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7601719 |
Compounds, methods and pharmaceutical compositions for inhibiting PARP
The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat,...
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7601718 |
Compositions useful as inhibitors of protein kinases
The present invention provides a compound of formula I:
or a pharmaceutically acceptable salt or mixtures thereof. These compounds are inhibitors of protein kinases, particularly...
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7569517 |
4-biphenyl-substituted pyrazolidin-3 5-diones pesticide agent and/or microbicide and/or herbicide
The invention relates to novel 4-biphenyl-substituted 4-substituted pyrazolidine-3,5-diones of the formula (I)
in which
A, D, G, W, X, Y and Z are as defined above, to processes and...
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7563893 |
3-Phenyl-cinnoline analogue and antitumor agent using the same
The present invention relates to a 3-phenyl-cinnoline compound or a physiologically acceptable salt thereof, and a cell proliferation inhibitor and an antitumor agent comprising the same, as an...
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7560450 |
Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to substituted xanthines of general formula
the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable...
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RE40793 |
Bicyclic benzamides of 3-or 4-substituted 4-(aminomethyl)-piperidine derivatives
The present invention of compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R 1 and R 2 ...
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7547697 |
Alkyl-pyridazine derivatives as 11b-HSD1 inhibitors
Compounds of formula (I):
as well as pharmaceutically acceptable salts and esters thereof for use as pharmaceutical compositions.
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7528139 |
Sulfonamides
Compounds of the formula (I), in which R 6 , R 7 , R 8 , R 9 and X have the meanings indicated in claim 1 , are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be...
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7517988 |
Hydroxamates as therapeutic agents
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore...
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7488739 |
Quinolone derivative or salt thereof
A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically...
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7485643 |
Bicyclic inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula I
and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 20 , R 21 , and R 22 are as defined in...
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7482345 |
P38 kinase inhibiting agents
Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof:
are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of...
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7465795 |
Compounds and uses thereof
This invention relates to novel compounds having the structural formula I below:
and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and...
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7459414 |
Herbicides
Compounds of formula
wherein the substituents have the meanings given in claim 1 , and agronomically tolerable salts, isomers and enantiomers of those compounds, are suitable for use as...
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7442794 |
Rearranged pentanols, a process for their production and their use as anti-inflammatory agents
The invention relates to the compounds of formula I,
a process for their production and their use as anti-inflammatory agents.
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7442793 |
Peptide deformylase inhibitors
Novel PDF inhibitors and novel methods for their use are provided.
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7419511 |
Compositions comprising at least one substituted carbocyanin derivative, processes for treating keratin fibers using them, device therefor and uses thereof
The disclosure provides compositions comprising, in a cosmetically acceptable medium, at least one direct dye, processes for treating keratin fibers, such as human keratin fibers, using the...
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7417062 |
Substituted arylamides
Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.
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7417041 |
Imidazopyrimidines as transforming growth factor (TGF) inhibitors
Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described....
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7329770 |
Esters as useful broad spectrum herbicidal compounds
The instant invention relates to the discovery of certain novel herbicidal esters of agriculturally active acids. These esters present agronomical advantages over traditional herbicidal products by...
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7317009 |
Pyrrolopyridazine derivatives
The invention relates to compound of the formula (I) or its salt, in which R 1 , R 2 , R 3 and R 4 are as defined in the description, their use of as medicament, the process for their preparation...
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7300932 |
Pyrrolo[1,2-b]pyridazine derivatives
Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the...
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7288650 |
Cyclic substituted fused pyrrolocarbazoles and isoindolones
The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused...
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7256287 |
Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
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7232826 |
Tyrosine kinase inhibitors
The present invention provides compounds of Formula I or II that are useful as anti-cancer agents and other diseases that can be treated by inhibiting tyrosine kinase enzymes
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RE39663 |
Electron-deficient nitrogen heterocycle-substituted fluorescein dyes
The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in...
