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8147725 Photochromic materials having extended pi-conjugated systems and compositions and articles including the same  
The present invention provides a photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the...
8129525 Long wavelength thiol-reactive fluorophores  
Reactive fluorescent dyes compositions and methods of using same are disclosed. Nile Red nucleus dyes are disclosed having thiol-reactive groups. Nile Red nucleus dyes are disclosed that exhibit a...
8039466 5-hydroxymethyl-oxazolidin-2-one antibacterials  
The invention relates to novel chimeric antibiotics of formula I wherein R1 represents OH, OPO3H2 or OCOR5;R2 represents H, OH or OPO3H2;R3 represents H or halogen;R4 is H, (C1-C3)alkyl, or...
7943609 Chiral fused [1,2]imidazo[4,5-C] ring compounds  
Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and...
7906506 Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods  
Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines,...
7892345 Method for producing transparent Pigment Violet 23  
The invention accordingly relates to a method for preparing transparent C.I. Pigment Violet 23 by salt kneading a Pigment Violet 23-crude in the presence of a crystalline salt and an organic...
7884099 Quinolone carboxylic acid-substituted rifamycin derivatives  
The compounds include substituted rifamycin derivatives in which a quinolone carboxylic acid pharmacophore is covalently bonded to a benzoxazinorifamycin or a spiropiperidinorifamycin. The...
7816519 Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings  
The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength...
7816406 Quinolone analogs  
The present invention provides quinolone analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs, and...
7749994 Pentacyclic kinase inhibitors  
The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z, Ra,...
7695930 Method for the detection, identification and/or quantification of microoganisms with peptidase activity using phenoxazinone derivatives as enzyme substrates  
The present invention relates to methods for the detection, identification and/or quantification of microorganisms with peptidase activity using enzymatic substrates with the following general...
7652134 Methods for converting quinolone esters into quinolone amides  
The present invention relates to methods of preparing compounds having formula (1), (2), (5), and ((6A)-(6D)) comprising contacting the corresponding ester, an amine with formula NHR1R2, and a...
7629458 Preparation of levofloxacin and hemihydrate thereof  
The invention provides a method for preparing levofloxacin hemihydrate, comprising: maintaining levofloxacin at a first elevated temperature in a first solvent;adding a polar solvent to precipitate...
7612063 Substituted quinobenzoxazine analogs  
The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are...
7514427 1,5,6,-substituted-2-oxo-3-cyano-1,6a-diaza-tetrahydro-fluoranthenes as anti-inflective agents  
HIV inhibitory compounds of formula: salts and stereoisomers thereof, wherein R1 and R2 are hydrogen or optionally substituted C1-10alkyl;R3 is n is 1, 2 or 3; R3a is nitro, cyano, amino, halo,...
7470683 Tetracyclic compounds  
Compounds of formula I, of trans relative configuration: wherein: X represents an oxygen atom or an NR2 group,Y represents a group selected from —CH2—, —(CH2)2— and —CH═CH—,R1 and R2, which may be ...
7462717 C6-and C9-substituted chromeno[4,3-c]isoxazoline derivatives and their use as anti-depressants  
The invention concerns substituted tricyclic isoxazoline derivatives, more in particular tricyclic dihydrobenzopyranoisoxazoline, dihydroquinolinoisoxazoline, dihydronaphthalenoisoxazoline and...
7435823 Compounds and methods of use  
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
7432372 Fluorinated resorufin compounds and their application  
The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the...
7425628 Methods for the purification of levofloxacin  
The invention provides a process for preparing levofloxacin hemihydrate, comprising: (A) dissolving levofloxacin in a solvent selected from the group consisting of acetonitrile, acetonitrile:H2O,...
7420054 Phenoxazinone derivatives as enzyme substrates and use thereof as indicator in the detection of microorganisms with peptidase activity  
The present invention relates to novel enzymatic substrates with the following general formula: where R1, R2, R3, R4, R5, R6, A and X are as defined in claim 1, the reaction media comprising the...
7402579 Quinobenzoxazine analogs and compositions  
The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof;wherein A, U, W, X, Z, B, L, R1, R3, R4 and...
7326258 Compositions comprising hydroxyalkyl direct dyes, implementation processes and uses thereof  
The present invention relates to a cosmetic composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising, in a suitable dyeing medium, at least one...
7312213 Substituted benzo[e][1,4]oxazino[3,2-g]isoindole compounds  
A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl,Z represents a group selected from hydrogen, halogen, linear or...
7268131 Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma  
Substituted [1,4]oxazino[2,3-g]indazols for lowering intraocular pressure and treating glaucoma are disclosed.
7265103 Substituted amino isoxazoline derivatives and their use as anti-depressants  
The invention concerns substituted amino isoxazoline derivatives, more in particular tricyclic dihydrobenzopyranoisoxazoline, dihydroquinolinoisozazoline, dihydronaphthalenoisoxazoline and...
