Matches 1 - 50 out of 338 1 2 3 4 5 6 7 >
Match Document Document Title
7384943 Substituted chroman derivatives  
The present invention relates to new piperidyl- or piperazinyl-substituted dihydro-2H-1-benzopyran derivatives having the formula (I) wherein X is N; Y is NR 2 CH 2 , CH 2 NR 2 , NR 2 CO, CONR...
7365196 Sulphonamido-substituted bridged bicycloalkyl derivatives  
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
7326696 Amino-methyl substituted tetracycline compounds  
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
7271168 Piperazine derivatives having SST1 antagonistic activity  
The invention provides compounds of formula ( 1 ) wherein X, R 1 and R 2 are as defined in the specification, their, preparation and to their use in treating, e.g., depression, anxiety and...
6916816 Phenanthryl piperazinyl dicarboxylic acids as selective NMDA receptor modulating agents  
Disclosed are compounds of formula (I) wherein: L is (a) optionally substituted by replacement of one or more of the hydrogen atoms on the phenanthrene ring system by one or more groups other than...
6916812 Alpha-aminoamide derivatives as melanocortin agonists  
Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the...
6906046 Pharmaceutical uses and synthesis of benzobicyclooctanes  
Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse...
6858599 Tricyclic compound having spiro union  
This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated...
6846925 Colchinol derivatives as angiogenesis inhibitors  
The invention related to colchinol derivatives of the formula (I): Wherein: R 1 ; R 2 and R 3 are each independently hydroxy, phosphoryloxy (—OP 3 H 2 ), C 1-4 alkoxy or an in vivo hydrolysable...
6831084 Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity  
This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's...
6828324 Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT1A activity  
This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's...
6821967 Substituted piperazine derivatives, the preparation thereof and their use as medicaments  
The present invention relates to substituted piperazine derivatives of general formula wherein R a , R b , R c , R f , R g , X, m and n are defined as in claim 1, the isomers and salts thereof,...
6818644 Substituted piperazine derivatives, the preparation thereof and their use as medicaments  
The present invention relates to substituted piperazine derivatives of general formula wherein R a , R b , R c R f , R g and m, n and X are defined as in claim 1, the isomers and salts...
6730784 Urea derivatives useful as synthetic intermediates  
Objects of the present invention are to create compounds having urea structure as basic structure and having a sulfur atom and an amide bond in side chains and to find pharmacological effects...
6720323 Colchinol derivatives as angiogenesis inhibitors  
The invention related to colchinol derivatives of the formula (I): Wherein: R 1 , R 2 and R 3 are each independently hydroxy, phosphoryloxy (—OPO 3 H 2 ), C 1-4 alkoxy or an in vivo...
6713651 β2-adrenergic receptor agonists  
Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also...
6703385 Tricyclic compounds having sPLA2-inhibitory activities  
The present invention provides a compound having sPLA 2 inhibiting activity. The compound represented by the formula (I): wherein R 1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20...
6683115 β2-adrenergic receptor agonists  
Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also...
6593497 β2-adrenergic receptor agonists  
The present invention is directed to multibinding compounds which are β2 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma,...
6541669 β2-adrenergic receptor agonists  
Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also...
6492355 Adamantane derivatives  
The invention provides compounds of general formula in which m, A, R 1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions...
6451801 Compounds and methods for treatment of asthma, allergy and inflammatory disorders  
The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting...
6387389 Sustained-release derivatives of hydroxylated analogs of substituted 1-&lsqb 2&lsqb bis(aryl)methoxy&rsqb ethyl&rsqb -piperazines and -homopiperazines and their use  
The present invention provides sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines, pharmaceutical compositions...
6323206 Chemokine receptor antagonists and methods of use therefor  
Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically...
6274583 Alpha 1a adrenergic receptor antagonists  
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha-1a adrenergic receptor antagonists. One application of these compounds...
6184224 Antitumor dibenzofluorene derivatives  
Dibenzofluorene derivatives having a formula selected from the group consisting of ##STR1## and salts thereof have antitumor activity. At least one of R 1 -R 13 in formula (I) or R 1 -R 12 in...
6133268 1,4-disubstituted piperazines  
The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R 1 , R 2 and r are as defined in the detailed part of the present description or...
6130221 Pharmaceutical agents that impede the initiation and progression of primary and secondary DMS disruptions  
Compositions comprising a pharmaceutically effective amount of a compound that impedes disruption of intact dense microspheres (DMS) by acting on DMS either to prevent disruption, or if disrupted,...
6130220 Sulfamide-metalloprotease inhibitors  
This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing...
6096888 Anthracyclinone derivatives and their use in amyloidosis  
The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of...
6063924 Soluble chromophores containing solubilising groups which can be easily removed  
Compounds of formula A(B) x (I), wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone,...
6057441 Substituted tetracyclic tetrahydrofuran derivatives  
6048877 Tetralone derivatives as antiarrhythmic agents  
Tetralone derivatives of the formula ##STR1## where R 1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo),...
6025493 N-piperazinylalkyl-2-anthracenecarboxamides  
Disclosed arm compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are the same or...
6015900 N-aminoalkylfluorenecarboxamides  
Disclosed are compounds of formula (I) or the pharmaceutically acceptable salts thereof wherein: ##STR1## G represents a group of the formula (a), (b) or (c) where R a and R b represent hydrogen,...
5998615 Anthracyclinone derivatives  
The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of...
5998412 Sulfamide-metalloprotease inhibitors  
This invention relates to sulfamides of formula (I) ##STR1## that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing...
5994543 Antibiotic bravomicins  
A novel class of antibiotics, designated bravomicins, is obtained by fermentation of a strain of Micromonospora polytrota. Six bioactive compounds, designated bravomicins A, B, C, D, E and F, are...
5916889 1,4-disubstituted piperazines  
The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R 1 , R 2 and r are as defined in the detailed part of the present description or...
5789587 Heterocyclic-fused lactams promote release of growth hormone  
There are disclosed certain novel compounds identified as heterocyclic-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the...
5712280 Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases  
Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a...
5703237 N-Aminoalkyl-2-anthraquinonecarboxamides; new dopamine receptor subtype specific ligands  
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are the same or different and...
5703235 N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands  
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are the same or...
5703083 N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands  
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addidon salts thereof wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 independently represent...
5686586 Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same  
A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula, X represents --CHCH--, O or S, ...
5659033 N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands  
Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein: G represents a group of the formula ##STR2## where R a and R b represent hydrogen, or...
5612479 Polyphenols containing mesogenic moieties as lateral substituents  
Novel polycyanate compositions containing one or more mesogenic moieties as lateral substituents are disclosed which provide improved processability relative to polycyanates containing one or more...
5607937 Piperazides of substituted phenylalanine derivatives as thrombin inhibitors  
The present invention relates to D,L-, L- and D-phenylalanine piperazides of formula (I) defined in claim 1 that inhibit blood coagulation, and thrombin and/or trypsin, respectively. The compounds...
5565457 Substituted sulfonamides  
The compounds are N-(2,3,4-trimethoxybenzyl)piperazines N'-substituted by a radical containing a sulfonamide group, and pharmaceutically tolerable salts thereof, useful for treating myocardial...
5508280 5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists  
This invention relates to novel derivatives of 5H-dibenzo (a,d)cycloheptenes, to the processes for their preparation, to their muscarinic receptor antagonist properties and to their end-use...
Matches 1 - 50 out of 338 1 2 3 4 5 6 7 >