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7605157 Tricyclic tetrahydroquinoline antibacterial agents  
The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and...
7557100 Antibacterial agents  
Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the...
7470684 Spiropiperidine derivatives as NK3 antagonists  
The present invention relates to a compound of formula I wherein R 1 , R 2 , R 3 , R 4 , R 7 , m and n are as defined herein. These compounds are high potential NK-3 receptor antagonists useful...
7423146 Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones  
A process for making a compound of formula 1 or a salt thereof, wherein: R 1 and R 2 are each independently H, halogen, or C 1-4 -alkyl, or R 1 and R 2 together are C 1-6 -alkylene; and R...
7419969 HIV integrase inhibitors: cyclic pyrimidinone compounds  
The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating...
7375104 Long acting beta-2-agonists and their use as medicaments  
A compound of formula 1′ wherein: V is —CH 2 —, —NH—, or —O—; R a and R b are each independently hydrogen, C 1-4 -alkyl, or halogen-C 1-4 -alkyl, or R a and R b together are...
7351706 Indol-3-yl-carbonyl-spiro-piperidine derivatives  
This invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiropiperidine-head group A...
7262294 Photochromatic pyrano-1,3-oxazinonaphthalene derivatives  
Photochromatic compounds belonging to the groups of chromenes and spiro-pyrans having general formula (I)
7261844 Photochromic contact lens having excellent discoloring characteristic  
A photochromic contact lens having a period of time for discoloring the contact lens from a colored state to the uncolored state shortened, wherein the photochromic contact lens is made of an...
7208490 Tricyclic tetrahydroquinoline antibacterial agents  
The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and...
7205296 Substituted 2H-1,3-benzoxazin-4(3H)-ones  
Substituted benzoxazin-4(3H)-ones are provided which are useful for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.
7183238 [1,2]-oxazine-3,5-diones  
The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a plurality of...
7122662 Tricyclic compound having spiro union  
This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated...
7115601 HIV integrase inhibitors  
Compounds of the present disclosure are spirocycle-substituted pyrimidinecarboxamides. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds....
7091198 2,5-disubstituted pyrimidine derivatives  
The present invention relates to novel 2,5-disubstituted pyrimidine derivatives which stimulate soluble guanylate cyclase, to processes for the preparation thereof, and to the use thereof for...
7071201 Quinoline derivatives  
A novel compound of the formula: wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R 1, R 2 , R 3 , R 4 , and R 5 represent each a substituent; n represents 0 or an integer...
6891038 Photochromic spiro(indoline)naphthoxazines  
A photochromic compound for incorporation into plastic articles, particularly into a plastic lens, is selected from a spiro(indoline)naphtho(2,1-b)(1,4)oxazine and a...
6858727 Intermediate of carbapenem antibiotics and process for the preparation thereof  
There is disclosed an azetidinone compound of the formula (I): wherein R is hydrogen, or a hydroxy protecting group, R 1 and R 2 are each independently alkyl of 1-15 carbon atoms, benzyl or...
6803471 Indolinospiropyran compounds and methods for their manufacture  
The present invention provides indolinospiropyran compounds and methods for their manufacture, which compounds are useful as photochromic compounds. The compounds of the invention are substituted...
6770707 Radicaly polymerisable compositions containing monofunctional monomers, resins and ophthalmic articles obtained from them, new monofunctional monomers  
Disclosed are radically polymerisable compositions which contain at least one monofunctional monomer and at least one difunctional monomer; resins which are obtainable by radical copolymerisation...
6740651 Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases  
Compounds of the formula having an inhibitory effect on signal transduction mediated by tyrosine kinases, and the use thereof for treating diseases, particularly tumoral diseases, diseases of...
6720420 Photochromic oxazine compounds and methods for their manufacture  
The present invention provides oxazine compounds having aromatic, heteroaromatic, or aliphatic substituents at the 2 position of the oxazine moiety. Additionally, a one pot method with excellent...
6414057 Photochromatic compounds, process for their preparation and their use in polymeric materials  
Photochromic compounds belonging to the group of spiro-isoindolino-oxazines having general formula (I). The above photochromatic compounds having general formula (I) have excellent photochromic...
6369056 Cyclic urea and cyclic amide derivatives  
This invention provides compounds of the formula: wherein: A, B and D are N or CH, with the proviso that A, B and D can not all be CH; R 1 and R 2 are independent substituents selected from H,...
6358948 Quinazolinone and benzoxazine derivatives as progesterone receptor modulators  
This invention provides compounds which are agonists and antagonists of the progesterone receptor having the general structure: wherein: R 1 and R 2 are independently selected from H, COR A ,...
6340751 Process for the preparation of 4-substituted azetidinone derivatives  
Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium...
6303673 Photochromic compounds  
A photochromic compound has the formula (I) wherein R 1 is selected from the group including substituted amino aryl moieties, substituted cyclic amino aryl moieties and substituted N-indolinoaryl...
