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7629348 |
Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides
What is described are compounds of the formulae (I) and (II)
where the symbols and indices have the meanings given in the description.
These compounds are suitable for controlling animal pests.
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7612068 |
Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives
The present invention relates to compounds of formula I wherein the substituents are as defined below. The compounds of formula I are useful for the treatment of diseases such as schizophrenia,...
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7598423 |
Potentiators of glutamate receptors
This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating...
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7598236 |
Diazabicyclic central nervous system active agents
Compounds of formula I
pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
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7589115 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-pro
pionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the...
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7589114 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-azetidine-carboxylic acids, esters and amides
Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonyl]-azetidin
e-carboxylic acids, esters and amides which exhibit good inhibitory effect upon the interaction of CAMs and...
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7569591 |
Gyrase inhibitors and uses thereof
The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions...
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7521452 |
Preparation of pharmaceutical salts of piperazine compounds
The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative...
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7495001 |
Benzannelated derivatives, their manufacture and use as pharmaceutical agents
There are presented compounds of the formula
wherein R 6 and R 7 is
R 4 and R 5 or R 5 and R 6 together with the carbon atoms to which they are attached, form a ring as...
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7488732 |
2-substituted pyrimidines
2-Substituted pyrimidines of the formula I
in which the index n and the substituents L, R a , R b , R c , R z , R u , R v , A′, A″ and A′″ are as defined in the description and:
R 1 ...
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7482349 |
Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated β-amyloid...
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7476673 |
Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors
Compounds of the formula
where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases...
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7465736 |
Azole methylidene cyanide derivatives and their use as protein kinase modulators
An azole derivative of formula (I)
a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of...
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7462637 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide
Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidi
ne-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are...
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7459556 |
Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols
The present invention relates to a process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols having the structural formula I
or a pharmaceutically acceptable salt or solvate thereof,...
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7427693 |
Polar liquid crystal
Compounds that are useful in compositions for flat panel displays, for example, are provided. The compounds provided are polar, and are useful in low threshold voltage mixtures. The compounds...
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7407974 |
Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
The present invention provides compounds of Formula (I):
wherein A, B, C, G, and W 1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
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7378446 |
Compound having anti-HCV activity and process for producing the same
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
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7358244 |
Azabicycloalkane compounds
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or...
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7358239 |
Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
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7342020 |
Arylpiperazines and their use as metalloproteinase inhibiting agents (MMP)
Arylpiperazines of formula (I) useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13
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7332499 |
Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides
N-(Sulfonyloxybiarylmethyl) aminocyclopropanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and...
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7317014 |
Bio-active pyrimidine molecules
The present invention relates to novel derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
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7314580 |
Compound, liquid-crystal composition and optical material
Disclosed is a liquid-crystal composition capable of providing a functional film that exhibits useful optical properties. The composition comprises a compound of the following formula (1) that...
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7291624 |
CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
This invention relates to pyrimidine derivatives of general formula I
in which R 1 , R 2 , X, A and B have the meanings that are contained in the description, as inhibitors of the...
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7291744 |
N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity
The present application describes modulators of chemokine receptors of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic...
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7288544 |
Pyrimidine compounds useful as N-type calcium channel antagonists
Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when...
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7279478 |
Cathepsin cysteine protease inhibitors
This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating...
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7265115 |
Diazabicyclic CNS active agents
Compounds of formula I:
or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
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7259163 |
4-(6-membered)-heteroaryl acyl pyrrolidine derivatives as HCV inhibitors
Novel anti-viral agents of Formula
wherein:
A represents OR 1 , NR 1 R 2 , or R 1 wherein R 1 and R 2 are hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R 1 and...
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7259157 |
N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
Compounds represented by Formula (I):
or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
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7244734 |
Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with NK1 antagonistic activity
The invention relates to hexahydro-pyrido[1,2-a]pyrazine derivatives having interesting neurokinin-NK 1 receptor antagonistic activity. The invention also relates to methods for the preparation of...
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7238717 |
CCR9 inhibitors and methods of use thereof
The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates...
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7202247 |
1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents...
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7199125 |
Spiro-cyclic compounds useful as anti-inflammatory agents
The present invention is directed to compounds having the formula (I):
useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(═O)— or...
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7195719 |
High polarization ferroelectric liquid crystal compositions
The invention relates to chiral nonracemic liquid crystal compounds having achiral tails comprising a perfluoroalkyl terminal portion which are useful as components in liquid crystal to impart high...
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7186725 |
Anti-inflammatory compositions and methods
The present invention provides compositions and their use in the treatment of inflammatory diseases caused by T-cell proliferation such as sepsis, inflammatory bowel diseases, autoimmune...
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7169925 |
Indole derivatives as interleukin-4 gene expression inhibitors
This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial,...
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7166609 |
Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
Pyrimidine-4,6-dicarboxylic acid diamides of the formula I
are suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for...
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7164019 |
Heterocyclic antiviral compounds
Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or...
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7145021 |
Analogs of terpene trilactones from Ginkgo biloba and related compounds and uses thereof
The subject invention provides compounds having the structure:
wherein R 1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R 2 is H, OH, a photoactivatable...
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7141596 |
Inhibitors of proteins that bind phosphorylated molecules
The present invention provides compounds that can modulate the activity of a target protein, such as a phosphatase, that selectively binds phosphorylated peptides or proteins. The present compounds...
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7135472 |
3-Heterocyclic benzylamide derivatives as potassium channel openers
The present invention provides novel 3-heterocyclic benzylamides and related derivatives having the general Formula I
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A and Het are as defined in the...
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7132537 |
Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential...
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7132414 |
Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation
The present invention relates to pharmaceutical compositions containing, as active ingredient, a compound of formula:
in which R 1 represents a radical —NHCOR 4 or —N(R 5 )—Y—R 6 , Y...
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7122547 |
Anthranilic acid amides and the use thereof as medicaments
The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products...
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7122675 |
Gamma secretase inhibitors
Novel aryl and heteroaryl sulfonamides are disclosed. The sulfonamides, which are gamma secretase inhibitors, are represented by the formula:
wherein Ar 1 and Ar 2 independently represent...
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7109203 |
Sulfonamide derivatives
Sulfonamide derivitives of the formula I wherein R 1 -R 6 are as defined in the description, processes for their production, their use as pharmaceuticals, particularly for use in the treatment or...
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7084144 |
Sulfonyl group containing compounds and their use for the treatment of erectile dysfunction
A compound having the general formula (I):
wherein: X is N or C; R 0 is H, a lower alkyl group, a lower O-alkyl group,
lower alkyl group, a benzyl group, a phenyl group, a heterocyclic...
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