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7312212 |
Aminopiperidine derivatives
Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
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7294629 |
Quinazoline derivatives
A compound of the formula (I)
or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer...
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7196080 |
Phenylpyridinecarbonylpiperazinederivative
The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. ...
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7101874 |
Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
The present invention provides a compound of formula I
or a pharmaceutically acceptable salt thereof wherein Y is —S(═O) n —, —S(═NR 8 )—, or —S(═NR 8 )(═O)—; Z is...
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6992092 |
Anti-diabetic agents
The present invention provides compounds of formula (I)
the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein...
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6921759 |
Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV...
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6894046 |
IL-5 inhibiting 6-azauracil derivatives
The present invention is concerned with the compounds of formula
the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to...
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6849732 |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
The invention relates to compounds of the formula 1 :
wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring...
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6844347 |
Substituted 4-amino-2aryl-pyrimidines, their production and use and pharmaceutical preparations containing same
The invention relates to compounds of formula I,
in which R 1 , R 2 , R 3 and R 4 have the meanings given in the claims. Said compounds are valuable active ingredients for the treatment and...
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6770596 |
Fused tricyclic compounds, process for their preparation, and herbicidal compositions containing them
Novel fused tricyclic compounds represented by formula (I) are described. Q, Y, —L—X—, A, A′, B, E, D, n and m are as defined in the disclosure. Also described are the processes for the...
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6743798 |
Substituted pyrazole derivatives condensed with six-membered heterocyclic rings
The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R 1 , R 2 , R 3 and A are each as defined, and to processes for their preparation and...
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6683081 |
Triazolotriazinones and the use thereof
The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
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6660732 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6656933 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6620810 |
4-thioxo-4,7-dihydro-thieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents
The invention provides a compound of formula I: wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as...
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6613772 |
Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments
Compounds of the formula I in which R 1 , R 2 , R 3 and Ar have the meanings indicated in the claims, are suitable for the production of pharmaceuticals, for example for the prophylaxis and...
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6608052 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as...
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6583146 |
Thiazolopyrimidine compounds, its production and use
Compounds represented by general formula (I): and salts thereof, exhibiting excellent adenosine A 3 receptor antagonism: wherein A is an optionally substituted benzene ring; B may be further...
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6579982 |
Pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, Ar 1 , Z, R 1 , R 2 and R 3 are as defined in the specification, and to...
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6559155 |
Pyrimidinone derivatives for the treatment of atherosclerosis
Pyrimidones of formula (I) are inhibitors of the enzyme LpPLA 2 and thereof use in treating inter alia atherosclerosis, in which: R 1 is COOH or a salt thereof, COOR 10 , CONR 11 R 12 , CN or...
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6518423 |
Benzopiperidine derivatives
Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in...
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6509338 |
Pyrazolo&lsqb 1,5-A&rsqb triazine corticotropin releasing factor antagonists
The present invention describes novel pyrazolo[1,5-a]triazines of formula: wherein R 3 is an alkyl, alkenyl, alkynyl, or cycloalkyl group, or pharmaceutically acceptable salt forms thereof,...
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6500948 |
Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
The invention relates to compounds of the formula 1: wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms...
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6479483 |
4-phenyl-pyridine derivatives
Compounds of the present invention are 4-phenyl-pyridine derivatives with activity as NK-1 receptor antagonists.
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6458950 |
Compounds and pharmaceutical compositions containing the same
A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the...
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6444809 |
Therapeutic heterocycles
Compounds of formula I wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of...
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6407103 |
Indeno &lsqb 1,2-c&rsqb pyrazol-4-ones and their uses
The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases,...
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6380387 |
4-Pyrimidinyl-n-acyl-l phenylalanines
Compounds of Formula I are disclosed, having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or...
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6358946 |
C-6 ring-substituted pyrido&lsqb 1,2-a&rsqb benzimidazole derivatives useful in treating central nervous system disorders
A C-6 ring-substituted pyrido[1,2-a]benzimidazole derivative of the formula: methods of preparation and pharmaceutical compositions containing a substituted pyrido[1,2-a]benzimidzole derivative...
