|
Match
|
Document |
Document Title |
|
|
7618969 |
Compounds which potentiate glutamate receptor and uses thereof in medicine
Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed:
wherein R 1 is C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, amino, monoC 1-4...
|
|
|
7612203 |
Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
The present invention provides rosuvastatin and intermediates thereof having a low level of alkylether impurity and processes for the preparation thereof.
|
|
|
7601715 |
Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a...
|
|
|
7598255 |
Pyrimidine compounds as serotonin receptor modulators
Certain pyrimidine-containing compounds are serotonin receptor modulators useful in the treatment of serotonin-mediated diseases.
|
|
|
7598236 |
Diazabicyclic central nervous system active agents
Compounds of formula I
pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
|
|
|
7598260 |
CDK-inhibitory pyrimidines, their production and use as pharmaceutical agents
This invention relates to pyrimidine derivatives of general formula I
in which R 1 , R 2 , X, A and B have the meanings that are contained in the description, as inhibitors of the...
|
|
|
7595317 |
Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases
The present application describes novel barbituric acid derivatives of formula I:
or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R 1 , R 2 , R 3 , R 4 , R 5 , n,...
|
|
|
7595316 |
Heteroaryloxy nitrogenous saturated heterocyclic derivative
Compound of the formula: (I) [wherein each of X 1 , X 2 and X 3 independently represents N or CH, W represents the formula (II):(II) or the formula (III):(III) and Y represents a group of the...
|
|
|
7592337 |
Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
|
|
|
7592452 |
Process for catalytically preparing aromatic or heteroaromatic nitriles
The present invention relates to a process for preparing optionally substituted aromatic or heteroaromatic nitriles starting from haloaromatics. These are reacted in a copper-catalysed reaction...
|
|
|
7589200 |
5-Fluoro-4N-phenyl-4-pyrimidineamine compounds
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
|
|
|
7589115 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-pro
pionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the...
|
|
|
7589114 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-azetidine-carboxylic acids, esters and amides
Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonyl]-azetidin
e-carboxylic acids, esters and amides which exhibit good inhibitory effect upon the interaction of CAMs and...
|
|
|
7589088 |
Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
Compounds are provided having the formula (I)
wherein R, B, X and Y are as defined herein.
|
|
|
7579465 |
Antiviral agents
This invention relates to compounds of formula I
their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the...
|
|
|
7576110 |
Benzothiazole cyclobutyl amine derivatives
Compounds of formula (I)
are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
|
|
|
7572817 |
2,5-disubstituted 3-mercaptopentanoic acid
The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus...
|
|
|
7572793 |
3-Substituted-4-pyrimidone derivatives
A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1:
wherein R 1 represents...
|
|
|
7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
|
|
|
7569688 |
Propane-1, 3-dione derivative
Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione...
|
|
|
7560566 |
Process for producing heteroaromatic carboxylic acids
A process for the production of a heteroaromatic carboxylic acid comprising contacting in the presence of a catalyst, a precursor of said carboxylic acid with an oxidant, such contact being...
|
|
|
7550494 |
Small molecules useful in the treatment of inflammatory disease
Compounds of the formula I
which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary are:
|
|
|
7550461 |
Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases
Disclosed are amide compounds of formula (I):
wherein Ar 1 , Q, Y and R 3 -R 6 of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory...
|
|
|
7547700 |
Aryl-[4-halo-4(heteroarylmethylamino)-methyl]-piperidin-1-1yl]-methanone derivatives, methods for production and use thereof as medicaments
The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or...
|
|
|
7541361 |
N-[4,5-diphenylpyrimidin-2-yl)methyl]amine derivatives, the preparation thereof and their therapeutic use
The invention relates to compounds of formula (I):
Wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. The invention also relates to a method for preparing the aforementioned...
|
|
|
7538138 |
Amines as histamine-3 receptor ligands and their therapeutic applications
Compounds of formula (I)
or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the...
|
|
|
7538072 |
Stem/leaf desiccant
A stem/leaf desiccant for crop plants which comprises as an active ingredient, a compound of formula (I):
wherein X represent CH or nitrogen; Z represents halogen; A represents oxygen, sulfur,...
