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7638514 |
Pesticidally active phenol derivatives
There are described compounds of formula (I) wherein X 1 and X 2 are each independently of the other fluorine, chlorine or bromine; A 1 and A 2 are, for example, a bond or a C 1 -C 6 alkylene...
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7625912 |
Mitotic kinesin inhibitors
The present invention relates to 2-phenylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
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7589095 |
4-phenyl-pyrimidine-2-carbonitrile derivatives
The invention relates to 4-phenyl-pyrimidine-2-carbonitrile derivatives having the general formula I
wherein each of the substituents is given the definition as set forth in the specification...
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7579357 |
Dipeptidyl peptidase inhibitors
Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I:
wherein the substituents are as described herein.
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7553840 |
4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
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7544688 |
Hetereoaryl nitrile derivatives
The invention provides compounds of Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use...
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7534798 |
Vanilloid receptor ligands and their use in treatments
Compounds having the general structure
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7531654 |
Process for producing substituted aniline compound
A substitute aniline compound represented by the following formula (6):
wherein, R 1 , R 2 and R 3 are each independently an alkyl group, an alkoxy group, an alkoxyalkyl group, a haloalkyl...
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7531532 |
Pyridine derivative and pyrimidine derivative
A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor...
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7524874 |
Vanilloid receptor ligands and their use in treatments
Compounds having the general structure
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7507738 |
5-protected aminopyrimidine compound, production method thereof and intermediate therefor
The present invention provides a production method of 5-aminopyrimidine compound represented by the formula (5) by reacting a glycine compound represented by the formula (1) with...
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7504405 |
Mitotic kinesin inhibitors
The present invention relates to compounds that are useful for treating cellular proliferative diseases, for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The...
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7491822 |
Production method of aminopyrimidine compound
Aminopyrimidine compounds represented by formula (3) may be efficiently prepared by reacting an azlactone compound represented by formula (1) with an amidine compound represented by formula (2) or...
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7488733 |
6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors
The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I)
methods for the production thereof, and the use thereof for producing medicaments utilized for improving...
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7482308 |
Difluoromethanesulfonyl anilide derivatives useful as herbicides
Novel difluoromethanesulfonamide derivatives of the formula (I) Difluoromethanesulfonamide derivatives represented by the formula wherein X represents halogen, Y represents CH or N, R 1 represents...
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7470699 |
Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
The present invention relates to certain trisubstituted aryl and heteroaryl derivatives of Formula (I) that are modulators of metabolism.
Accordingly, compounds of the present invention are...
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7459452 |
Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
4,5-Dihydroxypyrimidine-6-carboxamides of formula:
are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R 1 , R 2 , R 3 and R 4 are defined herein. These...
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7452896 |
Pyrimidine-sulfamides and their use as endothelian receptor antagonist
The invention relates to novel sulfamic acid amides of General Formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related...
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7439250 |
Compositions and methods related to fatty amino acid derivatives
The present invention concerns the use of methods and/or compositions related to the synthesis and use of fatty asparagine, cysteine and/or serine derivatives. In particular, the invention concerns...
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7435734 |
N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase
N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula:
are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R 1 , R 2 , R 3 and R 4 are defined...
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7423044 |
Pyrimidine derivatives useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure:
wherein:
B is alkyl of 1-4 carbons or alkoxy of 1-4 carbons; R 1 is aryl or Het optionally substituted with R 6 ; R 2 and...
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7402586 |
Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII:
wherein X is O or NR 9 and Het, R 1 , R 7 , R 8 , R 12 —R 15, R a , R b , R c , Z, and n...
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7402587 |
Crystalline forms of a pyridinyl-sulfonamide and their use as endothelin receptor antagonists
Crystalline forms A and B of 5-methyl-pyridine-2-sulfonic acid [6-methoxy-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-
yl]-amide of formula (I) are described, whereby form B is the most stable...
