Matches 51 - 100 out of 186 < 1 2 3 4 >
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6525000 Method for producing anellated triazoles and new anellated triazoles and their use  
A process for preparing fused triazoles of formula I where: X—X is C—O, C—S, C—SO, C—SO 2 , or C—NR 1 ; V is C═W 2 , R 1 R 2 C—C(═W 2 )— or C(═V 2 )—C(═W 2 ); W 1 , W 2...
6492364 Triazolo and derivatives as chemokine inhibitors  
Novel triazolo derivatives represented by the following formula and pharmaceutically acceptable salts thereof, as well as chemokine inhibitors containing the same as an effective component. These...
6486158 &lsqb 4,5&rsqb -fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia  
[4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in...
6476029 7-alkyl- and cycloalkyl-substituted imidazotriazinones  
The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of...
6458758 Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules  
Compositions and processes to alleviate free radical toxicity are disclosed based on the use of nitroxides in association with physiologically compatible macromolecules. In particular,...
6448248 Heterocyclic carboxylic acid derivatives, the production and use thereof as endothelin receptor antagonists  
The present invention relates to carboxylic acid derivatives of the formula I where the substituents have the meanings explained in the description, and to preparation and use as endothelin...
6420365 Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors  
Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein A, B, C, D, Y, R 1 , R 3 , R 4 , R 5 , and R 6 are variables defined herein, which...
6416922 Azomethine dye precursor, image-forming material, and image-forming method  
The present invention related to an azomethine dye precursor represented by the following general formula (1) and the image-forming material and image-forming method using the azomethine dye...
6362178 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors  
The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and...
6355638 Pyrazolo&lsqb 1,5-d&rsqb &lsqb 1,2,4&rsqb triazines for enhancing cognition  
Compounds according to Formula (I) or a salt thereof are GABA-A Alpha 5 ligands useful for enhancing cognition:
6316448 Pyrazolo[3,4-d][1,2,3] troazines having anticonvulsant activity and process for their preparation  
The invention relates to 3,6-dihydropyrazolo[3,4-d][1,2,3]triazin-4-ones and their tautomers, which contain a benzyl radical in the 6 position, processes for their preparation and their use as...
6166019 Piperazinyl pyrimidine dione compounds selective for adrenoceptors  
Compounds of Formula I and II and their pharmaceutically acceptable, salts, esters and prodrugs thereof are selective alpha-1D adrenoceptor anatagonists and may be useful for treating disease states.
6166015 Pyrrolidine derivatives-CCR-3 receptor antagonists  
This invention relates to certain 3-aminomethylpyrrolidine derivatives of Formula (I): ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their...
6103731 Imidazol[1,5-c]quinazolines; a new class of GABA brain receptor  
Disclosed are compounds of compounds of the formula: or the pharmaceutically acceptable nontoxic salts thereof wherein: X is oxygen, H 2 or sulfur Y is hydrogen, or optionally substituted...
6075016 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity  
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram, with improved selectivity with regard...
5955465 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones  
The present invention encompasses structures of the Formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: X is oxygen, H 2 , or sulfur; Y is oxygen or sulfur; ...
5869659 Heteroatom-containing cyclopentanopyridyl-oxazolidinones  
The present invention relates to heteroatom-containing cyclopentanopyridyl-oxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.
5808060 Fused isoindolones  
Disclosed are biologically active, non-indole-containing compounds referred to as fused isoindolones, which are represented by the following general formula: ##STR1## The fused indolones can be...
5786361 Pyridazino-, pyrimido-, pyrazino- and triazinoindoles, -pyrrolocycloalkenes or pyrrolooxocycloalkenes, or pyridopyrrolylpyrido compounds, compositions containing them, and use thereof to treat atherosclerosis  
Compounds of the formula (I): ##STR1## are prepared by reaction of the phenylacetic acid derivatives substituted by the appropriate heterocycles, optionally in an activated form, with...
5739326 Heterobicyclic herbicides  
Compounds of Formula I, and their N-oxides and agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein: X and Y are independently N or...
5726126 1-(3-heterocyclyphenyl)-S-triazine-2,6,6-oxo or thiotrione herbicidal agents  
There is provided a 1-(3-heterocyclylphenyl)-s-triazine-2, 4,6-oxo or thiotrione compound having the structural formula I ##STR1## Further provided are a composition and a method comprising that...
5658857 Imidazoazines  
The invention relates to new imidazoazines of the general formula (I) ##STR1## in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, D, E and G have the meanings given in the description, to processes...
5658906 Cysteine protease and serine protease inhibitors  
The present invention is directed to irreversible inhibitors of serine and cysteine proteases which most preferably contain a 1-oxytriazole or 1-oxyimidazole functionality. Methods for the use of...
5641763 N-phosphonylmethoxyalkyl derivatives of pyrimdine and purine bases and a therapeutical composition therefrom with antiviral activity  
This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and...
5633218 Herbicidal benzodioxoles and benzodioxanes  
Compounds of Formula I, and their N-oxides and agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation ##STR1## wherein: ##STR2## T is O or S; W is a...
5514678 Arthropodicidal 1,2,4-triazinyl amides  
Substituted amides, agricultural compositions containing them and a method to control arthropods in agronomic and non-agronomic environments, the amides having formula (I) wherein X is oxygen or...
