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7635702 |
Imidazole compounds as transforming growth factor (TGF) inhibitors
Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The...
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7625922 |
Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as therapeutic compounds
The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit...
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7612077 |
Crystalline forms of the anti-cancer compound ZD1839
The invention concerns certain crystalline solvates and hydrates of the compound of the Formula (I) which is known inter alia by way of the code number ZD1839. In particular, the invention concerns...
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7601713 |
Kinase inhibitors and their uses
The present disclosure provides compounds that inhibit protein kinases, such as JAK, Axl, or Syk kinases, compositions comprising the compounds and methods of using the compounds to inhibit protein...
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7598255 |
Pyrimidine compounds as serotonin receptor modulators
Certain pyrimidine-containing compounds are serotonin receptor modulators useful in the treatment of serotonin-mediated diseases.
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7582643 |
Heterocyclic compounds useful in treating diseases and conditions
The present invention relates to compounds of formula (I)
and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing...
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7576090 |
Benzazole analogues and uses thereof
The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof,
wherein
the substituents —Y are attached...
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7528137 |
Compounds, compositions, and methods
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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7491728 |
Pyrimidinone compounds as calcilytics
The pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
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7488435 |
Copper(I) complexes and processes for deposition of copper films by atomic layer deposition
The present invention relates to novel 1,3-diimine copper complexes and the use of 1,3-diimine copper complexes for the deposition of copper on substrates or in or on porous solids in an Atomic...
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7470693 |
Oxalamide derivatives as kinase inhibitors
The invention is directed to compounds having the following Formula I:
and methods of using them for the treatment of proliferative diseases.
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7470694 |
5,6-trimethylenepyrimidin-4-one compounds
Pyrimidone compounds of formula (I):
are inhibitors of the enzyme Lp-PLA 2 and are of use in treating atheroscelerosis.
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7465736 |
Azole methylidene cyanide derivatives and their use as protein kinase modulators
An azole derivative of formula (I)
a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of...
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7462620 |
Pyrimidinone derivatives and their use in the treatment of atherosclerosis
Compounds of formula (I):
are inhibitors of the enzyme Lp-PLA 2 and are of use in therapy, in particular for treating atherosclerosis.
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7456185 |
Substituted quinazoline compounds useful as p38 kinase inhibitors
Compounds having the formula (I),
are useful as p38 kinase inhibitors, wherein R 4 and R 5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R 6 and R 7 are...
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7442794 |
Rearranged pentanols, a process for their production and their use as anti-inflammatory agents
The invention relates to the compounds of formula I,
a process for their production and their use as anti-inflammatory agents.
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7439246 |
Fused heterocyclic kinase inhibitors
In general, the instant invention comprises compounds of Formulas I and II
including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase...
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7420056 |
Substituted bicyclic imidazo-3-ylamine compounds
Substituted bicyclic imidazo-3-yl-amine compounds are provided, as well as processes for the production thereof and pharmaceutical formulations containing these compounds. The use of these...
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7375102 |
Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
Compounds are provided having the formula:
wherein variables A 1 , A 2 , A 3 , A 4 , R 1 , R 2 , R 3 , R 4 , Q and L are as described herein. The subject compounds are useful for treatment of...
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7365066 |
Pyrazolopyridine derivatives as pharmaceutical agents
Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of...
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7365199 |
Dye-forming coupler, silver halide photographic light-sensitive material, and azomethine dye compound
A dye-forming coupler of formula (I), a silver halide photographic light-sensitive material containing the coupler, and an azomethine dye compound derived from the coupler:
wherein Q is a...
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7321033 |
3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention...
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7312180 |
Substituted 4-(4-trifluoromethylpyrazolyl)pyrimidines
A description is given of 4-(4-trifluoromethylpyrazolyl)pyrimidines of the formula (I) and of their use as herbicides.
In this general formula (I), R 1 , R 2 , R 3 and R 4 are various radicals...
