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7589094 |
N- (3-amino-2-hydroxy-propyl) substituted alkylamide compounds
Disclosed are compounds of the formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in...
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7390812 |
N, N'-disubstituted piperazine compounds and their use as analgesics
N,N′-disubstituted piperazine compounds, processes for the production thereof, and pharmaceutical preparations containing these compounds. The use of N,N′-disubstituted piperazine compounds for...
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7078407 |
4-hydroxycinnamamide derivatives as antioxidants and pharmaceutical compositions containing them
The present invention relates to 4-hydroxycinnamamide derivatives as antioxidants and pharmaceutical compositions containing them. More particularly, it relates to 4-hydroxycinnamamide derivatives...
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6887872 |
Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition...
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6881738 |
Analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders
The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease,...
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6875759 |
Substituted guanidines and the use thereof
A method for the treatment of cancer and pain in an animal subject is disclosed, comprising administering to said animal in need of such treatment an effective amount of a compound of formula I:
...
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6776911 |
Methods for surface modification of silica for use in capillary zone electrophoresis and chromatography
The present invention refers to the use of novel molecules able to bind tenaciously to silica, borosilicate and silicate surfaces, and thus to modify their properties and characteristics. When...
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6734177 |
Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain salts of discodermolide acid, pharmaceutical compositions containing said salts, the use of said salts in treating tumors and to a process for making said...
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6703425 |
Sulfonamide derivatives
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such...
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6579881 |
Indoles
A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: wherein A, B, C, D, T, Y, and Z each represent a methine or a...
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6448243 |
1,4-substituted cyclic amine derivatives
A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or...
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6281393 |
Polyols useful for preparing water blown rigid polyurethane foam
Mannich polyols having a viscosity of from 300 to 3,500 cps (0.3 to 3.5 Pa*s) at 25° C. are prepared by admixing a phenol, an alkanolamines, and formaldehyde mixed in molar ratios of from 1:1:1 to...
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6232314 |
Arylalkylpiperazine compounds as antioxidants
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6013801 |
Method for producing aminoethylethanolamine and/or hydroxyethyl piperazine
A method for preparing aminoethylethanolamine, and/or hydroxyethylpiperazine is described. Reaction of ethylene oxide with ethylendiamine, piperazine, or a mixture of both produces these compounds....
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5874436 |
Triphenylalkyl antimicrobial agents
The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use....
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5872117 |
1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
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5808160 |
Preparation of hydroxy-alkyl-substituted aminoalkynes with heterogenous catalysis
Hydroxyalkyl-substituted aminoalkynes of the general formula I ##STR1## where at least one of the substituents R 1 , R 4 or R 5 is hydroxyalkyl are prepared in a reaction with heterogeneous...
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5807855 |
1-piperazino-1,2-dihydroindene derivatives
Trans isomers of 1-piperazino-1,2-dihydroindene compounds having formula (I), ##STR1## wherein X and Y are hydrogen, halogen, trifluoromethyl, alkyl, alkylthio, trifluoromethylthio, alkoxy,...
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5773617 |
Deallylation reagent and deallylation method using said reagent
The present invention relates to a reagent and to a process which are useful, when carrying out an organic synthesis, for cleaving an allylic group from a function which is protected with the...
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5563271 |
N-(2-sulfatoethyl)piperazine sulfate and its preparation
Preparation of N-(2-sulfatoethyl)piperazine sulfate by reacting N-(2-hydroxyethyl)piperazine in a mixture of high- or relatively high-percentage sulfuric acid and oleum or chlorosulfonic acid at...
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5554793 |
Catalytic reforming of alkyleneamines
A process of reforming an alkyleneamine feedstock or a mixture of such feedstocks to an alkyleneamine or a mixture of alkyleneamines which is different from the feedstock or feedstock mixture. The...
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5491263 |
Aminoethylation process for production of substituted ethylene diamines
A process is disclosed for producing a substituted ethylenediamine, the process comprising reacting an oxazolidinone with a secondary amine or an alkanolamine. The process includes, in one aspect,...
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5476969 |
Highly reactive polyoxyalkylene-polyols containing tertiary amino groups in bonded form, their preparation, and their use for the preparation of polyisocyanate polyaddition products
The invention relates to highly reactive polyoxyalkylene-polyols prepared by oxyalkylation of an initiator molecule containing, in bonded form, at least 2 reactive hydrogen atoms and at least one...
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5464941 |
Biphenyl pyrazine compounds
The present invention provides novel substituted biphenyl pyrazines or pyrazine derivatives ("BPD") which are functional and have useful application as a monomer for a variety of high performance...
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5455352 |
Preparation of N-(2-hydroxyethyl)-piperazine
Preparation of N-(2-hydroxyethyl)-piperazine by reacting triethanolamine with ammonia in the presence of hydrogen at from 100° to 500° C. and from 10 to 500 bar over a heterogeneous catalyst in...
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5410086 |
Selective preparation of diethylenetriamine
This invention relates to a method for controlling the weight ratio of diethylenetriamine to piperazine in a process in which ethylenediamine, or a mixture of ethylenediamine and monoethanolamine,...
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5409931 |
1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are...
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5371088 |
1-aryl-4-piperazinylcyclohexanecarbonitriles, the preparation and use thereof
Compounds of the formula ##STR1## where Ar, R 1 , R 2 , P and Q have the meanings indicated in the description, and the preparation thereof are described. The compounds have antihypoxic and...