5491126 Substituted fused heterocyclic herbicides  
This invention relates to substituted fused heterocyclic compounds of Formula I which have utility as herbicides: ##STR1##
5472964 Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists  
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents....
5399560 1,2,4-triazine products resulting from the inhibition of advanced glycosylation  
The mechanism of the inhibition of advanced glycosylation by aminoguanidine and other hydrazine type compounds was investigated using a solution of one or two molecules of aminoguanidine or other...
5378679 Heteroaromatically condensed hydroxypyridonecarboxamides, their preparation and use  
Heteroaromatically condensed hydroxypyridonecarboxamides of the structure I ##STR1## where the substituents and the ring Q have the following meanings: R 1 hydrogen, hydroxyl, substituted or...
5332744 Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists  
Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in...
5284854 2-aminopyrimidinone derivatives  
2-Amino-pyrimidininone derivatives possessing serotonin-antagonistic and anti-histaminic properties. Compositions containing these compounds as the active ingredient. Method of treating subjects...
5256667 Quinazolinones and pyridopyrimidinones  
Substituted quinazolinones and pyridopyrimidines of structural formula I ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the renin-angiotensin system (RAS)...
5179093 Quinoline-diones  
Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein, R is H, halogen, (C 1 -C 6 ) alkyl, N(C 1 -C 6 alkyl/aryl) 2 , OH, O--(C 1 -C 6 ) alkyl/aryl, CH 2 OH,...
5069708 Pyrimido(5,4-e)-as-triazine-5,7(6H,8H)-diones  
Herbicidal agents containing a pyrimido[5,4-e]-as-triazine-5,7-(6H,8H)-dione Ia ##STR1## (R 1 , R 2 H, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 8 -alkenyl, phenyl or benzyl, R 3 ...
5028598 Oxetanocin derivatives and their salts as well as use thereof  
Oxetanocin derivatives represented by formula: ##STR1## wherein X represents H or ##STR2## or a pharmacologically acceptable salt thereof exhibit an anti-viral activity. Anti-viral compositions...
5017212 Sulfonylurea compounds and herbicidal use  
A compound of the general formula: ##STR1## wherein Q is a condensed heterocyclic group having an N atom in the bridgehead which may be substituted, W is O or S, R 1 and R 2 each are an alkyl...
4981507 Herbicidal triazoloazines  
Herbicidal triazoloazines of the formula ##STR1## in which A stands for nitrogen or for a radical C--R 3 , R 1 , R 2 and R 3 independently of one another each stand for hydrogen, hydroxyl,...
4959367 4-oxo-1,2,3-benzotriazines  
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein X is N or CH; R 1 and R 2 are the same or different and are hydrogen, halogen, CF 3 , C 1 -6 alkyl, C 1...
4921527 Herbicidal sulfonamides  
The invention relates to sulfonylurea compounds with a substituted or unsubstituted bicyclic nine-membered ring having one to five heteroatoms which are preemergent and/or postemergent herbicides...
4920119 Triazine derivatives  
Compounds of the formula ##STR1## wherein A represents a grouping of the formula ##STR2## in which R 1 and R 2 each individually represent hydrogen, halogen, trifluoromethyl, nitro, amino, cyano,...
4908056 Heterocyclic acyl sulfonamides  
This invention relates to novel heterocyclic carbonyl sulfonamides which are particularly useful as agricultural chemicals.
4908364 Substituted 3-phenyl-7H-thiazol[3,2-b][1,2,4]-triazin-7-ones  
Novel substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]-triazin-7-ones of the formula I are disclosed ##STR1## in which R 1 , R 2 and R 3 have the meaning recited in the specification. The compounds...
4880824 Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers  
Heterocyclic compounds of formulae (I) and (II): ##STR1## where R 1 and R 2 are alkyl, R 3 is H or alkyl, m is 2-5 and Het is a hetercycle such as thiazole, benzothiazole, substituted...
4778511 Fluorine-containing N-sulphenylated indazoles for use as bactericides and fungicides  
Novel fluorine-containing N-sulfenylated indazoles are prepared by reacting the corresponding indazoles with sulfenyl halides in the presence of a solvent and/or diluent and in the presence of an...
4743586 Method of treating hypertension using substituted imidazo[1,5-d]1,2,4-triazin-1(2H)-ones  
This disclosure describes compositions of matter containing certain substituted imidazo[1,5-d]-1,2,4-triazin-1(2H)-ones and the method of treating hypertension therewith.
4722929 Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same  
The invention relates to novel 2-phenyl-imidazoles of the formula ##STR1## and the tautomers and acid addition salts thereof, particularly the pharmacologically acceptable acid addition salts,...
4670438 Imidazo[4,5-c]pyridazine-3-ones, imidazo[4,5-d]pyridazine-4-ones, imidazo[4,]pyrazin-5-ones, purin-2-ones, purin-6-ones, and purin-2,6-diones useful as hypotensive or cardiotonic agents  
Compounds of the formula ##STR1## wherein A, B, C and D are --N, HN, R 3 N, OC, HC.tbd., HO--C.tbd. or R 3 SO 2 --O--C.tbd.; and R 1 and R 2 are substituents of various...
4656171 2-phenyl-imidazo-pyrazines, useful as cardiotonics  
Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N or --CH, provided, however, that at least two of them must be --N, and when A and C are both --N, at...
4636502 Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines  
This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.
Matches 51 - 100 out of 186 < 1 2 3 4 >