Matches 151 - 200 out of 369 < 1 2 3 4 5 6 7 8 >
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4777253 Process for preparation of racemate and optically active ofloxacin and related derivatives  
A process for producing racemic or optically active compounds of the formula: ##STR1## wherein R 1 is hydrogen, C 1 to C 6 alkyl or benzyl; and Z is amino or substituted amino. Also disclosed...
RE32761 3-arylcarbonyl and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use  
3-Arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, useful as analgesic, anti-rheumatic and anti-inflammatory agents, are prepared by reacting a 3-arylcarbonyl- or...
4772706 Process for quinoline-3-carboxylic acid antibacterial agents  
An improved process for the preparation of 7-substituted amino-1-alkyl- or cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarbox ylic acids is described where tetrafluorobenzoyl chloride is...
4772309 5-acylamino-pyrazoles, composition containing them, and herbicidal and plant growth regulating method of using them  
A 5-Acylamino-pyrazole derivatives of the formula ##STR1## in which R 1 represents hydrogen, halogen or nitro, R 2 represents hydrogen, alkyl, alkenyl, alkinyl or optionally substituted...
4767769 Antiulcer benzimidazole derivatives  
Compounds of formula I ##STR1## in which R 1 and R 2 , which may be the same or different, are hydrogen, a C 1 to C 3 alkyl group or R 1 and R 2 together with the nitrogen to which they are...
4766211 Chromogenic quinazolines  
Chromogenic quinazolines of formula ##STR1## wherein R is an aryl radical or a heterocyclic radical, Z 1 is oxygen or sulfur, Z 2 is oxygen, sulfur or ##STR2## R' is hydrogen, alkyl which...
4760061 Ether and ester derivatives of phenols  
Mono- or bis-complex esters or ethers of a phenol derivative of the formula NU--A--X--R 1 wherein NU is a defined mono- or bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl;...
4757070 3-oxadiazolyl-5-aminoalkyl-beta-carboline derivatives compositions and use  
Compounds of formula I ##STR1## wherein n is 0 or 1, R 1 is hydrogen or lower alkyl, R 2 and R 3 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or...
4753933 Anxiolytic amides derived from certain 1,8-naphthyridine-2-amines  
The invention provides new substituted amides of formula: R--CONH--Het in which: either R is cycloalkyl (3 to 6 carbons), cyclohexadienyl, phenyl, substituted phenyl or a heterocyclic systems...
4745110 Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use  
A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions...
4743609 Indole derivatives having gastric and antisecretory and cytoprotective properties, and pharmaceutical preparations containing same  
This invention provides a class of new indole derivatives which are useful as medicinal compounds having a mild inhibitory effect on the gastric acid secretion as well as a remarkably...
4742057 Antiallergic thiazole compounds  
A thiazole compound of allergically activity of the formula: ##STR1## wherein R 1 is amino optionally having suitable substituent(s), R 2 is hydrogen, lower alkyl or aryl, R 3 is hydrogen,...
4731365 5-aminoalkyl-beta-carboline derivatives, psycho tropic compositions and use  
Compounds of formula I ##STR1## wherein n is 0 or 1, R 1 is hydrogen or lower alkyl, R 2 and R 3 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or...
4728652 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure  
1,4-Dihydropyrimidines of the formula ##STR1## wherein X is sulfur or oxygen and R 4 is aryl or heterocyclo and disclosed. These compounds are useful as cardiovacular agents, particularly...
4727073 Pyrimidine derivatives and composition of the same  
The invention relates to new pyrimidine derivatives, useful in the treatment of cerebrovascular disease, of the formula: ##STR1## wherein Ar, R 1 , R 2 and R 3 are defined in the specification.
4725305 N'-(substituted-1,3,5-triazin-2-yl)-N"-subs tituted-N",N"'-bis-(substituted-benzenesulphonyl)-guanidines as herbicides  
Herbicidally active novel N,N'-bis-sulphonyl guanidines of the formula ##STR1## in which M is hydrogen, a metal or an ammonium radical, and R 4 , R 5 , R 40 and R 41 are various organic radicals.
