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7312242 |
Use of parthenolide derivatives as antileukemic and cytotoxic agents
Compounds of the formula having anti-tumor activity, wherein R 1 and R 2 are as described herein
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7244730 |
2-iminopyrrolidine derivatives
A 2-iminopyrrolidine derivative represented by the formula:
{wherein ring B represents a benzene ring, pyridine ring, etc.; R 101 –R 103 represent hydrogen, halogen, C 1-6 alkyl, etc.; R 5 ...
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6699858 |
Halogen substituted tetracyclic tetrahydrofuran derivatives
This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero, 1, 2,...
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6677353 |
Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6514967 |
Compound for preparing medicines for treating pathologies involving extracellular glutamate, and methods for obtaining same
The invention relates to compounds of the following general formula (I): in which: R 1 and R 2 represent a hydrogen atom, or form a ring, especially a benzene ring, R 3 represents a hydrogen...
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6455520 |
Benzamide derivatives and their use as cytokine inhibitors
The invention concerns amide derivatives of formula (I) wherein R 3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R 1 and R 2 is a group such as hydroxy, halogeno,...
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6340704 |
Cell differentiation inducing amide derivatives, their production and use
The present invention provides a compound represented by the formula: wherein R 1 is an amino group which may be substituted; R 2 is a hydrogen atom or a lower alkyl group which may be...
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6323206 |
Chemokine receptor antagonists and methods of use therefor
Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically...
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6153611 |
Piperazinyl-cyclohexanes and cyclohexenes
Novel non-dopaminergic antiischemic compounds have Formula I: ##STR1## wherein R=R 1 and is independently H, C 1 -4 alky C 1 -4 alkoxy, C 1 -4 trihaloalkyl or halogen, or R and R 1 may be taken...
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6113812 |
Photochromic articles
A photochromic article that includes a host material and a photochromic amount of a benzopyran compound, the benzopyran compound represented by one of the formulas: ##STR1## wherein R 1 , R 2 , R 3...
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5869490 |
Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
The compounds of formula I: ##STR1## wherein X is H 2 or O; R 1 is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or...
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5869520 |
Carbamoyloxylabdanes
Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions...
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5869662 |
Photochromic benzopyran compounds
Benzopyran compounds represented by the formulas: ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are selected from hydrogen, a stable organic radical, a...
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5847167 |
Carbamoyloxlabdanes
Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions...
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5847168 |
Photochromic compounds
A photochromic article that includes a host material and a photochromic amount of a naphthopyran compound, the naphthopyran compound represented by the formula: ##STR1## wherein R 1 ', R 2 ', R 3...
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5702645 |
Photochromic chromene derivatives
Described herein are photochromic compounds or a structural isomer of the photochromic compound, the photochromic compounds represented by the formula: ##STR1## wherein R 1 , R 2 , R 4 , R 5 , R 6...
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5646175 |
Carbamoyloxylabdane compounds
Novel carbamoyloxylabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure and treating cardiac failure utilizing compounds and compositions...
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5541183 |
Ginkgolide derivatives
The present invention is directed to new ginkgolide derivatives, which may be used for the prevention or treatment of various PAF-induced diseases, and the pharmaceutical uses of these derivatives....
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5428043 |
Tricyclic-cyclic amines as novel cholinesterase inhibitors
Compounds of the formula ##STR1## wherein ring A, ring B, ring D, R 2 , R 3 , R 4 , R 5 , R 6 ,R 11 , R 12 , R 13 , E, G, X and P are as defined below. The compounds of formula I are cholinesterase...
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5424455 |
Heterocyclic compounds for making red disperse dyes
A heterocyclic compound of the formula, ##STR1## wherein A and B are each hydrogen, halogen, alkyl or alkoxy, R 1 is alkylene having upto 6 carbon atoms, X is direct linkage or divalent group such...
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5332811 |
Etopside analogs
Compounds which are analogs of etoposide and which exhibit anti-tumor activity are disclosed. These compounds having the following structure: ##STR1## wherein R is selected from ##STR2## wherein R...