6288061 Imidazole derivatives  
The present invention relates to the imidazole derivative of the following formula (I) ##STR1## wherein R 1 is hydrogen, optionally substituted alkyl and the like, R 2 is hydrogen, optionally...
6191127 Substituted heterocycles and their use in medicaments  
6166010 Azine derivatives  
The invention relates to the use of azine derivatives, some of which are known, of the formula ##STR1## in which A represents substituted phenyl, or represents in each case optionally substituted...
6127365 Spiro-ketal derivatives and their use as therapeutic agents  
The present invention is directed to compounds of the formula (I): ##STR1## (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 9a , R 9b , m and n are as defined herein) which are tachykinin...
6100246 Spiro-piperidine derivatives as inhibitors of nitric oxide synthase  
There are provided novel compounds of formula (I) ##STR1## wherein A represents a benzo ring; a six membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms; or a five membered...
6080740 Spiro-ketal derivatives and their use as therapeutic agents  
The present invention is directed to spiro-ketal derivatives of the formula (I): ##STR1## (wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 9a , R 9b , m and n are defined herein) which are...
6030555 Photochromic spiroxazines, compositions and articles containing them  
The invention concerns photochromic compounds having a formula (I), where R 1 is a polycyclo group formed by at least one alicyclic group linked to, bridged or condensed, with at least one other...
6019914 Photochromic spirooxazine compounds, their use in the field of ophthalmic optics  
The new photochromic compounds according to the invention, of the spiro[indoline-[2,3']-benzoxazine] type, include at least one electron-withdrawing group attached to the benzoxazine structure in...
6011150 Azetidinone compound and process for preparation thereof  
There is disclosed an azetidinone compound of the formula [I]: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R 1 is a hydroxy-substituted lower alkyl group which may...
6002000 Chemiluminescent compounds and methods of use  
Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) combining a medium suspected of containing the analyte and a...
5936016 Photochromic compounds and methods for their use  
The present invention relates to photochromic compounds of spiro indoline 2,3'!-naphthoxazine! structure, characterized in that they contain, in the 6' position, a group R 6 chosen from the...
5905148 Photochromic spirooxazine polysiloxanes  
Polysiloxane copolymers containing both photochromic and lightstabilizing groups with enhanced UV-fatigue resistance can be used as coatings for devices with variable optical density, including...
5833885 Photochromic compounds  
A spiro (indolino) oxazine compound of general formula (I) ##STR1## wherein R 1 represents a group of the formula --NR 2 R 3 wherein each of R 2 and R 3 , which may be the same or different,...
5831090 Process for the preparation of photochromic compounds of the annelated spiro indoline 2,3'! benzoxazine!type  
The present disclosure relates to a process for the preparation of photochromic compounds of the annelated spiro indoline 2,3'!benzoxazine! type comprising the reaction of a Fisher base (I) having...
5808063 Photochromic spiro(indoline) fluoranthenoxazine compounds  
Described are novel photochromic spiro(indoline) fluoranthenoxazine compounds having certain substituents on the 1 and 3 positions of the indoline portion of the compounds and which may be...
5801243 Photochromic compounds (7)  
Disclosed are photochromic oxazine compounds, yielded by means of condensation of an aldehyde bearing in the α-position to the aldehyde group a halogen or hydroxy group (reacting agent 1), with...
5780626 Oxazine compounds  
Substituted 1,2 oxazine compounds having the formula ##STR1## wherein R 1 , R 2 and R 3 are independently hydrogen; C 1 -8 alkyl; carboxyl; C 1 -8 alkoxycarbonyl or optionally substituted phenyl...
5730908 Photochromatic and thermochromatic compounds and their application in polymeric materials  
A description follows of photochromatic and thermochromatic compounds, belonging to the group of spiro-indoline-oxazines, and their application in polymeric materials.
5728695 Spiroketal derivatives, compositions containing them and their use as therapeutic agents  
The present invention relates to spiroketal derivatives of formula (I) and pharmaceutically acceptable salts thereof wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 9a , R 9b , m and n are as defined...
5672600 Antimicrobial dithiocarbamoyl quinolones  
Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A 1 , A 2 , A 3 , R 1 , R 3 , R 4 , and R 6 form any of a variety of quinolone and related...
5641884 Spiro-naphtho-oxazine compound and photosensitive materials using the same  
A spiro-naphtho-oxaine compound having a specific substituent providing red color development which has been unknown in the past, and photosensitive materials containing the compound. Since the...
5565410 Heterocyclic diones as pesticides and plant growth regulators  
Substituted 3,5-dioxo-3,4,5,6-tetrahydrooxazines as herbicides.
5559231 Spiro-oxazine compounds  
A spiro-oxazine compound represented by the following general formula (A) or (A') is a photochromic compound having an excellent fatigue resistance to repetition of coloration and decoloration and...
Matches 1 - 50 out of 165 1 2 3 4 >