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7642255 |
Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated...
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7642303 |
Thermoplastic articles for packaging UV sensitive materials, processes for the articles production and use and novel UV absorbers
Thermoplastic composition and articles containing UV absorbers that protect the articles contents from harmful UV radiation are disclosed as well as methods for making the thermoplastic articles...
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7569526 |
Anti-oxidants in soluble oil base for metal working fluids
Disclosed herein is a method for reducing the oxidative and biological degradation of a metalworking fluid comprising adding thereto at least one antioxidant and at least one biocide.
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7550463 |
Carbamoylpyridone derivatives having inhibitory activity against HIV integrase
An object of the present invention provides a novel compound having the anti-viral activity, particularly, the HIV integrase inhibitory activity, and a drug containing the same, particularly, an...
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7507734 |
Pyridazinone derivatives
Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R 1 and R 2 are detailed in the description, as well as their physiologically acceptable...
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7476699 |
Amino- and hydroxysubstituted triphenyl-s-triazines as stabilizers
The present invention provides compounds having the formula:
in which R is hydrogen, hydroxy, halogen, C 1 -C 20 -alkyl, C 4 -C 12 cycloalkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 1 -C 20...
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7405296 |
Additives for fluorinated oils
Compounds of formula
wherein
R f is a (per)fluoropolyoxyalkylene chain having a number average molecular weight in the range 500-10,000; W 1 , W 2 , equal to or different from each...
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7354924 |
Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl...
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7268228 |
Optically active aziridine-2-carboxylate derivatives and a process for preparing them
This invention relates to compounds of Formula I having an aziridine-2-carboxylic group and a menthol group, a process for preparing such compounds, a method for obtaining optically active...
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7230098 |
Aminoheteroaryl compounds as protein kinase inhibitors
Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein...
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7214742 |
2-hydroxyphenyl-s-triazine crosslinkers for polymer networks
Compounds of the general formula I′
in which
R 1 is H, C 1 –C 12 alkyl; C 5 –C 12 cycloalkyl; C 2 –C 18 alkyl which is interrupted by one or more O; SR 4 ; OR 5 ; or is a group of...
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7135471 |
Aryl oximes
Aryl oxime derivatives of the formula (I), in which R 1 , R 2 , R 3 , X and B are as defined in claim 1 , act as phosphodiesterase IV inhibitors and can be employed for the treatment of...
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7129241 |
Pyridazine derivatives
Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis,...
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7122547 |
Anthranilic acid amides and the use thereof as medicaments
The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products...
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7064125 |
LPAAT-β inhibitors and uses thereof
The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity. The invention further relates to methods of treating cancer using...
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7026307 |
Method for producing 1,3-disubstituted 2-nitroguanidines
The present invention relates to a process for the preparation of compounds of the formula (I)
by reacting compounds of the formula (II)
in which
R 1 , R 2 , R 4 and Het are as...
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7026477 |
Process for preparing substituted phenylsulfonylureas from sulfonyl halides
The invention relates to a preparation process for a compound (I) or a salt thereof,
in which Q, X*, Y, Z, R, R 1 , R 2 and R 3 are as defined in claim 1 ,
which comprises
a)...
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6903097 |
Heterocycle carboxamides as antiviral agents
The present invention provides a compound of formula I
which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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6867250 |
Non-yellowing ortho-dialkyl aryl substituted triazine ultraviolet light absorbers
The invention relates generally to pyrimidines and triazines ultraviolet light absorbers containing a phenolic aromatic group(s) and a non-phenolic aromatic group(s) and the use thereof to protect...
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6855269 |
Phenyl ether-substituted hydroxyphenyl triazine ultraviolet light absorbers
This invention relates generally to phenyl ether substituted triazines compounds and compositions containing same and their use to protect against degradation by environmental forces. A method for...
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6846818 |
Selective inhibitors of cyclooxygenase-2
The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I:
pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The...
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6838415 |
Substituted benzoylisoxazoles and the use thereof as herbicides
The invention relates to novel substituted benzoylisoxazoles of the general formula (I),
in which
n represents the number 0, 1, 2 or 3, A represents a single bond or represents...
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6835329 |
Heteroaryl substituted hydroxyphenyltriazine uv-absorbers
The present invention provides compounds having the formula (1) in which each of the radicals R 1 , R 2 , R 3 and R 4 , independently, represent hydrogen, hydroxy, halogen, C 1 -C 20 -alkyl, C 1...
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6803349 |
Heterocyclic ring-containing compound and a lubricant composition using the same
A heterocyclic ring-containing compound represented by the following formula (1). In the formula, D represents a heterocyclic ring residue having a 5- to 7-membered ring structure and substituted...
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6773861 |
UV absorbent and preparation method thereof, compositions and image forming method
A UV absorbent represented by the following formula (1) [R 1 represents an alkenyl group, all of R 1 represent the same group, and R 2 , R 3 and R 4 independently represent a hydrogen atom, an...
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6706743 |
β3 adrenergic receptor agonists and uses thereof
The instant invention provides β 3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds,...
