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7452901 |
Anti-cancer phosphonate analogs
The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well...
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7442486 |
Radiation-sensitive compositions comprising oxazole derivatives and imageable elements based thereon
Radiation-sensitive element comprising: (a) one or more types of monomers each comprising at least one ethylenically unsaturated group accessible to a free-radical polymerization, (b) at least one...
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7351829 |
Compounds on the basis of 2- and 4-chromenylidene-merocyanines respectively, and their use
The invention relates to compounds based on merocyanines with the general formulas I and/or II,
where n=0 or an integer from 1 to 3, X=O or S and the residues R 1 to R 12 are the same or...
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7291642 |
Bradykinin-B1 antagonists, process for their preparation and their use as medicaments
The present invention provides bradykinin-B1 antagonists of the formula
in which A, Ar, G, Q, R 1 and R 4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and...
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7205307 |
Pyrimidines as novel openers of potassium ion channels
The present invention provides a genus of pyrimidine amides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.
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7160893 |
Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
This invention provides compounds defined by Formula I
or a pharmaceutically acceptable salt thereof,
wherein R 1 , Q, R 2 , R 3 , and R 4 are as defined in the specification. The invention...
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7119102 |
Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
Disclosed are compounds of formula (I):
wherein the variables R 1 , R 2 , R 3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK)...
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7119201 |
Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula
wherein X, A, Y, B, G, W, and R 1 are as defined in the...
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7067523 |
Use of pyrone carboxylates for controlling pests
Pests can be controlled by applying an effective amount of a compound of formula (1):
wherein R is C 2 –C 6 alkyl, C 3 –C 6 cycloalkyl, (C 3 –C 6 cycloalkyl)C 1 –C 2 alkyl,...
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6995262 |
Use of acylsulfonamido-substituted polymethine dyes as fluorescene dyes and/or markers
The invention relates to a novel polymethine dyes containing at least one acylsulfonamido group of the formula (I)
in which n, Y, A and R have the meaning given in the claims, and at least one...
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6919332 |
N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula
wherein X, A, Y, B, G, and R 1 are as defined in the...
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6914160 |
Oxytocin inhibitors
This invention relates to compounds of formula (I)
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6849622 |
Aliphatic nitrogenous five-membered ring compounds
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]:
wherein
A represents —CH 2 — or —S—, R 1 ...
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6841671 |
Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula
wherein said “A” is a 5-7 membered heterocyclic ring as defined in the...
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6833372 |
Non-peptide GnRH agents, Pharmaceutical compositions, and methods for their use
Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent...
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6800590 |
2-Pyrimidinyloxy-n-aryl-benzylamine derivatives,their processes and uses
This invention relates to new 2-pyrimidinyloxy-N-aryl-benzylamine derivatives, their preparation processes and uses as chemical herbicides in agriculture. The compound has the following structure: ...
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6765009 |
1,4-Disubstituted benzo-fused compounds
Disclosed are novel 1,4-disubstituted benzo-fused compounds wherein G, X, L, Q, n and Y are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or...
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6716845 |
Barbituric acid derivatives
The present invention pertains to derivatives of 5,5-disubstituted pyrimidine-2,4,6,-trianones having the formula: wherein R 1 , R 2 , R 3 , and R 4 are described herein. These compounds have...
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6713486 |
Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
2,4-pyrimidinedione derivatives of formula (I) having high antiviral activity against wild-type and mutant HIV-1 and low toxicity are useful for treating AIDS (I) wherein: R 1 is a C 6-10 aryl or...
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6706723 |
Pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, A, B and R 1 are as defined in the specification, and to pharmaceutical...
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6673925 |
Method of producing thiobarbituric acid derivatives
Method of producing thiobarbituric acid derivatives of formula I wherein R 1 is SH, S − M + or CH 3 S—, and M + is an alkali metal ion, by hydrogenolysis of a compound of formula II ...
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6656911 |
Serine protease inhibitors
The present invention relates to certain substituted oxadiazole, thiadiazoles and triazole peptoids which are useful as inhibitors of serine proteases. Compounds of the invention are useful for...
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6579982 |
Pyrimidine-2,4,6-trione metalloproteinase inhibitors
The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, Ar 1 , Z, R 1 , R 2 and R 3 are as defined in the specification, and to...
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6548512 |
Nitrogen containing heteroaromatics as factor Xa inhibitors
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and...
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6545006 |
Process for obtaining L-dihydroorotic acid and use thereof
The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa....
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6498164 |
Barbituric acid derivative and preventive and therapeutic agent for bone and cartilage containing the same
A compound of the formula wherein the substituents are as defined in the specification and solvates and salts thereof useful for treating bone and cartilage diseases.
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6472396 |
Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds
Compounds of formula I, useful as matrix metalloprotease inhibitors, wherein X, Y and Z are each oxygen; R 1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and...