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7192968 |
Ethylenediamine derivatives
The invention relates a compound represented by the formula (1):
Q 1 -Q 2 -C(═O)—N(R 1 )-Q 3 -N(R 2 )-T 1 -Q 4 ( 1...
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7189715 |
Compositions comprising zopiclone derivatives and methods of making and using the same
The invention is directed to racemic and stereomerically pure compounds of Formula 3:
and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation.
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7186720 |
Tetrahydropyridyl-alkyl-heterocycles, method for preparing the same and pharmaceutical compositions containing the same
The present invention relates to compounds of formula (I):
in which X represents N or CH; R 1 represents a hydrogen or halogen atom or a CF 3 group; R 2 and R 3 independently represent a...
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7166723 |
Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
Methods of preparing compounds of Formula I
are provided.
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7148249 |
Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
The present invention relates to heterocyclically substituted indolinones of general formula
wherein
R 1 to R 5 and X are defined as in claim 1, the tautomers, the diastereomers, the...
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7135470 |
Thienopyridazines as IKK inhibitors
The invention provides compounds of the formula I:
or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein: A, Y, Z and R 1 are as defined herein. Also provided are...
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7135471 |
Aryl oximes
Aryl oxime derivatives of the formula (I), in which R 1 , R 2 , R 3 , X and B are as defined in claim 1 , act as phosphodiesterase IV inhibitors and can be employed for the treatment of...
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7132418 |
Peptidyl heterocyclic ketones useful as tryptase inhibitors
The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment...
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7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
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7105661 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7087610 |
Benzothiazole antiviral agents
The invention encompasses a series of benzothiazole compounds which inhibit HIV entry and are useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions...
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7081526 |
Process for manufacturing morpholino-nucleotides, and use thereof for the analysis of and labelling of nucleic acid sequences
The invention relates to the use of morpholino-nucleosides of formula:
in which R 1 represents a nucleic base and R 2 represents a group corresponding to one of the following formulae:
...
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7081468 |
Ortho-substituted anthranilic acid amides and their use as medicaments
Ortho-substituted anthranilic acid amides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described.
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7074791 |
Pyrrolo[1,2-b]pyridazine compounds and their uses
Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors,...
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7064126 |
Compounds
The invention relates to thienopyridazinones of formula (I): wherein: R 1 is C 1-6 alkyl, C 2-6 alkenyl or C 3-6 cycloalkyl which is optionally substituted by C 1-6 alkyl, each of the above...
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7056917 |
Drug efflux pump inhibitor
A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I):
wherein,...
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7045522 |
8-Azabicyclo[3.2.1]oct-2-ene and -octane derivatives technical field
The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their...
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7030112 |
Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
Disclosed are pyrrolopyridazine compounds of the formula,
wherein the substituents are defined herein,
methods of preparing such compounds, and their use for the treatment of proliferative,...
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7030239 |
Compounds to treat Alzheimer's disease
The present invention is directed toward substituted hydroxyethylene compounds of formula (XII)
useful in treating Alzheimer's disease and other similar diseases.
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7015224 |
7-Tert-butyl-3-(2-fluorophenyl)-6-(2H-(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo (4,3b) pyridazine for the treatment of anxiety and convulsions
The compound (I) is a GABA a receptor ligand, functionally selective for the α2 and/or α3 subunit, and is useful in the treatment of deleterious mental states, in particular anxiety.
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6995154 |
Heterocyclic topoisomerase poisons
The invention provides compounds of formula I:
wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
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6989447 |
Compounds
Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.
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6924284 |
PARP inhibitors
The present invention provides compounds comprising a bicyclic aryl moiety, such as 2H-phthalazin-1-one or derivatives thereof, compositions comprising the same, and methods for producing and using...
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6911442 |
Quinoline derivatives as antibacterials
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or N-oxide thereof:
corresponding novel medicaments, pharmaceutical compositions and/or...
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