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6677353 |
Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6677341 |
(R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
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6664391 |
N-fluorotriazinium fluorinating agents
Novel N-fluorotriazinium electrophilic fluorinating agents have the Formula I: wherein three A moieties are independently CR, where each R is, independently, hydrogen, halogen, hydroxyl,...
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6635760 |
Ring fluorination of non-activated aromatic compounds
Aromatic compounds having one or more electron-withdrawing substituents are fluorinated, preferably in a nitromethane solvent, by contact with tri(halo- or trifluoromethyl) substituted...
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6624166 |
Pyridazines as interleukin-1β converting enzyme inhibitors
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R 1 is a halogen, or an oxygen linked leaving group including an aromatic ether, an alkyl...
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6617325 |
Biphenyl derivatives, production thereof and uses as medicines
The present invention relates to biphenyl derivatives of general formula wherein R a to R g and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically...
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6573219 |
Substituted heterocyclyl-2H-chromenes
The invention relates to novel substituted heterocyclyl-2H-chromenes of the general formula (I) in which R 1 , R 2 , R 3 , R 4 , R 5 Z are each as defined in the description, and to a process...
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6559100 |
2-benzoyl-cyclohexane-1,3-diones
Substituted 2-benzoylcyclohexane-1,3-diones of the formula I where: R 1 and R 2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6...
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6528648 |
Detecting reagent for double-stranded nucleic acid and double-stranded nucleic acid detecting method
The present invention provides a novel detecting reagent for double-stranded nucleic acid, and a method of using it to detect double-stranded nucleic acid formed by hybridization with a probe, with...
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6528455 |
Phenoxy-and thiophenoxy acrylic acid compounds as herbicides
Phenoxy- and thiophenoxyacrylic acid compounds of the formula I in which Het, R 1 , R 2 , R 3 , V, W and Z are as defined in claim 1 and processes for their preparation, intermediates for...
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6521609 |
Use of CGRP antagonists and CGRP release inhibitors for combating menopausal hot flushes
A method for treating menopausal hot flushes using CGRP antagonists and/or CGRP release inhibitors and the corresponding pharmaceutical compositions containing as active substance one or more CGRP...
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6469006 |
Antiviral indoleoxoacetyl piperazine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl...
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6462043 |
Method for producing substituted-2-nitroguanidine derivatives
The invention relates to a method for producing an organic compound of formula (I) and optionally its E/Z-isomers, E/Z-isomer mixtures and/or tautomers, each in free or salt form, R 1 representing...
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6448244 |
Water soluble azoles as broad-spectrum antifungals
The present invention concerns novel water-soluble azole compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof;...
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6432900 |
Ligand and complex for catalytically bleaching a substrate
The invention relates to ligands or complexes useful as catalysts for catalytically bleaching substrates with atmospheric oxygen, and as catalysts in the of treatment of textiles such as laundry...
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6403521 |
Catalyst comprising nitrogen-containing heterocyclic compound, and process for producing organic compound using the catalyst
A catalyst is for use in a reaction using an oxygen-atom-containing reactant and includes a nitrogen-containing heterocyclic compound of the following formula (1): wherein each of R 1 and R 2 ...
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6399620 |
Cycloalkyl derivatives as inhibitors of bone resporption and vitronectin receptor antagonists
There are described cycloalkyl derivatives of the formula (I) R 1 —Y—A—B—D—E—F—G (I) in which R 1 , Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and...
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6348591 |
Red-shifted trisaryl-1,3,5-triazine ultraviolet light absorbers
This invention relates generally to red-shifted trisaryl-1,3,5-triazines and the use thereof to protect against degradation by environmental forces, inclusive of ultraviolet light, actinic...
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6329523 |
Compounds having a plurality of nitrogenous substitutents
Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring...
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6319922 |
Propanoic acid derivatives
Propanoic acid derivatives of formula (1) are described: Ar--X 1 --Ar 1 --Z--R (1) in which Ar is a nitrogen base containing group; X 1 is linker atom or group; Ar 1 is an...
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6313097 |
Antagonists of calcitonin gene-related peptide
Compounds of the formula (I) ##STR1## wherein A, R, R 1 , R 2 , X 1 , X 2 , X 3 , and Y are as defined herein, and the tautomers and the pharmaceutically acceptable salts thereof, including...
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6306939 |
Poly-trisaryl-1,3,5-Triazine carbamate ultraviolet light absorbers
The present invention relates to novel carbamate containing trisaryl-1,3,5-triazines and the use thereof as an ultraviolet light absorber. In particular, the presently claimed compounds comprise a...
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6288065 |
Quinoxaline-carboxylic acid derivatives
The disclosure relates to quinoxaline derivates of Formula I ##STR1## wherein R 1 , R 4 , R 5 , R 6 , R 7 and R 8 are defined in the disclosure, as well as their production and use in...
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6281211 |
Substituted semicarbazides and the use thereof
This invention is related to substituted semicarbazides represented by Formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein: R 1 and R 2 are independently hydrogen,...
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