I): wherein R 1 is H, (C 1 -C 6 ) alkyl; R 2 and R 3 are H, (halo) (C 1 -C 6 ) alkyl, (C 3 -C 8 ) cycloalkyl,...
6437132 Thienopyridine derivatives, their intermediates and production thereof  
The present invention provides an intermediate for producing a thienopyridine derivative useful as a GnRH antagonist as well as an efficient and safe method for producing the same in an industrial...
Matches 101 - 150 out of 491 < 1 2 3 4 5 6 7 8 9 10 >