Patents in Class 544/254

Matches 1 - 50 out of 116

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Match	Document	Document Title
1	7622482	Chemical compounds This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
2	7589097	Triazol[4,5-d] pyramidine derivatives and their use as purinergic receptor antagonists The use of a compound of formula (I): wherein R 1 is selected from H, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, halogen, CN, NR 5 R 6 , NR 4 COR 5 , NR 4 CONR 5 R 6 , NR 4 CO 2 R 7 ...
3	7566722	Triazolopyrimidine derivatives as ADP P2Y₁₂receptor antagonists The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein R 1 and R 2 are as defined herein, and their methods of preparation...
4	7563781	Triazolopyrimidine derivatives The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.
5	7560458	Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors This invention concerns compounds of formula N-oxides, pharmaceutically acceptable addition salts, quaternary amines and stereochemically isomeric forms thereof, their use, pharmaceutical...
6	7407962	Heteroaryl compounds useful as inhibitors or protein kinases The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative...
7	7345047	Substituted [1,2,3]triazolo[4,5-d]pyrimidines The invention provides novel substituted cyclopentane compounds (in particular, substituted [1,2,3]triazolo[4,5-d]pyrimidines), their use as medicaments (in particular, their use as anti-thrombotic...
8	7339058	Process for the preparation of N-([1,2,4]triazolopyrimidin-2-yl)aryl sulfonamides The N-arylsulfilimine-catalyzed coupling of aromatic sulfonyl chlorides with N-([1,2,4]triazolopyrimidin-2-yl)amines to form N-([1,2,4]triazolo-pyrimidin-2-yl)aryl sulfonamides is improved by the...
9	7265124	Cristalline and amorphous form of a triazolo (4,5-D) pyridimine compound The invention provides new forms of a chemical compound of formula (I). The invention relates to forms of a chemical compound (I), in particular to crystalline and amorphous forms, more...
10	7250419	Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
11	7129244	Triazolopyrimidines and related analogs as HSP90-inhibitors A compound represented by Formula I, or a polymorph, ester, tautomer, enantiomer, diastereomer, pharmaceutically acceptable salt or prodrug thereof, Wherein R 1 is halogen, —OR 11 , —SR 11...
12	7115739	Triazole compounds useful as protein kinase inhibitors This invention describes novel triazole compounds of formula IX: wherein Z 1 is nitrogen or CR 9 and Z 2 is nitrogen or CH, provided that at least one of Z 1 and Z 2 is nitrogen; G is Ring...
13	7074929	Certain alkylene diamine-substituted heterocycles This invention relates to novel compounds, compositions, and methods for the treatment of physiological disorders associated with an excess of neuropeptide Y. The novel compounds encompassed by the...
14	7067663	Triazolo pyrimidine compounds Pyrimidine compound (I) useful as a pharmaceutical intermediate, a process for preparing the pyrimidine compound (I), to intermediates used in the process, and use of the pyrimidine...
15	7034032	Cyclopentan-2-ol-1-yl-[1,2,3]triazolo[4,5-D]pyrimidine compounds The invention provides novel 1,2,3-triazolo[4,5-d]pyrimidine compounds, such as those represented by formula (I): their use as medicaments, particularly in platelet aggregation disorders,...
16	6974868	Compounds The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
17	6858616	Nitrogen containing heterobicycles as factor Xa inhibitors The present application describes nitrogen containing heterobicyclics and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
18	6844348	2,3,4-cyclopentan-2,3,4-triol-1-yl compounds The invention provides a compound of formula (I): wherein R 1 is alkyl C 1-6 or alkenyl C 2-6 , both independently optionally substituted by one or more groups selected from alkyl C 1-5 or...
19	6790841	2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents Compounds which are active against viruses have the following Formulas: wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of...
20	6767910	Triazolo&lsqb 4,5-d&rsqb pyrimidinyl compounds Compounds of the formula (I) and their use as anti-platelet aggregation compounds.
21	6734180	NF-&kgr B inhibitor comprising an indan derivative as an active ingredient An inhibitor of NF-κB comprising as an active ingredient an indan derivative represented by the general formula (I) or a salt thereof.
22	6713483	&lsqb 1,2,3&rsqb -triazolo&lsqb 4,5-d&rsqb pyrimidine compounds The invention provides [1,2,3]-triazolo[4,5-d]pyrimidine analogue compounds of formula (I) The invention is also directed to pharmaceutical compositions containing the compounds, processes for...
23	6645965	Nitrate salts of antihypertensive medicines Nitric acid salts with medicines having an antihypertensive activity.
24	6635647	Decahydro-isoquinolines The invention provides compounds of formula (I) wherein A, B and R are as defined herein and the preparation thereof. The compounds of formula (I) are useful as somatostatin antagonists.
25	6525060	Triazolo(4,5-d)pyrimidine compounds Triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation. The compounds of the invention have the formula (I) as follows: ...