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6297258 |
Substituted 3-cyanoquinolines
This invention provides compounds of formula I having the structure ##STR1## wherein G 1 , G 2 , R 1 , R 4 , Z, n, and X are defined in the specification or a pharmaceutically acceptable salt...
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6218391 |
Triazinones and derivatives thereof
Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related...
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6200378 |
Thiazine indigo pigments, solid solutions thereof and their preparation
A compound according to the formula (I) ##STR1## wherein R 1 and R 2 are independently the atoms necessary to complete the formation of a substituted or unsubstituted aromatic or aliphatic...
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6159980 |
Pyrazinones and triazinones and their derivatives thereof
Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related...
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6147078 |
Pyrazinone thrombin inhibitors
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein ##STR2##
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6133264 |
Carbostyril derivatives for inhibiting skin erythema and/or skin pigmentation
The present invention provides an agent for inhibiting skin erythema and/or skin pigmentation, containing at least one selected from the group consisting of the carbostyril derivative and salt...
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6124306 |
Thioalkyl alpha substituted pyrimidine compounds
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R 4 is selected from the group...
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6093717 |
Imidazopyridine thrombin inhibitors
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein Y 1 and Y 2 are independently selected from the...
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6080738 |
Heterocyclic amide compounds and medicinal uses thereof
A heterocyclic amide compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof...
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6069141 |
Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
The present invention provides novel substituted amionphenyl isoxazoline derivatives of formula I ##STR1## wherein R 1 is H, alkyl, cycloalkyl, alkoxy, amino, or alkylamino; X and Y are the same...
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6001832 |
[1,2,4]triazolo[4,3-a]quinoxalinone derivatives, their preparation and use
The present invention relates to [1,2,4]triazolo[4,3-a]quinoxalinone compounds of the formula ##STR1## wherein R 1 is POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently...
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5965565 |
Piperidines promote release of growth hormone
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R 1 , R 1a , R...
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5958929 |
6-aryl pyrazolo 3,4-d! pyrimidin-4-ones and compositions and methods of use thereof
6-Aryl pyrazolo 3,4-d!pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or...
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5948785 |
Heterocyclic amide compounds and pharmaceutical use of the same
Heterocyclic amide compounds of the formula (I) ##STR1## wherein each symbol is as defined in the specification, pharmacologically acceptable salts thereof, pharmaceutical compositions thereof and...
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5866565 |
Substituted-4-amino-3-pyridinols
There are disclosed various substituted 4-amino-3-pyridinol compounds of the formula below, ##STR1## where R 1 , R 2 and R 3 are as defined in the specification, which are useful for alleviating...
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5854241 |
Pyrido 3,2,1-I,J! 3,1!benzoxazine derivatives
Disclosed are pyrido 3,2,1-i,j! 3,1!benzoxazine compounds of the formula (I): ##STR1## wherein z represents a radical having the formula: ##STR2## wherein B represents --CH 2 --, --O-- or a direct...
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5837708 |
Sulphonamides
Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders...
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5739130 |
Heterotricyclic derivatives, process for their preparation and pharmaceutical compositions containing them
Heterotricyclic derivatives of the formula: ##STR1## wherein R 1 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, nitro, amino or protected amino, R 2 is hydroxy, protected...
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5707930 |
4-cycloalkyl-5-substituted pyrimidine compounds useful as crop protection agents
Herbicidal 4-cycloalkyl-5-substituted pyrimidine compounds of the formula ##STR1## are described. Herbicidal compositions containing such substituted-pyrimidinyl compounds and methods of...
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5703231 |
Process for making antimicrobial compounds
The present invention provides a process for making a compound having a structure according to Formula (I) ##STR1## wherein A 1 , A 2 and A 3 are independently carbon or nitrogen and R 1 , R 3 ,...
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5674894 |
Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
The current invention discloses novel amidine derivatives with nitric oxide donating property that can inhibit platelet aggregation and promote vasodilation in a single compound.
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