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9040618 Rubber composition including a 1,2,4-triazine derivative  
A rubber composition for manufacturing tyres is based on one or more diene elastomers, one or more reinforcing fillers, and a vulcanization system. The vulcanization system includes one or more...
9040530 1,2,4-triazine-6-carboxamide kinase inhibitors  
Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for...
9034850 Gonadotropin releasing hormone receptor antagonist, preparation method thereof and pharmaceutical composition comprising the same  
Disclosed are compounds useful as gonadotrophin-releasing hormone (“GnRH”) receptor antagonist.
9024019 Insecticidal triazinone derivatives  
Compounds of the formula (I) or (I′), wherein the substituents are as defined in claim 1, are useful as pesticides.
9018224 Substituted cyclopropyl compounds useful as GPR119 agonists  
Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The...
9000155 Cyclic triazo sodium channel blockers  
The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The...
8987256 Oxo-heterocyclic substituted carboxylic acid derivatives and the use thereof  
The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment...
8969554 6-acyl-1,2,4-triazine-3,5-dione derivative and herbicides  
Disclosed are compounds exhibiting sufficient herbicidal activity at low application dosage when they are applied to soils and foliage, and an agrochemical composition using the same, in...
8940891 Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto  
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions...
8895553 Oligomer-containing substituted aromatic triazine compounds  
The invention relates to (among other things) methods for treatment comprising administering oligomer-containing substituted aromatic triazine compounds. A compound of the invention, when...
8846669 Oxazolidinone derivative and medical composition containing same  
Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group. In Formula 1, R...
8822465 Quinoline compound composing 1,2,4-triazine-dione and use thereof  
The present invention relates to a quinoline derivative represented by general formula (I) or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof, wherein Ar, R1, R2, R3, X, Y...
8816079 Amide derivative and use thereof as medicine  
Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a...
8809525 1,2,4-triazine-4-amine derivatives  
According to the invention there is provided a compound of formula A1 which may be useful in the treatment of a condition or disorder ameliorated by the inhibition of the A1-A2b or, particularly,...
8779129 Triazinedione derivatives as GABAB receptor modulators  
The present invention provides novel compounds of formula I wherein W1, W2, W3, W4, W5, B, X1, X2, X3, X4, X5, E and L are as defined herein; invention compounds are gamma amino butyrique acid...
8772479 Oligomer-containing substituted aromatic triazine compounds  
The invention relates to (among other things) oligomer-containing substituted aromatic triazine compounds. A compound of the invention, when administered by any of a number of administration...
8772291 Multicyclic compounds and methods of their use  
This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.
8765943 1,2,4-triazine suitable as a vulcanization accelerator and method for producing same  
A 1,2,4-triazine of formula (I): and its process of manufacture and use.
8754210 Method for preparing 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl) derivative and intermediate used therein  
Disclosed are: a method for preparing a 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin- 1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)thiophene-2-carboxa mide derivative, which is a...
8748599 Cyclic triazo sodium channel blockers  
The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The...
8748600 Cyclic triazo sodium channel blockers  
The present invention relates to triazine compounds having sodium channel blocking properties, and to use of the compounds for preparation of medicaments for treatment of associated disorders. The...
8703939 Method for preparing (R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl)oxazolidin-2-one derivatives  
Provided are a method for preparing (R)-3-(3-fluoro-4-(1-methyl-5, 6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(substituted methyl) oxazolidin-2-one derivatives, which are oxazolidinone antibiotic...
8697698 Pyrazole compounds useful as protein kinase inhibitors  
This invention describes novel pyrazole compounds of formula III: wherein Z1, Z2, and Z3 are as described in the specification; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1 is T-Ring D, wherein Ring D...
8691818 Cyclic triazo and diazo sodium channel blockers  
Compounds of general structure in which X and Y are each N or C with at least one of X and Y being N; Z is a single bond or an optionally substituted linking group R1 is hydrogen or a substituent...
8685964 Heterocyclic compounds as pesticides  
The present application relates to the use of heterocyclic compounds, some of which are known, for controlling animal pests including arthropods and in particular insects, furthermore to novel...