4707479 Circulation active dihydropyridine-3-carboxamides  
1,4-Dihyropyridinecarboxamides of the formula ##STR1## and salts thereof, are effective for treating cardiac insufficiency, thromboses, thromboembolisms and ischaemias, for influencing the...
4701453 Substituted indeno-pyridazinones  
Substituted 2,5-dihydro- and 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents.
4689414 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-pyrimidinecarboxylic acids and analogs  
Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R 1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH 2 ) n --Y 2...
4689325 Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives  
This invention relates to novel isoxazolo-pyrido-phenoxazine and isothiazolo-pyridophenoxazine derivatives having antibacterial properties and compositions containing methods of treating mammalian...
4687770 Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives  
This invention relates to novel isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives having antibacterial properties.
4684656 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and method of using them to lower blood pressure  
Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur; R 1 is alkyl, cycloalkyl, aryl,...
4684644 Basic monocarboxyamide derivatives of actagardine having antibiotic activity and compositions thereof  
The present invention is directed to a class of basic monocarboxyamide derivatives of actagardine. Actagardine (INN) is an antibiotic substance produced by actinoplanes strains such as Actinoplanes...
4666902 Tetrahydropyridazinone derivatives, processes for their preparation and their use  
Tetrahydropyridazinones of the formula I ##STR1## wherein R denotes an optionally substituted carbocyclic or heterocyclic radical, R 1 denotes hydrogen; alkyl; aralkyl, which is optionally...
4666905 Diphenylmethylene piperidines compositions and methods for their use  
Novel chemical compounds which are diphenylmethylene piperidine compounds are provided, as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of...
4659708 Anti-leishmanial lepidine derivatives  
The subject 8-[6-(N-heterocyclic-substituted)hexylamino]-6-methoxy lepidine erivatives have the formula: ##STR1## wherein Z represents methyl or, together with the two contiguous carbon atoms, the...
4659734 Olinecarboxylic acid derivatives  
A compound of the formula ##STR1## R 1 is hydrogen, alkali metal, alkaline earth metal, lower alkyl, pivaloyloxymethyl or phthalidyl; R 2 , R 3 , R 4 and R 5 are the same or different and are...
4652562 Quinoline derivatives and pharmaceutical compositions  
The invention relates to new quinoline derivatives of the general Formula I ##STR1## (wherein X stands for hydrogen, halogen or lower alkoxy; n is an integer of 1, 2 or 3; R 1 represents...
4640917 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones  
Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones of the formula ##STR1## in which n is one, two or three and the individual substituents R are independently of one another (a) hydrogen,...
4639447 Azolylnitriles, and fungicides containing these compounds  
Compounds of the formula ##STR1## where R 2 is a 5-membered or 6-membered heterocyclic structure possessing one or two hetero atoms or is phenyl which is unsubstituted or substituted by R n , R is...
4639436 Antidiabetic 3,4,5-trihydroxypiperidines  
The invention includes certain 3,4,5-trihydroxypiperidine compounds, methods for their preparation, compositions containing said 3,4,5-trihydroxypiperidine compounds and methods for the use of said...
4621082 Pyridopyrimidines, pharmaceutical compositions and use  
Pyridopyrimidines of the formula ##STR1## in which R 1 is optionally substituted aryl or heterocyclic, exhibit circulation active properties, especially renal vasodilating and diuretic action.
4618607 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives and pharmaceutical compositions  
1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives of the general formula: ##STR1## or acid addition salts thereof, wherein W is --CH or --N; Y is --CHCH--, --O--, --S--,...
4616019 Naphthyridine antibacterial compounds  
Naphthyridine compounds having the formula: ##STR1## wherein Z is an amine or an aliphatic heterocyclic group, R is a phenyl group or an aromatic heterocyclic group and R 1 is hydrogen or a...
4607032 Quino-benoxazine antibacterial compounds  
Quino-benoxazine compounds having the formula: ##STR1## wherein R 2 is one or more substituents, R 1 is a hydrogen or a carboxy-protecting group and Z is an amine group or an aliphatic...
