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7615632 |
Crystalline forms of temozolomide
Disclosed are novel crystalline forms of Temozolomide, methods of preparation thereof, medicaments including the novel crystalline forms of Temozolomide, and uses thereof in the treatment of...
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7612202 |
Process for preparing temozolomide
The present invention provides a process for preparing highly pure Temozolomide base which includes recovery from the purification mother liquors by using an anionic exchange resin. By treating...
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7579336 |
Pharmaceutical composition comprising temozolomide ester
The present invention discloses general formula I of Temozolomide-8-carboxylate compounds, the process for preparation, pharmaceutical compositions comprising the compounds and the use of the...
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7531668 |
2-arylcarboxamide-nitrogenous heterocycle compound
A compound represented by the formula [I]:
[wherein R 1 and R 2 are the same or different and each represents C 1-6 alkyl, C 3-8 cycloalkyl, et al; R 3a , R 3b , and R 4 are the same or...
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7498337 |
Acid secretion inhibitor
The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by...
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7446209 |
Synthesis of temozolomide and analogs
This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.
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7329757 |
Substituted iminoazines
The invention relates to novel substituted iminoazines of the general formula (I)
in which
R 1 , R 2 , R 3 , R 4 , Z 1 , Z 2 and Z 3 are each as defined in the disclosure, to a plurality of...
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7329651 |
Cannabimimetic ligands
Disclosed are heterocyclic compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. Also disclosed are methods of using the disclosed...
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7256287 |
Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
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7250512 |
Electroluminescent iridium compounds having red-orange or red emission and devices made with such compounds
The present invention is generally directed to electroluminescent Ir(III) complexes which have emission maxima in the red-orange to red region of the visible spectrum and devices that are made with...
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7238437 |
Light-emitting material comprising orthometalated iridium complex, light-emitting device, high efficiency red light-emitting device, and novel iridium complex
A light-emitting material comprises a compound having a partial structure represented by the following formulas (8), (20) and tautomers thereof:
wherein the variables are as defined in the...
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7230139 |
Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents
The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic...
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7217844 |
Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents
The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic...
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7186843 |
Aminomethylpyrrolidine derivatives having aromatic substituents
This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R...
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7173021 |
Synthesis of temozolomide esters as potent anticancer pro-drugs for topical and transdermal applications in treatments of cancers
This invention relates to the use of temozolomide esters (4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-
carboxylate esters) Formula 1 as potent anticancer pro-drugs for treatment of...
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7087751 |
Synthesis of temozolomide and analogs
This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process.
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7064201 |
Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
Compounds represented by the following structure (I) are disclosed:
as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first...
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7057049 |
Process for making substituted pyrazoles
This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted...
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7052783 |
Oxadiazole tetramers
This invention relates to tetraphenylmethane-based oxadiazole molecules that act as electron transporting materials to be used in electroluminescent devices. The oxadiazole compounds are of the...
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6900213 |
Bisaryl derivatives having FSH modulatory activity
The invention relates to bisaryl derivatives of the formula I,
wherein (R,R) is selected from (H,H), O, (H,CH 3 ), (H,OH) and (H,CN); Ar is substituted phenyl
and A is a group of formula II,...
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6900206 |
Indole, azaindole and related heterocyclic sulfonylureido piperazine derivatives
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with sulfonylureido...
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6852249 |
Prismatic supramolecules
This invention features a supramolecule having the following structures:
M is a transition metal atom that is rhenium (Re), manganese (Mn), chromium (Cr), molybdenum (Mo), tungsten (W), iron...
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6846926 |
Triazolyl-aminotriazine compositions, including salts
The present invention includes a salt compound having the chemical formula:
having a tricyclic structure with the third ring having either six or seven atoms.
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6683028 |
Cyclic guanidine derivatives and their use as pesticides
The invention relates to novel guanidine derivatives of the formula (I) in which A, R 1 , R 2 , R 3 and Z are as defined in the description, to a process for their preparation and to their use...
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6677339 |
Phenylalanine derivatives
Phenylalanine derivatives of formula (1) are described: in which: Ar 1 is an aromatic or heteroaromatic group; L 1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar...
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6673924 |
1,2,4-triazolol&lsqb 4,3-a&rsqb &lsqb 1,3,5&rsqb triazine-3,5,7-substituted precursor, and process, and compounds therefrom
The present invention includes a precursor compound pertaining to a 1,2,4-Triazolo[4,3-a][1,3,5] Triazine compound, particularly a 1,2,4-Triazolo[4,3-a][1,3,5] Triazine-3,5,7-Triamine, and novel...
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6657059 |
3,6BIS(1H-1,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine or salt thereof
The compound 3,6-bis(1H-1,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine and its salts are provided together with a propellant composition including an oxidizer, a binder and...