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5286881 |
Process for producing benzodifuranone compounds useful for dyeing or printing hydrophobic fiber materials
A benzodifuranone compounds of the formula, ##STR1## wherein R 1 and R 2 are each independently a naphthyl group or an unsubstituted or substituted phenyl group, which is useful for dyeing or...
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5246930 |
9-substituted compounds of 3α, 11α-epoxy-3,4,5,5aα,6,7,8,8a,9,11,11a-undecahydro-3β,6.al pha.,9-trimethylfurano[3,4-j][1,2]benzodioxepin, processes for their preparation and their use as antiprotozoal and antiviral agents
Compounds of formula I ##STR1## in which the substituted R has the given meaning, have an antimalarial and a antiviral activity.
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5225427 |
10-substituted ether derivatives of dihydroartemisinin, process for their preparation and their use as antiprotozoal agents
10-substituted ether derivatives of 3α, 12α-Epoxy-3,4,5 5aα, 6,7,8,8aα,9,10,12β, 12a-dodecahydro-10-hydroxy-3β,6α,9β-trimethylpyano-(4,3-j
) (1,2) benzodioxepin, also known as...
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5225436 |
Aryl substituted naphthalene derivatives
Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic...
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5223616 |
Heterocyclic disperse dye compound, their production and their use for dyeing or printing of hydrophobic fibers
A heterocyclic compound which is useful for dyeing or printing hydrophobic fiber materials and which has the following formula (I), ##STR1## wherein A 1 , A 2 , A 3 and A 4 are each hydrogen,...
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5053408 |
Hexitol derivatives having vasodilative activity
Disclosed is a hexitol derivative represented by the formula (I): ##STR1## wherein Q represents a formula selected from the group consisting of ##STR2## wherein a represents NH, O or S; each of...
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4997836 |
Trisubstituted piperazine compounds, their production and use
Novel trisubstituted piperazine compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R 1 , R 2 and R 3 are lower alkyl groups; A is a phenyl group, a...
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4981962 |
Substituted tetrathiotetracenes and tetraselenotetracenes
Substituted tetrathiotetracenes and tetraselenotetracenes of the formula I ##STR1## in which Z is --S-- or --Se-- and (a) R 1 , R 2 , R 3 and R 4 are H and R 5 to R 8 are each H and at least...
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4826975 |
Fused cycloaliphatic aminoalcohols
The invention is concerned with fused cycloaliphatic aminoalcohols having pharmacological activity as anti-hypertensive, platelet aggregation inhibiting, hypolipemic, antianoxic and spasmolytic...
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4826840 |
Cerebral protecting agent
An indene compound of the general formula (I): ##STR1## in which R 1 represents a lower alkyl group, R 2 represents a hydrogen atom, an aryl group or lower alkyl group, R 3 represents an alkyl...
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4684664 |
Derivatives of β-(4-isocyano-1,2,3,4-diepoxycyclopentyl) acrylic acid
Disclosed herein are derivatives of β-(4-isocyano-1,2,3,4-diepoxycyclopentyl)acrylic acid, the derivatives showing an antibacterial activity, an antifungal activity and an antimycoplasmal activity.
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4666904 |
Aminoacyllabdanes, pharmacuetical compositions and use
Novel aminoacyllabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.
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4652651 |
Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
The manufacture of 1-sulpho-2-oxazetidine derivatives of the formula ##STR1## in which Het is an optionally amino-substituted, 5- or 6-membered, aromatic heterocycle containing 1 or 2 nitrogen...
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4596804 |
Dibenz[b,e]oxepin compounds
A dibenz[b,e]oxepin compound having an antiallergic activity is represented by the following general formula: ##STR1## wherein R 1 represents a cyano group, a 5-tetrazolyl group, a carbamoyl group...
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4590274 |
Antihypertensive 1-[bis-(substituted phenyl)methyl]-4[2-(1,2,3,4-tetrahydro-substituted naphthalen-1-ylidene)ethyl]piperazines
Antihypertensive piperazineethylidenebenzocycloalkanes are provided. These compounds have the formula: ##STR1## wherein R 1 , R 2 and R 3 are independently C 1 -C 6 alkyl, hydrogen, C 1 -C 6 ...
