Patents in Class 544/58.6

Matches 1 - 50 out of 376

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Match	Document	Document Title
1	8143246	1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives The invention relates to 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivative having the general Formula I wherein R1 is H, (C1-6)alkyl (optionally substituted with oxo, (C1-3)alkyloxy,...
2	8063036	Benzamides and related inhibitors of factor Xa Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described....
3	RE42376	Substituted 3-cyanoquinolines This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are...
4	7928133	Compounds and compositions as hedgehog signaling pathway modulators The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from...
5	7888351	Organic compounds The present invention relates to compounds of the formula; and their use in therapy.
6	7829567	Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same Disclosed herein are novel imino-indeno[1,2-c]quinoline derivatives of formula (I): or a pharmaceutically acceptable salt or solvate thereof,wherein each of the substituents is given the definition...
7	7709466	Pyridazinone derivatives, methods for their production and their use as pharmaceuticals The present invention relates to pyridazinone compounds and their derivatives according to the general formula (I), with the substituents X, R1 and R2 defined herein, as well as their...
8	7704995	Protein kinase modulators and methods of use This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and...
9	7511036	Dihydrothiazine prodrugs of thiazolium agents Provided are compounds of the formula (and pharmaceutically acceptable salts thereof): wherein: R is hydrogen, methyl, hydroxymethyl or α-hydroxyethyl; R1 and R2 are independently selected from ...
10	7491732	Compositions and methods for inhibition of the JAK pathway The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
11	7442710	Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ andR1, R2,R3, R4,R5, and R6 are as defined in the specification and to pha...
12	7312212	Aminopiperidine derivatives Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
13	7294629	Quinazoline derivatives A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture...
14	7196080	Phenylpyridinecarbonylpiperazinederivative The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof....
15	7101874	Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein Y is —S(═O)n—, —S(═NR8)—, or —S(═NR8)(═O)—; Z is —NHC(═O)R1, —NHC(═S)R1, —NH-het1, —...
16	6992092	Anti-diabetic agents The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein R1,...
17	6921759	Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV...
18	6894046	IL-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 4; X...
19	6849732	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation The invention relates to compounds of the formula 1: wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms...
20	6844347	Substituted 4-amino-2aryl-pyrimidines, their production and use and pharmaceutical preparations containing same The invention relates to compounds of formula I, in which R1, R2, R3 and R4 have the meanings given in the claims. Said compounds are valuable active ingredients for the treatment and prophylaxis...
21	6770596	Fused tricyclic compounds, process for their preparation, and herbicidal compositions containing them Novel fused tricyclic compounds represented by formula (I) are described. Q, Y, —L—X—, A, A′, B, E, D, n and m are as defined in the disclosure. Also described are the processes for the manufac...
22	6743798	Substituted pyrazole derivatives condensed with six-membered heterocyclic rings The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R1, R2, R3 and A are each as defined, and to processes for their preparation and to their...
23	6683081	Triazolotriazinones and the use thereof The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof.
24	6660732	Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
25	6656933	Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
26	6620810	4-thioxo-4,7-dihydro-thieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents The invention provides a compound of formula I: wherein R1, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes...
27	6613772	Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments Compounds of the formula I in which R1, R2, R3 and Ar have the meanings indicated in the claims, are suitable for the production of pharmaceuticals, for example for the prophylaxis and therapy of...
28	6608052	Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as...
29	6583146	Thiazolopyrimidine compounds, its production and use Compounds represented by general formula (I): and salts thereof, exhibiting excellent adenosine A3 receptor antagonism: wherein A is an optionally substituted benzene ring; B may be further...
30	6579982	Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, Ar1, Z, R1, R2 and R3 are as defined in the specification, and to pharmaceutical...
31	6559155	Pyrimidinone derivatives for the treatment of atherosclerosis Pyrimidones of formula (I) are inhibitors of the enzyme LpPLA2 and thereof use in treating inter alia atherosclerosis, in which:R1 is COOH or a salt thereof, COOR10, CONR11R12, CN or CH2OH;R2 is a...
32	6518423	Benzopiperidine derivatives Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in...
33	6509338	Pyrazolo&lsqb 1,5-A&rsqb triazine corticotropin releasing factor antagonists The present invention describes novel pyrazolo[1,5-a]triazines of formula: wherein R3 is an alkyl, alkenyl, alkynyl, or cycloalkyl group, or pharmaceutically acceptable salt forms thereof, which...
34	6500948	Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof The invention relates to compounds of the formula 1: wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms...
35	6479483	4-phenyl-pyridine derivatives Compounds of the present invention are 4-phenyl-pyridine derivatives with activity as NK-1 receptor antagonists.
36	6458950	Compounds and pharmaceutical compositions containing the same A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the...
37	6407103	Indeno &lsqb 1,2-c&rsqb pyrazol-4-ones and their uses The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases,...
38	6380387	4-Pyrimidinyl-n-acyl-l phenylalanines Compounds of Formula I are disclosed, having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or damage...
39	6358946	C-6 ring-substituted pyrido&lsqb 1,2-a&rsqb benzimidazole derivatives useful in treating central nervous system disorders A C-6 ring-substituted pyrido[1,2-a]benzimidazole derivative of the formula: methods of preparation and pharmaceutical compositions containing a substituted pyrido[1,2-a]benzimidzole derivative as...
40	6297258	Substituted 3-cyanoquinolines This invention provides compounds of formula I having the structure ##STR1##wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which...
41	6218391	Triazinones and derivatives thereof Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1##and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related...
42	6200378	Thiazine indigo pigments, solid solutions thereof and their preparation A compound according to the formula (I) ##STR1##wherein R1 and R2 are independently the atoms necessary to complete the formation of a substituted or unsubstituted aromatic or aliphatic carbocyclic...
43	6159980	Pyrazinones and triazinones and their derivatives thereof Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related...
44	6147078	Pyrazinone thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein ##STR2##
45	6133264	Carbostyril derivatives for inhibiting skin erythema and/or skin pigmentation The present invention provides an agent for inhibiting skin erythema and/or skin pigmentation, containing at least one selected from the group consisting of the carbostyril derivative and salt...
46	6124306	Thioalkyl alpha substituted pyrimidine compounds The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R4 is selected from the group...
47	6093717	Imidazopyridine thrombin inhibitors Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein Y1 and Y2 are independently selected from the...
48	6080738	Heterocyclic amide compounds and medicinal uses thereof A heterocyclic amide compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof...
49	6069141	Substituted aminophenyl isoxazoline derivatives useful as antimicrobials The present invention provides novel substituted amionphenyl isoxazoline derivatives of formula I ##STR1## wherein R1 is H, alkyl, cycloalkyl, alkoxy, amino, or alkylamino; X and Y are the same and...
50	6001832	[1,2,4]triazolo[4,3-a]quinoxalinone derivatives, their preparation and use The present invention relates to [1,2,4]triazolo[4,3-a]quinoxalinone compounds of the formula ##STR1## wherein R1 is POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are...

Matches 1 - 50 out of 376

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