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7642303 |
Thermoplastic articles for packaging UV sensitive materials, processes for the articles production and use and novel UV absorbers
Thermoplastic composition and articles containing UV absorbers that protect the articles contents from harmful UV radiation are disclosed as well as methods for making the thermoplastic articles...
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7605166 |
Methods and compositions for treating rheumatoid arthritis
This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha-4 integrin or an...
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7598423 |
Potentiators of glutamate receptors
This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating...
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7598260 |
CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
This invention relates to pyrimidine derivatives of general formula I
in which R 1 , R 2 , X, A and B have the meanings that are contained in the description, as inhibitors of the...
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7582759 |
Diastereomeric purification of rosuvastatin
The invention relates to diastereomerically pure rosuvastatin and processes for preparing diastereomerically pure rosuvastatin and its intermediates.
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7569604 |
Heterocyclic derivatives for modulation of calcium channels
Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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7524955 |
Process for the preparation of pyrimidine compounds
A process for the preparation of a compound of Formula (I) and intermediates useful therein are provided. The process comprises reacting a compound of formula R 1 —CO—CH 2 -E with a compound of...
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7514446 |
Pyrimidine compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7511140 |
Process for preparing the calcium salt of rosuvastatin
An improved process for manufacture of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl)(methylsulfo
nyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, which is useful for...
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7507738 |
5-protected aminopyrimidine compound, production method thereof and intermediate therefor
The present invention provides a production method of 5-aminopyrimidine compound represented by the formula (5) by reacting a glycine compound represented by the formula (1) with...
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7468367 |
Ethylene diamine derivatives and their use as orexin-receptor antagonists
This invention relates to heterocyclic substituted ethylene diamine derivatives and their use as pharmaceuticals.
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7417048 |
Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets
Novel peripheral antinociceptive compounds are disclosed having a pharmacophore unit that target small-diameter nerve fibers that transmit signals of pain and discomfort from the soma and viscera....
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7396927 |
Process for preparation of rosuvastatin calcium
The present invention provides processes for preparing calcium salts of statin, particularly rosuvastatin calcium salt substantially free of impurities on an industrial scale.
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7338958 |
Sulfoximine-substituted pyrimidines as CDK-and/or VEGF inhibitors, their production and use as pharmaceutical agents
This invention relates to pyrimidine derivatives of general formula I
in which Q, R 1 , R 2 , R 3 , R 4 , R 5 , X, and m have the meanings that are contained in the description, as inhibitors...
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7332487 |
Nitrogen-containing 5-membered ring compound
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]:
wherein symbols in the formula have the following meanings;
...
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7291624 |
CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
This invention relates to pyrimidine derivatives of general formula I
in which R 1 , R 2 , X, A and B have the meanings that are contained in the description, as inhibitors of the...
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7282608 |
Inhibitors of histone deacetylase
The invention provides compoods and methods for treating cell proliferative-diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds...
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7256288 |
Heteroaryl carboxylic acid amides
The invention relates to novel heteroaryl carboxamides, a process for their preparation, and pharmaceutical compositions containing them. These materials are useful for the treatment and/or...
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7250418 |
Compounds as CRF1 receptor antagonists
The present invention relates to compounds of Formula I,
or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compounds of the inventions are CRF 1 ...
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7235561 |
Compound and a composition including such a compound
This invention relates to pyrimidine derivatives of general formula I
in which R 1 , R 2 , X, A and B have the meanings that are contained in the description, as inhibitors of the...
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7223759 |
Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of...
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7205302 |
Heterocyclic compound derivatives and medicines
The present invention provides a compound which is useful as a PGI 2 receptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition...
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7199239 |
Chemical compounds
A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof,
Wherein:
R 1 and R 2 are independently hydrogen or C 1-3 alkyl; X represents a...
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7189755 |
Pyrrolidine melanocortin-specific compounds
Melanocortin receptor-specific pyrrolidine compounds having the structure:
and stereoisomer and pharmaceutically acceptable salts thereof, where R 1 , R 2 , and R 3 are as described in the...
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7189848 |
Substituted sulfonylaminomethylbenzoic acid (derivatives) and their preparation
The present invention relates to a compound of the formula (I)
The compound according to the invention is suitable for the preparation of herbicidal active substances such as sulfonylureas.