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6632305 |
1,2,4-triazolo&lsqb 4,3-a&rsqb &lsqb 1,3,5&rsqb triazine-3,5,7-substituted precursor, and process, and compounds therefrom
The present invention includes a precursor compound pertaining to a 1,2,4-Triazolo[4,3-a][1,3,5]Triazine compound, particularly a 1,2,4-Triazolo[4,3-a][1,3,5]Triazine-3,5,7-Triamine, and novel...
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6602889 |
5-heteroaryl substituted indoles
The present invention relates to compounds having general formula (I) as defined herein, or a pharmaceutically acceptable acid addition salt thereof. The compounds are selective α 1 -adrenoceptor...
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6602366 |
Triazolyl-tetrazinyl-aminotriazine compounds useful in pyrotechnic compositions and process thereof
Pyrotechnic compositions use a salt or complex of a triazolyl-tetrazinyl-aminotriazine compound. The general chemical structure of the triazolyl-tetrazinyl-aminotriazine is: with values of the...
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6573262 |
Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
The invention comprises substituted indoleoxoacetic piperazine derivatives of general Formula I, compositions thereof and their use as antiviral agents, and particularly for treating HIV infection.
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6538010 |
Compounds and methods for promoting smoking cessation
Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
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6458227 |
Propellant containing 3;6-BIS(1H-1,2,3,4-Tetrazol-5-ylamino)-1,2,4,5-tetrazine or salts thereof
The compound 3,6-bis(1H-1,2,3,4-tetrazol-5-ylamino)-1,2,4,5-tetrazine and its salts are provided together with a propellant composition including an oxidizer, a binder and...
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6423842 |
Muscarinic agonists and antagonists
The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes...
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6423716 |
Nitrogenous heterocyclic compounds
The present invention relates to nitrogen-containing heterocyclic compounds represented by formula (I): wherein W represents 1,4-piperazinediyl, etc.; U represents NR 1 R 2 (wherein R 1 ...
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6399620 |
Cycloalkyl derivatives as inhibitors of bone resporption and vitronectin receptor antagonists
There are described cycloalkyl derivatives of the formula (I) R 1 —Y—A—B—D—E—F—G (I) in which R 1 , Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and...
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6376428 |
Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production
The dihalopropene compounds of the general formula [I] have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.
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6369084 |
Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
This invention encompasses the novel compounds of formula A, which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester...
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6365598 |
Pyrroloquinolines for treatment of obesity
A chemical compound of formula (I), wherein R 1 to R 3 are independently selected from hydrogen and alkyl; R 4 is selected from hydrogen, alkyl, alkoxy, formyl and cyano; X 1 is selected from N...
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6350759 |
Dihydro- and tetrahydro-quinoline compounds
Compound of formula (I): wherein: R 1 represents hydrogen or wherein A is as defined in the description, R 2 and R 3 each independently represents alkyl, cycloalkyl, heterocycloalkyl,...
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6340679 |
Guanidine derivatives as inhibitors of cell adhesion
The present invention relates to acylguanidine derivatives of the formula I in which R 1 , R 2 , R 4 , Ar, X and n have the meanings indicated in the claims, their physiologically tolerable...
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6297252 |
Imidazo[1,5-c]quinazolines; A new class of GABA brain receptor ligands
Disclosed are compounds of compounds of the formula: ##STR1## or the pharmaceutically acceptable nontoxic salts thereof wherein: X is oxygen, H 2 or sulfur Y is hydrogen, or optionally...
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6162915 |
Process for heterocyclic sulfonyl chloride compounds
Chlorosulfonyl substituted aromatic heterocyclic compounds, such as 2-chlorosulfonyl[1,2,4]triazolo[1,5-c]pyrimidine compounds, were prepared in good yield by chloroxidation of di(aromatic...
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6103731 |
Imidazol[1,5-c]quinazolines; a new class of GABA brain receptor
Disclosed are compounds of compounds of the formula: or the pharmaceutically acceptable nontoxic salts thereof wherein: X is oxygen, H 2 or sulfur Y is hydrogen, or optionally substituted...
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6100252 |
Heterocyclic compounds and their use as angiotensin antagonists
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6093821 |
Process for preparing steroid receptor modulator compounds
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds,...
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6083959 |
Quinoline derivatives, processes for their preparation and their use as medicaments
A compound of the formula: ##STR1## wherein R 1 is lower alkyl, R 2 is hydrogen, lower alkyl or a heterocyclic group, R 3 is hydrogen, lower alkyl or halogen, R 4 is lower alkyl or...
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6075016 |
6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram, with improved selectivity with regard...
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6071913 |
Angiotensin II receptor antagonistic 1,2,4-triazin-5-one derivatives
Disclosed are novel 1,2,4-triazin-5-one biphenyl derivatives having structural formula (I) useful as non-peptide antagonists of angiotensin II receptor: ##STR1## where R 1 represents alkyl,...
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5965496 |
Fluorine-containing compounds and use thereof
A fluorine-containing polyether compound, a lubricant, and a magnetic recording medium comprising the lubricant.
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