|
Match
|
Document |
Document Title |
|
|
7598423 |
Potentiators of glutamate receptors
This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating...
|
|
|
7589090 |
Diaminopyrimidines as P2X3 and P2X2/3 modulators
Compounds and methods for treating diseases mediated by a P2X 3 and/or a P2X 2/3 receptor antagonist, the compounds being of formula (I):
wherein R 1 , R 2 , R 3 and R 4 are as defined herein.
|
|
|
7547782 |
Met kinase inhibitors
The present invention is directed to compounds having the formula I or II:
including salts thereof, and methods for using them for the treatment of cancer.
|
|
|
7547700 |
Aryl-[4-halo-4(heteroarylmethylamino)-methyl]-piperidin-1-1yl]-methanone derivatives, methods for production and use thereof as medicaments
The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or...
|
|
|
7538072 |
Stem/leaf desiccant
A stem/leaf desiccant for crop plants which comprises as an active ingredient, a compound of formula (I):
wherein X represent CH or nitrogen; Z represents halogen; A represents oxygen, sulfur,...
|
|
|
7531547 |
Diaminopyrimidines as P2X3 and P2X2/3 modulators
Compounds and methods for treating diseases mediated by a P2X 3 and/or a P2X 2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a...
|
|
|
7491827 |
Aryl sulfonamides useful as inhibitors of chemokine receptor activity
The present invention provides compounds of general formula I:
or a pharmaceutically acceptable salt thereof, wherein R 1 , X, Z, R 2 , X 1 , Ar, n, R 3 and R 4 are defined generally and in...
|
|
|
7491728 |
Pyrimidinone compounds as calcilytics
The pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
|
|
|
7446210 |
Factor Xa compounds
The present invention is directed to novel compounds of Formula I:
and forms and pharmaceutical compositions thereof, and the use thereof as inhibitors of Factor Xa.
|
|
|
7442701 |
Amino-heterocycles as VR-1 antagonists for treating pain
The present invention provides a compound of formula (I): wherein V represents NR 5 , O, S, SO or S(O) 2 ; W and X each independently represent CH or N; Y represents N, CH or C—Ar 2 , with the...
|
|
|
7429667 |
Phenylamino isothiazole carboxamidines as MEK inhibitors
The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamid
ines. Also...
|
|
|
7368479 |
Alpha-sulfonylamino-acetonitriles
The invention relates to α-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar 1 , and Ar 2 ...
|
|
|
7361654 |
Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
|
|
|
7358239 |
Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z...
|
|
|
7317016 |
Methods of treating medical conditions using sulfonate-substituted pyrazolopyridine derivatives
This invention relates to methods of treatment of cardiovascular disorders, thromboembolic disorders, inflammation, and disorders of the central nervous system using pyrazol pyridine derivatives of...
|
|
|
7291622 |
Medical uses of carbamate-substituted pyrazolo-pyridine derivatives
This invention relates to methods for treating sexual dysfunction, by administering a compound of the formula
wherein R 1 is H or a di-C 1-6 -alkylaminocarbonyl radical, and R 2 is a radical...
|
|
|
7268145 |
Thiobenzimidazole derivatives
The present invention is a thiobenzimidazole derivative represented by the following formula (1)
or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically...
|
|
|
7244737 |
Process for the preparation of azoxystrobin and analogues thereof
The present invention relates to a compound of the general formula:
wherein R 1 is a 4-pyrimidinyl ring substituted at the 6-position by halo, hydroxy, 2-cyanophenoxy, 2,6-difluorophenoxy,...
|
|
|
7232926 |
Method for the production of sulphamic acid halogenides
The present invention relates to a process for preparing sulfamoyl halides of primary or secondary amines, comprising the following steps:
i) reacting a primary or secondary amine A1 with at...
|
|
|
7230026 |
Selected fused pyrrolocarbazoles
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also...
|
|
|
7205302 |
Heterocyclic compound derivatives and medicines
The present invention provides a compound which is useful as a PGI 2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition...
|
|
|
7205328 |
Oxindoles with anti-HIV activity
The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents,...
|
|
|
7195719 |
High polarization ferroelectric liquid crystal compositions
The invention relates to chiral nonracemic liquid crystal compounds having achiral tails comprising a perfluoroalkyl terminal portion which are useful as components in liquid crystal to impart high...
|
|
|
7196089 |
EP4 receptor antagonists
Compounds of formula (I):
wherein: R 2 is H or an optionally substituted C 1-4 alkyl group; Y is either —(CH 2 ) n —X—, where n is 1 or 2 and X is O, S, S(═O), S(═O) 2 , or NR N1 ,...
|
|
|
7176199 |
Aryl-substituted alicyclic compound and medical composition comprising the same
An aryl-substituted alicyclic compound of the formula (I):
wherein U is 1,4,5,6-tetrahydropyrimidin-2-yl, etc., A is phenylene, etc., B is piperidine-1,4-diyl, etc., Z is —CONH—, etc., R 3 ...
