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7595313 |
Nitric oxide donating diuretic compounds, compositions and methods of use
The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one...
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7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
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7494990 |
2-(piperidin-4-yl)-4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
The compounds of a certain formula (1),
in which R1, R2, R3 and R9 have the meanings as given in the description, are novel effective PDE4 inhibitors.
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7482339 |
2-Naphthylimino-1,3-thiazine derivative
The formula (I):
wherein each of R 2 and R 3 is, same or different, C2-C4 alkyl or the like; or R 2 and R 3 are taken together with the adjacent carbon atom to form a 5 to 8 membered...
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7199118 |
Benzothiazine derivatives, their preparation and use
This invention relates to novel benzothiazine derivatives of Formula I useful as modulators of the AMPA sensitive glutamate receptors, pharmaceutical compositions comprising such compounds and...
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7122662 |
Tricyclic compound having spiro union
This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated...
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7001910 |
Thiazolidinedione derivatives as antidiabetic agents
The present invention refers to compounds of the general formula (I), to their possible pharmaceutically acceptable salts and tautomeric forms. The present invention also refers to a process for...
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6916807 |
Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula
wherein said ring X is a 5-7 membered heterocyclic ring, and wherein...
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6916806 |
Medicinal composition containing 1,3-thiazine derivative
A compound of the formula (I) having a binding activity to the cannabinoid type 2 receptor:
wherein R 1 is optionally substituted heterocyclic group or the like; R 2 and R 2 each is...
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6900201 |
N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trio
ne metalloproteinase inhibitors of the formula
wherein ring X is a 5-7 membered heterocyclic ring,...
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6849732 |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
The invention relates to compounds of the formula 1 :
wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring...
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6756371 |
Phthalazinone derivatives as PDE4 inhibitors
The compounds of formula (I) in which R1, R2, A, B and Ar have the meanings as given in the description are novel effective PDe4 inhibitors
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6743798 |
Substituted pyrazole derivatives condensed with six-membered heterocyclic rings
The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R 1 , R 2 , R 3 and A are each as defined, and to processes for their preparation and...
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6683709 |
Photochromic pyran compounds
Photochromic pyran compounds and their use in synthetic resin objects of all types, especially for ophthalmic applications, particularly spiro compounds having a fluorene structure derived from...
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6667306 |
Platelet ADP receptor inhibitors
The invention relates to novel compounds of formula (I) containing fused heterocyclic ring systems which are effective platelet ADP receptor inhibitors: In formula (I), W is carbon or nitrogen,...
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6472398 |
Spiropiperidine derivatives as melanocortin receptor agonists
Certain novel spiropiperidine derivatives of structural formula Ia wherein the substituents are as defined herein are agonists of the human melanocortin receptor(s) and, in particular, are...
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6451804 |
Heteroalkylamino-substituted bicyclic nitrogen heterocycles
The invention provides compounds represented by the formula: wherein R 1 , R 2 , R 3 , R 4 , and n are as defined in the Summary of the Invention; and individual isomers, racemic or non-racemic...
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6444819 |
Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands
Disclosed are compounds of the formula: or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH; R 1 , R 2 and R 3 independently...
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6407232 |
Ionic metal complex and process for synthesizing same
The invention relates an ionic metal complex represented by the general formula (1): wherein M is an element of groups 3-15 of the periodic table; A a+ represents a metal ion, onium ion or...
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6369057 |
Quinoxalines, processes for their preparation and their use
Compounds of the formula I or Ia in which n and the substituents R 1 , R 5 and x have the meaning mentioned have an antiviral activity.
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6191127 |
Substituted heterocycles and their use in medicaments
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6100246 |
Spiro-piperidine derivatives as inhibitors of nitric oxide synthase
There are provided novel compounds of formula (I) ##STR1## wherein A represents a benzo ring; a six membered heterocyclic aromatic ring containing 1 to 3 nitrogen atoms; or a five membered...
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6060469 |
Spiro-piperidine derivatives and their use as tachykinin antagonists
The present invention relates to compounds of formula (I), ##STR1## wherein R 1 represents halogen, hydroxy, C 1 -6 alkyl group optionally substituted by one or three fluorine atoms, C 1 -6 alkoxy...
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6013652 |
Spiro-substituted azacycles as neurokinin antagonists
Disclosed are spiro-substituted azacycles of formula I are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma. In particular compounds of...
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6011150 |
Azetidinone compound and process for preparation thereof
There is disclosed an azetidinone compound of the formula [I]: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R 1 is a hydroxy-substituted lower alkyl group which may...
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6002000 |
Chemiluminescent compounds and methods of use
Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) combining a medium suspected of containing the analyte and a...
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5994350 |
3-spiro-indolin-2-one derivatives as vasopressin and/or oxytocin receptor ligands
The subject of the invention is indolin-2-one derivatives of formula: ##STR1## in which: W represents a --CH 2 -- or --SO 2 -- group; Cy forms, with the carbon to which it is bonded, a...