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4556657 |
6-(1,8-Naphthyridin-2-yl)-dithiino[1,4][2,3-c]-pyrroles useful as tranquillizing and anticonvulsant agents
New compounds of the formula: ##STR1## wherein X represents hydrogen, halogen, alkyl (1 to 4 C), alkoxy (1 to 4 C), cyano or nitro, R represents alkyl (1 to 4 C) optionally substituted by hydroxy,...
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4465848 |
Spectinomycin compounds
The present specification provides novel antimicrobial analogs of spectinomycin and intermediates and processes for their preparation. Particularly described are novel 3'-diazo-secospectinomycin...
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4463001 |
6-Substituted 6H-dibenzo[b,d]pyran derivatives and process for their preparation
The present invention relates to new 6-substituted 6H-dibenzo [b,d]pyran derivatives, to a process for their preparation and pharmaceutical and veterinary compositions containing them.
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4459306 |
Tricyclic ethers, their process of preparation and their use as medicines
This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the...
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4434295 |
Anti-atherosclerotic 6,7-dihydro-7,7-disubstituted-khellin analogs
The present specification provides novel analogs of khellin. These analogs are all useful as antiatherosclerotic agents. Particularly, the present specification provides 4-methoxy, 9-methoxy, or...
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4315006 |
Benzoxocin derivatives having anxiolytic and anti-convulsant activities
Compounds are disclosed of general formula ##STR1## wherein R 1 represents a hydrogen atom or C 1 -4 alkyl or C 2 -4 alkenyl group, or the group COANH 2 , CSANH 2 , or COANHCOCH 2 NH 2 in which...
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4276294 |
Benzofurylpiperazines
1-(2-phenyl-3-benzofuryl)-piperazines, e.g. those of the formula ##STR1## R=H, alkyl or halo R', R"=H, alkyl, alkoxy, alkylenedioxy, alkylthio or halo R°=H, alkyl or hydroxyalkyl n=2 or 3...
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4252810 |
9,10-Dihydro-4H-benzo[4,5]cyclohepta [1,2-b]thiophen-4,9-imines
9,10-Dihydro-4H-benzo[4,5]cyclohepta [1,2-b]thiophen-4,9-imines, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment...
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4182889 |
Process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decanes
A process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,0 3 ,7 ] decane derivatives is disclosed, wherein a 10-methylen-3-iodomethyl compound of the formula ##STR1## is hydrogenated to obtain a...
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4166062 |
1-Alkoxyethanol-isochromans, -isothiochromans, -2-benzoxepins, and -2-benzothiepins
1-Alkoxyethanol-isochromas, -isothiochromas, -2-benzoxepins, and -2-benzothiepins are described. These compounds are useful for preparing the corresponding aminoalkoxyalkyl derivatives that possess...
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4161589 |
Spirodipyrans
Spirodipyrans of the formula ##STR1## where A is the radical of a fused benzene ring or 2,1-naphthalene ring, the rings being unsubstituted or substituted by alkyl, alkoxy, nitro, chlorine, bromine...
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4148897 |
1,2-Dihydronaphthalene derivatives and pharmaceutical composition
Novel 1,2-dihydronaphthalene derivatives of the formula ##STR1## wherein R 1 and R 2 , independently of each other, are hydrogen, nitro, amino, halogen, or hydroxyl which may be protected, and R 3...
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4144337 |
1,4-Substituted piperazinyl derivatives useful as psychostimulants
The invention provides compounds of formula I, ##STR1## wherein each of R 1 and R 4 , which may be the same or different, is hydrogen, halogen, alkyl or alkoxy; each of R 2 and R 3 is hydrogen,...
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4130646 |
1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
Compounds having the structure ##STR1## and pharmaceutically acceptible salts thereof, wherein R 1 is hydrogen, halogen, hydroxy, alkanoyloxy, alkoxy, alkylthio, alkyl, trifluoromethyl or...
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