|
|
|
7135569 |
Process for the preparation of pyridinyl and pyrimidinyl mono-fluorinated beta keto-esters
The present invention relates to a process for preparing pyridinyl and pyrimidinyl mono-fluorinated beta keto esters of formula (I):
wherein: R1 represents a pyridine ring or a pyrimidine...
|
|
|
7125881 |
Use of pyrimidine—or triazine—2 carbonitiles for treating diseases associated with cysteine prostease activity and novel pyrimidine-2-carbonitile derivatives
The present invention therefore provides use of a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors...
|
|
|
7115613 |
Selected fused pyrrolocarbazoles
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also...
|
|
|
7112674 |
Organic electroluminescent device based on 2,5-diaminoterephthalic acid derivatives
The invention relates to an organic electroluminescent device which contains 2,5-diaminoterephthalic acid derivatives of formula 1a as emitter substances in one or several emitter layers in a pure...
|
|
|
7112585 |
Pyrimidine derivatives as corticotropin releasing factor inhibitors
The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF...
|
|
|
7109148 |
Stem/leaf desiccant
A stem/leaf desiccant for crop plants which comprises as an active ingredient, a compound of formula (I):
wherein X represent CH or nitrogen; Z represents halogen; A represents oxygen, sulfur,...
|
|
|
7105523 |
Carbamate-substituted pyrazolopyridine-derivatives
This invention relates to compounds of the formula
wherein R 1 is H or a di-C 1-6 -alkylaminocarbonyl raical, and R 2 is a radical of the formula —O—C(X)—NR 3 R 4 wherein X is O or S....
|
|
|
RE39266 |
Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their...
|
|
|
7087768 |
Fumagillol derivatives and preparing method thereof
The disclosure relates to a fumagillol compound which can be usefully used not only as an angiogenesis inhibiting agent showing a superior angeogenesis inhibitory effect with less toxicity, but...
|
|
|
7067664 |
Corticotropin releasing factor antagonists
Corticotropin-releasing factor (CRF) antagonists having the formulae
wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and...
|
|
|
7026270 |
Biocidal compounds and their preparation
This invention concerns new biocidal compounds of formula (I) wherein R is H or CH 3 . Of particular interest are two isomers that are named malayamycin A and desmethylmalayamycin A. These isomers,...
|
|
|
6936597 |
Prodrugs of anticancer agents employing substituted aromatic acids
Polymeric prodrugs of the formula:
wherein
B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing...
|
|
|
6930208 |
3-Keto- or 3- oxime-ether-substituted benzoylcyclohexanediones
What is described are derivatives of benzoylcyclohexanediones of the formula (I) and their use as herbicides.
In this formula (I), R 1a , R 1b , R 1c , R 2 , R 3 , R 4 and R 5 denote various...
|
|
|
6924251 |
Substituted benzoylcyclohexandiones
The invention relates to novel substituted benzoylcyclohexanediones of the general formula (I),
in which
m, n, A, R 1 , R 2 , R 3 , R 4 and Z are each as defined in the description,
and...
|
|
|
6921767 |
Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
The present invention relates to a class of compounds represented by the Formula I
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
|
|
|
6919345 |
Sulfonate substituted pyrazol pyridine derivatives
This invention relates to pyrazol pyridine derivatives of formula (I)
wherein R 1 is a radical of the formula −O—SO 2 —R 3 in which R 3 is optionally substituted C 1—6 —alkyl,...
|
|
|
6916820 |
Neurotrophic substituted pyrimidines
The present invention relates to a series of substituted pyrimidines, to pharmaceutical compositions which contain them, to methods for their preparation and to their use in therapy, particularly...
|
|
|
6906051 |
Lactone integrin antagonists
The present invention relates to a class of compounds represented by the Formula I:
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
|
|
|
6884804 |
Inhibitors of Src and other protein kinases
The present invention provides compounds of formula I:
wherein A is N or CR, and G, R 1 , R 2 and R 3 are as described in the specification. These compounds are inhibitors of protein kinase,...
|
|
|
6867210 |
Aryl substituted pyrimidines
This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I:
or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A 1 , A 2 , A 3...
|
|
|
6864252 |
Hydrazinyl and nitrogen oxide pyrazoles
The present invention relates to hydrazinyl and nitrogen oxide pyrazoles of the formula I:
wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m, X, R 1 through R 5 are as defined in the...
|
|
|
6844295 |
Benzoxazole compound, process for producing the same, and herbicide
The present invention relates to benzoxazole compounds represented by the following formula (I):
wherein R 1 to R 4 may be the same or different from each other, and each represent a...
|
|
|
6831081 |
4-Oxo-4,7-dihydrothieno&lsqb 2,3-b&rsqb pyridine-5-carboxamides as antiviral agents
The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.
|
|
|
6825208 |
Tetrahydroquinoline derivatives as antithrombotic agents
This invention relates generally to tetracyclic tetrahydroquinoline compounds, and analogues thereof, and pharmaceutically acceptable salt forms thereof, which are selective inhibitors of serine...
|
|
|
6806230 |
Pyrimidine derivatives and herbicides containing them
Pyrimidine derivatives having excellent herbicidal activities for crop plants and selectivity between crop plants and weeds, are presented. Pyrimidine derivatives represented by the following...
|