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6451738 |
Substituted thienyl(Amino)-sulphonyl(thio)ureas as herbicides
The invention relates to novel substituted thienyl(amino)sulphonyl(thio)ureas of the formula (I) in which A represents nitrogen or a CH grouping, E represents a single bond or an NH grouping, Q...
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6406533 |
6,13-dihydroquinacridone derivatives
A 6,13-dihydroquinacridone derivative of formula I: (MO 3 S) m —Q—[CH 2 —(X)—(Y) n ] o (I) wherein: Q represents a 6,13-dihydroquinacridone moiety of formula II; A and B each...
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6369002 |
N-heteroaryl-substituted pyridine derivatives and their use as herbicides
Compounds of formula 1 wherein R 1 is hydrogen, fluorine, chlorine, bromine or methyl; R 2 is C 1 -C 4 alkyl, C 1 -C 4 halogenalkyl, halogen, hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 halogenalkoxy,...
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6342604 |
Substitute pyrimidine compounds and the use thereof
The present invention relates to the use of pyrimidine compounds of the following formula: wherein R 1 , R 2 , R 3 , A, B and Ar have the meanings indicated in the description. The compounds...
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6335332 |
Barbituric acid derivatives with antimetastatic and antitumor activity
The invention is directed to barbituric acid derivatives having inhibitory activity for matrix maetalloproteases comprised of formula (I): pharmaceutical compositions thereof, processes for...
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6300337 |
Acetamide derivative and use thereof
The present Invention relates to a novel acetamide derivative represented by the following Formula 1, which has an inhibition activity for chymotrypsin type proteases and is useful as an inhibitor...
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6274728 |
Soluble chromophores having improved solubilizing groups
Compounds of formula A(B) x (I), wherein x is an integer from 1 to 8, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, indanthrone,...
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6268310 |
Oxazole derivative, process for producing the same, and herbicide
The present invention is directed to oxazole derivatives represented by the formula [I]; ##STR1## wherein A represents a nitrogen atom or a R 3 -substituted carbon atom; B represents a nitrogen...
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6264733 |
Pigment particle growth and/or crystal phase directors
Pigment particle growth and/or crystal phase directors of the following formula: (MO 3 S) m --Q--(CH 2 --(X)--(Y) n ) o wherein: Q represents a pigment moiety; M represents a metal...
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6254669 |
Bleed reduction agents for ink printing inks
A compound of the Formula (1) and salts thereof: ##STR1## wherein: Ar, Ar 1 , J, J 1 , X, X 1 W, W 1 , L and m are as defined in the description. The compounds of Formula (1) are useful as...
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6187929 |
Dye usable for photographic lightsensitive material, fine solid particle dispersion of said dye and silver halide photographic lightsensitive material containing said fine solid particle dispersion of said dye
A dye represented by the following formula (1); Formula (1) ##STR1## wherein A represents an acidic nucleus, L 1 , L 2 and L 3 represent a methine group, n represents 0, 1 or 2, Z...
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6177437 |
Inhibitors of Herpes Simplex virus uracil-DNA glycosylase
The invention is directed to novel 6-aromatic substituted uracil compounds of formula I ##STR1## therapeutic compositions comprising the compounds, and methods of treating Herpes simplex virus Type...
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6174901 |
Substituted pyridine and pyridazine compounds and methods of use
Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies,...
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6100252 |
Heterocyclic compounds and their use as angiotensin antagonists
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6063924 |
Soluble chromophores containing solubilising groups which can be easily removed
Compounds of formula A(B) x (I), wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone,...
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6057269 |
Benzylhydroxylamines and intermediates used to prepare them
Benzylhydroxylamines I ##STR1## (X=--N(R 7 )--O--; Y=O, S; R 1 =halogen, CN, NO 2 , CF 3 ; R 2 =H, halogen; R 3 =H, NH 2 , CH 3 ; R 4 =H, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl,...
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6051722 |
Compounds, polymers, resin compositions and nonlinear optical devices
The present invention provides, as heteroaromatic compounds made functional so as to be used for nonlinear optical materials, compounds represented by the following general formula (1), and also...
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6034089 |
Aryl thiophene derivatives as PDE IV inhibitors
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the...
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6013777 |
Process for the preparation of fluorescent pigments
Compounds of formula A(B) x , (I), wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone,...
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6008350 |
Process for the production of cyanine dyes
The present invention relates to a process for the production of cyanine dyes with their methine chain showing group (M) and the charge compensation occuring by linked end groups through...
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6005096 |
Pyrimidine derivatives
A compound having the structure ##STR1## wherein R 1 is H or a linker group; R 24 is independently halo or C 1 -C 2 haloalkyl; R 25 is independently --SH, --OH, S or O; A is...
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5977367 |
N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R 1 , R 2 , R 3 , R 4 are the same or different and represent hydrogen, C...
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5962685 |
Oxazole derivatives, process for producing the same, and herbicide
The present invention is directed to oxazole derivatives represented by the formula I!; ##STR1## wherein A represents a nitrogen atom or a R 3 -substituted carbon atom; B represents a nitrogen...
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