8648073 Certain dipeptidyl peptidase inhibitors  
Provided are certain dipeptidyl peptidase inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
8618287 Derivatives of triazines and uracils, their preparation and their application in human therapeutics  
The present invention relates to derivatives of general formula I wherein: —W represents nitrogen, —R1 represents: •a hydrogen or a linear or branched C1-C5 alkyl radical or, •a C1-C3 alkyl...
8552183 Process for the covalent coupling of two molecules by means of a diels-alder reaction with inverse electron requirement  
The present invention relates to a process for linking two molecules by means of a Diels Alder reaction with inverse electron requirement (DARinv), comprising the following steps: reaction of a...
8524712 Triazinone and diazinone derivatives useful as HSP90 inhibitors  
The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the...
8492540 1,2,4,-triazin-3,5-dione compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor  
The invention relates to compounds of the formula I: whereinA is a saturated or unsaturated hydrocarbon chain having a chain length of 4 to 6 carbon atoms, the hydrocarbon chain being...
8486927 Crystalline forms of lamotrigine  
The invention is directed to novel crystalline forms of lamotrigine. These novel crystalline forms of lamotrigine have improved dissolution and in-vivo absorption profile, as compared to pure...
RE44354 Amyloid plaque aggregation inhibitors and diagnostic imaging agents  
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to...
RE44338 Amyloid plaque aggregation inhibitors and diagnostic imaging agents  
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to...
8461080 Aluminum silicate-free, highly concentrated suspension concentrates of metribuzin  
The invention relates to aqueous, aluminum silicate-free, highly concentrated suspension concentrates, containing the active substance metribuzin, one or more surfactants based on nonionic...
8435990 Dihydropyrimidone amides as P2X7 modulators  
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5, Ra and Rb are as defined herein. Also disclosed are methods of making the compounds and...
8415368 Acid secretion inhibitor  
The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented...
8410098 N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-OXO-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof  
Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5- dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III and utilized for preparing...
8344138 Triazinedione derivatives as GABAB receptor modulators  
The present invention provides novel compounds of formula I wherein W1, W2, W3, W4, W5, B, X1, X2, X3, X4, X5, E and L are as defined herein; invention compounds are gamma amino butyrique acid...
8309740 One-pot synthesis of fluorinated ionic liquids  
The present invention relates to a method for one-pot synthesis of ionic liquid with fluoroalkyl group, more particularly to a method for one-pot synthesis of ionic liquid with fluoroalkyl group...
8293898 Luminophores  
There is described novel organo-platinum luminophores comprising a complex of formula I: The luminophores have application as the emissive component in organic light emitting diodes.
RE43748 Nitrogen-containing heterocyclic carboxamide derivatives or salts thereof and antiviral agents comprising the same  
Nitrogen-containing heterocyclic carboxamide derivatives represented by the following general formula: wherein ring A is a substituted or unsubstituted pyrazine, pyrimidine, pyridazine or triazine...
8258130 Pyrimidine hydrazide compounds as PGDS inhibitors  
This invention is directed to a compound of formula (I): wherein R1, R2, R3, R4 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to...
8242113 Oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone pharmaceutical compositions thereof  
Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic...
8232275 2,2-bis-(hydroxymethyl)cyclopropylidenemethyl-purines and -pyrimidines as antiviral agents  
Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine...
8217168 Azabicyclo [3. 1. 0] hexyl derivatives as modulators of dopamine D3 receptors  
The present invention relates to novel compounds of formula (I) or a salt thereof: wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8-...
8217063 Lactam-substituted dicarboxylic acids and use thereof  
The present application relates to novel lactam-substituted dicarboxylic acid derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their...
8188269 Functionalized compositions for improved immobilization  
The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their...
8178525 FXA inhibitors with cyclic amidoxime or cyclic amidrazone as P4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof  
Disclosed are novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical...
8168786 Radiolabeled compounds and uses thereof  
The present invention relates to Radiolabeled Compounds and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a...
8106193 Luminophores  
There is described novel organo-platinum luminophores comprising a complex of formula (I). The luminophores have application as the emissive component in organic light emitting diodes.