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5981523 |
Compounds and methods for treating multiple sclerosis
This invention provides thiomorpholinone compounds useful for treating multiple sclerosis of formula I wherein: R 1 and R 2 are each independently selected from C 1 -C 8 alkyl; C 2 -C 8 ...
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5945413 |
Aspartyl protease inhibitors
This invention relates to a novel class of compounds that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized...
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5929072 |
1H-2,1,3-benzothiadiazine-2,2-dioxide compounds or derivatives thereof
A pharmaceutical compound having the formula: ##STR1## in which n is 1 or 2, m is 1 or 2, p is 1 to 6, q is 0 or 1 to 3, R 1 and R 2 are each hydrogen or C 1 -4 alkyl, R 3 , R 4 and R 5 ...
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5922748 |
Indole derivatives as 5-HT agonists
Compounds of formula (I) ##STR1## wherein R and R 1 are hydrogen, C 1 -4 alkyl or are linked to form a ring, A is a cycloalkyl or alkyl-cycloalkyl group, n is an integer from 0 to 3, W is...
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5874382 |
Cyclic sulfonamide herbicides
Compounds of Formula I and II, and their agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein X is a direct bond; O; S; NH; N(C 1 -C...
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5783579 |
Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists
The invention relates to compounds of the formula ##STR1## wherein Z, R c , y, m, u, Ar 2 , n, X, R c ', I and Ar 2 are as described herein. These compounds are neurokinin antagonists. These...
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5760029 |
Spirocycle integrin inhibitors
This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3- 8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro- 4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are...
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5728693 |
Arthropodicidal oxadiazine-thiadiazine-or triazine-carboxanilides
Arthropodicidal compounds, compositions and use of compounds having the formula ##STR1##
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5726126 |
1-(3-heterocyclyphenyl)-S-triazine-2,6,6-oxo or thiotrione herbicidal agents
There is provided a 1-(3-heterocyclylphenyl)-s-triazine-2, 4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that...
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5696145 |
1-benzyl-1,3-dihydroindol-2-one derivatives, their preparation and the pharmaceutical compositions in which they are present
The present invention relates to 1-benzyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## to their preparation and to the pharmaceutical compositions in which they are present. These...
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5597819 |
Phenothiazine cytokine inhibitors
New benzothiazine derivatives corresponding to the general formula I: ##STR1## in which: X represents halogen, n represents 0, 1, or 2, B represents the following formula: ##STR2## in which:...
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5591848 |
Spiroconjugated charge-transfer dyes for optical applications
New intramolecular charge-transfer organic dyes are described. The design of these molecules is based on the phenomenon of spiroconjugation, and it provides a modular approach to the preparation of...
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5578593 |
Spiro piperidines and homologs promote release of growth hormone
There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote...
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5559233 |
Methods for preparing n-substituted heterocyclic derivatives
The invention relates to processes for preparing N-substituted heterocyclic compounds of formula (I) ##STR1##
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5550229 |
Alkylation process for preparing azetidinone compound and starting compound therefor
Novel process for preparing azetidinone compound of the formula [III]: ##STR1## wherein R 1 is H or lower alkyl, R 2 and R 3 combine together with the adjacent nitrogen to form heterocyclic...
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5457199 |
Piperidine compounds for use as stabilizers for organic materials
The present invention relates to novel piperidine compounds of the formula (I) ##STR1## in which X 1 , X 2 , X 3 and n are as defined in the text. The compounds of the invention can be used as...
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5447927 |
Pesticidal aminomethylheterocyclic compounds
Fungicidally active compounds of the formula ##STR1## in which X represents oxygen or sulphur, R represents cycloalkyl, or represents optionally substituted aryl, or represents the radical...
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5416065 |
Herbicidal thiadiazabicyclooctanes
Thiadiazabicyclooctanes of formula I ##STR1## wherein Z is oxygen or sulfur; R 53 is hydrogen or C 1 -C 6 alkyl; R 54 is C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 3 -C 6 alkenyloxy,...
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5407943 |
Azaspiro quinolone antibacterial agents
Quinolone carboxylic acids of the formula ##STR1## wherein R 1 , R 2 , A and Y are as defined herein, and R 3 is ##STR2## have antibacterial properties.
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5373009 |
Dibenzofuranyl esters of N-heterocyclic carboxylic acids
A compound of the formula: ##STR1## wherein R 1 and R 2 are, independently, halo, trifluoromethyl, cyano, nitro, alkyl, alkoxy, --CO 2 H, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, mono-...
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5352788 |
N-substituted heterocyclic derivatives
The invention relates to processes for preparing N-substituted heterocyclic compounds of formula (I) ##STR1## wherein the substituents are as described in the specification, and to intermediates....
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5296477 |
Aminoalkyl benzoxazine and benzthiazine compounds having a high 5-HT.sub.1A affinity
Compounds of general formula (I): ##STR1## wherein R 1 , R 2 , R 3 , n, X and A are defined in the description. Medicinal products containing the same are useful as antidepressives or anxiolytics...
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5196434 |
Heterocycle-substituted alkylamines compounds
Compound of general formula (I): ##STR1## where R 1 , R 2 , R 3 , n, X and A are defined in the description. Medicinal products.
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