4595539 Preparation of penem derivatives and azetidinone intermediates  
Certain 2-substituted-2-penem-3-carboxylic acid compounds and pharmaceutically-acceptable salts thereof can be prepared from the appropriate xanthate or trithiocarbonate by desulfurization and...
4579845 Antihypertensive cyanoguanidines  
This invention relates to novel tri-substituted guanidines linked to a piperidine ring. More specifically, it relates to cyanoguanidines of formula I ##STR1## wherein R 1 , R 2 , R 3 , R 4 are...
4576943 Pyrazolo[1,5-a]pyrimidines  
This disclosure describes certain pyrazolo[1,5-a]pyrimidines useful as hypotensive and/or anxiolytic agents, or as agents for the treatment of cognitive and related neural behavioral problems in...
4564613 Pyridoindole derivatives, compositions and use  
Pyridoindoles of the formula ##STR1## in which R 1 represents hydrogen or C 1 -C 4 -alkyl, which is optionally substituted by the radical ##STR2## R 2 and R 3 represent H or form a bond, or R...
4562184 Substituted-aminohydroxypropoxy-thiadiazoles, β-blocking compositions and use  
Novel substituted-aminohydroxypropoxy-thiadiazoles and pharmaceutically acceptable salts thereof exhibit β-adrenergic blocking activity.
4556658 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-di hydro-4-oxo-quinoline-3-carboxylic acids and antibacterial agents containing these compounds  
The invention relates to 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoli ne-3-carboxyli c acids, processes for their preparation and compositions containing them as antibacterial...
4552879 Benzoheterocyclic compounds and pharmaceutical composition thereof  
A benzoheterocyclic compound of the formula (I) ##STR1## wherein R 1 , R 2 , R 3 and n are as defined, and its pharmaceutically acceptable salts, processes for preparing same and antibacterial...
4549022 4-Pyridone-3-carboxylic acid derivatives  
The invention relates to 4-pyridone-3-carboxylic acid derivatives, a process for the preparation thereof and pharmaceutical compositions containing same. The 4-pyridone-3-carboxylic acid...
4547511 Heterocyclic carboxamides, compositions containing such compounds, processes for their preparation and methods of treatment therewith  
This invention relates to novel heterocyclic carboxamides which increase the activity of the immune system and to the preparation thereof. The invention is also concerned with pharmaceutical...
4546188 Substituted 1,2-diaminocyclobutene-3,4-diones  
Certain 1-(substituted amino)-2-(amino or substituted amino)cyclobutene-3,4-diones are potent histamine H 2 -antagonists useful in the treatment of peptic ulcers.
4544654 Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof  
Novel substituted sulfonamidobenzamides are described as useful antiarrhythmic agents. Their use in the treatment of cardiac arrhythmias, especially re-entrant arrhythmias, via the prolongation of...
4539318 Tertiary aminohydroxypropoxy substituted thiadiazoles, pharmaceutical compositions and use  
Novel tertiary aminohydroxypropoxy substituted thiadiazole compounds exhibit α 1 -adrenoceptor and serotonin antagonism and are also useful as antihypertensive agents.
4537895 Isoquinoline derivatives  
The invention relates to new 4-aryl-2-methyl-1,2,3,4-tetrahydro-isoquinoline derivatives of the general Formula I ##STR1## and salts thereof wherein R stands for hydrogen, lower alkyl or halogen...
4537960 Preparation of carbamates  
N- and O-substituted carbamates are prepared by reacting urea with an aminopropanol at 140° C. or above. The compounds obtained by the novel process are useful starting materials for the...
4532348 1-(Substituted phenylthiocarbamyl) 3,3-disubstituted formamidines and their use as pharmaceutical agents  
1-(Substituted phenylthiocarbamyl) 3,3-disubstituted formamidine compounds having the structural formula ##STR1## wherein n is 1, 2 or 3, R is alkyl having 1 to 6 carbon atoms, alkoxy having 1...
Matches 151 - 200 out of 369 < 1 2 3 4 5 6 7 8 >