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7179916 |
Process for the preparation of rosuvastatin
The present invention provides a process for the preparation of the rosuvastatin intermediate FPP—CHO and its conversion to rosuvastatin and pharmaceutically acceptable salts thereof.
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7173129 |
Sulfonamide-substituted chalcone derivatives and their use to treat diseases
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents...
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7169802 |
Fused pyrrolocarbazoles
The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also...
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7160886 |
Acylated piperazine derivatives as melanocortin-4 receptor agonists
Certain novel N-acylated piperazine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
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7161004 |
Processes to produce intermediates for rosuvastatin
Intermediate compounds for preparing rosuvastatin are prepared by a process comprising oxidizing hydroxy groups to aldehyde groups, using sodium hypochlorite and 2,2,6,6-tetramethyl piperidinyl oxy...
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7153862 |
αv integrin receptor antagonists
The present invention relates to novel alkanoic acid derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present...
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7129352 |
Crystalline salts of 7-′4-(4-fluorophenyl) -6-isopropyl-2-′methyl (methylsulfonyl) amino!pyrimidin-5-yl!- (3R, 5S) -3, 5-dihydroxyhept-6-enoic acid
The invention relates to crystalline salts of the compound (E)-7-[4-(4-fluorophenyl)isopropyl-2-[methyl(methylsulfonyl)
amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid of formula (I),...
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7125879 |
HIV inhibiting pyrimidines derivatives
This invention concerns HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms...
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7125883 |
Integrin receptor ligands
The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations...
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7087617 |
Substituted pyrimidine derivatives
This invention relates to compounds of Formula I,
a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug...
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7067664 |
Corticotropin releasing factor antagonists
Corticotropin-releasing factor (CRF) antagonists having the formulae
wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and...
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6987119 |
Imidazol-2-carboxamide derivatives as raf kinase inhibitors
Compounds of formula (I):
wherein X is O, CH 2 , S or NH, or the moiety X—R 1 is hydrogen;
V is CH or N; R 1 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, arylC 1-6 alkyl,...
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6914160 |
Oxytocin inhibitors
This invention relates to compounds of formula (I)
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6906051 |
Lactone integrin antagonists
The present invention relates to a class of compounds represented by the Formula I:
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
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6903132 |
Non-peptide GnRH agents, pharmaceutical compositions and methods for their use
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active...
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6875867 |
Process for preparing chiral diol sulfones and dihydroxy acid HMG CoA reductase inhibitors
A process is provided for preparing chiral diol sulfones of the structure
where R 3 is preferably
where R 4a is preferably aryl such as phenyl, and R 1a is preferably alkyl such as...
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6867213 |
(2S)-2-(adamantan-1-ylmethoxycarbonylamino)-3-(4-(2-(1,4,5,6-tetrhydropyrimidin-2-ylcarbamoyl)ethyl)benzoylamino)propionic acid isopropyl ester, its preparation and its use
(2S)-2-(Adamantan-1-ylmethoxycarbonylamino)-3-(4-(2-(1,4,5,6
-tetrahydropyrimidin-2-ylcarbamoyl)ethyl)benzoylamino)propio
nic acid isopropyl ester, its preparation and its use The present...
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6841554 |
Crystalline salts of 7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3r,5s)-3,5-dihydroxyhept-6-enoic acid
The invention relates to crystalline salts of the compound (E)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl(methyl-sulf
onyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic
acid of formula...
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6838458 |
5-(alkylidene-cycloalkyl)-and 5-(alkylidene-heterocyclyl)-pyrazoles
The present invention relates to 5-(alkylidene-cycloalkyl)-pyrazoles and 5-(alkylidene-heterocyclyl)-pyrazoles of the formula I:
wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m, B,...
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6806230 |
Pyrimidine derivatives and herbicides containing them
Pyrimidine derivatives having excellent herbicidal activities for crop plants and selectivity between crop plants and weeds, are presented. Pyrimidine derivatives represented by the following...
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6797714 |
Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
This invention is related to novel carboxyl substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
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6767908 |
Substituted imidazoles having cytokine inhibitory activity
There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which may be useful for the treatment of cytokine mediated diseases such as arthritis.
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6720327 |
Lactone integrin antagonists
The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula...
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6686367 |
Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: wherein Z 1 , Z 2 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are...
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6686364 |
Benzamidine derivatives and their use as anti-coagulants
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention,...
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