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4904299 |
Herbicidal N-hydroxy-N'-sulfonylguanidines
Novel N-hydroxy-N'-sulfonylguanidine compounds are described which possess significant herbicidal and plant growth regulant activity for control of undesired vegetation.
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4892575 |
Herbicidal sulfonamides
Herbicidal sulfonamides such as 2-[[[4-(methylamino)-6-(2, 2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]-aminocarbonyl]amino
sulfonyl]benzo ic acid, methyl ester are useful as herbicides and plant...
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4853025 |
Benzylsulfonylureas and arylsulfamoylureas
Benzylsulfonylureas and arylsulfamoylureas are useful as pre-emergent and post-emergent herbicides and as plant growth regulants.
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4829062 |
Benzothiazine dioxide derivatives
A series of novel oxyalkyl ether derivatives of various enolic oxicam compounds have been prepared, including certain novel enol oxyalkyl ethers of...
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4820842 |
2-substituted-1,4-dihydropyridines
The present invention provides a process for preparing a 5-cyano-2-substituted-1,4-dihydropyridine compound having cardiovascular activity.
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4797483 |
Process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
A process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carb
oxamide 1,1-dioxide, which may be used as a non-steroidal analgesic and anti-inflammatory drug. The process...
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4748174 |
Water soluble salts of an NSAID with meglumine/glucamine
The water soluble acid addition salts of an NSAID, such as acetylsalicylic acid, fenbufen, diflunisal, piroxicam, naproxen, or the like, with either glucamine or meglumine (N-methylglucamine) are...
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4746357 |
Herbicidal acetylenic triazines
Sulfonylureas derived from acetylenic pyrimidines and triazines, useful as pre- and postemergence herbicides. Typical of this group is...
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4732898 |
2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
The present invention are 2-(2-aryl-2-oxo-alkylidene) analogs of 1,2,3,4-tetrahydropyridine-3,5-pyridinecarboxylic acids and particularly esters thereof having valuable calcium antagonist and...
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4705555 |
Herbicidal triazines
Aryl and heteroaryl sulfonimidamides which also contain a pyrimidine or triazine heterocycle are useful as general or selective preemergent and postemergent herbicides.
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4694080 |
2H-1,2-benzothiazine derivatives
Certain substituted-4-hydroxy-(or 4-acyloxy-)2H-1,2-benzothiazine 1,1-dioxides having at the 3-position a 2-substituted-1,3,4-oxadiazol-5-yl, a 2-substituted-tetrazol-5-yl or a...
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4689069 |
Herbicidal acetylenic pyrimidines and triazines
Sulfonylureas derived from acetylenic pyrimidines and triazines, useful as pre- and postemergence herbicides. Typical of this group is...
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4683306 |
Process for the preparation of 3,4-dihydro-2-substituted-2H-1,2-thiazine-carboxylic acid 1,1-dioxide derivatives
Process for the preparation of 3,4-dihydro-2-substituted-4(or 3)-oxo-2H-1,2-thiazine-3(or 4)-carboxylic acid 1,1,-dioxide magnesium chelate derivatives and its acids by reacting appropriately...
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4666506 |
Herbicidal pyrimidines
Aryl and heteroaryl sulfonimidamides which also contain a pyrimidine or triazine heterocycle are useful as general or selective preemergent and postemergent herbicides.
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4656273 |
Process for producing sulfonylureas
There is described a novel process for producing sulfonylureas of formula I ##STR1## wherein R 1 is hydrogen or alkyl, R 2 is ##STR2## E is N-- or CH--, R 3 is alkyl, alkoxy or halogen,...
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4623486 |
[4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
Certain novel p-aminomethylbenzoyl derivatives of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-ca
rboxamide 1,1-dioxide and several other closely-related known oxicams have been...
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4610982 |
Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
Certain novel 2-acetoxybenzoyl and ring-substituted α-arylpropionyl derivatives of 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-ca
rboxamide 1,1-dioxide and several other...
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4599406 |
Process for preparing 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives and intermediates therefor
The process for the preparation of derivatives of 2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide of the formula ##STR1## wherein R represents hydroxy (Ia) or substituted...
