Patents in Class 544/301

Matches 1 - 50 out of 231

1 2 3 4 5 >

Match	Document	Document Title
1	7482355	Pyrimidine derivatives as modulators of chemokine receptor activity Compounds of formula (1), pharmaceutically acceptable salts, solvates and in vivo hydrolysable esters thereof, have activity as pharmaceuticals, in particular as modulators of chemokine receptor...
2	7456191	N-Aryl-sulfoximine-substituted pyrimidines as CDK-and/or VEGF inhibitors, their production and use as pharmaceutical agents This invention relates to pyrimidine derivatives of general formula (I) in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of...
3	7358239	Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
4	7205307	Pyrimidines as novel openers of potassium ion channels The present invention provides a genus of pyrimidine amides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.
5	7119201	Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, W, and R 1 are as defined in the...
6	RE39266	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their...
7	7074925	N-substituted derivatives of 5-oxyiminobarbituric acid N-substituted derivatives of 5-oximinobarbituric add of the general formula where X is sulfur; R 1 is selected from the group consisting of saturated or unsaturated alkyl, cycloalkyl, aryl...
8	7067663	Triazolo pyrimidine compounds Pyrimidine compound (I) useful as a pharmaceutical intermediate, a process for preparing the pyrimidine compound (I), to intermediates used in the process, and use of the pyrimidine...
9	RE39056	4-Azasteroids for treatment of hyperandrogenic conditions Compounds of structural Formula (I) and pharmacologically acceptable salts and esters thereof possess 5α-reductase inhibitory activity. These compounds inhibit 5α-reductase type 1 and type...
10	6960688	Use of compounds for the elevation of pyruvate dehydrogenase activity The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said...
11	6919332	N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, and R 1 are as defined in the...
12	6900222	Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein...
13	6841671	Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said “A” is a 5-7 membered heterocyclic ring as defined in the...
14	6833372	Non-peptide GnRH agents, Pharmaceutical compositions, and methods for their use Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent...
15	6800590	2-Pyrimidinyloxy-n-aryl-benzylamine derivatives,their processes and uses This invention relates to new 2-pyrimidinyloxy-N-aryl-benzylamine derivatives, their preparation processes and uses as chemical herbicides in agriculture. The compound has the following structure: ...
16	6720421	PHENYLURETHANE COMPOUNDS AND METHODS FOR PRODUCING SAME, ASYMMETRIC UREA COMPOUNDS AND METHODS FOR PRODUCING SAME, BARBITURIC ACID DERIVATIVE, AND DIAZO THERMAL RECORDING MATERIAL CONTAINING THE DERIVATIVE Phenylurethane compounds of the following general formula (1); asymmetric urea compounds of the following general formula (10) obtained from the phenylurethane compounds; barbituric acid...
17	6716845	Barbituric acid derivatives The present invention pertains to derivatives of 5,5-disubstituted pyrimidine-2,4,6,-trianones having the formula: wherein R 1 , R 2 , R 3 , and R 4 are described herein. These compounds have...
18	6713486	Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof 2,4-pyrimidinedione derivatives of formula (I) having high antiviral activity against wild-type and mutant HIV-1 and low toxicity are useful for treating AIDS (I) wherein: R 1 is a C 6-10 aryl or...
19	6706723	Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, A, B and R 1 are as defined in the specification, and to pharmaceutical...
20	6680385	Catalytic preparation of aryl methyl ketones using a molecular oxygen-containing gas as the oxidant A method for the preparation of aryl methyl ketones converts a variety of ethyl arenas to the corresponding aryl methyl ketones using a dioxygen-containing gas as the oxidant. The catalyst used for...
21	6664393	N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I, in which A, L, Y, and k have the meanings indicated in the specification and claims. The compounds of the formula I are valuable...
22	6624309	Benzoic acid derivatives and related compounds as antiarrhythmic agents Benzoic acid derivatives of the formula where X is oxygen, sulfur, —NH, —NR 1 , —N—CN, —N—OR 1 or —N—NO 2 ; Y is a single bond, —C═C—, or —NH; R 1 is alkyl, alkenyl,...
23	6600044	Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof,...
24	6583161	Benzenesulfonamides and benzamides as therapeutic agents The invention provides compounds, compositions and methods relating to novel aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as...
25	6579982	Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, Ar 1 , Z, R 1 , R 2 and R 3 are as defined in the specification, and to...
26	6552030	Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: wherein Z 1 , Z 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are...
27	6498164	Barbituric acid derivative and preventive and therapeutic agent for bone and cartilage containing the same A compound of the formula wherein the substituents are as defined in the specification and solvates and salts thereof useful for treating bone and cartilage diseases.