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7365069 |
Pyrimidone derivatives
The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
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7358239 |
Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
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7351733 |
Tetrahydrocarbazole derivatives and their pharmaceutical use
The present invention relates to novel compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
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7338958 |
Sulfoximine-substituted pyrimidines as CDK-and/or VEGF inhibitors, their production and use as pharmaceutical agents
This invention relates to pyrimidine derivatives of general formula I
in which Q, R 1 , R 2 , R 3 , R 4 , R 5 , X, and m have the meanings that are contained in the description, as inhibitors...
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7335672 |
Vanilloid receptor ligands and their use in treatments
Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache,...
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7326715 |
4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
Disclosed herein are 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives having Formula I,
wherein each of the substituents is given the definition as set forth in the specification...
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7323465 |
Alkansulfonamides as endothelin antagonists
The invention relates to novel alkansulfonamides of structure (I), wherein R 1 is a lowel alzyl group and the other variables are as defined in the description, and their use as active ingredients...
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7320975 |
2-(2-pyridyl)-5-phenyl-6-aminopyrimidine, method and intermediate products for the production and use thereof for combating noxious fungi
The invention relates to 2-(2-pyridyl)-5-phenyl-6-aminopyrimidines of formula I, wherein the substitutes and the index have the following meaning: R 1 represents halogen, hydroxy, hyano, hxo,...
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7317014 |
Bio-active pyrimidine molecules
The present invention relates to novel derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
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7312209 |
Acridone inhibitors of IMPDH enzyme
Compounds having the formula (I),
wherein R 3 is selected from H, OH and NH 2 ; R 30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O) 2 —; or W may be —CH 2...
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7309788 |
Method for preparing pyrimidinone compound and pharmaceutically acceptable salts thereof
A process for preparing pyrimidinone compound and salts thereof The method of the present invention enables the convenience to produce the pyrimidinone derivatives in high yields, which...
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7301022 |
Vanilloid receptor ligands and their use in treatments
Compounds having the general structure
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7291730 |
Pyrimidine compounds and their use
Pyrimidine compounds of formula (1):
wherein R 1 is C 3 -C 7 alkynyl optionally substituted with halogen; R 2 and R 3 are independently hydrogen or the like; and R 4 is C 3 -C 7 ...
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7285549 |
Sulfamides and their use as endothelin receptor antagonists
The invention relates to novel sulfamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for...
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7271263 |
Process for production of substituted aniline compound
The present invention provides a process for producing a substituted aniline compound represented by the following general formula (6):
(in the formula, R 1 , R 2 and R 3 are each...
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7223769 |
Pyrimidine compounds and their use as pesticides
The present invention relates to a pyrimidine compound of formula (1):
wherein R 1 is C 3 –C 7 alkynyl; R 2 is hydrogen, halogen, or C 1 –C 3 alkyl; and R 3 is C 1 –C 8 alkyl that...
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7217712 |
4-Substituted-5-cyano-1H-pyrimidin-6-(thi)ones as GSK-3 inhibitors
The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions...
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7205307 |
Pyrimidines as novel openers of potassium ion channels
The present invention provides a genus of pyrimidine amides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.
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7183287 |
Substituted pyrimidinones
Disclosed are compounds Formula I
and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 4 , and R 5 are defined herein. These compounds are useful for treating diseases and...
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7179812 |
Diazine derivatives
The present invention provides compounds of formula (I):
their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the...
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7169790 |
5-substituted 2-aryl-4-pyrimidinones
Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly...
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7166595 |
Compounds, methods and compositions
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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7157581 |
Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their...
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7148219 |
Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
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7145007 |
Process for the preparation of (pyrimidin-2-yl) methyl ketones
A process for the preparation, of (pyrimidin-2-yl)methyl ketones of the general formula (I),
in which R 1 is in each case a C 1-10 -alkyl group, a C 3-8 -cycloalkyl group, an allyl group or an...
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7141670 |
Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones
A process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones of general formula (I), in which R is in each case a C 1-10 -alkyl group, a C 3-8 -cycloalkyl group, an alkyl group or an aryl-C 1-4...
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7135467 |
HIV integrase inhibitors
Compounds useful for treating HIV are disclosed having the general formula
wherein R 1 , R 2 , and B are as defined in the specification. Compositions containing the compounds and methods for...
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