26	6525056	Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (CRH) antagonists, useful for treating cns and stress-related disorders Corticotropin releasing factor (CRF) antagonists of Formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress...
27	6458950	Compounds and pharmaceutical compositions containing the same A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the...
28	6458796	Dihydro-&lsqb 1,2,3&rsqb triazolo-&lsqb 4,5-d&rsqb pyrimidin-7-one The present invention relates to novel dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one, to processes for their preparation and to their use as medicaments, in particular as inhibitors of...
29	6455322	Competition binding assay for detecting P2YADP receptor ligands The invention provides a competition binding assay for detecting P2Y ADP receptor ligands.
30	6436945	Substituted O6-benzyl-8-aza-guanines The present invention provides AGT inactivating compounds, for example, substituted O 6 -benzyl-8-aza-guanines of the formula wherein R, for example, is pivaloyloxymethyl as well as...
31	6423716	Nitrogenous heterocyclic compounds The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): wherein W represents 1,4-piperazinediyl, etc.; U represents NR 1 R 2 (wherein R 1 ...
32	6376667	Solid phase synthesis of heterocycles Methods and compounds for the synthesis of heterocycles, including pyrimidine-2,4-diones, are disclosed. Also disclosed are solid supports useful for solid phase synthesis, and methods for making...
33	6369064	Triazolo(4,5-d)pyrimidine compounds Triazolo[4,5-d]pyrimidine compounds are provided of the formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the specification. Compositions containing the compounds are...
34	6297232	Triazolo[4,5-D]pyrimidinyl derivatives and their use as medicaments The invention relates to triazolo[4,5-d]pyrimidin-3-yl derivatives which are useful in the treatment of platelet aggregation disorders.
35	6251910	1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists Compounds of formula having the following stereochemistry ##STR1## wherein R, R 1 , R 2 , R 3 and R 4 are as defined in the specification. The compounds are useful as P 2T receptor antagonists.
36	RE37234	Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO n -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such...
37	6165942	Heterocycle-fused pyrimidinone derivative and herbicidal composition A compound represented by the general formula (I) and a salt thereof: ##STR1## wherein: Rf represents a (C 1 -C 4 )haloalkyl group; X.about.Y represents NN or CHN or the like; A represents a...
38	6156766	Benzamide compounds and pharmaceutical use thereof Benzamide compounds of the formula ##STR1## wherein each symbol is defined in the specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical...
39	6156756	Triazolo [4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
40	6124300	Aryloxy- and arylthio- fused pyridines and pyrimidines and derivatives Novel compounds and pharmaceutical compositions thereof, and methods of using same in treating anxiety, depression, and other psychiatric and neurological disorders. The novel compounds provided by...
41	6107300	Arylamino fused pyrimidines Corticotropin releasing factor (CRF) antagonists of formula I or formula II: ##STR1## and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
42	6046207	Benzopyranopyrrole and benzopyranopyridine α-1 adrenergic compounds The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic...
43	6030973	Heterocyclic compounds having antidiabetic hypolipidemia and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable...
44	5962684	Method of preparation of dideoxycarbocyclic nucleosides A therapeutic method is provided, employing an antiviral compound of the general formula: ##STR1## wherein Z is H, OR' or N(R) 2 , wherein R' is H, (C 1 -C 4 )alkyl, aryl, CHO, (C 1 -C 16...
45	5929079	Trans cyclopentanyl azaadenyl analogs useful as immunosuppressants This invention relates to Trans cyclopentanyl purine analogs of the formula (1) ##STR1## wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative...
46	5880129	Methods of inhibiting invasion and metastasis of malignant solid tumors A discovery underlying this invention is the concordance between particular cellular signaling mechanisms and cancer cell growth and metastasis. It has now been discovered that certain compounds...
47	5869659	Heteroatom-containing cyclopentanopyridyl-oxazolidinones The present invention relates to heteroatom-containing cyclopentanopyridyl-oxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.
48	5807854	Pyrimidone derivatives with antifungal activity Compounds of general formula I and their salts and solvates are antifungal agents and as such are useful in the treatment of various fungal infections. Pharmaceutical compositions including these...
49	5763608	Process for preparing pyrimidine derivatives The present invention provides a process for preparing a 5,6-dihydro-3H-pyrimidin-4-one derivatives which comprises the steps of (a) dehydrating a N-acyl beta amino acid in the presence of a...
50	5747496	Inhibitors of platelet aggregation Compounds of the formula (I) ##STR1## wherein B is O or CH 2 ; X is selected from NR 1 R 2 , SR 1 , and C 1 -C 7 alkyl; Y is selected SR 1 , NR 1 R 2 , and C 1 -C 7 alkyl; R 1 and...

Matches 1 - 50 out of 116

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