28	6472396	Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds Compounds of formula I, useful as matrix metalloprotease inhibitors, wherein X, Y and Z are each oxygen; R 1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and...
29	6369273	Chemical compounds and their use to elevate pyruvate dehydrogenase activity The use of a compound of the formula (I): wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or...
30	6342504	Aromatic heterocyclic derivatives as enzyme inhibitors The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof,...
31	6335332	Barbituric acid derivatives with antimetastatic and antitumor activity The invention is directed to barbituric acid derivatives having inhibitory activity for matrix maetalloproteases comprised of formula (I): pharmaceutical compositions thereof, processes for...
32	6329523	Compounds having a plurality of nitrogenous substitutents Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring...
33	6288071	1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
34	6281219	Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof The present invention provides compounds of Formula I ##STR1## methods for their preparation and their use as acaricidal and insecticidal agents.
35	6254669	Bleed reduction agents for ink printing inks A compound of the Formula (1) and salts thereof: ##STR1## wherein: Ar, Ar 1 , J, J 1 , X, X 1 W, W 1 , L and m are as defined in the description. The compounds of Formula (1) are useful as...
36	6242455	Pyrimidin-2,4,6-trion derivatives, method for producing the same and medicinal products containing these compounds Compounds of formula I ##STR1## wherein R1, R2, R3 and R4 have the meanings indicated in the specification. The compounds are useful as inhibitors of metalloproteases of the M2, M3 family and...
37	6200984	Naphtho-imidazo pyridine derivatives useful in treating central nervous system disorders A compound of the general formula I: ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions, processes for preparing the compounds and...
38	6177437	Inhibitors of Herpes Simplex virus uracil-DNA glycosylase The invention is directed to novel 6-aromatic substituted uracil compounds of formula I ##STR1## therapeutic compositions comprising the compounds, and methods of treating Herpes simplex virus Type...
39	6162808	Compounds
40	6133276	Compounds and methods for increasing endogenous levels of corticotropin-releasing factor Ligand inhibitors for increasing levels of free corticotropin-releasing factor (CRF) in the brain are disclosed. Such ligand inhibitors cause release of CRF from the CRF/CRF-bind protein complex....
41	6103907	Phenylalkylcarboxylic acid compounds and compositions for treating hyperglycemia Phenylalkylcarboxylic acid compounds of the formula: ##STR1## wherein R 1 represents an alkyl group and the like, R 2 represents an alkylene group, R 3 represents a hydrogen atom and the like, X...
42	6087498	Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds There is provided a process for the preparation of unsymmetrical 4,6-bis(aryloxy)pyrimidine compounds. The unsymmetrical 4,6-bis(aryloxy)pyrimidine compounds are useful as pesticidal agents.
43	6077954	Substituted heterocyclic compounds Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring...
44	6057269	Benzylhydroxylamines and intermediates used to prepare them Benzylhydroxylamines I ##STR1## (X=--N(R 7 )--O--; Y=O, S; R 1 =halogen, CN, NO 2 , CF 3 ; R 2 =H, halogen; R 3 =H, NH 2 , CH 3 ; R 4 =H, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl,...
45	6008351	Aromatic hetherocyclic derivatives as enzyme inhibitors The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof,...
46	6008350	Process for the production of cyanine dyes The present invention relates to a process for the production of cyanine dyes with their methine chain showing group (M) and the charge compensation occuring by linked end groups through...
47	5990339	Phenylacetic acid derivatives, and use as fungicides The present invention relates to phenylacetic acid derivatives of the formula I ##STR1## where the substituents and the index have the following meanings: X is NOCH 3 , CHOCH 3 , CHCH 3 and [sic]...
48	5942535	a!-Annelated pyrrole derivatives and pharmaceutical use thereof The present invention relates to heterocyclic compounds of the formula ##STR1## in which R 1 -R 7 , B, a and X have the meanings recited in the specification. These compounds are usable in the...
49	5936086	Classes of non-sensitizing infra-red dyes for use in photosensitive elements A novel class of non-sensitizing infra-red dyes derived from heptamethine dyes with indolenine nuclei is disclosed. They are useful as filter-, acutance- or antihalation dyes for photographic...
50	5889013	Pyrimidine acyclonucleoside derivatives The present invention relates to novel pyrimidine acyclonucleoside derivatives represented by the following general formula (I), antiviral agents containing the derivatives as the active...

Matches 1 - 50 out of 231

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