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4589911 |
Fused N-phenylsulfonyl-N-triazinylureas
Fused N-phenylsulfonyl-N'-triazinylurea of formula I ##STR1## wherein Z is oxygen or sulfur, R 1 is hydrogen, halogen, nitro, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, cyano, or a --X--R 5 ,...
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4587335 |
Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[(N-(2-pyridinyl)carboxamide)] -1,1-dioxide, phosphoric ester
The present invention refers to a new process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)ca
rboxamide]-1,1 -dioxide, its phosphoric ester and the obtained phosphoric...
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4582831 |
Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor
A novel crystalline form of the monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carb
oxamide 1,1-dioxide has been prepared. This novel crystalline form is...
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4581178 |
Addition of aldehydes to organic compounds having a carbon-hydrogen bond activated by a nitro or nitrile group
Low valent transition metal complexes containing small cone angle phosphine or arsine ligands efficiently catalyze addition of aldehydes to compounds or groups having a C--H bond activated by a...
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4578460 |
N-6-aminopurinyl-4-hydroxy-2-methyl-2H-1,2-benxothiazine-3-carboxamide 1,1-dioxide compound
The invention relates to a derivative of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide of the formula: ##STR1## in which X is 6-aminopurinyl. The above compound exhibits...
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4567179 |
Antiinflammatory salts of piroxicam
Improved antiinflammatory salts of piroxicam with antidepressant doxepin, with bronchodilator pirbuterol or isoproterenol, with H 2 -antagonist inhibitor...
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4551525 |
Process for preparing N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1- dioxide
A process for preparing N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carb
oxamide-1,1-di oxide which comprises reacting an...
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4551452 |
Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
Certain enol ether derivatives of oxicams (1,1-dioxides of N-heteroaryl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carbo
xamides and...
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4540692 |
Anti-inflammatory N-(1-oxo-2,4,6-cycloheptatrienyl)2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use
The invention relates to novel tropone derivatives, of antiinflammatory, analgesic and antirheumatic activity, of the formula: ##STR1## wherein R 1 is hydrogen or lower alkyl, R 2 is hydrogen,...
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4536573 |
Process and intermediates for production of benzothiazine carboxamides
A novel compound of the formula ##STR1## wherein R is hydrogen, benzyl or (C 1 -C 3 )alkyl; R 1 is benzyl or (C 1 -C 4 )alkyl and Z 1 taken together with --CN-- forms a heterocyclic group Z...
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4533664 |
Antithrombotic N-(6-chloro-pyrazin-2-yl)-4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1 ,1-dioxide derivatives, composition, and method of use
Compounds of the formula ##STR1## wherein R 1 is hydrogen, methyl, methoxy, fluorine or chlorine; and R 2 is hydrogen, methyl, ethyl or n-propyl; and non-toxic, pharmacologically acceptable...
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4506071 |
Process for preparing microcrystalline isoxicam
A new process for the preparation of microcrystalline isoxicam having a particle size of about 1-30 μm which comprises dissolving isoxicam in a mixture consisting of a solvent miscible with water...
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4489077 |
3-Isoxa-zolyl-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxides
4-Hydroxy-N-[5-[(substituted hetero)methyl]-3-isoxazolyl]-2H-1,2-benzothiazine-3-carboxam
ide 1,1-dioxides as agents for treating pain in mammals resulting from inflammation.
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4483982 |
Processes for preparing piroxicam and intermediates leading thereto
Processes for the preparation of the antiinflammatory agent piroxicam and intermediates leading thereto, the first of which comprises reacting N-methylsaccharin with (N-2-pyridyl)haloacetamides and...
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4478996 |
Process for the preparation of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides
A process for the preparation of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-di
oxides, of the formula: ##STR1## in which R may be phenyl, aryl substituted with halogen (Cl, Br or I)...
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4477661 |
Process for the preparation of 4-hydroxy-3-(heterocyclocarbamoyl)-2H-1,2-benzothiazine-1,1-dioxides
The present invention provides a process for the preparation of 4-hydroxy-3-(heterocyclocarbamoyl)-2H-1,2-benzothiazine-1,1-
dioxides of the general formula: ##STR1## wherein R 1 is a hydrogen...