|
|
|
7537912 |
Methods of measuring luminogenic activity with a protected coelenterazine
A method of measuring the enzymatic activity of a luciferase includes contacting a luminogenic protein, such as a luciferase, with a protected luminophore to form a composition; and detecting light...
|
|
|
7534795 |
Compounds and their use related to compositions for treating disease
Novel compounds and their uses are disclosed herein.
|
|
|
7521451 |
Isoindoline derivative
Provided is a novel isoindoline compound of the formula (I):
The compound is useful for anesthesia by inducing sedation in a mammal.
|
|
|
7514446 |
Pyrimidine compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
|
|
|
7514432 |
Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis
The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as...
|
|
|
7511137 |
Stereoisomers and stereoisomeric mixtures of 1-(2,4-pyrimidinediamino)-2-cyclopentanecarboxamide synthetic intermediates
The present invention provides stereoisomers and stereoisomeric mixtures of 1-(2,4-pyrimidinediamino), 2-formamido cyclopentyl intermediates useful for the preparation of compounds having...
|
|
|
7511125 |
Pyrimidine derivatives for labeled binding partners
Compounds having structure (1)
wherein R 1 is —H a protecting group, a linker or a binding partner; and R 2 and R 34 are as defined in the specification. The invention also provides...
|
|
|
7507821 |
Process for preparing Imatinib
A novel process is disclosed for producing Imatinib, using the precursor 2-chloro-4-(3-pyridyl)-pyrimidine, thus improving Imatinib preparation via an alternative synthetic route, avoiding the use...
|
|
|
7504397 |
mTOR inhibitor compounds
Compounds of formula I:
A-B-C (I)
and isomers, salts, solvates, chemically...
|
|
|
7495000 |
Variolin derivatives and their use as antitumor agents
Variolin derivatives of formula (5) are provided, wherein the substituent groups defined by X 2 , R 1 , R 2 , R 3 , R 6 , R 7 and R 12 are each independently selected from the group consisting of...
|
|
|
7488732 |
2-substituted pyrimidines
2-Substituted pyrimidines of the formula I
in which the index n and the substituents L, R a , R b , R c , R z , R u , R v , A′, A″ and A′″ are as defined in the description and:
R 1 ...
|
|
|
7481847 |
Dye composition comprising at least one cationic hydrazone direct dye, dyeing process, and multi-compartment devices
The present disclosure relates to a composition for dyeing human keratin fibers, comprising at least one cationic direct dye of formula (I), described herein, and at least one cosmetic agent chosen...
|
|
|
7479494 |
3-monosubstituted tropane derivatives as nociceptin receptor ligands
Compounds of the formula
or a pharmaceutically acceptable salt thereof, wherein
R 1 is aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl,...
|
|
|
7468437 |
Phenyl pyrrolidine ether tachykinin receptor antagonists
The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular...
|
|
|
7462637 |
Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide
Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidi
ne-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are...
|
|
|
7459552 |
Method for producing cyclic diamine derivative or salt thereof
The present invention is directed to a method for producing a cyclic diamine compound (3) or a salt thereof through the following scheme:
(wherein Ar represents a phenyl group, a pyridyl group,...
|
|
|
7456281 |
Nucleic acid melting analysis with saturation dyes
Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A...
|
|
|
7456185 |
Substituted quinazoline compounds useful as p38 kinase inhibitors
Compounds having the formula (I),
are useful as p38 kinase inhibitors, wherein R 4 and R 5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R 6 and R 7 are...
|
|
|
7439345 |
Supramolecular pairing system, its preparation and use
The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula:
and oligomers thereof.
|
|
|
7429592 |
Cyanoanthranilamide derivatives and the use thereof as medicaments
Substituted cyanoanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds...
|
|
|
7427693 |
Polar liquid crystal
Compounds that are useful in compositions for flat panel displays, for example, are provided. The compounds provided are polar, and are useful in low threshold voltage mixtures. The compounds...
|
|
|
7420056 |
Substituted bicyclic imidazo-3-ylamine compounds
Substituted bicyclic imidazo-3-yl-amine compounds are provided, as well as processes for the production thereof and pharmaceutical formulations containing these compounds. The use of these...
|
|
|
7405214 |
Nucleoside derivatives and therapeutic use thereof
The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions...
|