7235552 Cholenic acid amides and pharmaceutical compositions thereof  
Novel sterol derivatives of formula (I), in which: R1 represents a hydroxyl group or protected hydroxyl group, R2 represents a hydrogen atom and a double bond is present at c, or R1 and R2 together...
7229989 Blue 3H-naphtho[2,1-b]pyran compounds and use thereof in photochromic articles  
Photochromic 3H-naphtho[2,1-b]pyran compounds corresponding to formula I in which the groups R1 to R7 and B′ have defined meanings and the use of such photochromic compounds in synthetic resin a...
7169922 Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings  
The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength...
7101999 Oxazine derivatives  
The invention relates to oxazine derivatives by means of which a broad spectrum of material to be examined can be marked and identified using fluorescence techniques.
6984641 Carboline derivatives as PDE5 inhibitors  
Selective inhibitors of cGMP-specific PDE, and use of the compounds and salts and solvates thereof as therapeutic agents, are disclosed.
6932961 Oxazinocarbazoles for the treatment of CNS diseases  
The present invention provides isotopically labeled oxazinocarbazole derivatives having a ring connecting position 8 (C-8) and position 9 (N-9), and more specifically, provides compounds of formula...
6930105 Tetracyclicazaindoles and indolines having 5-HT activity  
The present invention provides compounds of Formula (I): wherein R1, R2, R3, R4, R5, and R6, have any of the values defined in the specification, as well as pharmaceutical compositions comprising...
6900204 Antimicrobial agents and uses thereof  
The invention features compounds that act as antimicrobial agents and/or antimicrobial enhancer agents, compositions that include the antimicrobial enhancer agents of the invention, and methods for...
6825184 1,4-Disubstituted benzo-fused urea compounds  
Disclosed are compounds of the formulas (I) & (II) shown below which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds. wherein G, X, A and Q are...
6815544 Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds  
An efficient process is described for the synthesis of 5, a key intermediate for the synthesis of the potent antitumor agents ecteinascidin 743 (1) and phthalascidin (2) from the readily available...
6777406 Substituted pyrroloquinolines and pyridoquinolines as serotinin agonists and antagonists  
The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein is R1, R6a, R6b, R7, R8, R9, X, b, m,...
6720316 Therapeutic 5-HT ligand compounds  
The present invention provides compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and Z have any of the values defined in the specification, as well as pharmaceutical compositions...
6720420 Photochromic oxazine compounds and methods for their manufacture  
The present invention provides oxazine compounds having aromatic, heteroaromatic, or aliphatic substituents at the 2 position of the oxazine moiety. Additionally, a one pot method with excellent...
6686349 Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors  
The invention relates to novel tetracyclic pyrroloquinolone derivatives of the formula (I) or (II): wherein all variables are as herein defined, pharmaceutical compositions containing the compounds...
6638934 Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonist and antagonists ligands  
The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a): or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R4b, R5, R6, R7, R8, R9, n,...
6608055 Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition  
The invention relates to crystalline anhydrous (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9 -dimethyl-3-oxa-9-azoniatricyclo[3.3.1.022,4]nonane-bromide, processes for preparing it and ...
6531471 Morpholinone and morpholine derivatives and uses thereof  
This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human α1a receptors. This invention is also related to uses of these compounds for ...
6517630 Pigments having improved colouristic properties and process for their preparation  
The present invention is directed to a pigment of the formula which, in a gravure ink, has a lightness L* of not more than 48, a chroma C* of at least 53 and a hue angle h of from 295 to 315.
6515123 Triphendioxazine pigments, intermediates, their method of making and uses thereof  
The invention is directed to carbamate group containing non chloranil based triphendioxazine compounds useful as pigments which are readily convertible into the corresponding triphendioxazine...
6476021 Compounds having cGMP-PDE inhibitory effect  
Novel fused tetracyclic heterocyclic compounds having a potent and highly selective effect of inhibiting cyclic GMP phosphodiesterase (cGMP-PDE) and a high safety; a process for producing the same;...
6468996 Substituted hetero-polycyclic compounds as PPARα and PPAR&ggr activators  
The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the...
6465644 Sulfonated &lsqb 8,9&rsqb benzophenoxazine dyes and the use of their labelled conjugates  
Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a...
6440507 Unsymmetrical dioxazine compound dichroic dye liquid crystal composition and liquid crystal display element  
An unsymmetrical dioxazine compound represented by the formula (1-1) or (1-2) below, a dichroic dye, a liquid crystal composition containing the same, and a liquid crystal display element...
6358947 Tetracyclic progesterone receptor modulator compounds and methods  
Nonsteroidal compounds that are high affinity, high selectivity modulators for progesterone receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds,...
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