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5367050 |
Polyether polyol production of a flexible urethane foam and shaped article therefrom
A polyether polyol produced by using an N-amino-ethylpiperazine-ethylene oxide aduct as an initiator and addition-polymerizing an alkylene oxide thereto and having a molecular weight of about 2000...
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5352677 |
Cinnamamide derivative
Cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from...
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5326873 |
Palladium catalyzed addition of amines to 3,4-epoxy-1-butene
A method of forming 4-amino-2-buten-1-ol using 3,4-epoxy-1-butene is disclosed. A nitrogen nucleophile (e.g., an amine) is reacted with 3,4-epoxy-1-butene in the presence of a polymer-bound complex...
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5326762 |
Inhibitors of acyl-coenzyme A: cholesterol acyl transferase
Amides of the formula ##STR1## wherein R 1 and R 2 are independently heteroaryl, X-substituted heteroaryl, X-substituted phenyl, N-substituted triazinyl or N-substituted imidazolyl; and in...
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5292910 |
Use of hydrophobized hydrotalcites as catalysts for ethoxylation or propoxylation
A process for the catalyzed ethoxylation or propoxylation of compounds selected from the group consisting of organic compounds containing active H atoms, esters of fatty acids containing 2 to 22...
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5283246 |
Trimetazidine compounds
The compounds are substituted trimetazidine useful for the treatment of ischaemic pathologies and peripheral vascular pathology. A compound disclosed is...
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5281595 |
Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
The invention relates to compounds having anti-ischaemic activity, memory enhancing activity and anti-convulsive activity of the formulae 1A and 1B ##STR1## wherein R 1 +R 2 together form an...
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5256786 |
Catalytic reforming of cyclic alkyleneamines
A process of reforming cyclic alkyleneamines to amine-extended cyclic alkyleneamines involving contacting a cyclic alkyleneamine or mixture of cyclic alkyleneamines in the liquid phase with a...
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5254689 |
Piperdinyl and piperazinyl derivatives
Compounds of the formula: ##STR1## in which R 1 is alkylsulfonamido of 1 to 6 carbon atoms, arylsulfonamido of 6 to 10 carbon atoms, --NO 2 , --CN, 1-imidazolyl or 1,2,4-triazol-1-yl; Y is...
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5247087 |
Epoxy modified water clarifiers
Dithiocarbamic salts made from the reaction products of certain polyamines and epoxides have been found to be useful to clarify water, particularly the oil-in-water emulsions which accompany crude...
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5245032 |
Catalytic processes for the preparation of N,N,N-trisubstituted nitrogen-containing compounds
A process for preparing N,N,N-trisubstituted nitrogen-containing compounds which comprises contacting a carboxylated N,N,N-trisubstituted nitrogen-containing compound with a mixed metal oxide...
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5239105 |
Catalytic formation of diarylcarbonates
Diphenylcarbonate is produced by contacting phenol with phosgene or phenylchloroformate or mixture thereof in the presence of one or more heterogeneous catalysts. The catalysts include Group VB...
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5234934 |
Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same
The invention relates to novel racemic or optically active aminopropanol derivatives of formula I ##STR1## wherein R and R 1 are independently hydrogen atom, halogen atom, lower alkoxy, or...
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5231230 |
Selective production of diethylenetriamine
This invention relates to a process for making amines having a high yield weight percent of diethylenetriamine (DETA) by condensing an amino compound in the presence of a condensation catalyst...
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5225600 |
Amines catalysis using group VIB metal-containing condensation catalysts
This invention relates to a process for making amines by condensing an amino compound in the presence of a Group VIB metal-containing condensation catalyst. This invention also relates to an...
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5225598 |
Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
This invention relates to a process for making amines having a high yield weight percent of linear pentaethylenehexamine (L-PEHA) and hydroxyethyldiethylenetriamine (HEDETA) by condensing an amino...
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5225599 |
Selective production of linear triethylenetetramine and aminoethylethanolamine
This invention relates to a process for making amines having a high yield weight percent of linear triethylenetetramine (L-TETA) and aminoethylethanolamine (AEEA) by condensing an amino compound in...
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5220071 |
Selective production of pentaethylenehexamine and hydroxyethyltriethylenetetramine
This invention relates to a process for making amines having a high yield weight percent of pentaethylenehexamine (PEHA) and hydroxyethyltriethylenetetramine (HETETA) by condensing an amino...
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5215989 |
Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
Compounds of structural formula: ##STR1## wherein Ar is an aromatic ring, B is a cyclic moiety fused to Ar of 5-7 members, X and Y are bridging groups, Q is a nitrogen containing heterocycle, R 2 ...
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5214213 |
Selective production of linear tetraethylenepentamine and hydroxyethyldiethylenetriamine
This invention relates to a process for making amines having a high yield weight percent of linear tetraethylenepentamine (L-TEPA) and hydroxyethyldiethylenetriamine (HEDETA) by condensing an amino...
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5214142 |
Processes for the preparation of aminoethers
A process for preparing aminoethers, particularly bis[2-(N,N-dialkylamino)alkyl]ethers, which comprises contacting a carboxylated aminoether with a metal oxide catalyst under conditions effective...
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5214215 |
Selective production of aminoethylethanolamine
This invention relates to a process for making amines having a high yield weight percent of aminoethylethanolamine (AEEA) by condensing an amino compound in the presence of a condensation catalyst...
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