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7638536 |
2-Acylaminothiazole derivative or salt thereof
A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on...
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7612060 |
Triazoles and methods of use
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7598250 |
Cyclic amine BACE-1 inhibitors having a heterocyclic substituent
Disclosed are novel compounds of the formula
or a pharmaceutically acceptable salt or solvate thereof, wherein
R 1 is
X is —O—, —C(R 14 ) 2 — or —N(R)—; Z is...
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7595322 |
Heterocyclic sulfonamides as modulators of cardiac sarcomeres
Certain substituted sulfonamide derivatives of Formula I selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart...
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7582635 |
Therapeutic agents useful for treating pain
A compound of formula:
wherein Ar 1 , A, R 3 , x, and m are as disclosed herein and Ar 2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt...
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7544687 |
Substituted α-piperazinyl phenylpropionic acid derivatives as hPPAR α and/or hPPAR γ agonists
The present invention relates to a compound of formula I, racemates, optically active isomers, or pharmaceutically acceptable salts or solvates thereof, and a pharmaceutical composition comprising...
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7544683 |
Cyclohexyl derivatives
The present invention relates to compounds of formula I
wherein R 1 and R 2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are...
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7534887 |
Thiazoline derivative and use of the same
A thiazoline derivative represented by Formula (I):
wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent...
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7514438 |
Melanin concentrating hormone receptor antagonist
Novel compounds, or pharmaceutically-acceptable salts, tautomers or prodrugs thereof, of Formula I
wherein A, W, X, Z, R 1 -R 3 , and R 8 are as defined in the specification, are provided....
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7514439 |
Oxime derivative and preparations thereof
The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]:
wherein Ring A is aryl or heteroaryl;
...
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7504400 |
MTP inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles
The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant...
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7491821 |
Inhibitors of P2X3
Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genitourinary, gastrointestinal, and respiratory disorders:
wherein
R 1 is —C(═S)CH 3 , pyridyl,...
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7449468 |
Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
The present invention provides a compound of formula (I):
wherein R 1 -R 5 , R 25 , R 26 , Y, y, and X 2 are as defined herein. The compounds activate human peroxisome proliferater...
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7432269 |
Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents
The invention relates to compounds of the general formula (I):
to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands...
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7396830 |
Piperazine amidines as antiviral agents
This disclosure provides compounds of Formula I
as described herein having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure...
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7396834 |
4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders
Compounds of general formula: wherein R 1 and R 2 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared....
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7390825 |
Process for the preparation of oxazolidinones and method of use thereof
Substituted oxazolidinone of the formula:
wherein R 2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.
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7365077 |
Piperazine bis-amide derivatives and their use as antagonists of the orexin receptor
Disclosed are piperazine bis-amide derivatives useful as antagonists of the orexin receptor and pharmaceutical compositions containing the same.
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7335660 |
Isochroman compounds for treatment of CNS disorders
This invention relates to compounds of formula (I)
where R 1 to R 12 , —W—V—, —X—Y—, p and n have the values defined in claim 1 , their preparation and use as pharmaceuticals for...
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7329749 |
Piperazinylcarbonylquinolines and -isoquinolines
Compound of the formula (I) in which R 1 , R 2 and alk are as defined in Claim 1, are potent 5-HT 2A antagonist and are suitable for the treatment of psychoses, schizophrenia, depression,...
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7320978 |
Oxazole derivatives, preparation and therapeutic use thereof
This invention relates to compounds of formula (I):
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as described herein. The invention further relates to a method for prevention...
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7300939 |
Substituted 1-propiolylpiperazine compounds, their preparation and use
Substituted 1-propiolylpiperazine compounds corresponding to formula I
in which X denotes N or C—R 2 , and n is an integer from 0 to 8, a method for producing such substituted...
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7265134 |
Tyrosine kinase inhibitors
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
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7220744 |
Monocyclic substituted phenyl methanones
The present invention relates to compounds of formula I
wherein
R 1 , R 2 , X 1 , and X 2 are as defined in the specification
and to pharmaceutically acceptable acid addition salts...
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7214679 |
Piperidine/piperazine-type inhibitors of p38 kinase
Compounds of the formula:
wherein the substituents are as defined herein are useful for treating conditions mediated by p38 kinase.
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7214694 |
3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors
Compounds of formula (I):
wherein the substituents are as defined herein, and their salt, solvates, and prodrugs are procollagen C-proteinase (PCP) inhibitors useful in treating conditions...
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7189712 |
1,3-Oxazole compounds for the treatment of cancer
Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods...
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7160886 |
Acylated piperazine derivatives as melanocortin-4 receptor agonists
Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
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7119203 |
Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors
This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter...
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7119086 |
Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
The invention relates to compounds of formula:
and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards...
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7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
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7098212 |
Piperazine derivatives
The present invention relates to compounds of the formula I
and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein....
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7087576 |
Dipeptide phenyl ethers
Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or...
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7056924 |
Substituted heterocyclic compounds
Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent...
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7026321 |
Substituted heterocyclic compounds
Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent...
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7026314 |
Therapeutic chromone compounds
Provided herein is a compound of the formula (I) wherein said compound is useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating,...
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7012075 |
Cathepsin cysteine protease inhibitors
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for...
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6984652 |
Gyrase inhibitors
Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each...
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6969711 |
Cyclic diamine compounds and medicine containing the same
The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same. The present invention relates to a compound represented by the formula (I) or...
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6969713 |
Piperidine and piperazine acetamide derivatives
The invention provides piperidine and piperazine derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the...
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6956040 |
Oxazolidinone piperazinyl derivatives as potential antimicrobials
The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I
with the variables as defined within, and to...
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6936715 |
Lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
Compounds of the formulae
wherein the substituents are as defined in the specification useful for inhibiting NO synthase and regenerate antioxidants.
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6924278 |
Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists
This invention relates to piperazine derivatives of the formula:
wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation...
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6900206 |
Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with sulfonylureido...
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6867299 |
Oxamide IMPDH inhibitors
Disclosed are compounds of the general formula
which are oxamide derivatives and inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH).
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6852718 |
Phenylsulphonylipiperazinyl derivatives as 5-HT receptor ligands
A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted piperazine ring are selective antagonists of the human 5-HT 2A receptor and are...
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6838461 |
N-(indolcarbonyl-)piperazine derivatives
Compounds of the formula I
in which R 1 , R 2 , R 4 and R 5 have the meanings indicated in claim 1 , are potent 5-HT 2A antagonists and are suitable for the treatment of psychoses,...
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6833453 |
Methods of producing oxazolidinone compounds
Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a...
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6821991 |
2-substituted thiazolidinones as β-3 adrenergic receptor agonists
This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined hereinbefore or a pharmaceutically acceptable salt...
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6747030 |
Piperazine derivatives as 5-HT1B antagonists
Piperazine derivatives of formula(1), processes for their preparation, pharmaceutical compositions containing them in the treatment of CNS and other disorders and in their use in therapy as 5-HT...
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