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7307168 |
Process for the preparation of 3-{2-′4- (6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyllethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido′1,2-methyl-4h-pyrido′,2-a!pyrimidin-4-one
The invention relates to a process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl
}-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on
e of the Formula...
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7297700 |
Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
Bicycloheteroaryl compounds are disclosed that have a formula represented by the following:
The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and...
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7256287 |
Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
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7253168 |
Substituted 1-benzyl-4-substituted piperazine analogues
Compounds of Formula I are provided, in which variables are as described herein:
Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly...
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7232902 |
Process to prepare (1-carboxymethyl)-pyrimidinone compounds
The invention relates to a process for the preparation of certain pyrimidinone compounds.
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7223766 |
Bi-cyclic pyrimidine inhibitors of TGFβ
Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating...
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7223767 |
Tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists
Compounds of the formula (I):
and pharmaceutically acceptable salts or prodrugs thereof, wherein m, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. The invention also provides...
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7192949 |
Substituted bicyclic pyrimidinones as a mitotic kinesin KSP inhibitors
The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
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7176310 |
Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
This invention is directed to compound of the following formula (I):
wherein R 1 , R 2 , R 3 and R 4 are as described herein. These compounds and pharmaceutical compositions containing the...
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7169924 |
Pyrimidinone derivatives and their use in the treatment of atherosclerosis
Compound of formula (I):
are disclosed in which:
R 1 is an aryl group, optionally substituted by 1, 2, 3 or 4 substituents which may be the same or different selected from C (1-6)...
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7166595 |
Compounds, methods and compositions
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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7161002 |
Syntheses of quinazolinones
The present invention provides novel quinazolinone compositions of matter comprising enantiomerically pure compound represented by Formula I:
or a pharmaceutically acceptable salt thereof,...
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7160890 |
Compounds specific to adenosine A3 receptor and uses thereof
This invention pertains to compounds which specifically inhibit the adenosine A 3 receptor and the use of these compounds to treat a disease associated with A 3 adenosine receptor in a subject,...
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7153861 |
5,6 -Trimethylenepyrimidin-4-one compounds
Pyrimidone compounds of formula (I):
are inhibitors of the enzyme Lp-PLA 2 and are of use is treating atheroscelerosis.
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7138398 |
Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them
The present invention relates to compounds of formula (I) wherein R 1 , R 2 and R 3 have the meanings given in the claims. Said compounds are valuable active agents in medicaments for the...
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7119111 |
2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use
Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and...
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7105682 |
Substituted amine derivatives and methods of use
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7102009 |
Substituted amine derivatives and methods of use
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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RE39266 |
Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their...
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7098330 |
Pyrazolylamine substituted quinazoline compounds useful as protein kinase inhibitors
This invention describes novel pyrazole compounds of formula III:
wherein Ring D is a 5–7 membered monocyclic ring or 8–10 membered bicyclic ring selected from aryl, heteroaryl,...
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7087627 |
Combinations for the treatment of diseases involving angiogenesis
Compositions for the inhibition of the formation of new vasculature by angiogenesis are provided comprising the combination of a vasculature damaging agent and an inhibitor of the formation or...
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RE39197 |
Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods...
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7071190 |
Inhibitors to tubulin polymerization
The invention relates to the inhibition of tubulin polymerization. The invention provides compounds and methods for inhibiting tubulin polymerization. The invention also provides compositions and...
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7067662 |
CXCR3 antagonists
Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which...
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7026479 |
Process for the production of quinazolines
The invention provides a process for the production of a compound of formula (A), or a pharmaceutically acceptable salt or solvate thereof,
wherein R 1 , R 2 , R 3 , and R 4 are as defined...
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6989446 |
Process for the preparation of 3-aryl-benzofuranones
Process for the preparation of compounds of formula I
wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula V
wherein the general...
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6982332 |
Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering CNS activity
Compounds exhibiting CNS activity in mammalian species, having the structure
wherein A is an optionally heterocyclic 5 or 6 membered aromatic ring system;
R 2 is an organyl group...
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