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4474956 |
Process for the preparation of 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
In the preparation of 4-hydroxy-2-methyl-N-2-pyridyl-2H-benzothiazine-3-carboxamid
e 1,1-dioxide by reacting the corresponding 3-methoxycarbonyl compound with 2-aminopyridine, a dramatic increase...
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4469866 |
Intermediates for production of benzothiazine carboxamides
A novel compound of the formula ##STR1## wherein R is hydrogen, benzyl or (C 1 -C 3 )alkyl; R 1 is benzyl or (C 1 -C 4 )alkyl and Z 1 taken together with --CN-- forms a heterocyclic group Z...
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4461768 |
Anti-inflammatory 1,2-benzothiazines
A new benzothiazine derivative, that is N-(2-pyridyl)-2-methyl-4-cinnamoyloxy-2H-1,2-benzothiazine-3
-carboxamido 1,1-dioxide has been prepared. Owing to its peculiar ester structure, obtained by...
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4434163 |
Water-soluble benzothiazine dioxide salts
The water-soluble lysine and arginine salts of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carb
oxamide 1,1-dioxide have been prepared. These novel salts are useful in therapy as...
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4434164 |
Crystalline benzothiazine dioxide salts
The water-soluble ethylenediamine, monoethanolamine and diethanolamine salts of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carb
oxamide 1,1-dioxide have been prepared. These novel...
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4388105 |
Herbicidal cyclic sulfonamides of phenoxybenzoic acids
There are provided herbicidal cyclic sulfonamides of phenoxybenzoic acids.
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4376768 |
Benzothiazine derivative
N-(6-chloro-2-pyridyl)-3,4-dihydro-2-methyl-4-oxo-2H-1,2-ben
zothiazine-3-ca rboxamide 1,1-dioxide that is a novel benzothiazine derivative. The compound is characterized by a low degree of...
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4327091 |
N,N-Di and N,N,N-tri(hydroxy-lower alkyl) ammonium salts of substituted 3,4-dihydro-2H-1,2-benzothiazine 1,1 dioxide and pharmaceutical compositions thereof
3,4-Dihydro-2H-1,2-benzothiazine 1,1-dioxides of the formula ##STR1## wherein Ph represents a substituted or unsubstituted 1,2-phenylene radical, R represents a substituted or unsubstituted...
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4294961 |
Benzothiazine 1,1-dioxides
Certain benzothiazine compounds, metal complexes thereof and solutions of said compounds in essentially water-immiscible, liquid hydrocarbon solvents are disclosed. These compounds have in their...
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4289879 |
Synthetic method and intermediate for piroxicam
2-Methoxyethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide is an advantageous ester precursor for piroxicam (4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carbo
xamide...
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4233299 |
4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts thereof
Compounds of the formula ##STR1## wherein R 1 is hydrogen, methyl or ethyl; R 2 is methyl, ethyl or n-propyl; and Y is hydrogen, methyl, methoxy, fluorine or chlorine; and non-toxic,...
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4213980 |
Azathianaphthalenes
3,4-Dihydro-2H-1,2-benzothiazine 1,1-dioxides of the formula ##STR1## wherein Ph represents a substituted or unsubstituted 1,2-phenylene radical, R represents a substituted or unsubstituted...
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RE29836 |
4-Hydroxy-3-(3-isoxazolylcarbamoyl)-2H-1,2-benzothiazine 1,1-dioxides and process for their production
Compounds having the following structural formula are disclosed: ##STR1## wherein R 1 is hydrogen or methyl and R 2 , and R 3 are hydrogen or alkyl. These compounds are useful as...
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4116964 |
2-[(N-2-pyridylcarbamoyl)methyl]saccharin
A novel process for preparing 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides is disclosed. The process involves the base catalyzed rearrangement of a saccharinacetamide of structure I to...
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4100347 |
3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
Process for production of 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic
acid-1,1-dioxide by hydrolysis, in the presence of hydroxide ions, of an alkyl or aralkyl ester thereof...
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RE29669 |
Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carb
oxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycine
amides,...
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